Methylthiouracil_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylthiouracil perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylthiouracil_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.353519
FN1 fibronectin 1 0.266149
COL6A3 collagen, type VI, alpha 3 0.150298
NDRG1 N-myc downstream regulated 1 0.148441
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0935299
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0684963
VEGFA vascular endothelial growth factor A 0.0606608
TIMP3 TIMP metallopeptidase inhibitor 3 0.0482632
FTH1 ferritin, heavy polypeptide 1 0.0438148
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0404641
BHLHE40 basic helix-loop-helix family, member e40 0.0404154
ATP13A3 ATPase type 13A3 0.0401237
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.038993
TRIO trio Rho guanine nucleotide exchange factor 0.038574
COL5A1 collagen, type V, alpha 1 0.0362145
CDH13 cadherin 13 0.035978
FBN1 fibrillin 1 0.0357272
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0350936
LOXL2 lysyl oxidase-like 2 0.0334955
CADM1 cell adhesion molecule 1 0.032904
AXL AXL receptor tyrosine kinase 0.0327242
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0291834
POTEF POTE ankyrin domain family, member F 0.0270408
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0267884
P4HB prolyl 4-hydroxylase, beta polypeptide 0.024424
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0229118
GOLGA4 golgin A4 0.022463
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0223372
LOX lysyl oxidase 0.0223104
ANKRD11 ankyrin repeat domain 11 0.021998
PDE10A phosphodiesterase 10A 0.021897
F3 coagulation factor III (thromboplastin, tissue factor) 0.0218216
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0213184
ZFAND3 zinc finger, AN1-type domain 3 0.0196911
ACTG1 actin gamma 1 0.019373
MLF1 myeloid leukemia factor 1 0.0188214
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.018511
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.017723
RND3 Rho family GTPase 3 0.0173884
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0173028
COPA coatomer protein complex, subunit alpha 0.0172948
COL7A1 collagen, type VII, alpha 1 0.0172522
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0172193
B2M beta-2-microglobulin 0.0171948
CALR calreticulin 0.0168453
QKI QKI, KH domain containing, RNA binding 0.0167176
POSTN periostin, osteoblast specific factor 0.0166787
GARS1 glycyl-tRNA synthetase 1 0.0166678
CLINT1 clathrin interactor 1 0.0160518
ANXA1 annexin A1 0.0160348
TSC22D2 TSC22 domain family, member 2 0.0153889
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0152625
CA12 carbonic anhydrase XII 0.0150959
HELZ helicase with zinc finger 0.0150788
MBNL1 muscleblind-like splicing regulator 1 0.0145603
CCNY cyclin Y 0.0142017
FNIP1 folliculin interacting protein 1 0.0139777
SPAG9 sperm associated antigen 9 0.0139379
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0139157
NAMPT nicotinamide phosphoribosyltransferase 0.0137579
DDIT4 DNA-damage-inducible transcript 4 0.0136994
SRP54 signal recognition particle 54kDa 0.013687
KMT2C lysine (K)-specific methyltransferase 2C 0.0135983
SQLE squalene epoxidase 0.0135959
ARF4 ADP-ribosylation factor 4 0.013542
TMED9 transmembrane emp24 protein transport domain containing 9 0.0134823
EEF2 eukaryotic translation elongation factor 2 0.0134816
FXR1 fragile X mental retardation, autosomal homolog 1 0.013317
COL6A2 collagen, type VI, alpha 2 0.0132746
WASF2 WAS protein family, member 2 0.0132468
TTC3 tetratricopeptide repeat domain 3 0.0131387
MAP4 microtubule-associated protein 4 0.0131231
AFF4 AF4/FMR2 family, member 4 0.0131097
TGFBI transforming growth factor, beta-induced, 68kDa 0.0128397
RICTOR RPTOR independent companion of MTOR, complex 2 0.0127721
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0127231
DSTN destrin (actin depolymerizing factor) 0.0126224
GOLGA2 golgin A2 0.0125759
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0124605
PGM3 phosphoglucomutase 3 0.0124061
WAC WW domain containing adaptor with coiled-coil 0.012294
CCNL1 cyclin L1 0.0122396
NBAS neuroblastoma amplified sequence 0.0122225
CD109 CD109 molecule 0.0120217
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0119856
MRPS6 mitochondrial ribosomal protein S6 0.011971
TRPS1 trichorhinophalangeal syndrome I 0.0119442
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0118654
FKBP10 FK506 binding protein 10, 65 kDa 0.0118556
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0118155
GJA1 gap junction protein, alpha 1, 43kDa 0.0117658
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.0115217
HOOK2 hook microtubule-tethering protein 2 0.0115021
RAB2A RAB2A, member RAS oncogene family 0.0114433
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0113247
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0112615
HYOU1 hypoxia up-regulated 1 0.0112613
