Metyrapone Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/4174
Similar Terms
Downloads & Tools

Genes

192 proteins with high or low expression in Metyrapone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ZNF428 zinc finger protein 428 1.78
SRD5A3 steroid 5 alpha-reductase 3 1.52
TPM4 tropomyosin 4 1.4
TPM1 tropomyosin 1 (alpha) 1.32
CCDC57 coiled-coil domain containing 57 1.27
TPM3 tropomyosin 3 1.23
PTMS parathymosin 1.2
CCDC97 coiled-coil domain containing 97 1.14
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 1.12
JPT1 Jupiter microtubule associated homolog 1 1.06
PTMA prothymosin, alpha 1.05
RMDN2 regulator of microtubule dynamics 2 0.92
BAG3 BCL2-associated athanogene 3 0.9
STMN1 stathmin 1 0.89
TPM2 tropomyosin 2 (beta) 0.88
C17ORF80 chromosome 17 open reading frame 80 0.88
STMN2 stathmin 2 0.88
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 0.87
ANGPTL4 angiopoietin-like 4 0.87
EID2 EP300 interacting inhibitor of differentiation 2 0.83
PPP1R2B PPP1R2 family member B 0.8
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.79
KHSRP KH-type splicing regulatory protein 0.77
TCEAL8 transcription elongation factor A (SII)-like 8 0.76
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 0.75
BAG4 BCL2-associated athanogene 4 0.75
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 0.73
SOD1 superoxide dismutase 1, soluble 0.72
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) 0.71
HIST2H2AA3 histone cluster 2, H2aa3 0.7
BORCS6 BLOC-1 related complex subunit 6 0.69
CALU calumenin 0.68
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted 0.68
LYSMD1 LysM, putative peptidoglycan-binding, domain containing 1 0.67
IGBP1 immunoglobulin (CD79A) binding protein 1 0.66
CDC14A cell division cycle 14A 0.64
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 0.64
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 0.64
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) 0.63
MED8 mediator complex subunit 8 0.63
OSTF1 osteoclast stimulating factor 1 0.63
MCRIP1 MAPK regulated corepressor interacting protein 1 0.62
GTF2A1 general transcription factor IIA, 1, 19/37kDa 0.61
CD58 CD58 molecule 0.61
TTC1 tetratricopeptide repeat domain 1 0.61
NDEL1 nudE neurodevelopment protein 1-like 1 0.6
RCN1 reticulocalbin 1, EF-hand calcium binding domain 0.6
WTAP Wilms tumor 1 associated protein 0.59
MED30 mediator complex subunit 30 0.59
NES nestin 0.58
CLNS1A chloride channel, nucleotide-sensitive, 1A 0.58
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.58
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 0.58
DERPC DERPC proline and glycine rich nuclear protein 0.57
RNF126 ring finger protein 126 0.57
TMOD3 tropomodulin 3 (ubiquitous) 0.56
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 0.56
RNF115 ring finger protein 115 0.55
ZNF346 zinc finger protein 346 0.55
SKA3 spindle and kinetochore associated complex subunit 3 0.55
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 0.55
TIPIN TIMELESS interacting protein 0.54
SPPL2A signal peptide peptidase like 2A 0.53
TSSC4 tumor suppressing subtransferable candidate 4 0.53
NRBF2 nuclear receptor binding factor 2 0.52
FUBP1 far upstream element (FUSE) binding protein 1 0.52
GCSH glycine cleavage system protein H (aminomethyl carrier) 0.51
ETAA1 Ewing tumor-associated antigen 1 0.51
MCPH1 microcephalin 1 0.51
ZNF503 zinc finger protein 503 0.51
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.5
TANK TRAF family member-associated NFKB activator 0.5
CNPY2 canopy FGF signaling regulator 2 0.5
MYCBP MYC binding protein 0.5
HIST3H2BB histone cluster 3, H2bb 0.5
ATXN1L ataxin 1-like 0.5
NASP nuclear autoantigenic sperm protein (histone-binding) 0.49
SUMF2 sulfatase modifying factor 2 0.49
CFAP36 cilia and flagella associated protein 36 0.48
RAMAC RNA guanine-7 methyltransferase activating subunit 0.48
NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase) 0.48
TMOD1 tropomodulin 1 0.47
TMSB10 thymosin beta 10 0.47
GTSF1 gametocyte specific factor 1 0.47
ZYX zyxin 0.47
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 0.46
ZWINT ZW10 interacting kinetochore protein 0.46
UQCRB ubiquinol-cytochrome c reductase binding protein 0.46
PFDN4 prefoldin subunit 4 0.46
EIF3C eukaryotic translation initiation factor 3, subunit C 0.46
BCL9 B-cell CLL/lymphoma 9 0.46
DNAH6 dynein, axonemal, heavy chain 6 0.45

