Methylthiouracil_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylthiouracil perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Methylthiouracil_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EZR ezrin 0.0569618
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0469337
SLC38A2 solute carrier family 38, member 2 0.0408274
SAMD4A sterile alpha motif domain containing 4A 0.0383536
LPP LIM domain containing preferred translocation partner in lipoma 0.0383025
TGFBR3 transforming growth factor, beta receptor III 0.0362396
PDE4D phosphodiesterase 4D, cAMP-specific 0.0362088
NBAS neuroblastoma amplified sequence 0.032841
DSCAM Down syndrome cell adhesion molecule 0.0323797
KDM4C lysine (K)-specific demethylase 4C 0.0321853
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0316147
SMYD3 SET and MYND domain containing 3 0.0313865
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0305774
HELZ helicase with zinc finger 0.0304448
ZNF292 zinc finger protein 292 0.0283908
ANXA1 annexin A1 0.0283897
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0283715
ZCCHC7 zinc finger, CCHC domain containing 7 0.0283359
AHNAK AHNAK nucleoprotein 0.0280931
PYGB phosphorylase, glycogen; brain 0.0277168
ZFAND3 zinc finger, AN1-type domain 3 0.0274549
KMT2C lysine (K)-specific methyltransferase 2C 0.0274193
BIRC6 baculoviral IAP repeat containing 6 0.0272785
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0266366
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0265586
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0263733
PTPRG protein tyrosine phosphatase, receptor type, G 0.0259794
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.025974
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0259625
GOLGA4 golgin A4 0.0255627
PICALM phosphatidylinositol binding clathrin assembly protein 0.0249376
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0243058
EML4 echinoderm microtubule associated protein like 4 0.0243052
EFNA5 ephrin-A5 0.0242817
NFIA nuclear factor I/A 0.0241802
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0240947
PDGFC platelet derived growth factor C 0.0240543
TJP1 tight junction protein 1 0.0239338
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0237307
QKI QKI, KH domain containing, RNA binding 0.0235513
RBM39 RNA binding motif protein 39 0.0233111
SOX6 SRY (sex determining region Y)-box 6 0.0232028
KMT2E lysine (K)-specific methyltransferase 2E 0.0231863
GLI2 GLI family zinc finger 2 0.0229795
SENP6 SUMO1/sentrin specific peptidase 6 0.0229708
SEC31A SEC31 homolog A (S. cerevisiae) 0.0226054
ZNF644 zinc finger protein 644 0.0224853
FNDC3B fibronectin type III domain containing 3B 0.0224191
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0223253
TFG TRK-fused gene 0.0222716
ANK2 ankyrin 2, neuronal 0.0220211
SPPL3 signal peptide peptidase like 3 0.0215026
ZEB1 zinc finger E-box binding homeobox 1 0.0213584
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0213118
ADAM10 ADAM metallopeptidase domain 10 0.0212717
COG5 component of oligomeric golgi complex 5 0.0211494
NCKAP1 NCK-associated protein 1 0.0211418
MSI2 musashi RNA-binding protein 2 0.0210827
EGFR epidermal growth factor receptor 0.0210201
FAT1 FAT atypical cadherin 1 0.0207737
TNRC6B trinucleotide repeat containing 6B 0.0205321
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0204872
EEF2 eukaryotic translation elongation factor 2 0.0203867
DENND1A DENN/MADD domain containing 1A 0.0203781
YEATS2 YEATS domain containing 2 0.0203402
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0202984
ANKRD36 ankyrin repeat domain 36 0.0202657
RHBDD1 rhomboid domain containing 1 0.0202024
PDE4B phosphodiesterase 4B, cAMP-specific 0.0201839
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0201533
TRERF1 transcriptional regulating factor 1 0.0201047
HDAC9 histone deacetylase 9 0.0198832
BRWD1 bromodomain and WD repeat domain containing 1 0.0198238
SEC24D SEC24 family member D 0.0197264
ZMYM2 zinc finger, MYM-type 2 0.019674
NF1 neurofibromin 1 0.019577
NCOR1 nuclear receptor corepressor 1 0.0194687
CANX calnexin 0.0194015
EXT1 exostosin glycosyltransferase 1 0.0193755
ZNF608 zinc finger protein 608 0.0192793
WDFY3 WD repeat and FYVE domain containing 3 0.0192154
TOP2B topoisomerase (DNA) II beta 180kDa 0.0191865
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0191321
PLCE1 phospholipase C, epsilon 1 0.0187944
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0186129
TRA2A transformer 2 alpha homolog (Drosophila) 0.0185989
TAC4 tachykinin 4 (hemokinin) 0.0185688
FAM91A1 family with sequence similarity 91, member A1 0.0185256
CALU calumenin 0.0185005
SFPQ splicing factor proline/glutamine-rich 0.0183791
USP47 ubiquitin specific peptidase 47 0.0182926
