| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methylthiouracil perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Methylthiouracil_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 0.0847764 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0634854 |
| C3 | complement component 3 | 0.0609723 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0538122 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0538042 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.053321 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0439205 |
| AHSG | alpha-2-HS-glycoprotein | 0.0428044 |
| RPL11 | ribosomal protein L11 | 0.040148 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0400031 |
| VEGFA | vascular endothelial growth factor A | 0.0382281 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0344347 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0337038 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0329292 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.032412 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0316272 |
| A2M | alpha-2-macroglobulin | 0.0315333 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0310546 |
| RPS6 | ribosomal protein S6 | 0.0301662 |
| RPS12 | ribosomal protein S12 | 0.0298607 |
| RPS8 | ribosomal protein S8 | 0.0297541 |
| RPL37A | ribosomal protein L37a | 0.0284913 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0282557 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0265571 |
| TF | transferrin | 0.0260295 |
| TRIM26 | tripartite motif containing 26 | 0.0254705 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0250841 |
| CALR | calreticulin | 0.0248794 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0248235 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0247934 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0246691 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0240995 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0240102 |
| GOLGA4 | golgin A4 | 0.0235659 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.023401 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0232302 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.02245 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.022125 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0215019 |
| QKI | QKI, KH domain containing, RNA binding | 0.02124 |
| RPL5 | ribosomal protein L5 | 0.0211707 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0205757 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0205095 |
| RBM39 | RNA binding motif protein 39 | 0.0204883 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0204458 |
| PCBP2 | poly(rC) binding protein 2 | 0.0204394 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.020306 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0202883 |
| FTL | ferritin, light polypeptide | 0.0200796 |
| CPE | carboxypeptidase E | 0.0200742 |
| RPS3 | ribosomal protein S3 | 0.0199442 |
| CRY1 | cryptochrome circadian clock 1 | 0.0197477 |
| RACK1 | receptor for activated C kinase 1 | 0.0195972 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.0194791 |
| SDC4 | syndecan 4 | 0.0191226 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0189972 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0189318 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0188884 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0186774 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0179324 |
| AFDN | afadin, adherens junction formation factor | 0.01792 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.017894 |
| RPL3 | ribosomal protein L3 | 0.0176107 |
| CFB | complement factor B | 0.0175938 |
| SIK3 | SIK family kinase 3 | 0.0175097 |
| RPL9 | ribosomal protein L9 | 0.0173834 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0171766 |
| RPL31 | ribosomal protein L31 | 0.0171461 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.016843 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0166507 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0166105 |
| KRT8 | keratin 8, type II | 0.0164701 |
| RPS27A | ribosomal protein S27a | 0.0161805 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0161023 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0160248 |
| RPL7A | ribosomal protein L7a | 0.0157521 |
| DTNA | dystrobrevin, alpha | 0.015661 |
| MYO1B | myosin IB | 0.0152658 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0151353 |
| RPL23 | ribosomal protein L23 | 0.0151292 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.014952 |
| RPLP0 | ribosomal protein, large, P0 | 0.0148741 |
| CCN2 | cellular communication network factor 2 | 0.0148282 |
| RPS14 | ribosomal protein S14 | 0.0145942 |
| RPS13 | ribosomal protein S13 | 0.01437 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0143695 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0143431 |
| RPS24 | ribosomal protein S24 | 0.0143288 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0141545 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.014134 |
| MED13L | mediator complex subunit 13-like | 0.0140854 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0140699 |
| RPL34 | ribosomal protein L34 | 0.0139711 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0139577 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0139391 |
| NDRG1 | N-myc downstream regulated 1 | 0.0138894 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0138427 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0138018 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0137888 |
