| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Methylthiouracil perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Methylthiouracil_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.244274 |
| EXT1 | exostosin glycosyltransferase 1 | 0.200447 |
| LDHA | lactate dehydrogenase A | 0.127471 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.125145 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.114876 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.112949 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.112359 |
| SPAG9 | sperm associated antigen 9 | 0.108839 |
| POTEF | POTE ankyrin domain family, member F | 0.106026 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.101065 |
| USP34 | ubiquitin specific peptidase 34 | 0.0978569 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0954363 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0863971 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0858341 |
| FLNB | filamin B, beta | 0.0833049 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0823662 |
| TXNRD1 | thioredoxin reductase 1 | 0.0817224 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0816421 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0803958 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0801534 |
| COL5A2 | collagen, type V, alpha 2 | 0.0763362 |
| PGK1 | phosphoglycerate kinase 1 | 0.0762776 |
| CANX | calnexin | 0.0761354 |
| NAV2 | neuron navigator 2 | 0.0745511 |
| MSI2 | musashi RNA-binding protein 2 | 0.0734877 |
| ASPH | aspartate beta-hydroxylase | 0.0723585 |
| RORA | RAR-related orphan receptor A | 0.0697623 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0682963 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0679177 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0657206 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0652288 |
| ZNF638 | zinc finger protein 638 | 0.0629833 |
| FNIP1 | folliculin interacting protein 1 | 0.0629407 |
| VCL | vinculin | 0.0611673 |
| PDE10A | phosphodiesterase 10A | 0.0602468 |
| PTK2 | protein tyrosine kinase 2 | 0.0584935 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.058456 |
| SYT1 | synaptotagmin I | 0.0552442 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.054297 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0534849 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0517543 |
| GOLGA4 | golgin A4 | 0.0493055 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0476368 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0467125 |
| TENM3 | teneurin transmembrane protein 3 | 0.0451237 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0446919 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0437867 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0433165 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0430236 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0430127 |
| MYO1E | myosin IE | 0.0407328 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.039568 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0393264 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0391724 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.03834 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0381279 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0378015 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0372377 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0369634 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0369179 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0365812 |
| MEST | mesoderm specific transcript | 0.0365329 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0362657 |
| ERBIN | erbb2 interacting protein | 0.0358354 |
| CERS6 | ceramide synthase 6 | 0.0356047 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0355456 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0344995 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0343751 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0341974 |
| PKM | pyruvate kinase, muscle | 0.0341431 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0329641 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0314312 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0311718 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0306236 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0306146 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0303591 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0302159 |
| STIP1 | stress-induced phosphoprotein 1 | 0.029349 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0281921 |
| CMIP | c-Maf inducing protein | 0.028184 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0274229 |
| GPHN | gephyrin | 0.0270902 |
| ATXN7 | ataxin 7 | 0.025331 |
| CDH13 | cadherin 13 | 0.0249123 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0245614 |
| RTN4 | reticulon 4 | 0.0244869 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0242911 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0240318 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0237353 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0231832 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0229314 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0228499 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0227247 |
| INTS6 | integrator complex subunit 6 | 0.0224568 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0221366 |
| ANXA2 | annexin A2 | 0.0219845 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0219697 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0210503 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0208285 |
| HMGA1 | high mobility group AT-hook 1 | 0.0191404 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.145691 |
| RPS6 | ribosomal protein S6 | -0.145016 |
| EGFR | epidermal growth factor receptor | -0.140214 |
| TMSB10 | thymosin beta 10 | -0.135153 |
| SLTM | SAFB-like, transcription modulator | -0.12819 |
| FN1 | fibronectin 1 | -0.122447 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.104303 |
| ANKRD12 | ankyrin repeat domain 12 | -0.103173 |
| RPLP1 | ribosomal protein, large, P1 | -0.101003 |
| VIM | vimentin | -0.0982515 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0946834 |
| MCL1 | myeloid cell leukemia 1 | -0.0917706 |
| MYO10 | myosin X | -0.0897675 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.085559 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0840546 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.08223 |
| ATP11A | ATPase, class VI, type 11A | -0.0799849 |
| PTMA | prothymosin, alpha | -0.0794303 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.078455 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.075375 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0732135 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0723609 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0712275 |
| APP | amyloid beta (A4) precursor protein | -0.0708953 |
| OSMR | oncostatin M receptor | -0.0698046 |
| CD44 | CD44 molecule (Indian blood group) | -0.0697317 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0669349 |
| SMAD3 | SMAD family member 3 | -0.0661853 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.065398 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0647639 |
| PCBP2 | poly(rC) binding protein 2 | -0.0644841 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0632086 |
| PRKCA | protein kinase C, alpha | -0.0624257 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0611273 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0602491 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0601935 |
| DENND5B | DENN/MADD domain containing 5B | -0.060143 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0582015 |
| ITGA6 | integrin, alpha 6 | -0.0581426 |
| MT2A | metallothionein 2A | -0.055477 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0549358 |
| ATP9B | ATPase, class II, type 9B | -0.0546976 |
| SRPK2 | SRSF protein kinase 2 | -0.0530964 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0528863 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0521693 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0518267 |
| OXR1 | oxidation resistance 1 | -0.051058 |
| JMJD1C | jumonji domain containing 1C | -0.0508903 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0508283 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0504912 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0483533 |
| ATXN1 | ataxin 1 | -0.0482844 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0436143 |
| HMGA2 | high mobility group AT-hook 2 | -0.0409566 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0403189 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0386124 |
| GRB10 | growth factor receptor-bound protein 10 | -0.038246 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0376522 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0372876 |
| CUL4A | cullin 4A | -0.0369869 |
| CNKSR3 | CNKSR family member 3 | -0.0363474 |
| FMN1 | formin 1 | -0.0355307 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0343578 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0336012 |
| LSAMP | limbic system-associated membrane protein | -0.0335383 |
| COPA | coatomer protein complex, subunit alpha | -0.0334156 |
| ADIPOR2 | adiponectin receptor 2 | -0.032024 |
| B2M | beta-2-microglobulin | -0.0311225 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0300335 |
| RPS12 | ribosomal protein S12 | -0.0297517 |
| FMNL2 | formin-like 2 | -0.0289998 |
| MAP4 | microtubule-associated protein 4 | -0.0284435 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0280116 |
| BBX | bobby sox homolog (Drosophila) | -0.0270679 |
| VGF | VGF nerve growth factor inducible | -0.0269046 |
| CALR | calreticulin | -0.024835 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0232691 |
| ENO1 | enolase 1, (alpha) | -0.0232465 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0225891 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0223784 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0221093 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0210356 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0207049 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.020616 |
| CTIF | CBP80/20-dependent translation initiation factor | -0.0198971 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0183203 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0165914 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0164681 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | -0.0161782 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0160883 |
| TLK1 | tousled-like kinase 1 | -0.0160727 |
| SMYD3 | SET and MYND domain containing 3 | -0.0144673 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0142217 |
| ACTG1 | actin gamma 1 | -0.0122208 |
| DENND1A | DENN/MADD domain containing 1A | -0.0122165 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0121658 |
| RPL26 | ribosomal protein L26 | -0.012046 |
| NBEAL1 | neurobeachin-like 1 | -0.0118656 |
| ANKRD11 | ankyrin repeat domain 11 | -0.011543 |
| TCF12 | transcription factor 12 | -0.0102526 |