PCGF5 polycomb group ring finger 5 0.0182833
SETD5 SET domain containing 5 0.0180992
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0180843
NUP58 nucleoporin 58 0.0178893
CD47 CD47 molecule 0.0177754
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0177599
TCF12 transcription factor 12 0.0176547
FNIP1 folliculin interacting protein 1 0.0175553
HDLBP high density lipoprotein binding protein 0.0175388

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.383758
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.289827
TPT1 tumor protein, translationally-controlled 1 -0.155252
RPS6 ribosomal protein S6 -0.13504
RPL35A ribosomal protein L35a -0.11147
RPS8 ribosomal protein S8 -0.111209
RPL34 ribosomal protein L34 -0.0763015
RPLP1 ribosomal protein, large, P1 -0.0760991
RPL19 ribosomal protein L19 -0.0749693
RPS19 ribosomal protein S19 -0.0745546
PKM pyruvate kinase, muscle -0.0742742
RPL31 ribosomal protein L31 -0.0690814
RPS23 ribosomal protein S23 -0.0674281
RPLP2 ribosomal protein, large, P2 -0.0673932
RPS13 ribosomal protein S13 -0.0660444
RPL23 ribosomal protein L23 -0.0653753
RPL9 ribosomal protein L9 -0.0642161
RPL12 ribosomal protein L12 -0.0639647
RPS3 ribosomal protein S3 -0.0629937
RPL37A ribosomal protein L37a -0.0616233
RPS25 ribosomal protein S25 -0.0608895
S100A6 S100 calcium binding protein A6 -0.0599791
HSPB1 heat shock 27kDa protein 1 -0.058012
RPL26 ribosomal protein L26 -0.0569352
S100A4 S100 calcium binding protein A4 -0.0556884
RPS21 ribosomal protein S21 -0.0542163
RPL36 ribosomal protein L36 -0.0537057
MYL12B myosin, light chain 12B, regulatory -0.0522937
S100A9 S100 calcium binding protein A9 -0.052133
RPL32 ribosomal protein L32 -0.0509822
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0508918
ARL4C ADP-ribosylation factor-like 4C -0.0501336
RPL11 ribosomal protein L11 -0.0500294
PFN1 profilin 1 -0.0497834
RPLP0 ribosomal protein, large, P0 -0.0489579
CCND1 cyclin D1 -0.0489181
RPS14 ribosomal protein S14 -0.0487704
ACTG1 actin gamma 1 -0.0480061
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0477206
TMSB10 thymosin beta 10 -0.0475628
RPL7A ribosomal protein L7a -0.0467471
RPS24 ribosomal protein S24 -0.0462861
BMP10 bone morphogenetic protein 10 -0.045199
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0448896
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0439913
S100A10 S100 calcium binding protein A10 -0.0434264
RPS17 ribosomal protein S17 -0.0422361
RPS27A ribosomal protein S27a -0.0415891
RPL28 ribosomal protein L28 -0.0406824
EIF1 eukaryotic translation initiation factor 1 -0.040651
RPL8 ribosomal protein L8 -0.0390183
GNAS GNAS complex locus -0.0381364
RACK1 receptor for activated C kinase 1 -0.0376367
RPS12 ribosomal protein S12 -0.0371543
RPS16 ribosomal protein S16 -0.0369961
RPL30 ribosomal protein L30 -0.0368079
PRDX2 peroxiredoxin 2 -0.0364849
RPS11 ribosomal protein S11 -0.036109
RPL36A ribosomal protein L36a -0.035955
TPM4 tropomyosin 4 -0.0342735
ENO1 enolase 1, (alpha) -0.0333817
RPS29 ribosomal protein S29 -0.0333027
RPS27 ribosomal protein S27 -0.0332065
RPL5 ribosomal protein L5 -0.0323475
MT2A metallothionein 2A -0.0320409
RPL27A ribosomal protein L27a -0.0313357
RPL18 ribosomal protein L18 -0.0313002
RPS10 ribosomal protein S10 -0.0311435
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0309687
FTL ferritin, light polypeptide -0.0309221
TUBB4B tubulin, beta 4B class IVb -0.0302205
TM4SF1 transmembrane 4 L six family member 1 -0.0300916
PTMS parathymosin -0.0297137
EMP3 epithelial membrane protein 3 -0.0289303
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0288165
EBNA1BP2 EBNA1 binding protein 2 -0.028454
RPL13A ribosomal protein L13a -0.0275045
HMGA1 high mobility group AT-hook 1 -0.0272644
RPS15 ribosomal protein S15 -0.0271966
VCL vinculin -0.0271066
ATF4 activating transcription factor 4 -0.0270737
RPL37 ribosomal protein L37 -0.0270453
TPI1 triosephosphate isomerase 1 -0.0268966
RPS5 ribosomal protein S5 -0.0267374
ASTN2 astrotactin 2 -0.0267003
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0263902
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0258124
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0256528
TUBA1B tubulin, alpha 1b -0.0253464
IGF2 insulin-like growth factor 2 -0.0253133
RPL15 ribosomal protein L15 -0.0250984
S100A11 S100 calcium binding protein A11 -0.0250857
FOXP1 forkhead box P1 -0.0250642
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0243174
B2M beta-2-microglobulin -0.0240962
LOC112694756 uncharaterized LOC112694756 -0.0240078
RPL35 ribosomal protein L35 -0.0239365
RPL10A ribosomal protein L10a -0.023927
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0238996
HLA-B major histocompatibility complex, class I, B -0.0229441