Microtubule Gene Set

Dataset COMPARTMENTS Experimental Protein Localization Evidence Scores 2025
Category proteomics
Type cellular component
Description Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. (Gene Ontology, GO_0005874)
External Link http://purl.obolibrary.org/obo/GO_0005874
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Genes

256 proteins localized to the Microtubule cellular component in low- or high-throughput protein localization assays from the COMPARTMENTS Experimental Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
DTNBP1 dystrobrevin binding protein 1 3.182
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.813
IL17RC interleukin 17 receptor C 2.534
CCDC57 coiled-coil domain containing 57 2.46
DEPDC4 DEP domain containing 4 2.441
IFT20 intraflagellar transport 20 2.441
NUTF2 nuclear transport factor 2 2.441
SRPX2 sushi-repeat containing protein, X-linked 2 2.441
CCDC40 coiled-coil domain containing 40 2.441
KIAA1671 KIAA1671 2.441
NAP1L1 nucleosome assembly protein 1-like 1 2.441
ZDHHC18 zinc finger, DHHC-type containing 18 2.441
RPL22L1 ribosomal protein L22-like 1 2.441
SEPTIN12 septin 12 2.441
FTH1 ferritin, heavy polypeptide 1 2.441
RASEF RAS and EF-hand domain containing 2.436
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) 2.395
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 2.369
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.293
TSPAN33 tetraspanin 33 2.259
COL11A1 collagen, type XI, alpha 1 2.259
ZNF347 zinc finger protein 347 2.259
NME8 NME/NM23 family member 8 2.259
SKA1 spindle and kinetochore associated complex subunit 1 2.259
EFNB1 ephrin-B1 2.259
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 2.259
MAP4 microtubule-associated protein 4 2.168
HAS3 hyaluronan synthase 3 2.138
KARS1 lysyl-tRNA synthetase 1 2.095
KIFAP3 kinesin-associated protein 3 2.083
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 2.077
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 2.077
RHBDD3 rhomboid domain containing 3 2.077
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 2.077
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 2.077
TEKT2 tektin 2 (testicular) 2.072
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 2.067
DCXR dicarbonyl/L-xylulose reductase 2.042
RABIF RAB interacting factor 2.032
RPL6 ribosomal protein L6 2.032
SYNJ2 synaptojanin 2 2.012
USP44 ubiquitin specific peptidase 44 2.005
CDK16 cyclin-dependent kinase 16 1.994
ZC4H2 zinc finger, C4H2 domain containing 1.986
GYS1 glycogen synthase 1 (muscle) 1.983
SEPTIN7 septin 7 1.983
WAPL WAPL cohesin release factor 1.961
PGAP2 post-GPI attachment to proteins 2 1.956
ADAL adenosine deaminase-like 1.956
ZNF654 zinc finger protein 654 1.956
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 1.954
IRAK4 interleukin-1 receptor-associated kinase 4 1.929
AGA aspartylglucosaminidase 1.923
MYSM1 Myb-like, SWIRM and MPN domains 1 1.895
MAP2K5 mitogen-activated protein kinase kinase 5 1.895
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa 1.895
FBXO30 F-box protein 30 1.895
LDLRAP1 low density lipoprotein receptor adaptor protein 1 1.895
RNF141 ring finger protein 141 1.895
PIAS1 protein inhibitor of activated STAT, 1 1.895
ACVR2B activin A receptor, type IIB 1.895
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 1.895
SPRY2 sprouty homolog 2 (Drosophila) 1.895
PLCD1 phospholipase C, delta 1 1.895
TMEM116 transmembrane protein 116 1.895
ASRGL1 asparaginase like 1 1.895
DPY19L3 dpy-19-like 3 (C. elegans) 1.895
CELF2 CUGBP, Elav-like family member 2 1.878
GIGYF1 GRB10 interacting GYF protein 1 1.877
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 1.869
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae) 1.864
DZIP1L DAZ interacting zinc finger protein 1-like 1.862
EML4 echinoderm microtubule associated protein like 4 1.818
IDO1 indoleamine 2,3-dioxygenase 1 1.815
NUDCD2 NudC domain containing 2 1.805
GKN1 gastrokine 1 1.805
CENPE centromere protein E, 312kDa 1.805
CNFN cornifelin 1.805
TRAPPC8 trafficking protein particle complex 8 1.805
OTUD7B OTU deubiquitinase 7B 1.805
