Methylthiouracil_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylthiouracil perturbation in SNU-423 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Methylthiouracil_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.167752
SOD2 superoxide dismutase 2, mitochondrial 0.093191
PDE10A phosphodiesterase 10A 0.0595372
IGFBP3 insulin-like growth factor binding protein 3 0.0591186
GLIS3 GLIS family zinc finger 3 0.0587639
FTH1 ferritin, heavy polypeptide 1 0.0580124
VCAN versican 0.0536073
TRIO trio Rho guanine nucleotide exchange factor 0.0499231
COL6A3 collagen, type VI, alpha 3 0.0428183
VEGFA vascular endothelial growth factor A 0.0427324
NDRG1 N-myc downstream regulated 1 0.0410752
FRMD4A FERM domain containing 4A 0.0405299
HDAC9 histone deacetylase 9 0.0403841
DST dystonin 0.0373433
TENT5A terminal nucleotidyltransferase 5A 0.0366183
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0348549
BICC1 BicC family RNA binding protein 1 0.0347306
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0344535
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0340541
CADM1 cell adhesion molecule 1 0.0330982
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0327783
FNIP1 folliculin interacting protein 1 0.0306085
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0304983
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0286776
AFF4 AF4/FMR2 family, member 4 0.0284167
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0273301
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0270536
ATXN1 ataxin 1 0.0270476
SLC38A2 solute carrier family 38, member 2 0.0269316
RND3 Rho family GTPase 3 0.0250581
EHBP1 EH domain binding protein 1 0.0249158
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.0248171
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0246272
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0244333
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0237894
HMGA2 high mobility group AT-hook 2 0.0229802
RBMS3 RNA binding motif, single stranded interacting protein 3 0.022402
EXT1 exostosin glycosyltransferase 1 0.0219966
TNS3 tensin 3 0.0210171
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0209446
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0209066
KLF12 Kruppel-like factor 12 0.0205538
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0202379
HELZ helicase with zinc finger 0.0201241
MBNL1 muscleblind-like splicing regulator 1 0.019429
AFF3 AF4/FMR2 family, member 3 0.0193643
COL5A1 collagen, type V, alpha 1 0.0192505
RAI14 retinoic acid induced 14 0.0189477
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0189008
JMJD1C jumonji domain containing 1C 0.0187648
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0183271
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0179879
RNF213 ring finger protein 213 0.0179449
FNDC3B fibronectin type III domain containing 3B 0.0177291
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0177169
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0176233
WDFY1 WD repeat and FYVE domain containing 1 0.0175431
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0174547
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0173726
SDK1 sidekick cell adhesion molecule 1 0.0169001
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.016741
CLTC clathrin, heavy chain (Hc) 0.0166629
MSN moesin 0.0166101
SMYD3 SET and MYND domain containing 3 0.0165153
AHR aryl hydrocarbon receptor 0.0163125
ADAM12 ADAM metallopeptidase domain 12 0.0162673
ESYT2 extended synaptotagmin-like protein 2 0.0162662
ANXA1 annexin A1 0.0162292
LRRC7 leucine rich repeat containing 7 0.0159784
ATP13A3 ATPase type 13A3 0.0159143
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0158613
FRMD5 FERM domain containing 5 0.0158538
DIAPH2 diaphanous-related formin 2 0.0157691
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0156409
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0156125
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0155745
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0154569
ZBTB20 zinc finger and BTB domain containing 20 0.015222
SFTPA2 surfactant protein A2 0.0151068
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0150228
CCNL1 cyclin L1 0.0148489
ARHGAP24 Rho GTPase activating protein 24 0.0148447
LOX lysyl oxidase 0.0146947
PICALM phosphatidylinositol binding clathrin assembly protein 0.0146504
LCOR ligand dependent nuclear receptor corepressor 0.0144256
WDR27 WD repeat domain 27 0.0144232
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0142729
ANO6 anoctamin 6 0.0141112
CD164 CD164 molecule, sialomucin 0.0140576
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0140539
ATM ATM serine/threonine kinase 0.0139212
MYOF myoferlin 0.0138976
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0138342