low expression

Symbol Name Standardized Value
MARCHF7 membrane associated ring-CH-type finger 7 -2.31
MYH7B myosin, heavy chain 7B, cardiac muscle, beta -2.03
KSR2 kinase suppressor of ras 2 -1.87
MYO7B myosin VIIB -1.73
HBA1 hemoglobin, alpha 1 -1.68
YPEL5 yippee-like 5 (Drosophila) -1.55
SHANK3 SH3 and multiple ankyrin repeat domains 3 -1.53
ALDH1L2 aldehyde dehydrogenase 1 family, member L2 -1.26
BMT2 base methyltransferase of 25S rRNA 2 homolog -1.23
CCDC158 coiled-coil domain containing 158 -1.18
C12ORF60 chromosome 12 open reading frame 60 -1.16
CD151 CD151 molecule (Raph blood group) -0.98
LSM10 LSM10, U7 small nuclear RNA associated -0.97
LARP6 La ribonucleoprotein domain family, member 6 -0.95
DENND5A DENN/MADD domain containing 5A -0.9
MYH13 myosin, heavy chain 13, skeletal muscle -0.9
ZMYND19 zinc finger, MYND-type containing 19 -0.89
B2M beta-2-microglobulin -0.8
CCNDBP1 cyclin D-type binding-protein 1 -0.68
RASA2 RAS p21 protein activator 2 -0.68
INVS inversin -0.68
RETREG1 reticulophagy regulator 1 -0.66
ADCY10 adenylate cyclase 10 (soluble) -0.66
TPK1 thiamin pyrophosphokinase 1 -0.64
N6AMT1 N-6 adenine-specific DNA methyltransferase 1 (putative) -0.62
IER3IP1 immediate early response 3 interacting protein 1 -0.61
TIPE1 TNF alpha induced protein 8 like 1 -0.6
ADGRG6 adhesion G protein-coupled receptor G6 -0.6
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 -0.58
MYH4 myosin, heavy chain 4, skeletal muscle -0.58
GPR108 G protein-coupled receptor 108 -0.56
FBF1 Fas (TNFRSF6) binding factor 1 -0.55
TTN titin -0.54
SPAG17 sperm associated antigen 17 -0.54
ZSCAN26 zinc finger and SCAN domain containing 26 -0.53
DNAH2 dynein, axonemal, heavy chain 2 -0.52
SPTB spectrin, beta, erythrocytic -0.52
SON SON DNA binding protein -0.51
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 -0.51
TUBAL3 tubulin, alpha-like 3 -0.5
ZNF675 zinc finger protein 675 -0.48
TMEM64 transmembrane protein 64 -0.46
REPS2 RALBP1 associated Eps domain containing 2 -0.46
KIAA0825 KIAA0825 -0.46
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa -0.45
RBX1 ring-box 1, E3 ubiquitin protein ligase -0.45
CCAR2 cell cycle and apoptosis regulator 2 -0.44
HINFP histone H4 transcription factor -0.44
TBC1D13 TBC1 domain family, member 13 -0.43
LMX1B LIM homeobox transcription factor 1, beta -0.43
APLP1 amyloid beta (A4) precursor-like protein 1 -0.42
SYPL1 synaptophysin-like 1 -0.42
ZNF114 zinc finger protein 114 -0.42
CABLES1 Cdk5 and Abl enzyme substrate 1 -0.41
FJX1 four jointed box 1 (Drosophila) -0.41
LMF2 lipase maturation factor 2 -0.4
ANKRD10 ankyrin repeat domain 10 -0.4
ZFP30 ZFP30 zinc finger protein -0.4
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.39
LRRC7 leucine rich repeat containing 7 -0.39
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) -0.39
PTPDC1 protein tyrosine phosphatase domain containing 1 -0.39
TRIB3 tribbles pseudokinase 3 -0.38
NDFIP2 Nedd4 family interacting protein 2 -0.38
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.38
AP5B1 adaptor-related protein complex 5, beta 1 subunit -0.38
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -0.37
STYK1 serine/threonine/tyrosine kinase 1 -0.37
RAD9A RAD9 homolog A (S. pombe) -0.37
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 -0.36
IFITM3 interferon induced transmembrane protein 3 -0.36
CYB5A cytochrome b5 type A (microsomal) -0.35
CD81 CD81 molecule -0.35
OSTM1 osteopetrosis associated transmembrane protein 1 -0.35
WDR59 WD repeat domain 59 -0.35
TMEM87B transmembrane protein 87B -0.35
MON1A MON1 secretory trafficking family member A -0.35
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.34
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 -0.34
RNF139 ring finger protein 139 -0.34
NUDT16 nudix (nucleoside diphosphate linked moiety X)-type motif 16 -0.33
MT1E metallothionein 1E -0.33
CCDC102A coiled-coil domain containing 102A -0.33
TRAPPC3 trafficking protein particle complex 3 -0.33
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.33
FAM199X family with sequence similarity 199, X-linked -0.33
SNX7 sorting nexin 7 -0.32
FBXL2 F-box and leucine-rich repeat protein 2 -0.32
PSMG4 proteasome (prosome, macropain) assembly chaperone 4 -0.32
MFAP3L microfibrillar-associated protein 3-like -0.32
RELT RELT tumor necrosis factor receptor -0.32
VWA5A von Willebrand factor A domain containing 5A -0.32
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.32
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 -0.31
CCDC117 coiled-coil domain containing 117 -0.31
ENC1 ectodermal-neural cortex 1 (with BTB domain) -0.31
F2 coagulation factor II (thrombin) -0.31
EIF3K eukaryotic translation initiation factor 3, subunit K -0.31
ALG11 ALG11, alpha-1,2-mannosyltransferase -0.31
KMT2C lysine (K)-specific methyltransferase 2C -0.31