Midostaurin Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9829523
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Genes

199 proteins with high or low expression in Midostaurin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ANKRD24 ankyrin repeat domain 24 2.74
ZSCAN32 zinc finger and SCAN domain containing 32 2.57
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 2.26
NR4A1 nuclear receptor subfamily 4, group A, member 1 2.19
TP53 tumor protein p53 2.14
TBX3 T-box 3 2.13
F5 coagulation factor V (proaccelerin, labile factor) 2.08
ARHGAP44 Rho GTPase activating protein 44 2.06
CLK1 CDC-like kinase 1 1.88
F10 coagulation factor X 1.63
PHLDA3 pleckstrin homology-like domain, family A, member 3 1.55
APLP1 amyloid beta (A4) precursor-like protein 1 1.53
CLK4 CDC-like kinase 4 1.42
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 1.36
TP53I3 tumor protein p53 inducible protein 3 1.34
SCN11A sodium channel, voltage gated, type XI alpha subunit 1.34
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 1.28
SYCP1 synaptonemal complex protein 1 1.24
DUSP4 dual specificity phosphatase 4 1.24
HBA1 hemoglobin, alpha 1 1.22
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 1.22
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.21
KMT2B lysine (K)-specific methyltransferase 2B 1.16
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.12
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 1.03
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4 1.02
SHROOM3 shroom family member 3 1.01
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.01
HIST2H2AA3 histone cluster 2, H2aa3 1.0
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.0
ALPK3 alpha-kinase 3 0.99
ZBTB38 zinc finger and BTB domain containing 38 0.98
RREB1 ras responsive element binding protein 1 0.96
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.94
TM7SF3 transmembrane 7 superfamily member 3 0.94
LAMA3 laminin, alpha 3 0.9
FAS Fas cell surface death receptor 0.87
CTHRC1 collagen triple helix repeat containing 1 0.86
TTC14 tetratricopeptide repeat domain 14 0.85
OPTN optineurin 0.85
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.84
DLG5 discs, large homolog 5 (Drosophila) 0.83
ITGA1 integrin, alpha 1 0.82
TMUB1 transmembrane and ubiquitin-like domain containing 1 0.82
GAS2L3 growth arrest-specific 2 like 3 0.82
C5ORF24 chromosome 5 open reading frame 24 0.8
BIRC5 baculoviral IAP repeat containing 5 0.79
ATF6B activating transcription factor 6 beta 0.76
REPS2 RALBP1 associated Eps domain containing 2 0.76
SPIN4 spindlin family, member 4 0.75
NEIL1 nei endonuclease VIII-like 1 (E. coli) 0.75
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 0.74
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.74
DCDC1 doublecortin domain containing 1 0.74
COQ8A coenzyme Q8A 0.73
FUBP1 far upstream element (FUSE) binding protein 1 0.73
ZNF12 zinc finger protein 12 0.73
GLMP glycosylated lysosomal membrane protein 0.73
H1-2 H1.2 linker histone, cluster member 0.72
TRAF4 TNF receptor-associated factor 4 0.72
H1FX H1 histone family, member X 0.72
ZYX zyxin 0.72
KLHL36 kelch-like family member 36 0.72
ZNF280B zinc finger protein 280B 0.72
CDCA3 cell division cycle associated 3 0.72
KIF20A kinesin family member 20A 0.72
ATF3 activating transcription factor 3 0.72
ENKD1 enkurin domain containing 1 0.71
VTN vitronectin 0.71
MARCKS myristoylated alanine-rich protein kinase C substrate 0.71
CDCA8 cell division cycle associated 8 0.7
TPM4 tropomyosin 4 0.7
MYL9 myosin, light chain 9, regulatory 0.69
FDXR ferredoxin reductase 0.69
INCENP inner centromere protein antigens 135/155kDa 0.69
MAST2 microtubule associated serine/threonine kinase 2 0.69
ACTA1 actin, alpha 1, skeletal muscle 0.69
FHIT fragile histidine triad 0.68
NT5E 5'-nucleotidase, ecto (CD73) 0.68
CD58 CD58 molecule 0.68
ABHD4 abhydrolase domain containing 4 0.68
CLK2 CDC-like kinase 2 0.68
HLA-F major histocompatibility complex, class I, F 0.67
H1-3 H1.3 linker histone, cluster member 0.67
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.67
LAMC2 laminin, gamma 2 0.66
PDLIM3 PDZ and LIM domain 3 0.66
CMIP c-Maf inducing protein 0.66
PLEC plectin 0.65
RNF167 ring finger protein 167 0.65
LAMA5 laminin, alpha 5 0.65
NDFIP1 Nedd4 family interacting protein 1 0.64
FOSL2 FOS-like antigen 2 0.64
MEGF6 multiple EGF-like-domains 6 0.64
LAMC3 laminin, gamma 3 0.64
IQGAP3 IQ motif containing GTPase activating protein 3 0.64
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.64
HJURP Holliday junction recognition protein 0.64
KIAA1210 KIAA1210 0.63

