Methylthiouracil_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylthiouracil perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylthiouracil_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.123419
RPS4Y1 ribosomal protein S4, Y-linked 1 0.119634
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.119106
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.118322
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.097721
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0966771
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0906417
TXNRD1 thioredoxin reductase 1 0.0860543
APP amyloid beta (A4) precursor protein 0.0817201
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0807894
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0803535
FMNL2 formin-like 2 0.0763713
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0728732
ACTG1 actin gamma 1 0.0721062
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0691651
CAVIN1 caveolae associated protein 1 0.0663143
FLNB filamin B, beta 0.0653849
EEF2 eukaryotic translation elongation factor 2 0.064392
ZFAND3 zinc finger, AN1-type domain 3 0.0613898
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.060848
PTK2 protein tyrosine kinase 2 0.057581
COPA coatomer protein complex, subunit alpha 0.0564703
MACF1 microtubule-actin crosslinking factor 1 0.0553098
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0551889
ERBIN erbb2 interacting protein 0.0551283
FOS FBJ murine osteosarcoma viral oncogene homolog 0.055033
DOCK4 dedicator of cytokinesis 4 0.0539566
FGB fibrinogen beta chain 0.0536538
EIF4A3 eukaryotic translation initiation factor 4A3 0.0505355
ANXA1 annexin A1 0.0504368
TM4SF1 transmembrane 4 L six family member 1 0.0502439
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0500628
ANXA2 annexin A2 0.0487623
RBM39 RNA binding motif protein 39 0.0483825
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0482467
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0475765
USP3 ubiquitin specific peptidase 3 0.0474774
KDM3A lysine (K)-specific demethylase 3A 0.0469315
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0465398
SLC38A2 solute carrier family 38, member 2 0.0461803
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0456798
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0456222
CALR calreticulin 0.0451609
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0447615
WAC WW domain containing adaptor with coiled-coil 0.0445838
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0441186
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.043962
LDHA lactate dehydrogenase A 0.043897
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0431305
RBM25 RNA binding motif protein 25 0.0426626
POTEF POTE ankyrin domain family, member F 0.0423149
SLC38A1 solute carrier family 38, member 1 0.0418046
SIK3 SIK family kinase 3 0.0415738
EIF1 eukaryotic translation initiation factor 1 0.0414486
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0411379
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0408098
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0407452
IQGAP1 IQ motif containing GTPase activating protein 1 0.0404288
TRIO trio Rho guanine nucleotide exchange factor 0.04006
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0400544
RICTOR RPTOR independent companion of MTOR, complex 2 0.0397486
PUM1 pumilio RNA-binding family member 1 0.0397459
TPD52 tumor protein D52 0.0397353
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0379857
TRA2A transformer 2 alpha homolog (Drosophila) 0.0379846
VDAC1 voltage-dependent anion channel 1 0.0379608
RAB1A RAB1A, member RAS oncogene family 0.0378224
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0376162
CYRIB CYFIP related Rac1 interactor B 0.0372146
FAM107B family with sequence similarity 107, member B 0.0372073
GLG1 golgi glycoprotein 1 0.0371897
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0367081
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0366183
CFDP1 craniofacial development protein 1 0.0364911
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0362372
RASAL2 RAS protein activator like 2 0.0362079
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0360262
MTMR3 myotubularin related protein 3 0.0352365
EXT1 exostosin glycosyltransferase 1 0.0350997
PARD3 par-3 family cell polarity regulator 0.0350956
NOP58 NOP58 ribonucleoprotein 0.0350483
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0349279
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0345782
WIPF2 WAS/WASL interacting protein family, member 2 0.034326
UBAP2L ubiquitin associated protein 2-like 0.0343091
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.034237
FNBP1L formin binding protein 1-like 0.0338661
BIRC6 baculoviral IAP repeat containing 6 0.0331715
FTL ferritin, light polypeptide 0.0331138
LPP LIM domain containing preferred translocation partner in lipoma 0.0331021
