Methylthiouracil_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylthiouracil perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylthiouracil_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.174585
MACC1 metastasis associated in colon cancer 1 0.155439
SPTBN1 spectrin, beta, non-erythrocytic 1 0.129188
MYO1E myosin IE 0.0916654
ITGA6 integrin, alpha 6 0.0864514
RUNX1 runt-related transcription factor 1 0.0849982
MBNL2 muscleblind-like splicing regulator 2 0.0832984
EZR ezrin 0.0772434
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0723316
EPS8 epidermal growth factor receptor pathway substrate 8 0.0694406
NAMPT nicotinamide phosphoribosyltransferase 0.0643567
BTBD9 BTB (POZ) domain containing 9 0.0630529
EPSTI1 epithelial stromal interaction 1 (breast) 0.0609253
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.059616
ARHGAP26 Rho GTPase activating protein 26 0.0579812
CCNL1 cyclin L1 0.0578156
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0565779
GMDS GDP-mannose 4,6-dehydratase 0.0565549
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0552014
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0549105
CDHR2 cadherin-related family member 2 0.0529211
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.052869
TRIM2 tripartite motif containing 2 0.0516309
TJP1 tight junction protein 1 0.0515936
ERBIN erbb2 interacting protein 0.0511974
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0505231
TMC5 transmembrane channel-like 5 0.0492342
STK24 serine/threonine kinase 24 0.0490034
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0487624
PTBP3 polypyrimidine tract binding protein 3 0.0487107
AKAP13 A kinase (PRKA) anchor protein 13 0.0484219
SPAG9 sperm associated antigen 9 0.0476975
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0465373
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0457631
PRKCA protein kinase C, alpha 0.0446137
ATXN1 ataxin 1 0.044142
RNF213 ring finger protein 213 0.0440942
LOC102724023 ES1 protein homolog, mitochondrial 0.0440383
ANXA1 annexin A1 0.043948
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0435589
LCN2 lipocalin 2 0.0432211
VMP1 vacuole membrane protein 1 0.0425218
BCLAF1 BCL2-associated transcription factor 1 0.0421098
DSCAM Down syndrome cell adhesion molecule 0.0421093
GCLC glutamate-cysteine ligase, catalytic subunit 0.0418033
SEC31A SEC31 homolog A (S. cerevisiae) 0.0416266
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0405479
MSI2 musashi RNA-binding protein 2 0.0402205
RAB7A RAB7A, member RAS oncogene family 0.0394612
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0392689
ATP11A ATPase, class VI, type 11A 0.0388985
DSPP dentin sialophosphoprotein 0.0387788
ANXA2 annexin A2 0.0386663
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0383999
MEIS2 Meis homeobox 2 0.0382639
SPATA13 spermatogenesis associated 13 0.0379273
ZNF292 zinc finger protein 292 0.0378927
EPHB2 EPH receptor B2 0.0376388
MUC13 mucin 13, cell surface associated 0.0367701
GOLGB1 golgin B1 0.0361662
LPP LIM domain containing preferred translocation partner in lipoma 0.03571
SERINC5 serine incorporator 5 0.034583
OCLN occludin 0.0343812
ETNK1 ethanolamine kinase 1 0.0331984
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0329382
MECOM MDS1 and EVI1 complex locus 0.0329249
RBM39 RNA binding motif protein 39 0.0327777
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0326371
ZNRF3 zinc and ring finger 3 0.0325867
FNIP1 folliculin interacting protein 1 0.0322898
FNDC3B fibronectin type III domain containing 3B 0.0316765
NCKAP5 NCK-associated protein 5 0.0316233
B2M beta-2-microglobulin 0.0316066
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0314059
AHI1 Abelson helper integration site 1 0.0310888
MX2 MX dynamin-like GTPase 2 0.0310695
PRELID2 PRELI domain containing 2 0.0309759
ARHGAP5 Rho GTPase activating protein 5 0.0309437
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0308102
EHF ets homologous factor 0.0300943
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0298536
SPDYA speedy/RINGO cell cycle regulator family member A 0.0293175
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0289039
AOPEP aminopeptidase O (putative) 0.0288863
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0287917
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0287809
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0287014
ASPH aspartate beta-hydroxylase 0.0284129
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0283085
RABGAP1L RAB GTPase activating protein 1-like 0.0282869
SYNE2 spectrin repeat containing, nuclear envelope 2 0.028177
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0280932
EXT1 exostosin glycosyltransferase 1 0.0280371
FOXP1 forkhead box P1 0.0279597
PTK2 protein tyrosine kinase 2 0.0279429
