Methylthiouracil_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylthiouracil perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylthiouracil_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.0978546
ZCCHC7 zinc finger, CCHC domain containing 7 0.0772349
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0639283
COPA coatomer protein complex, subunit alpha 0.0628603
CCNL1 cyclin L1 0.0616779
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0604304
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0585203
RICTOR RPTOR independent companion of MTOR, complex 2 0.0573236
EGR1 early growth response 1 0.0498488
POTEF POTE ankyrin domain family, member F 0.0465509
USP34 ubiquitin specific peptidase 34 0.0451742
TXNRD1 thioredoxin reductase 1 0.0450639
UBE2H ubiquitin-conjugating enzyme E2H 0.0441577
JMJD1C jumonji domain containing 1C 0.0427911
RAB7A RAB7A, member RAS oncogene family 0.0417326
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0398986
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0391279
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0382515
CSNK1A1 casein kinase 1, alpha 1 0.0374719
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0368456
EXT1 exostosin glycosyltransferase 1 0.0362493
VMP1 vacuole membrane protein 1 0.0330471
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0329841
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0316936
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0308224
CLTC clathrin, heavy chain (Hc) 0.0300121
NUP58 nucleoporin 58 0.0297104
NDRG1 N-myc downstream regulated 1 0.0297051
ANXA5 annexin A5 0.0284476
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0279925
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0279635
WDR43 WD repeat domain 43 0.02772
ARF4 ADP-ribosylation factor 4 0.0267515
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0260211
CRY1 cryptochrome circadian clock 1 0.0257308
SND1 staphylococcal nuclease and tudor domain containing 1 0.0251949
BBX bobby sox homolog (Drosophila) 0.0250533
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0245945
GOLT1B golgi transport 1B 0.0244834
FMNL2 formin-like 2 0.0243645
ZFAND3 zinc finger, AN1-type domain 3 0.023985
SEPTIN2 septin 2 0.0238853
NCKAP1 NCK-associated protein 1 0.0236053
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0234862
IGF2 insulin-like growth factor 2 0.023435
MEMO1 mediator of cell motility 1 0.0229351
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0228356
PYGL phosphorylase, glycogen, liver 0.0228183
PTK2 protein tyrosine kinase 2 0.022606
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0225998
PHF21A PHD finger protein 21A 0.0225993
CAMKMT calmodulin-lysine N-methyltransferase 0.0225468
ANO6 anoctamin 6 0.0224694
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0222662
WNK1 WNK lysine deficient protein kinase 1 0.0222643
GPHN gephyrin 0.0222141
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0221979
NABP1 nucleic acid binding protein 1 0.0220606
ADAR adenosine deaminase, RNA-specific 0.0219025
MLF1 myeloid leukemia factor 1 0.0217554
AKAP9 A kinase (PRKA) anchor protein 9 0.0217477
BLTP1 bridge-like lipid transfer protein family member 1 0.0215931
ATXN2 ataxin 2 0.0215782
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0215004
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.021431
TMEM39A transmembrane protein 39A 0.0213649
CPNE1 copine I 0.0213378
ADAM17 ADAM metallopeptidase domain 17 0.0211005
PRPF8 pre-mRNA processing factor 8 0.0210876
BRD2 bromodomain containing 2 0.0210009
HIPK1 homeodomain interacting protein kinase 1 0.0209392
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0208494
TAS2R14 taste receptor, type 2, member 14 0.0208209
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0207922
UBA6 ubiquitin-like modifier activating enzyme 6 0.0207896
NCAPG2 non-SMC condensin II complex, subunit G2 0.0207591
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0207129
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0204194
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0204069
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0201049
MSN moesin 0.0200787
TFG TRK-fused gene 0.0200678
SEC31A SEC31 homolog A (S. cerevisiae) 0.0200613
SNX27 sorting nexin family member 27 0.0199751
MED13L mediator complex subunit 13-like 0.0199005
AFF3 AF4/FMR2 family, member 3 0.019689
ASXL2 additional sex combs like transcriptional regulator 2 0.0196832
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0196558
SRRM2 serine/arginine repetitive matrix 2 0.0195984
PDE4D phosphodiesterase 4D, cAMP-specific 0.0195714
QKI QKI, KH domain containing, RNA binding 0.0194336
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0194065
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.019391
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0192664
SUCO SUN domain containing ossification factor 0.0191613