| OLA1 | Obg-like ATPase 1 | 0.0137768 |
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.192555 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.116092 |
| IGF2 | insulin-like growth factor 2 | -0.0985007 |
| EHBP1 | EH domain binding protein 1 | -0.0980521 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0825371 |
| MT2A | metallothionein 2A | -0.074242 |
| GPC6 | glypican 6 | -0.0701305 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0667037 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0611343 |
| FRMD5 | FERM domain containing 5 | -0.0567185 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0461119 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0445107 |
| NPAS2 | neuronal PAS domain protein 2 | -0.040987 |
| ASPH | aspartate beta-hydroxylase | -0.0381084 |
| DST | dystonin | -0.0363967 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0363369 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0322793 |
| TMSB10 | thymosin beta 10 | -0.0316856 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0297679 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.029682 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0296522 |
| RNF213 | ring finger protein 213 | -0.0279847 |
| ATXN1 | ataxin 1 | -0.0275548 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0271996 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0271169 |
| RIGI | RNA sensor RIG-I | -0.0269079 |
| ATP10A | ATPase, class V, type 10A | -0.0263989 |
| FERMT1 | fermitin family member 1 | -0.0244829 |
| RUNX1 | runt-related transcription factor 1 | -0.0229874 |
| CP | ceruloplasmin (ferroxidase) | -0.0221747 |
| VCL | vinculin | -0.0211031 |
| ITGA1 | integrin, alpha 1 | -0.0210244 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0201633 |
| PTCHD4 | patched domain containing 4 | -0.0200508 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0194986 |
| OSMR | oncostatin M receptor | -0.0194035 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0193063 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0191499 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0184306 |
| TPM4 | tropomyosin 4 | -0.0179203 |
| FOXP1 | forkhead box P1 | -0.0176872 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0169983 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0168852 |
| MX2 | MX dynamin-like GTPase 2 | -0.0165451 |
| RNASET2 | ribonuclease T2 | -0.0165057 |
| ENO1 | enolase 1, (alpha) | -0.01621 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0161008 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0157592 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0156615 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0153117 |
| RAI14 | retinoic acid induced 14 | -0.0150456 |
| CNKSR3 | CNKSR family member 3 | -0.0150434 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0148403 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.014532 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.014504 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.014502 |
| ENKUR | enkurin, TRPC channel interacting protein | -0.0144706 |
| NHSL1 | NHS-like 1 | -0.0140937 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0139544 |
| AHNAK | AHNAK nucleoprotein | -0.0136448 |
| PEG3 | paternally expressed 3 | -0.0135447 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0133536 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.013311 |
| VCAN | versican | -0.0132428 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0131904 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.012985 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0127704 |
| MT1X | metallothionein 1X | -0.0125708 |
| TMEM45B | transmembrane protein 45B | -0.0124432 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0122422 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.012139 |
| ARHGAP18 | Rho GTPase activating protein 18 | -0.0120607 |
| TMEM123 | transmembrane protein 123 | -0.0119621 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0118975 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.0116304 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0115913 |
| SVIL | supervillin | -0.0115748 |
| HMGA1 | high mobility group AT-hook 1 | -0.0114959 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0113899 |
| HMGA2 | high mobility group AT-hook 2 | -0.0112513 |
| ACTN1 | actinin, alpha 1 | -0.0112182 |
| FILIP1L | filamin A interacting protein 1-like | -0.0112166 |
| KIAA1217 | KIAA1217 | -0.0111253 |
| BCL2L1 | BCL2-like 1 | -0.0110903 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0110753 |
| RASA2 | RAS p21 protein activator 2 | -0.0109878 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0109487 |
| H1-0 | H1.0 linker histone | -0.0107826 |
| BMERB1 | bMERB domain containing 1 | -0.0107194 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0106837 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0106789 |
| ITGB5 | integrin, beta 5 | -0.0106137 |
| PERP | PERP, TP53 apoptosis effector | -0.0106116 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0104568 |
| PRKCA | protein kinase C, alpha | -0.0104485 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | -0.0104282 |
| MAP1B | microtubule-associated protein 1B | -0.0103721 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0103618 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0103504 |
| RAB3B | RAB3B, member RAS oncogene family | -0.0103021 |
