Metolazone Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/4170
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Genes

200 proteins with high or low expression in Metolazone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ZNF175 zinc finger protein 175 1.69
IQSEC2 IQ motif and Sec7 domain 2 1.1
GGT1 gamma-glutamyltransferase 1 1.06
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 0.95
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.75
UBE2G2 ubiquitin-conjugating enzyme E2G 2 0.58
CXXC5 CXXC finger protein 5 0.58
ADARB1 adenosine deaminase, RNA-specific, B1 0.57
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.54
ZBTB38 zinc finger and BTB domain containing 38 0.52
ZNF189 zinc finger protein 189 0.48
ZNF3 zinc finger protein 3 0.48
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.48
UROS uroporphyrinogen III synthase 0.46
UNC13A unc-13 homolog A (C. elegans) 0.45
SLX4 SLX4 structure-specific endonuclease subunit 0.43
SLC41A3 solute carrier family 41, member 3 0.43
ZSWIM1 zinc finger, SWIM-type containing 1 0.43
SAYSD1 SAYSVFN motif domain containing 1 0.42
RPL26 ribosomal protein L26 0.41
H3C1 H3 clustered histone 1 0.41
KLF10 Kruppel-like factor 10 0.41
FAM117A family with sequence similarity 117, member A 0.4
FGFR4 fibroblast growth factor receptor 4 0.4
ZNF337 zinc finger protein 337 0.39
RNF111 ring finger protein 111 0.38
ICK intestinal cell (MAK-like) kinase 0.38
PRR3 proline rich 3 0.38
BTBD10 BTB (POZ) domain containing 10 0.37
YBX3 Y box binding protein 3 0.37
RAB4B RAB4B, member RAS oncogene family 0.36
SERF2 small EDRK-rich factor 2 0.36
ZCCHC10 zinc finger, CCHC domain containing 10 0.36
TCF7 transcription factor 7 (T-cell specific, HMG-box) 0.35
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.35
PLEK pleckstrin 0.35
KMT5C lysine methyltransferase 5C 0.35
HIST3H2BB histone cluster 3, H2bb 0.34
PROSER3 proline and serine rich 3 0.34
ATG4D autophagy related 4D, cysteine peptidase 0.33
ZNF888 zinc finger protein 888 0.33
FAM174A family with sequence similarity 174, member A 0.33
BTBD7 BTB (POZ) domain containing 7 0.33
SCLT1 sodium channel and clathrin linker 1 0.33
RUFY3 RUN and FYVE domain containing 3 0.33
MOCS1 molybdenum cofactor synthesis 1 0.32
ZNF566 zinc finger protein 566 0.32
CSNK1G2 casein kinase 1, gamma 2 0.32
FEM1A fem-1 homolog a (C. elegans) 0.32
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 0.3
ADAT2 adenosine deaminase, tRNA-specific 2 0.3
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 0.3
HOXB7 homeobox B7 0.3
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.3
IRAK2 interleukin-1 receptor-associated kinase 2 0.29
ZNF174 zinc finger protein 174 0.29
CECR2 cat eye syndrome chromosome region, candidate 2 0.29
KLHL42 kelch-like family member 42 0.29
YIF1B Yip1 interacting factor homolog B (S. cerevisiae) 0.29
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.29
BAIAP2 BAI1-associated protein 2 0.29
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae) 0.28
CEP63 centrosomal protein 63kDa 0.28
ZNF696 zinc finger protein 696 0.28
KLC1 kinesin light chain 1 0.28
SNPH syntaphilin 0.28
ARID5B AT rich interactive domain 5B (MRF1-like) 0.28
ASIC1 acid sensing (proton gated) ion channel 1 0.27
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 0.27
SIX5 SIX homeobox 5 0.27
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.27
TUBD1 tubulin, delta 1 0.27
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.27
EIF1AX eukaryotic translation initiation factor 1A, X-linked 0.27
TYRO3 TYRO3 protein tyrosine kinase 0.26
ODC1 ornithine decarboxylase 1 0.26
TNNC2 troponin C type 2 (fast) 0.26
PPP1R2B PPP1R2 family member B 0.26
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 0.26
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 0.26
CCDC85B coiled-coil domain containing 85B 0.26
DNAAF2 dynein, axonemal, assembly factor 2 0.26
ANKRD26 ankyrin repeat domain 26 0.26
SON SON DNA binding protein 0.26
METRN meteorin, glial cell differentiation regulator 0.25
MSLN mesothelin 0.25
AXL AXL receptor tyrosine kinase 0.25
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.25
ZNF513 zinc finger protein 513 0.25
GLI4 GLI family zinc finger 4 0.25
BBS1 Bardet-Biedl syndrome 1 0.25
KLHL5 kelch-like family member 5 0.24
CCHCR1 coiled-coil alpha-helical rod protein 1 0.24
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.24
UNC93B1 unc-93 homolog B1 (C. elegans) 0.24
NFIB nuclear factor I/B 0.24
LIPT2 lipoyl(octanoyl) transferase 2 (putative) 0.24
SARDH sarcosine dehydrogenase 0.24
COMTD1 catechol-O-methyltransferase domain containing 1 0.23
GPBP1 GC-rich promoter binding protein 1 0.23

