Methylthiouracil_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Methylthiouracil perturbation in SW 900 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Methylthiouracil_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.238801
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.218888
FN1 fibronectin 1 0.129933
TRIO trio Rho guanine nucleotide exchange factor 0.128016
NDRG1 N-myc downstream regulated 1 0.108368
FNDC3B fibronectin type III domain containing 3B 0.0881156
AHR aryl hydrocarbon receptor 0.0848929
TXNIP thioredoxin interacting protein 0.0779427
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0775429
CXCL8 chemokine (C-X-C motif) ligand 8 0.077375
CANX calnexin 0.0732261
PTK2 protein tyrosine kinase 2 0.0648534
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0642682
SFTPA2 surfactant protein A2 0.0625467
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.061741
CD109 CD109 molecule 0.0575897
TXNRD1 thioredoxin reductase 1 0.0566439
RICTOR RPTOR independent companion of MTOR, complex 2 0.0554928
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0538775
FAM13A family with sequence similarity 13, member A 0.0532927
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0528722
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0500883
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.049699
PKM pyruvate kinase, muscle 0.0495169
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.048882
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0486119
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0478432
SOD2 superoxide dismutase 2, mitochondrial 0.0477736
TPR translocated promoter region, nuclear basket protein 0.0476582
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0473578
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0455023
LMNA lamin A/C 0.0438486
EREG epiregulin 0.0429268
PRRC2C proline-rich coiled-coil 2C 0.0425594
FTH1 ferritin, heavy polypeptide 1 0.0421645
B2M beta-2-microglobulin 0.0409926
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0406856
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0406342
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0401295
HELZ helicase with zinc finger 0.0400591
DST dystonin 0.0398079
MBNL1 muscleblind-like splicing regulator 1 0.039557
PGK1 phosphoglycerate kinase 1 0.0393743
RBM39 RNA binding motif protein 39 0.0391789
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0390506
PDE4D phosphodiesterase 4D, cAMP-specific 0.0386931
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0381894
ENO1 enolase 1, (alpha) 0.038173
MCTP2 multiple C2 domains, transmembrane 2 0.0379041
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0378718
SMAD3 SMAD family member 3 0.0367348
CD44 CD44 molecule (Indian blood group) 0.0366725
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0356838
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0356833
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0353956
MARCHF6 membrane associated ring-CH-type finger 6 0.0352803
WAC WW domain containing adaptor with coiled-coil 0.0348198
ZNF292 zinc finger protein 292 0.0346091
LIFR leukemia inhibitory factor receptor alpha 0.034114
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0336987
IDS iduronate 2-sulfatase 0.0333802
TM9SF3 transmembrane 9 superfamily member 3 0.0332509
DENND5B DENN/MADD domain containing 5B 0.0328295
SPAG9 sperm associated antigen 9 0.03281
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0327854
SUCO SUN domain containing ossification factor 0.0326149
CLTC clathrin, heavy chain (Hc) 0.0325548
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0324599
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0323752
SLTM SAFB-like, transcription modulator 0.0321908
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0321452
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0318945
GLIS3 GLIS family zinc finger 3 0.0318346
INSIG2 insulin induced gene 2 0.0318048
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0315176
CDC73 cell division cycle 73 0.0314876
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0312221
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0310744
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0307996
APLP2 amyloid beta (A4) precursor-like protein 2 0.0307722
SEC31A SEC31 homolog A (S. cerevisiae) 0.0307484
PELI1 pellino E3 ubiquitin protein ligase 1 0.0307029
NAP1L1 nucleosome assembly protein 1-like 1 0.030528
APP amyloid beta (A4) precursor protein 0.0304879
PRELID2 PRELI domain containing 2 0.0303444
BIRC3 baculoviral IAP repeat containing 3 0.0303289
DOCK5 dedicator of cytokinesis 5 0.0302775
EZR ezrin 0.0301841
IL6ST interleukin 6 signal transducer 0.0300949
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0296541
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0293231
UGCG UDP-glucose ceramide glucosyltransferase 0.0292565
MYH9 myosin, heavy chain 9, non-muscle 0.0291709
