| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methylthiouracil perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Methylthiouracil_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.322128 |
| TXNRD1 | thioredoxin reductase 1 | 0.247416 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.132564 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0958474 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0897366 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0872569 |
| CES1 | carboxylesterase 1 | 0.0869979 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0838079 |
| MKI67 | marker of proliferation Ki-67 | 0.074324 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0703156 |
| SPAG9 | sperm associated antigen 9 | 0.0699726 |
| NDRG1 | N-myc downstream regulated 1 | 0.0663907 |
| FAM13A | family with sequence similarity 13, member A | 0.0631799 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.059034 |
| ARRDC3 | arrestin domain containing 3 | 0.0555842 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0527581 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0517925 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0508693 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0442229 |
| TES | testin LIM domain protein | 0.0431861 |
| HYOU1 | hypoxia up-regulated 1 | 0.0411486 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0408724 |
| RBM39 | RNA binding motif protein 39 | 0.0406304 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.040429 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0402214 |
| AGO2 | argonaute RISC catalytic component 2 | 0.040072 |
| SUCO | SUN domain containing ossification factor | 0.0397758 |
| CANX | calnexin | 0.0396766 |
| RUNX1 | runt-related transcription factor 1 | 0.0395912 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0394937 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.039005 |
| CCNL1 | cyclin L1 | 0.0385639 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0378659 |
| HDLBP | high density lipoprotein binding protein | 0.0371657 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0368885 |
| SON | SON DNA binding protein | 0.0360839 |
| USP34 | ubiquitin specific peptidase 34 | 0.0359853 |
| TOP1 | topoisomerase (DNA) I | 0.0358982 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0357847 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0354346 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.035098 |
| PCBP2 | poly(rC) binding protein 2 | 0.0344465 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0343851 |
| GRAMD1B | GRAM domain containing 1B | 0.0340947 |
| NGLY1 | N-glycanase 1 | 0.0339802 |
| TMF1 | TATA element modulatory factor 1 | 0.033954 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0338364 |
| ZNF292 | zinc finger protein 292 | 0.0338099 |
| YTHDC1 | YTH domain containing 1 | 0.0336037 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0330593 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0330367 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0329455 |
| FAT1 | FAT atypical cadherin 1 | 0.0324018 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0318764 |
| TMEM165 | transmembrane protein 165 | 0.0315321 |
| SMAD3 | SMAD family member 3 | 0.0310115 |
| GOLGB1 | golgin B1 | 0.030423 |
| JMJD1C | jumonji domain containing 1C | 0.0302704 |
| OGA | O-GlcNAcase | 0.0302211 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0295456 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0292637 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0291289 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | 0.028985 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.028837 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0286858 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0282145 |
| ANO6 | anoctamin 6 | 0.0280449 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0278397 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0278122 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0278122 |
| NPTN | neuroplastin | 0.0274904 |
| UBC | ubiquitin C | 0.0274364 |
| NCKAP1 | NCK-associated protein 1 | 0.027308 |
| HELZ | helicase with zinc finger | 0.0272502 |
| DTNA | dystrobrevin, alpha | 0.0271801 |
| ZNF638 | zinc finger protein 638 | 0.0271701 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0271589 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0271036 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0268825 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0268299 |
| CUL4A | cullin 4A | 0.0267796 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0265901 |
| PAPOLA | poly(A) polymerase alpha | 0.0263777 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0261628 |
| ATP13A3 | ATPase type 13A3 | 0.025848 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0254528 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0253506 |
| RTN4 | reticulon 4 | 0.024841 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.024553 |
| FRYL | FRY-like | 0.0245103 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0244306 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0243961 |
| POTEF | POTE ankyrin domain family, member F | 0.0242356 |
| CCNG2 | cyclin G2 | 0.0242093 |
