MicroRNAs in cancer Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article. (Kyoto Encyclopedia of Genes and Genomes, hsa05206)
External Link https://www.kegg.jp/entry/hsa05206
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Genes

160 proteins participating in the MicroRNAs in cancer pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ATM ATM serine/threonine kinase
BAK1 BCL2-antagonist/killer 1
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2 BCL2-like 2
BMF Bcl2 modifying factor
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BRCA1 breast cancer 1, early onset
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CCND2 cyclin D2
CCNE1 cyclin E1
CCNE2 cyclin E2
CCNG1 cyclin G1
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDCA5 cell division cycle associated 5
CDK6 cyclin-dependent kinase 6
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDPF1 cysteine-rich, DPF motif domain containing 1
CLSTN1 calsyntenin 1
COMMD3-BMI1 COMMD3-BMI1 readthrough
CREBBP CREB binding protein
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DICER1 dicer 1, ribonuclease type III
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
EFNA1 ephrin-A1
EFNA2 ephrin-A2
EFNA3 ephrin-A3
EFNA4 ephrin-A4
EFNA4-EFNA3 EFNA4-EFNA3 readthrough
EFNA5 ephrin-A5
EGFR epidermal growth factor receptor
EP300 E1A binding protein p300
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
EZR ezrin
FGFR3 fibroblast growth factor receptor 3
FOXP1 forkhead box P1
FSCN1 fascin actin-bundling protein 1
FZD9 frizzled class receptor 9
GLS2 glutaminase 2 (liver, mitochondrial)
GRB2 growth factor receptor-bound protein 2
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HMGA2 high mobility group AT-hook 2
HMOX1 heme oxygenase 1
HNRNPK heterogeneous nuclear ribonucleoprotein K
HOXD10 homeobox D10
HRAS Harvey rat sarcoma viral oncogene homolog
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KIF23 kinesin family member 23
LNCEGFL7OS lncRNA EGFL7 opposite strand
LONP1 lon peptidase 1, mitochondrial
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH3 notch 3
NOTCH4 notch 4
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLAU plasminogen activator, urokinase
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCE protein kinase C, epsilon
PRKCG protein kinase C, gamma
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RDX radixin
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RHOA ras homolog family member A
RNASE3 ribonuclease, RNase A family, 3
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPTOR regulatory associated protein of MTOR, complex 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC4 SHC (Src homology 2 domain containing) family, member 4
SIRT1 sirtuin 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC45A3 solute carrier family 45, member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLTM SAFB-like, transcription modulator
SOCS1 suppressor of cytokine signaling 1
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPRY2 sprouty homolog 2 (Drosophila)
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STMN1 stathmin 1
TGFB2 transforming growth factor, beta 2
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TNN tenascin N
TNNC1 troponin C type 1 (slow)
TNR tenascin R
TNXB tenascin XB
TP53 tumor protein p53
TP63 tumor protein p63
TPM1 tropomyosin 1 (alpha)
TRIM71 tripartite motif containing 71, E3 ubiquitin protein ligase
UBE2I ubiquitin-conjugating enzyme E2I
VEGFA vascular endothelial growth factor A
VIM vimentin
WNT3 wingless-type MMTV integration site family, member 3
WNT3A wingless-type MMTV integration site family, member 3A
ZEB1 zinc finger E-box binding homeobox 1
ZEB2 zinc finger E-box binding homeobox 2
ZFPM2 zinc finger protein, FOG family member 2