Methylthiouracil_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylthiouracil perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylthiouracil_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0929589
GRB10 growth factor receptor-bound protein 10 0.0687598
IGFBP3 insulin-like growth factor binding protein 3 0.062272
TRIO trio Rho guanine nucleotide exchange factor 0.0557557
KDM2A lysine (K)-specific demethylase 2A 0.0494415
NAMPT nicotinamide phosphoribosyltransferase 0.0488853
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.04774
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0471699
GOLGA4 golgin A4 0.0434096
ATP13A3 ATPase type 13A3 0.0415253
SOD2 superoxide dismutase 2, mitochondrial 0.0397764
RICTOR RPTOR independent companion of MTOR, complex 2 0.0384238
PDE4D phosphodiesterase 4D, cAMP-specific 0.0370549
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.036983
ZEB2 zinc finger E-box binding homeobox 2 0.0360804
PCBP2 poly(rC) binding protein 2 0.0351198
COPA coatomer protein complex, subunit alpha 0.0343548
SMAD3 SMAD family member 3 0.033583
RBM39 RNA binding motif protein 39 0.032375
HELZ helicase with zinc finger 0.0304533
KMT2C lysine (K)-specific methyltransferase 2C 0.0301933
VMP1 vacuole membrane protein 1 0.0294332
NBAS neuroblastoma amplified sequence 0.0286313
UBA6 ubiquitin-like modifier activating enzyme 6 0.0281633
FAM13A family with sequence similarity 13, member A 0.027853
ITCH itchy E3 ubiquitin protein ligase 0.0277006
SIK3 SIK family kinase 3 0.027341
DOCK5 dedicator of cytokinesis 5 0.0268596
VEGFA vascular endothelial growth factor A 0.0266853
USP34 ubiquitin specific peptidase 34 0.0266782
RUNX2 runt-related transcription factor 2 0.0266304
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0261206
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0253394
NGLY1 N-glycanase 1 0.025082
MEF2A myocyte enhancer factor 2A 0.0249563
PICALM phosphatidylinositol binding clathrin assembly protein 0.0237452
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0236726
SRP54 signal recognition particle 54kDa 0.0236252
FNIP1 folliculin interacting protein 1 0.0234957
STRN3 striatin, calmodulin binding protein 3 0.0234771
OSMR oncostatin M receptor 0.0233407
COG5 component of oligomeric golgi complex 5 0.023313
SEC23A Sec23 homolog A (S. cerevisiae) 0.023286
FTH1 ferritin, heavy polypeptide 1 0.0225112
PRELID2 PRELI domain containing 2 0.0223819
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0222955
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0222796
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0222211
SPAG9 sperm associated antigen 9 0.0221301
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0221271
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0220811
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0220101
KYNU kynureninase 0.0219722
MYH9 myosin, heavy chain 9, non-muscle 0.0218499
BHLHE40 basic helix-loop-helix family, member e40 0.0218045
YME1L1 YME1-like 1 ATPase 0.0214183
PSD3 pleckstrin and Sec7 domain containing 3 0.0213256
RAB8B RAB8B, member RAS oncogene family 0.021271
DST dystonin 0.0211341
MON2 MON2 homolog (S. cerevisiae) 0.0208685
AKAP13 A kinase (PRKA) anchor protein 13 0.0208444
CD109 CD109 molecule 0.0207989
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0207314
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0205217
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0205133
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0204808
SETD5 SET domain containing 5 0.0204084
LOX lysyl oxidase 0.0203341
GPC6 glypican 6 0.0202899
MYO1B myosin IB 0.0202387
WAC WW domain containing adaptor with coiled-coil 0.0197501
RUNX1 runt-related transcription factor 1 0.0197411
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.019458
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0194292
PIAS2 protein inhibitor of activated STAT, 2 0.0193941
SEC31A SEC31 homolog A (S. cerevisiae) 0.0191427
DSCAM Down syndrome cell adhesion molecule 0.0190056
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0187351
ETV6 ets variant 6 0.0185726
ELL2 elongation factor, RNA polymerase II, 2 0.018411
YEATS2 YEATS domain containing 2 0.0183103
SBF2 SET binding factor 2 0.0183013
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0182531
ZNF292 zinc finger protein 292 0.0179051
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0178243
CHD1 chromodomain helicase DNA binding protein 1 0.017806
SUCO SUN domain containing ossification factor 0.0177291
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0171939
TGM2 transglutaminase 2 0.0170439
VEGFC vascular endothelial growth factor C 0.0167773
ZFAND3 zinc finger, AN1-type domain 3 0.016622
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0166018
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0165624