| COPA | coatomer protein complex, subunit alpha | 0.0240657 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0238247 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0236444 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.023546 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0234892 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0234806 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.168512 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.109453 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0948303 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0906694 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0879423 |
| S100A10 | S100 calcium binding protein A10 | -0.0723278 |
| LAMC2 | laminin, gamma 2 | -0.0691317 |
| INTS6 | integrator complex subunit 6 | -0.0680708 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0648959 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0642628 |
| EFNA5 | ephrin-A5 | -0.0593667 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0587661 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0548915 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0536336 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0513331 |
| PTMA | prothymosin, alpha | -0.0491991 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0451993 |
| STC1 | stanniocalcin 1 | -0.043176 |
| RPS3 | ribosomal protein S3 | -0.0424671 |
| CST3 | cystatin C | -0.0382931 |
| ACTG1 | actin gamma 1 | -0.0371119 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0369743 |
| SP100 | SP100 nuclear antigen | -0.0366004 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0354631 |
| MYO1E | myosin IE | -0.0352825 |
| SEC61G | Sec61 gamma subunit | -0.034476 |
| RPL35A | ribosomal protein L35a | -0.0337511 |
| ASPH | aspartate beta-hydroxylase | -0.031729 |
| KRT7 | keratin 7, type II | -0.0316216 |
| CCND1 | cyclin D1 | -0.0316143 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0310341 |
| EGR1 | early growth response 1 | -0.030537 |
| RPL34 | ribosomal protein L34 | -0.030464 |
| RPS25 | ribosomal protein S25 | -0.0300191 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0295114 |
| RPS24 | ribosomal protein S24 | -0.0294985 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0293462 |
| GNAS | GNAS complex locus | -0.0291495 |
| CUX1 | cut-like homeobox 1 | -0.0289517 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0289403 |
| RPL31 | ribosomal protein L31 | -0.0287205 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0285004 |
| TRIM56 | tripartite motif containing 56 | -0.0282831 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0281852 |
| AREG | amphiregulin | -0.0271714 |
| RPS27A | ribosomal protein S27a | -0.0264256 |
| HOMER1 | homer scaffolding protein 1 | -0.0263047 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0262769 |
| VCL | vinculin | -0.025923 |
| TPM4 | tropomyosin 4 | -0.0257895 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0257558 |
| RPS17 | ribosomal protein S17 | -0.0257397 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0255811 |
| MYO1D | myosin ID | -0.025409 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0247761 |
| KRT18 | keratin 18, type I | -0.0242353 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0240787 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0240771 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0240706 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0234237 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0231292 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0227603 |
| RPL19 | ribosomal protein L19 | -0.0226135 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0225878 |
| RPLP1 | ribosomal protein, large, P1 | -0.0222382 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0222291 |
| FBXO11 | F-box protein 11 | -0.0221992 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0220148 |
| S100A6 | S100 calcium binding protein A6 | -0.02199 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0219591 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0217824 |
| RPS12 | ribosomal protein S12 | -0.0217777 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0217718 |
| RPS29 | ribosomal protein S29 | -0.0217356 |
| KRT19 | keratin 19, type I | -0.0217235 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0213678 |
| PRKCA | protein kinase C, alpha | -0.0212124 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.021186 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0211403 |
| AHNAK | AHNAK nucleoprotein | -0.0210369 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0207888 |
| RPL23 | ribosomal protein L23 | -0.0207206 |
| RPS19 | ribosomal protein S19 | -0.0205538 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0205301 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0204745 |
| LAMB3 | laminin, beta 3 | -0.0204169 |
| IER3 | immediate early response 3 | -0.0201315 |
| S100A9 | S100 calcium binding protein A9 | -0.0200654 |
| RPL37A | ribosomal protein L37a | -0.0199544 |
| SDC4 | syndecan 4 | -0.0198251 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0197238 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0196861 |
| HLA-B | major histocompatibility complex, class I, B | -0.019571 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0191423 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0190774 |
| TNS3 | tensin 3 | -0.0187046 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0186502 |
| BMERB1 | bMERB domain containing 1 | -0.0185339 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | -0.0183917 |
| RPS21 | ribosomal protein S21 | -0.0182818 |