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0279101
TSC22D1 TSC22 domain family, member 1 0.027487
CLTC clathrin, heavy chain (Hc) 0.0272656
PHACTR4 phosphatase and actin regulator 4 0.0271932
UBC ubiquitin C 0.0269945

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.0550611
PHF3 PHD finger protein 3 -0.0489523
PTMA prothymosin, alpha -0.0480679
MUC20 mucin 20, cell surface associated -0.0335774
RPL34 ribosomal protein L34 -0.0334394
RPL35A ribosomal protein L35a -0.0329545
IFI6 interferon, alpha-inducible protein 6 -0.032694
RPS6 ribosomal protein S6 -0.0311485
RPLP1 ribosomal protein, large, P1 -0.029926
RPL23 ribosomal protein L23 -0.0278008
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0274715
RPS19 ribosomal protein S19 -0.0242312
TMSB10 thymosin beta 10 -0.0241223
SMAD3 SMAD family member 3 -0.0239752
MT2A metallothionein 2A -0.0239323
RPS27 ribosomal protein S27 -0.0239258
RPS29 ribosomal protein S29 -0.0238152
PLSCR2 phospholipid scramblase 2 -0.0231781
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0228261
NPSR1 neuropeptide S receptor 1 -0.0213364
TM4SF19 transmembrane 4 L six family member 19 -0.0202398
MPHOSPH8 M-phase phosphoprotein 8 -0.0200837
RPS8 ribosomal protein S8 -0.0198852
RPL37 ribosomal protein L37 -0.0196527
FTL ferritin, light polypeptide -0.0194773
RPS12 ribosomal protein S12 -0.0185003
ACTG1 actin gamma 1 -0.0182815
CSTB cystatin B (stefin B) -0.0181209
LOC112694756 uncharaterized LOC112694756 -0.0178368
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0175752
RPL18 ribosomal protein L18 -0.0174817
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0168978
VCL vinculin -0.0168112
RPL9 ribosomal protein L9 -0.0166453
IFI27 interferon, alpha-inducible protein 27 -0.0165195
RPL11 ribosomal protein L11 -0.0162792
KRT19 keratin 19, type I -0.0162159
RPS24 ribosomal protein S24 -0.0161426
RPL28 ribosomal protein L28 -0.0161095
BICRAL BICRA like chromatin remodeling complex associated protein -0.0158267
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0157981
RPL26 ribosomal protein L26 -0.0156894
RPS3 ribosomal protein S3 -0.015684
RPL13A ribosomal protein L13a -0.0155648
RPL30 ribosomal protein L30 -0.0154592
S100A9 S100 calcium binding protein A9 -0.0148905
RPS20 ribosomal protein S20 -0.0148797
RPL12 ribosomal protein L12 -0.0146663
HMGB1 high mobility group box 1 -0.0146366
USP53 ubiquitin specific peptidase 53 -0.0145451
RACK1 receptor for activated C kinase 1 -0.0144712
WSB1 WD repeat and SOCS box containing 1 -0.0144703
RPL37A ribosomal protein L37a -0.0144427
RPLP2 ribosomal protein, large, P2 -0.0144291
GCC2 GRIP and coiled-coil domain containing 2 -0.0143937
RPS14 ribosomal protein S14 -0.01437
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0143581
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0142676
RPS23 ribosomal protein S23 -0.0141521
ISG15 ISG15 ubiquitin-like modifier -0.0140872
RPL31 ribosomal protein L31 -0.0138904
S100A6 S100 calcium binding protein A6 -0.0138538
CST3 cystatin C -0.013795
INTS6 integrator complex subunit 6 -0.0137427
RPS17 ribosomal protein S17 -0.0136988
RPL38 ribosomal protein L38 -0.0136667
NBR1 neighbor of BRCA1 gene 1 -0.0132792
CTSB cathepsin B -0.0132735
TNS4 tensin 4 -0.0131064
RPL19 ribosomal protein L19 -0.0130377
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0130079
TFF3 trefoil factor 3 (intestinal) -0.0129852
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0129007
HLA-A major histocompatibility complex, class I, A -0.0128608
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0127007
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0125828
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0124622
EFHD2 EF-hand domain family, member D2 -0.0123196
TUT4 terminal uridylyl transferase 4 -0.012083
S100P S100 calcium binding protein P -0.0119143
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0118775
RPL7L1 ribosomal protein L7-like 1 -0.0118226
ZNF106 zinc finger protein 106 -0.0117467
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta -0.0116652
KPNB1 karyopherin (importin) beta 1 -0.0115452
MPRIP myosin phosphatase Rho interacting protein -0.0113956
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0112619
SEC62 SEC62 homolog (S. cerevisiae) -0.011241
FAM162A family with sequence similarity 162, member A -0.0111064
RPS5 ribosomal protein S5 -0.0110983
H1-0 H1.0 linker histone -0.011064
KCNK6 potassium channel, two pore domain subfamily K, member 6 -0.011034
LASP1 LIM and SH3 protein 1 -0.0110242
TTF1 transcription termination factor, RNA polymerase I -0.0109973
RPS4X ribosomal protein S4, X-linked -0.0109445
APOL2 apolipoprotein L, 2 -0.0109364
DYNC2I1 dynein 2 intermediate chain 1 -0.0108734
NHSL3 NHS like 3 -0.0107223
C6ORF62 chromosome 6 open reading frame 62 -0.0106523
TNRC6C trinucleotide repeat containing 6C -0.0106079