Methylthiouracil_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylthiouracil perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylthiouracil_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.157459
FNDC3B fibronectin type III domain containing 3B 0.143427
POTEF POTE ankyrin domain family, member F 0.12723
TRIO trio Rho guanine nucleotide exchange factor 0.116297
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.101651
NDRG1 N-myc downstream regulated 1 0.100838
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0802957
TSC22D2 TSC22 domain family, member 2 0.075496
ERBIN erbb2 interacting protein 0.0704761
GRB10 growth factor receptor-bound protein 10 0.0656768
ASPH aspartate beta-hydroxylase 0.0625268
MYO6 myosin VI 0.0609349
SAMD4A sterile alpha motif domain containing 4A 0.0598646
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0591381
ELL2 elongation factor, RNA polymerase II, 2 0.0563275
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0553755
ADAM9 ADAM metallopeptidase domain 9 0.0551793
COPA coatomer protein complex, subunit alpha 0.0543775
LPP LIM domain containing preferred translocation partner in lipoma 0.0525006
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0513782
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0501487
LIMCH1 LIM and calponin homology domains 1 0.049708
PTK2 protein tyrosine kinase 2 0.0495224
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0490577
FAM13A family with sequence similarity 13, member A 0.046867
ITCH itchy E3 ubiquitin protein ligase 0.0456667
EFNA5 ephrin-A5 0.0450274
DSCAM Down syndrome cell adhesion molecule 0.0448886
AKAP13 A kinase (PRKA) anchor protein 13 0.0443307
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0440575
MACF1 microtubule-actin crosslinking factor 1 0.0433178
MYH9 myosin, heavy chain 9, non-muscle 0.042918
CCNL1 cyclin L1 0.0419983
FLNB filamin B, beta 0.0415695
LMO7 LIM domain 7 0.0412758
NPEPPS aminopeptidase puromycin sensitive 0.0409633
TMF1 TATA element modulatory factor 1 0.0405352
MBNL1 muscleblind-like splicing regulator 1 0.0405352
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0404525
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0398651
RCOR1 REST corepressor 1 0.0397708
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0394927
PDLIM5 PDZ and LIM domain 5 0.0393804
KDM6A lysine (K)-specific demethylase 6A 0.0393653
STRN3 striatin, calmodulin binding protein 3 0.0387918
KMT2E lysine (K)-specific methyltransferase 2E 0.0386496
SEC23A Sec23 homolog A (S. cerevisiae) 0.0381299
MYO5B myosin VB 0.037932
KMT2C lysine (K)-specific methyltransferase 2C 0.0375012
IGFBP3 insulin-like growth factor binding protein 3 0.0373765
UBA6 ubiquitin-like modifier activating enzyme 6 0.0373757
RICTOR RPTOR independent companion of MTOR, complex 2 0.037094
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0369868
NAV2 neuron navigator 2 0.036422
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0360956
FAM3C family with sequence similarity 3, member C 0.0355342
APLP2 amyloid beta (A4) precursor-like protein 2 0.035392
ARRDC3 arrestin domain containing 3 0.0353094
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0343783
CD109 CD109 molecule 0.034257
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0340601
RNF145 ring finger protein 145 0.0338522
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0338433
ERRFI1 ERBB receptor feedback inhibitor 1 0.0337464
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0336784
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0336375
EXT1 exostosin glycosyltransferase 1 0.0335124
MSN moesin 0.0333455
HELZ helicase with zinc finger 0.0332812
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0332625
ALCAM activated leukocyte cell adhesion molecule 0.032991
JMJD1C jumonji domain containing 1C 0.0329338
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0325568
LAMC2 laminin, gamma 2 0.0321494
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0317746
CDC73 cell division cycle 73 0.0313234
ZFAND3 zinc finger, AN1-type domain 3 0.0308708
NAMPT nicotinamide phosphoribosyltransferase 0.0308525
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0307927
SGMS2 sphingomyelin synthase 2 0.0306511
MARCHF6 membrane associated ring-CH-type finger 6 0.0306019
RBM39 RNA binding motif protein 39 0.0300966
USP9X ubiquitin specific peptidase 9, X-linked 0.0297419
EZR ezrin 0.0296808
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.029473
UBE2H ubiquitin-conjugating enzyme E2H 0.0287669
TFG TRK-fused gene 0.0287504
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0286255
SMAD3 SMAD family member 3 0.0285735
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0284668
TPM3 tropomyosin 3 0.0284459
RASA2 RAS p21 protein activator 2 0.0283551
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0283507