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0189125
SPRED2 sprouty-related, EVH1 domain containing 2 0.0189076
HELZ helicase with zinc finger 0.0189039
SREBF2 sterol regulatory element binding transcription factor 2 0.0187889
SRP54 signal recognition particle 54kDa 0.0187289

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.167317
TFPI2 tissue factor pathway inhibitor 2 -0.146791
RPS27A ribosomal protein S27a -0.13112
UBC ubiquitin C -0.127709
PTMA prothymosin, alpha -0.114296
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.112512
RPL23 ribosomal protein L23 -0.10639
VIM vimentin -0.0943033
RPS3 ribosomal protein S3 -0.0921149
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.079323
RPS8 ribosomal protein S8 -0.073521
RPL26 ribosomal protein L26 -0.067618
AHNAK AHNAK nucleoprotein -0.0675506
RPS29 ribosomal protein S29 -0.0598207
ENO1 enolase 1, (alpha) -0.0550656
RPL37 ribosomal protein L37 -0.0541103
RPS27 ribosomal protein S27 -0.0529468
RPS12 ribosomal protein S12 -0.052732
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0513587
RPS21 ribosomal protein S21 -0.0480816
RPS19 ribosomal protein S19 -0.0475168
RPLP1 ribosomal protein, large, P1 -0.0474765
RPL5 ribosomal protein L5 -0.0460707
RPL19 ribosomal protein L19 -0.0456714
MYL12B myosin, light chain 12B, regulatory -0.0455434
RPL37A ribosomal protein L37a -0.0450614
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0432259
RPL12 ribosomal protein L12 -0.0422174
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0416338
TPT1 tumor protein, translationally-controlled 1 -0.0399484
TM4SF1 transmembrane 4 L six family member 1 -0.0397143
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0396753
RPLP2 ribosomal protein, large, P2 -0.0389564
RPL31 ribosomal protein L31 -0.0388753
RPL36 ribosomal protein L36 -0.0382922
CAVIN1 caveolae associated protein 1 -0.0379236
RPS17 ribosomal protein S17 -0.0364212
RPL38 ribosomal protein L38 -0.0362648
SET SET nuclear proto-oncogene -0.0348528
RPS10 ribosomal protein S10 -0.0347334
RPL27 ribosomal protein L27 -0.0346444
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0336564
RPL34 ribosomal protein L34 -0.0328757
BASP1 brain abundant, membrane attached signal protein 1 -0.0325421
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0312533
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0307912
RPS15 ribosomal protein S15 -0.0304525
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0303321
IFI6 interferon, alpha-inducible protein 6 -0.0302968
RPL36A ribosomal protein L36a -0.0300181
RPL9 ribosomal protein L9 -0.0294858
RPL28 ribosomal protein L28 -0.029432
RPS4X ribosomal protein S4, X-linked -0.0292918
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E -0.029101
TPM2 tropomyosin 2 (beta) -0.0290162
ATP5F1E ATP synthase F1 subunit epsilon -0.0288916
RPL8 ribosomal protein L8 -0.0286975
LOC112694756 uncharaterized LOC112694756 -0.0284375
RPL35 ribosomal protein L35 -0.0276518
PRRC2C proline-rich coiled-coil 2C -0.0274487
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0261365
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0261141
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0260866
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0260034
PCBP2 poly(rC) binding protein 2 -0.0260018
LDHB lactate dehydrogenase B -0.0259087
EEF1G eukaryotic translation elongation factor 1 gamma -0.0250123
HMGB2 high mobility group box 2 -0.0248922
RPS25 ribosomal protein S25 -0.0246439
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.024639
S100A6 S100 calcium binding protein A6 -0.0243959
FTL ferritin, light polypeptide -0.0239695
RPL18 ribosomal protein L18 -0.0234659
RPL32 ribosomal protein L32 -0.0234188
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0234053
PLCB4 phospholipase C, beta 4 -0.0229831
YBX1 Y box binding protein 1 -0.0228973
SFPQ splicing factor proline/glutamine-rich -0.0228465
RPL11 ribosomal protein L11 -0.0226256
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -0.0226197
NAP1L1 nucleosome assembly protein 1-like 1 -0.0226037
BLTP2 bridge-like lipid transfer protein family member 2 -0.0222895
HLA-B major histocompatibility complex, class I, B -0.0220543
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.021932
APP amyloid beta (A4) precursor protein -0.0218755
RRM2 ribonucleotide reductase M2 -0.0218029
RPS23 ribosomal protein S23 -0.0215237
RPL35A ribosomal protein L35a -0.0213784
RPS14 ribosomal protein S14 -0.021376
RPS13 ribosomal protein S13 -0.0213449
RIMS2 regulating synaptic membrane exocytosis 2 -0.0212905
RPL30 ribosomal protein L30 -0.0212319
CDK12 cyclin-dependent kinase 12 -0.0211681
RPL4 ribosomal protein L4 -0.0211551
EIF5B eukaryotic translation initiation factor 5B -0.0208914
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0208712
RPS11 ribosomal protein S11 -0.020533
CCND2 cyclin D2 -0.0203504
CCND1 cyclin D1 -0.0202534
NACA nascent polypeptide-associated complex alpha subunit -0.0202344