NCKAP5 NCK-associated protein 5 0.0138257
MACF1 microtubule-actin crosslinking factor 1 0.0135119
MAP4 microtubule-associated protein 4 0.0134966
KDM4C lysine (K)-specific demethylase 4C 0.0134328
STAG2 stromal antigen 2 0.0132566
TENM2 teneurin transmembrane protein 2 0.0132293
MYO9A myosin IXA 0.0130763

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.250883
TMSB10 thymosin beta 10 -0.181363
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.163007
HLA-B major histocompatibility complex, class I, B -0.146265
FTL ferritin, light polypeptide -0.125187
MT2A metallothionein 2A -0.117782
RPL23 ribosomal protein L23 -0.108906
TPT1 tumor protein, translationally-controlled 1 -0.103779
IER3 immediate early response 3 -0.103461
PTMA prothymosin, alpha -0.101084
RPS27A ribosomal protein S27a -0.0937048
RPS12 ribosomal protein S12 -0.0855254
RPS3 ribosomal protein S3 -0.0837575
RPLP2 ribosomal protein, large, P2 -0.0816768
ENO1 enolase 1, (alpha) -0.0781902
UBC ubiquitin C -0.0776827
RPS6 ribosomal protein S6 -0.0741359
RPL37A ribosomal protein L37a -0.0736434
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0711561
RPLP1 ribosomal protein, large, P1 -0.0682536
RPS24 ribosomal protein S24 -0.0674597
RPS8 ribosomal protein S8 -0.0647482
RPL26 ribosomal protein L26 -0.0568391
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0554501
RPL35A ribosomal protein L35a -0.0554494
RPS19 ribosomal protein S19 -0.0554234
RPL12 ribosomal protein L12 -0.0530473
RPS23 ribosomal protein S23 -0.0523451
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0489081
RPL36A ribosomal protein L36a -0.0478487
RPS13 ribosomal protein S13 -0.0472544
RPL36 ribosomal protein L36 -0.0460288
RPL19 ribosomal protein L19 -0.0455421
RPL9 ribosomal protein L9 -0.0450561
RPL31 ribosomal protein L31 -0.0442853
MYH9 myosin, heavy chain 9, non-muscle -0.0440467
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0424469
RPS17 ribosomal protein S17 -0.0419455
PCBP2 poly(rC) binding protein 2 -0.0395105
B2M beta-2-microglobulin -0.0394619
RPS25 ribosomal protein S25 -0.0384317
IFITM3 interferon induced transmembrane protein 3 -0.0376858
RPS10 ribosomal protein S10 -0.0376632
RPS4X ribosomal protein S4, X-linked -0.037161
RPS29 ribosomal protein S29 -0.0371514
TPM4 tropomyosin 4 -0.036793
VCL vinculin -0.0359963
HLA-A major histocompatibility complex, class I, A -0.035552
RPL28 ribosomal protein L28 -0.035364
BASP1 brain abundant, membrane attached signal protein 1 -0.0353553
IFI6 interferon, alpha-inducible protein 6 -0.0345258
RPS14 ribosomal protein S14 -0.0336034
RPL35 ribosomal protein L35 -0.033345
RPS21 ribosomal protein S21 -0.0322195
RPL38 ribosomal protein L38 -0.0321568
RPL34 ribosomal protein L34 -0.0318853
RPL37 ribosomal protein L37 -0.0317506
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0316453
COL1A1 collagen, type I, alpha 1 -0.0315582
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0313214
RPS16 ribosomal protein S16 -0.0305976
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0303414
NAP1L1 nucleosome assembly protein 1-like 1 -0.030245
STC1 stanniocalcin 1 -0.0301806
EEF1G eukaryotic translation elongation factor 1 gamma -0.0301619
PKM pyruvate kinase, muscle -0.0298625
SQSTM1 sequestosome 1 -0.0298266
RPL5 ribosomal protein L5 -0.0295632
CALR calreticulin -0.0294173
RACK1 receptor for activated C kinase 1 -0.0289453
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0288333
RPL15 ribosomal protein L15 -0.0288309
RPS5 ribosomal protein S5 -0.0284658
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0278604
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0278311
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0278081
RPL32 ribosomal protein L32 -0.0271264
RPS27 ribosomal protein S27 -0.0267741
RPL11 ribosomal protein L11 -0.0265248
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0262028
ADM adrenomedullin -0.0261531
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0261341
CD63 CD63 molecule -0.026109
RPL8 ribosomal protein L8 -0.0258186
AHNAK AHNAK nucleoprotein -0.0256666
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0256157
RPL27A ribosomal protein L27a -0.0255424
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0254621
NAMPT nicotinamide phosphoribosyltransferase -0.0250239
ACTG1 actin gamma 1 -0.0248083
LOC112694756 uncharaterized LOC112694756 -0.0246597
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0245802
RPS20 ribosomal protein S20 -0.0244297
ELL2 elongation factor, RNA polymerase II, 2 -0.0242653
RPL13A ribosomal protein L13a -0.0240303
RPL7A ribosomal protein L7a -0.0238731
SDC4 syndecan 4 -0.0237715
RPL27 ribosomal protein L27 -0.0237351
IFI16 interferon, gamma-inducible protein 16 -0.0236744
ANXA2 annexin A2 -0.0235743