low expression

Symbol Name Standardized Value
UNKL unkempt family zinc finger-like -0.62
MYL3 myosin, light chain 3, alkali; ventricular, skeletal, slow -0.59
POF1B premature ovarian failure, 1B -0.53
XIRP1 xin actin binding repeat containing 1 -0.53
TSPAN3 tetraspanin 3 -0.46
ATE1 arginyltransferase 1 -0.43
CCN3 cellular communication network factor 3 -0.42
CA8 carbonic anhydrase VIII -0.41
CA3 carbonic anhydrase III -0.4
CYBA cytochrome b-245, alpha polypeptide -0.4
VIM vimentin -0.39
DUSP14 dual specificity phosphatase 14 -0.39
TMEM63A transmembrane protein 63A -0.39
SLC35B1 solute carrier family 35, member B1 -0.38
CNTN1 contactin 1 -0.38
ANKRD18B ankyrin repeat domain 18B -0.38
RABEP2 rabaptin, RAB GTPase binding effector protein 2 -0.37
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.37
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.37
PLPP3 phospholipid phosphatase 3 -0.37
HOXA10 homeobox A10 -0.36
NDFIP1 Nedd4 family interacting protein 1 -0.34
CLTA clathrin, light chain A -0.34
PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 -0.34
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.34
C15ORF41 chromosome 15 open reading frame 41 -0.33
MTMR4 myotubularin related protein 4 -0.32
IRX4 iroquois homeobox 4 -0.32
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted -0.32
TULP4 tubby like protein 4 -0.32
JPT1 Jupiter microtubule associated homolog 1 -0.32
FAM102B family with sequence similarity 102, member B -0.32
IGFBP6 insulin-like growth factor binding protein 6 -0.32
CENPT centromere protein T -0.31
PEMT phosphatidylethanolamine N-methyltransferase -0.31
CCDC9 coiled-coil domain containing 9 -0.31
DEPTOR DEP domain containing MTOR-interacting protein -0.3
SRXN1 sulfiredoxin 1 -0.3
CCPG1 cell cycle progression 1 -0.3
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 -0.3
NEU3 sialidase 3 (membrane sialidase) -0.29
BET1 Bet1 golgi vesicular membrane trafficking protein -0.29
ACTL8 actin-like 8 -0.29
POLR2M polymerase (RNA) II (DNA directed) polypeptide M -0.29
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.29
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.28
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 -0.28
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.28
LZTS1 leucine zipper, putative tumor suppressor 1 -0.28
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.28
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.27
CBX7 chromobox homolog 7 -0.27
NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7kDa -0.27
GREB1 growth regulation by estrogen in breast cancer 1 -0.27
CCDC158 coiled-coil domain containing 158 -0.27
RARG retinoic acid receptor, gamma -0.27
NFE2L2 nuclear factor, erythroid 2-like 2 -0.26
GDF15 growth differentiation factor 15 -0.26
PTPDC1 protein tyrosine phosphatase domain containing 1 -0.26
DAP death-associated protein -0.26
MDM1 Mdm1 nuclear protein homolog (mouse) -0.26
SH2D5 SH2 domain containing 5 -0.26
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.26
OSTM1 osteopetrosis associated transmembrane protein 1 -0.26
MARCKSL1 MARCKS-like 1 -0.26
HOXB9 homeobox B9 -0.26
KIAA1324L KIAA1324-like -0.26
FN1 fibronectin 1 -0.25
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.25
GVINP1 GTPase, very large interferon inducible pseudogene 1 -0.25
HGFAC HGF activator -0.25
PRG4 proteoglycan 4 -0.25
ABHD18 abhydrolase domain containing 18 -0.25
CHMP4C charged multivesicular body protein 4C -0.25
MT-ND4 NADH dehydrogenase, subunit 4 (complex I) -0.25
ERG28 ergosterol biosynthesis 28 homolog -0.25
TMEM120B transmembrane protein 120B -0.25
HSP90AA4P heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene -0.24
LRP1 low density lipoprotein receptor-related protein 1 -0.24
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.24
FCHO1 FCH domain only 1 -0.24
JAK3 Janus kinase 3 -0.24
OASL 2'-5'-oligoadenylate synthetase-like -0.24
PGPEP1 pyroglutamyl-peptidase I -0.24
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.24
FCHSD2 FCH and double SH3 domains 2 -0.23
YIPF6 Yip1 domain family, member 6 -0.23
HPS1 Hermansky-Pudlak syndrome 1 -0.23
CASP10 caspase 10, apoptosis-related cysteine peptidase -0.23
TMEM177 transmembrane protein 177 -0.23
AGTRAP angiotensin II receptor-associated protein -0.23
C9ORF72 chromosome 9 open reading frame 72 -0.23
ZNF92 zinc finger protein 92 -0.23
ATF3 activating transcription factor 3 -0.23
CDK18 cyclin-dependent kinase 18 -0.23
RBX1 ring-box 1, E3 ubiquitin protein ligase -0.23
TMEM248 transmembrane protein 248 -0.23
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -0.22
DNAH6 dynein, axonemal, heavy chain 6 -0.22
ANKRD39 ankyrin repeat domain 39 -0.22