ANKRD10 ankyrin repeat domain 10 1.805
ANKRD24 ankyrin repeat domain 24 1.805
NAE1 NEDD8 activating enzyme E1 subunit 1 1.802
TMEM186 transmembrane protein 186 1.786
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 1.786
DIAPH3 diaphanous-related formin 3 1.782
POLR1F RNA polymerase I subunit F 1.78
ESAM endothelial cell adhesion molecule 1.774
MPZL1 myelin protein zero-like 1 1.774
TMEM200C transmembrane protein 200C 1.774
TMEM138 transmembrane protein 138 1.774
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 1.774
WDR11 WD repeat domain 11 1.774
TMEM45A transmembrane protein 45A 1.774
KLK10 kallikrein-related peptidase 10 1.77
MEGF6 multiple EGF-like-domains 6 1.759
TMEM115 transmembrane protein 115 1.75
MAPK1 mitogen-activated protein kinase 1 1.75
RBM39 RNA binding motif protein 39 1.74
DGLUCY D-glutamate cyclase 1.725
TMEM25 transmembrane protein 25 1.722
STK32B serine/threonine kinase 32B 1.714
TTLL9 tubulin tyrosine ligase-like family member 9 1.714
LARP6 La ribonucleoprotein domain family, member 6 1.714
EMC1 ER membrane protein complex subunit 1 1.714
IGBP1 immunoglobulin (CD79A) binding protein 1 1.714
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 1.714
TBCA tubulin folding cofactor A 1.714
MRPL18 mitochondrial ribosomal protein L18 1.714
KIF26B kinesin family member 26B 1.714
NEK8 NIMA-related kinase 8 1.714
HOXC8 homeobox C8 1.714
WWC2 WW and C2 domain containing 2 1.714
TTBK2 tau tubulin kinase 2 1.714
HMMR hyaluronan-mediated motility receptor (RHAMM) 1.713
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.711
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1.705
MCM7 minichromosome maintenance complex component 7 1.698
KANSL2 KAT8 regulatory NSL complex subunit 2 1.695
IQCB1 IQ motif containing B1 1.691
PPDPF pancreatic progenitor cell differentiation and proliferation factor 1.691
TOR1AIP1 torsin A interacting protein 1 1.689
ZBTB18 zinc finger and BTB domain containing 18 1.688
NDRG1 N-myc downstream regulated 1 1.677
KNSTRN kinetochore-localized astrin/SPAG5 binding protein 1.677
TMT1B thiol methyltransferase 1B 1.668
F11R F11 receptor 1.668
COLEC11 collectin sub-family member 11 1.668
DENND5B DENN/MADD domain containing 5B 1.668
CISH cytokine inducible SH2-containing protein 1.668
WBP1L WW domain binding protein 1-like 1.668
TSPAN12 tetraspanin 12 1.668
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 1.668
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa 1.663
SRRM3 serine/arginine repetitive matrix 3 1.662
SQLE squalene epoxidase 1.66
ZNF148 zinc finger protein 148 1.656
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 1.653
GFM1 G elongation factor, mitochondrial 1 1.653
ADAM23 ADAM metallopeptidase domain 23 1.653
TMTC3 transmembrane and tetratricopeptide repeat containing 3 1.653
DUSP6 dual specificity phosphatase 6 1.653
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 1.653
TCTN3 tectonic family member 3 1.653
ZNF415 zinc finger protein 415 1.623
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.623
ZNF81 zinc finger protein 81 1.623
LZTS1 leucine zipper, putative tumor suppressor 1 1.623
NUCB1 nucleobindin 1 1.623
SUSD1 sushi domain containing 1 1.623
CEP57 centrosomal protein 57kDa 1.623
SPAG1 sperm associated antigen 1 1.623
IFT22 intraflagellar transport 22 1.623
ESRRA estrogen-related receptor alpha 1.623
CLNS1A chloride channel, nucleotide-sensitive, 1A 1.619
FANCL Fanconi anemia, complementation group L 1.613
C1RL complement component 1, r subcomponent-like 1.592
MRRF mitochondrial ribosome recycling factor 1.592
LRRC34 leucine rich repeat containing 34 1.584
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 1.584
SCYL3 SCY1-like 3 (S. cerevisiae) 1.584
SLC29A4 solute carrier family 29 (equilibrative nucleoside transporter), member 4 1.577
IFT43 intraflagellar transport 43 1.577
RORA RAR-related orphan receptor A 1.577
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 1.577
ACVR1C activin A receptor, type IC 1.573
KIF2B kinesin family member 2B 1.568
RETREG2 reticulophagy regulator family member 2 1.568
CRACDL CRACD like 1.562