VEGFA vascular endothelial growth factor A 0.0282889
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0281742
IQGAP1 IQ motif containing GTPase activating protein 1 0.028138
RUNX1 runt-related transcription factor 1 0.0281367
PPARD peroxisome proliferator-activated receptor delta 0.0280024
ZNF148 zinc finger protein 148 0.0279966
YTHDC1 YTH domain containing 1 0.0279596

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.23877
PTMA prothymosin, alpha -0.205395
TMSB10 thymosin beta 10 -0.15467
TPT1 tumor protein, translationally-controlled 1 -0.120676
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111792
RPL35A ribosomal protein L35a -0.109045
RPLP1 ribosomal protein, large, P1 -0.0981295
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0924081
RPL34 ribosomal protein L34 -0.0742237
RPS8 ribosomal protein S8 -0.0719336
RPS29 ribosomal protein S29 -0.0713379
RPL23 ribosomal protein L23 -0.068906
RPLP2 ribosomal protein, large, P2 -0.0656582
ACTG1 actin gamma 1 -0.0647312
RPS19 ribosomal protein S19 -0.0638604
EIF1 eukaryotic translation initiation factor 1 -0.0623473
RPS3 ribosomal protein S3 -0.0606963
ISG15 ISG15 ubiquitin-like modifier -0.057994
RPS6 ribosomal protein S6 -0.0579221
IFI27 interferon, alpha-inducible protein 27 -0.0570516
RPL37A ribosomal protein L37a -0.0561133
S100A10 S100 calcium binding protein A10 -0.0560133
RPS13 ribosomal protein S13 -0.0554082
RPS23 ribosomal protein S23 -0.0533261
RPL8 ribosomal protein L8 -0.0522454
MT2A metallothionein 2A -0.0509357
RPL9 ribosomal protein L9 -0.048737
RPS27A ribosomal protein S27a -0.0483893
RPL12 ribosomal protein L12 -0.0461233
IFI6 interferon, alpha-inducible protein 6 -0.0451859
S100A6 S100 calcium binding protein A6 -0.0449491
RPS27 ribosomal protein S27 -0.0437435
IFITM3 interferon induced transmembrane protein 3 -0.043229
RPS14 ribosomal protein S14 -0.0430523
G0S2 G0/G1 switch 2 -0.0425771
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0423131
RPL31 ribosomal protein L31 -0.0418919
RPS10 ribosomal protein S10 -0.0406139
RPS25 ribosomal protein S25 -0.0385888
RPS17 ribosomal protein S17 -0.0373384
RPL38 ribosomal protein L38 -0.0371943
RPL28 ribosomal protein L28 -0.0370282
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0366394
RPL36 ribosomal protein L36 -0.0364573
CSTB cystatin B (stefin B) -0.0362015
RPL37 ribosomal protein L37 -0.0359502
RPL19 ribosomal protein L19 -0.0353945
RPS21 ribosomal protein S21 -0.0349831
RPS24 ribosomal protein S24 -0.0346246
HLA-B major histocompatibility complex, class I, B -0.0342972
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0338511
RPS12 ribosomal protein S12 -0.0336069
RACK1 receptor for activated C kinase 1 -0.0332538
RPL32 ribosomal protein L32 -0.0325672
RPL15 ribosomal protein L15 -0.0315077
RPL11 ribosomal protein L11 -0.0311361
RPS16 ribosomal protein S16 -0.0310632
UQCRB ubiquinol-cytochrome c reductase binding protein -0.030336
RPL36A ribosomal protein L36a -0.0295268
VIM vimentin -0.0290052
RPL27A ribosomal protein L27a -0.0289525
C15ORF48 chromosome 15 open reading frame 48 -0.0287982
RPS15 ribosomal protein S15 -0.0284994
RPS11 ribosomal protein S11 -0.027552
RPS20 ribosomal protein S20 -0.0272053
UPP1 uridine phosphorylase 1 -0.0269385
RPLP0 ribosomal protein, large, P0 -0.0268394
WSB1 WD repeat and SOCS box containing 1 -0.0263021
IFITM1 interferon induced transmembrane protein 1 -0.0250384
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0248699
RPL35 ribosomal protein L35 -0.0242949
RPL26 ribosomal protein L26 -0.0242787
RPL30 ribosomal protein L30 -0.024051
RPL7A ribosomal protein L7a -0.0236642
RPL27 ribosomal protein L27 -0.023506
IFI16 interferon, gamma-inducible protein 16 -0.0233054
MDK midkine (neurite growth-promoting factor 2) -0.0228607
HMGB1 high mobility group box 1 -0.0228377
HMGB2 high mobility group box 2 -0.0227591
GNAS GNAS complex locus -0.0224329
CD63 CD63 molecule -0.0223805
S100A11 S100 calcium binding protein A11 -0.0223035
PHLDA2 pleckstrin homology-like domain, family A, member 2 -0.0220972
RPS5 ribosomal protein S5 -0.0220028
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0219504
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0216929
HSPB1 heat shock 27kDa protein 1 -0.0214403
HMGA1 high mobility group AT-hook 1 -0.0212618
ATP5F1E ATP synthase F1 subunit epsilon -0.0211827
KPNB1 karyopherin (importin) beta 1 -0.0209881
IFIH1 interferon induced with helicase C domain 1 -0.02024
RPL13A ribosomal protein L13a -0.0201999
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.020198
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0201575
COX7C cytochrome c oxidase subunit VIIc -0.0201233
RPL5 ribosomal protein L5 -0.0200479
SQSTM1 sequestosome 1 -0.0199115
ENO1 enolase 1, (alpha) -0.0198171
GPX4 glutathione peroxidase 4 -0.0196027
TBCA tubulin folding cofactor A -0.0194722