SEC24A SEC24 family member A 0.0165054
ADD3 adducin 3 (gamma) 0.0162971
HDAC9 histone deacetylase 9 0.0162784
IL1R1 interleukin 1 receptor, type I 0.0162194
TP53BP1 tumor protein p53 binding protein 1 0.0160754
PDLIM5 PDZ and LIM domain 5 0.0159984
ANKRD36 ankyrin repeat domain 36 0.0158917

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.2605
VIM vimentin -0.226369
TMSB10 thymosin beta 10 -0.217007
MT2A metallothionein 2A -0.148992
FTL ferritin, light polypeptide -0.125151
RPLP1 ribosomal protein, large, P1 -0.115108
RPL35A ribosomal protein L35a -0.0901686
PTMA prothymosin, alpha -0.0857039
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0789901
RPS19 ribosomal protein S19 -0.0747761
TPT1 tumor protein, translationally-controlled 1 -0.0685233
RPS6 ribosomal protein S6 -0.0625386
RPL31 ribosomal protein L31 -0.0621634
RPLP2 ribosomal protein, large, P2 -0.0618874
RPS29 ribosomal protein S29 -0.0595737
IER3 immediate early response 3 -0.0595065
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0593055
EIF1 eukaryotic translation initiation factor 1 -0.0583289
RPS24 ribosomal protein S24 -0.0572398
RPL34 ribosomal protein L34 -0.0564594
RPS8 ribosomal protein S8 -0.0554556
RPL23 ribosomal protein L23 -0.0543853
RPL32 ribosomal protein L32 -0.0520189
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.051139
RPL37A ribosomal protein L37a -0.0508793
RPS21 ribosomal protein S21 -0.0502436
STC1 stanniocalcin 1 -0.0483575
C15ORF48 chromosome 15 open reading frame 48 -0.0479441
RPL36 ribosomal protein L36 -0.0477831
TFPI2 tissue factor pathway inhibitor 2 -0.0470378
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0449267
S100A10 S100 calcium binding protein A10 -0.044431
RPS13 ribosomal protein S13 -0.0429587
HLA-B major histocompatibility complex, class I, B -0.0427352
RPL12 ribosomal protein L12 -0.0416071
RPS12 ribosomal protein S12 -0.0412748
NAP1L1 nucleosome assembly protein 1-like 1 -0.040965
IFI6 interferon, alpha-inducible protein 6 -0.0402795
RPL11 ribosomal protein L11 -0.0395853
RPL19 ribosomal protein L19 -0.0394547
RPS11 ribosomal protein S11 -0.0379414
RPL38 ribosomal protein L38 -0.0374117
RPS16 ribosomal protein S16 -0.0372664
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0370795
RPL37 ribosomal protein L37 -0.0369617
ENO1 enolase 1, (alpha) -0.0363649
RPS23 ribosomal protein S23 -0.0357772
RPS3 ribosomal protein S3 -0.0355693
RPL28 ribosomal protein L28 -0.0354153
RPS25 ribosomal protein S25 -0.0348265
S100A6 S100 calcium binding protein A6 -0.0347373
RPLP0 ribosomal protein, large, P0 -0.0344764
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0338872
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0331167
RPL9 ribosomal protein L9 -0.032728
IFITM3 interferon induced transmembrane protein 3 -0.0320602
B2M beta-2-microglobulin -0.0320325
RPL5 ribosomal protein L5 -0.0313177
RPS27 ribosomal protein S27 -0.0309995
HMGA1 high mobility group AT-hook 1 -0.0291906
PKM pyruvate kinase, muscle -0.0285092
RPS5 ribosomal protein S5 -0.0283676
RPS17 ribosomal protein S17 -0.0279555
NDRG1 N-myc downstream regulated 1 -0.0270842
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0270363
TM4SF1 transmembrane 4 L six family member 1 -0.0269566
VDAC1 voltage-dependent anion channel 1 -0.0267709
ANGPTL4 angiopoietin-like 4 -0.0266535
SLC38A1 solute carrier family 38, member 1 -0.0265199
RPL7A ribosomal protein L7a -0.0265057
RPL30 ribosomal protein L30 -0.0263955
CDH13 cadherin 13 -0.0263652
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0261976
SEC61G Sec61 gamma subunit -0.0260418
S100A9 S100 calcium binding protein A9 -0.0259062
BTG1 B-cell translocation gene 1, anti-proliferative -0.0258548
RPL26 ribosomal protein L26 -0.0257292
IFIH1 interferon induced with helicase C domain 1 -0.025695
RACK1 receptor for activated C kinase 1 -0.0251982
RPL15 ribosomal protein L15 -0.0250862
RPL13A ribosomal protein L13a -0.0247997
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0246968
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0245168
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0243852
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0242468
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0241443
WSB1 WD repeat and SOCS box containing 1 -0.0239132
RPS20 ribosomal protein S20 -0.0236731
RPS10 ribosomal protein S10 -0.0234889
EGR1 early growth response 1 -0.0234745
TMSB4X thymosin beta 4, X-linked -0.0233124
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0232598
RPL27A ribosomal protein L27a -0.0230394
GNAS GNAS complex locus -0.0229659
HLA-A major histocompatibility complex, class I, A -0.0226512
RPS27A ribosomal protein S27a -0.0224394
ACTG1 actin gamma 1 -0.0221774
LOC102724023 ES1 protein homolog, mitochondrial -0.0221342
LDHA lactate dehydrogenase A -0.0219594
RPS15 ribosomal protein S15 -0.0219206