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 1.562
CFAP54 cilia and flagella associated 54 1.562
ERP29 endoplasmic reticulum protein 29 1.562
KIF18A kinesin family member 18A 1.562
EIF4A2 eukaryotic translation initiation factor 4A2 1.562
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa 1.558
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) 1.551
CWC27 CWC27 spliceosome-associated protein homolog (S. cerevisiae) 1.55
CRYBG1 crystallin beta-gamma domain containing 1 1.54
PCIF1 PDX1 C-terminal inhibiting factor 1 1.532
ARL6 ADP-ribosylation factor-like 6 1.532
CCDC117 coiled-coil domain containing 117 1.532
IGF2 insulin-like growth factor 2 1.532
PACS1 phosphofurin acidic cluster sorting protein 1 1.532
OFD1 oral-facial-digital syndrome 1 1.532
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2 1.532
TACC1 transforming, acidic coiled-coil containing protein 1 1.532
DOCK9 dedicator of cytokinesis 9 1.532
B4GALNT4 beta-1,4-N-acetyl-galactosaminyl transferase 4 1.532
CEP120 centrosomal protein 120kDa 1.532
EXOC1 exocyst complex component 1 1.532
CKAP2 cytoskeleton associated protein 2 1.532
SPTAN1 spectrin, alpha, non-erythrocytic 1 1.532
CHMP5 charged multivesicular body protein 5 1.532
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 1.532
SP4 Sp4 transcription factor 1.512
KATNB1 katanin p80 (WD repeat containing) subunit B 1 1.506
DGCR8 DGCR8 microprocessor complex subunit 1.506
ZNF397 zinc finger protein 397 1.506
SCAF1 SR-related CTD-associated factor 1 1.506
PRKCI protein kinase C, iota 1.505
MAPK3 mitogen-activated protein kinase 3 1.503
RPUSD2 RNA pseudouridylate synthase domain containing 2 1.502
FAM91A1 family with sequence similarity 91, member A1 1.502
FRYL FRY-like 1.496
DLK1 delta-like 1 homolog (Drosophila) 1.495
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 1.493
MTMR4 myotubularin related protein 4 1.491
ZSCAN12 zinc finger and SCAN domain containing 12 1.486
EMC3 ER membrane protein complex subunit 3 1.486
S100A14 S100 calcium binding protein A14 1.486
SHCBP1 SHC SH2-domain binding protein 1 1.486
ACSF2 acyl-CoA synthetase family member 2 1.486
CDC42 cell division cycle 42 1.486
GLIPR2 GLI pathogenesis-related 2 1.486
SYTL5 synaptotagmin-like 5 1.486
BUD31 BUD31 homolog (S. cerevisiae) 1.48
AXIN2 axin 2 1.48
ALKBH2 alkB, alkylation repair homolog 2 (E. coli) 1.476
XKR4 XK, Kell blood group complex subunit-related family, member 4 1.459
ZNF83 zinc finger protein 83 1.459
TIMELESS timeless circadian clock 1.459
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 1.459
CDC7 cell division cycle 7 1.459
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 1.459
PGM3 phosphoglucomutase 3 1.451
N4BP1 NEDD4 binding protein 1 1.449
RELL1 RELT-like 1 1.441
ARHGAP39 Rho GTPase activating protein 39 1.441
SCLT1 sodium channel and clathrin linker 1 1.441
NUAK1 NUAK family, SNF1-like kinase, 1 1.441
PRC1 protein regulator of cytokinesis 1 1.441
ARL13B ADP-ribosylation factor-like 13B 1.441
KLK6 kallikrein-related peptidase 6 1.428
OCRL oculocerebrorenal syndrome of Lowe 1.423
ENSA endosulfine alpha 1.418
ZNF263 zinc finger protein 263 1.418
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 1.418
CRY1 cryptochrome circadian clock 1 1.418
ELMO1 engulfment and cell motility 1 1.411
SDHAF3 succinate dehydrogenase complex assembly factor 3 1.411
ZNF44 zinc finger protein 44 1.411
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 1.411
PRMT9 protein arginine methyltransferase 9 1.411
SLC38A6 solute carrier family 38, member 6 1.411
CEP131 centrosomal protein 131kDa 1.404
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 1.403
MAP7 microtubule-associated protein 7 1.395
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal 1.395
SEPTIN10 septin 10 1.395
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 1.395
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 1.394
DST dystonin 1.386
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 1.386
ZBTB49 zinc finger and BTB domain containing 49 1.386
AIDA axin interactor, dorsalization associated 1.386
CGREF1 cell growth regulator with EF-hand domain 1 1.38