TMEM156 transmembrane protein 156 0.0290344
ITGA1 integrin, alpha 1 0.0285704
EEF2 eukaryotic translation elongation factor 2 0.028418
ETV6 ets variant 6 0.0284005
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.028253
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0281006
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0280439

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.0813376
TMSB10 thymosin beta 10 -0.0720308
NTN4 netrin 4 -0.0461197
PALLD palladin, cytoskeletal associated protein -0.0437538
PTMA prothymosin, alpha -0.0426193
EGR1 early growth response 1 -0.0274479
FTL ferritin, light polypeptide -0.0272585
RPLP1 ribosomal protein, large, P1 -0.0261314
NRG1 neuregulin 1 -0.0250889
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0248349
INTS6 integrator complex subunit 6 -0.0242569
TPM4 tropomyosin 4 -0.023342
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0225097
RPL37A ribosomal protein L37a -0.0224854
FHL2 four and a half LIM domains 2 -0.0217234
TPT1 tumor protein, translationally-controlled 1 -0.0210701
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0209478
RPS27 ribosomal protein S27 -0.0205159
CCDC138 coiled-coil domain containing 138 -0.020342
CLIP2 CAP-GLY domain containing linker protein 2 -0.0202403
RPS19 ribosomal protein S19 -0.0201407
S100A10 S100 calcium binding protein A10 -0.0196715
TGFB1 transforming growth factor, beta 1 -0.0196065
RPL35A ribosomal protein L35a -0.0195217
ACTG1 actin gamma 1 -0.0192534
RPS6 ribosomal protein S6 -0.0192269
GLCCI1 glucocorticoid induced 1 -0.0183711
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.017888
PDLIM5 PDZ and LIM domain 5 -0.0178572
RPL34 ribosomal protein L34 -0.0174439
MT2A metallothionein 2A -0.0160237
RPS29 ribosomal protein S29 -0.0158296
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0153092
S100A9 S100 calcium binding protein A9 -0.0153002
RPL28 ribosomal protein L28 -0.0150673
ZBTB7A zinc finger and BTB domain containing 7A -0.0147781
SOX4 SRY (sex determining region Y)-box 4 -0.0147605
GON4L gon-4-like (C. elegans) -0.0144298
WWTR1 WW domain containing transcription regulator 1 -0.0143922
UBAP2 ubiquitin associated protein 2 -0.0143873
RPL38 ribosomal protein L38 -0.0142269
RPS12 ribosomal protein S12 -0.0141527
NXN nucleoredoxin -0.0140109
SEPTIN9 septin 9 -0.0137581
RPS26 ribosomal protein S26 -0.0136602
RPL36 ribosomal protein L36 -0.0133998
RPL31 ribosomal protein L31 -0.0128455
AEBP2 AE binding protein 2 -0.012493
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0124704
WSB1 WD repeat and SOCS box containing 1 -0.0124409
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0122255
NAV1 neuron navigator 1 -0.0122223
IGFBP3 insulin-like growth factor binding protein 3 -0.0121414
RPL23 ribosomal protein L23 -0.0121239
HMGA2 high mobility group AT-hook 2 -0.0115764
UBXN4 UBX domain protein 4 -0.0115346
RPS28 ribosomal protein S28 -0.0113771
ASTN2 astrotactin 2 -0.0113361
RPS17 ribosomal protein S17 -0.0113056
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase -0.0112931
RPLP2 ribosomal protein, large, P2 -0.0112622
ZNF644 zinc finger protein 644 -0.0111367
SDC2 syndecan 2 -0.0111045
ACOXL acyl-CoA oxidase-like -0.0110652
RTN3 reticulon 3 -0.0109527
ADIPOR2 adiponectin receptor 2 -0.0109341
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0108022
RPL8 ribosomal protein L8 -0.0107853
RPS8 ribosomal protein S8 -0.010783
LRRC23 leucine rich repeat containing 23 -0.0107777
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0105872
SLC35F3 solute carrier family 35, member F3 -0.0104835
RPL19 ribosomal protein L19 -0.010471
CYB5R3 cytochrome b5 reductase 3 -0.0104391
NALF1 NALCN channel auxiliary factor 1 -0.0104105
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0103945
GRB10 growth factor receptor-bound protein 10 -0.0103878
S100A6 S100 calcium binding protein A6 -0.010344
TENM4 teneurin transmembrane protein 4 -0.0102822
ECE1 endothelin converting enzyme 1 -0.0102768
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0100625
PCNX4 pecanex 4 -0.0100208
PURA purine-rich element binding protein A -0.00994996
IFI6 interferon, alpha-inducible protein 6 -0.0098939
EPAS1 endothelial PAS domain protein 1 -0.00979863
BICD1 bicaudal D homolog 1 (Drosophila) -0.0097617
TUFT1 tuftelin 1 -0.00972863
WASF2 WAS protein family, member 2 -0.00972819
RPS2 ribosomal protein S2 -0.00970004
ADGRE2 adhesion G protein-coupled receptor E2 -0.00962032
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.00942944
HMGB1 high mobility group box 1 -0.00938695
FBXO28 F-box protein 28 -0.00934026
AGO2 argonaute RISC catalytic component 2 -0.00930876
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.00916514
RIC8B RIC8 guanine nucleotide exchange factor B -0.00904527
RSU1 Ras suppressor protein 1 -0.00893785
IFI27 interferon, alpha-inducible protein 27 -0.00890007
WIPF1 WAS/WASL interacting protein family, member 1 -0.00889792
COX6C cytochrome c oxidase subunit VIc -0.00886656