HIPK1 homeodomain interacting protein kinase 1 0.0111839
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0111182
TRAM2 translocation associated membrane protein 2 0.0110901

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.178844
MT2A metallothionein 2A -0.176946
VIM vimentin -0.157139
TMSB10 thymosin beta 10 -0.110623
ENO1 enolase 1, (alpha) -0.0977648
UBC ubiquitin C -0.081872
CD44 CD44 molecule (Indian blood group) -0.074917
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0663273
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0647008
COL1A1 collagen, type I, alpha 1 -0.0575936
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0519054
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0510433
STC1 stanniocalcin 1 -0.0469659
PTMA prothymosin, alpha -0.0469117
MT1X metallothionein 1X -0.0423547
RPS27A ribosomal protein S27a -0.0419447
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0418786
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0402421
RPL23 ribosomal protein L23 -0.0366795
WWTR1 WW domain containing transcription regulator 1 -0.0362016
TM4SF1 transmembrane 4 L six family member 1 -0.0334141
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0306329
AHNAK AHNAK nucleoprotein -0.0297132
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0294045
RPS8 ribosomal protein S8 -0.0292662
IER3 immediate early response 3 -0.0287487
IFI6 interferon, alpha-inducible protein 6 -0.0285334
INHBA inhibin, beta A -0.0276538
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0271903
LDHA lactate dehydrogenase A -0.0271423
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0264623
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0262409
IGFBP7 insulin-like growth factor binding protein 7 -0.0260756
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0260063
LOC112694756 uncharaterized LOC112694756 -0.0253241
ECE1 endothelin converting enzyme 1 -0.0249928
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0243915
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0239747
S100A9 S100 calcium binding protein A9 -0.0232926
RPS19 ribosomal protein S19 -0.0228476
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0224139
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.02225
PKM pyruvate kinase, muscle -0.0220005
RPL26 ribosomal protein L26 -0.0217339
KLF7 Kruppel-like factor 7 (ubiquitous) -0.021501
ALCAM activated leukocyte cell adhesion molecule -0.0212165
HAS2 hyaluronan synthase 2 -0.0206678
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0201554
RPL36 ribosomal protein L36 -0.0196764
RPLP2 ribosomal protein, large, P2 -0.0195118
S100A10 S100 calcium binding protein A10 -0.0193946
RPL37A ribosomal protein L37a -0.0192972
HLA-B major histocompatibility complex, class I, B -0.0190654
ASPH aspartate beta-hydroxylase -0.0182402
RPS3 ribosomal protein S3 -0.0182384
RPLP1 ribosomal protein, large, P1 -0.0178312
MX2 MX dynamin-like GTPase 2 -0.0177755
SMAD3 SMAD family member 3 -0.0177681
RPL12 ribosomal protein L12 -0.0174088
SAMD9 sterile alpha motif domain containing 9 -0.0169902
RPS12 ribosomal protein S12 -0.016981
RPL19 ribosomal protein L19 -0.0168383
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0167227
PCBP2 poly(rC) binding protein 2 -0.0166463
MTSS1 metastasis suppressor 1 -0.0164017
PDIA4 protein disulfide isomerase family A, member 4 -0.0162902
NAV1 neuron navigator 1 -0.0154477
RPS15 ribosomal protein S15 -0.0153437
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0152471
DUSP6 dual specificity phosphatase 6 -0.0151363
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0146394
KIAA1217 KIAA1217 -0.0144284
TPT1 tumor protein, translationally-controlled 1 -0.0142416
S100A6 S100 calcium binding protein A6 -0.0141551
RPS11 ribosomal protein S11 -0.0141161
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.013768
IL6ST interleukin 6 signal transducer -0.0136699
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0136121
TNIP1 TNFAIP3 interacting protein 1 -0.013555
CD59 CD59 molecule, complement regulatory protein -0.0134485
RPS2 ribosomal protein S2 -0.013172
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0130321
FTL ferritin, light polypeptide -0.0129192
HMGA2 high mobility group AT-hook 2 -0.0128594
ZBTB20 zinc finger and BTB domain containing 20 -0.0128395
RPS13 ribosomal protein S13 -0.0127885
STK17A serine/threonine kinase 17a -0.0126969
RPL8 ribosomal protein L8 -0.012686
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0125744
JUN jun proto-oncogene -0.0125417
IL6 interleukin 6 -0.0125312
RPL35A ribosomal protein L35a -0.0124064
MYO9B myosin IXB -0.0123166
RPL38 ribosomal protein L38 -0.0121985
RPS20 ribosomal protein S20 -0.0121217
RPL31 ribosomal protein L31 -0.012087
RPS5 ribosomal protein S5 -0.0120443
ANGPTL4 angiopoietin-like 4 -0.0119936
GLIS3 GLIS family zinc finger 3 -0.0118995
FBXO32 F-box protein 32 -0.0118146