TPM3 tropomyosin 3 0.0330696
BRD2 bromodomain containing 2 0.032826
DST dystonin 0.0326459
SVIL supervillin 0.0325066
SEC31A SEC31 homolog A (S. cerevisiae) 0.0324722
ANKRD11 ankyrin repeat domain 11 0.032219
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0320961
MARCHF6 membrane associated ring-CH-type finger 6 0.0320769
IFRD1 interferon-related developmental regulator 1 0.0320386
CYTH1 cytohesin 1 0.0318449

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.222852
MT2A metallothionein 2A -0.203003
PDE4D phosphodiesterase 4D, cAMP-specific -0.189647
PM20D1 peptidase M20 domain containing 1 -0.135989
RPLP1 ribosomal protein, large, P1 -0.0676354
RPS19 ribosomal protein S19 -0.0616847
RPS2 ribosomal protein S2 -0.0567083
RPS21 ribosomal protein S21 -0.0505813
RPL23 ribosomal protein L23 -0.0502292
AKAP12 A kinase (PRKA) anchor protein 12 -0.0496843
WWOX WW domain containing oxidoreductase -0.0462059
RPL19 ribosomal protein L19 -0.043197
RPS12 ribosomal protein S12 -0.0425836
RPL37A ribosomal protein L37a -0.0407412
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0405038
RPS29 ribosomal protein S29 -0.0381302
RPL36 ribosomal protein L36 -0.0380324
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0379202
RPS17 ribosomal protein S17 -0.0364439
RPL28 ribosomal protein L28 -0.0356824
RPS27A ribosomal protein S27a -0.0328841
RPS23 ribosomal protein S23 -0.0319105
ATP5F1E ATP synthase F1 subunit epsilon -0.0308643
RPS27 ribosomal protein S27 -0.0307926
RPS6 ribosomal protein S6 -0.0301083
RPS25 ribosomal protein S25 -0.0292907
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0285471
RPL9 ribosomal protein L9 -0.0282119
UQCRB ubiquinol-cytochrome c reductase binding protein -0.027795
RPS8 ribosomal protein S8 -0.0262215
PFN1 profilin 1 -0.0261462
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0260628
RPS11 ribosomal protein S11 -0.0250126
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0244913
RPL36A ribosomal protein L36a -0.0241209
GRAMD1B GRAM domain containing 1B -0.0239514
RPL18 ribosomal protein L18 -0.0231332
PFDN2 prefoldin subunit 2 -0.0224255
ASTN2 astrotactin 2 -0.0214723
ANKRD12 ankyrin repeat domain 12 -0.0207716
RPLP2 ribosomal protein, large, P2 -0.0203463
S100A11 S100 calcium binding protein A11 -0.0201551
SMOC1 SPARC related modular calcium binding 1 -0.0199328
RPS14 ribosomal protein S14 -0.0199021
MKI67 marker of proliferation Ki-67 -0.0197365
RPL5 ribosomal protein L5 -0.0195708
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0189036
RPL12 ribosomal protein L12 -0.0185943
UBXN4 UBX domain protein 4 -0.0185403
C15ORF48 chromosome 15 open reading frame 48 -0.0183127
ROMO1 reactive oxygen species modulator 1 -0.0181645
RPL27 ribosomal protein L27 -0.0181607
RPL31 ribosomal protein L31 -0.0178834
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa -0.0178549
RPL32 ribosomal protein L32 -0.0174501
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0174192
RAD51B RAD51 paralog B -0.0173439
RPL37 ribosomal protein L37 -0.0172463
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0171163
EPGN epithelial mitogen -0.0169157
PDE10A phosphodiesterase 10A -0.0168986
RPL38 ribosomal protein L38 -0.0168719
RPL35 ribosomal protein L35 -0.0168028
RPS20 ribosomal protein S20 -0.0167559
RPL36AL ribosomal protein L36a-like -0.0167361
RPS15 ribosomal protein S15 -0.0166227
CKLF chemokine-like factor -0.0165252
EHBP1 EH domain binding protein 1 -0.0163957
PTMS parathymosin -0.0159216
CENPF centromere protein F, 350/400kDa -0.0157523
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0155713
CNRIP1 cannabinoid receptor interacting protein 1 -0.0155263
LAMA5 laminin, alpha 5 -0.0154514
PABPN1 poly(A) binding protein, nuclear 1 -0.0154041
CBX3 chromobox homolog 3 -0.0153137
SERF2 small EDRK-rich factor 2 -0.0151869
RPL21 ribosomal protein L21 -0.0150293
RPS18 ribosomal protein S18 -0.01498
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0149454
RPS13 ribosomal protein S13 -0.0148265
COX6C cytochrome c oxidase subunit VIc -0.0145136
PRKN parkin RBR E3 ubiquitin protein ligase -0.0144981
RSPO3 R-spondin 3 -0.0144343
RPL23A ribosomal protein L23a -0.0143671
RPL30 ribosomal protein L30 -0.0143199
ALCAM activated leukocyte cell adhesion molecule -0.0141183
RPL35A ribosomal protein L35a -0.0139431
MGST1 microsomal glutathione S-transferase 1 -0.0137512
MT1X metallothionein 1X -0.0136317
CDCP1 CUB domain containing protein 1 -0.0134738
MRPL33 mitochondrial ribosomal protein L33 -0.0134537
EGR1 early growth response 1 -0.0134505
BPTF bromodomain PHD finger transcription factor -0.0134079
PRELID2 PRELI domain containing 2 -0.0133103
ATP5MK ATP synthase membrane subunit k -0.0133095
TCEAL4 transcription elongation factor A (SII)-like 4 -0.0132534
GPC6 glypican 6 -0.0131981
COX7C cytochrome c oxidase subunit VIIc -0.0131138
AREG amphiregulin -0.0130844
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0130156