low expression

Symbol Name Standardized Value
ODC1 ornithine decarboxylase 1 -2.13
BAIAP2 BAI1-associated protein 2 -2.0
DUSP6 dual specificity phosphatase 6 -1.73
VSIR V-set immunoregulatory receptor -1.59
PRKCD protein kinase C, delta -1.58
AKR1C3 aldo-keto reductase family 1, member C3 -1.51
JAG1 jagged 1 -1.48
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 -1.45
TIAM1 T-cell lymphoma invasion and metastasis 1 -1.43
MELK maternal embryonic leucine zipper kinase -1.43
NGFR nerve growth factor receptor -1.41
BCAR1 breast cancer anti-estrogen resistance 1 -1.29
GLCCI1 glucocorticoid induced 1 -1.29
PHETA1 PH domain containing endocytic trafficking adaptor 1 -1.28
PRKCQ protein kinase C, theta -1.23
N4BP1 NEDD4 binding protein 1 -1.23
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 -1.21
IFFO1 intermediate filament family orphan 1 -1.2
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group) -1.15
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 -1.12
CCPG1 cell cycle progression 1 -1.1
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -1.09
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 -1.07
WWC1 WW and C2 domain containing 1 -1.07
CASP2 caspase 2, apoptosis-related cysteine peptidase -1.05
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -1.04
WWC3 WWC family member 3 -1.04
MYO10 myosin X -1.03
ZRANB1 zinc finger, RAN-binding domain containing 1 -1.01
BCAR3 breast cancer anti-estrogen resistance 3 -0.99
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.99
HOXB4 homeobox B4 -0.97
RAB19 RAB19, member RAS oncogene family -0.96
AMD1 adenosylmethionine decarboxylase 1 -0.95
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.94
ZNF417 zinc finger protein 417 -0.94
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 -0.93
FBXW8 F-box and WD repeat domain containing 8 -0.92
TTN titin -0.92
CCNF cyclin F -0.91
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -0.91
SH3RF1 SH3 domain containing ring finger 1 -0.89
SYT1 synaptotagmin I -0.87
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.86
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.86
CLCN2 chloride channel, voltage-sensitive 2 -0.86
MFSD14B major facilitator superfamily domain containing 14B -0.86
MACC1 metastasis associated in colon cancer 1 -0.85
GEM GTP binding protein overexpressed in skeletal muscle -0.85
NES nestin -0.84
WBP2 WW domain binding protein 2 -0.82
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -0.82
RHOBTB3 Rho-related BTB domain containing 3 -0.81
PRKACB protein kinase, cAMP-dependent, catalytic, beta -0.81
TOR3A torsin family 3, member A -0.8
STK4 serine/threonine kinase 4 -0.8
NKIRAS1 NFKB inhibitor interacting Ras-like 1 -0.79
PRSS8 protease, serine, 8 -0.79
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) -0.79
ARHGAP29 Rho GTPase activating protein 29 -0.78
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -0.78
GSE1 Gse1 coiled-coil protein -0.78
HOXB8 homeobox B8 -0.78
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -0.78
STK3 serine/threonine kinase 3 -0.78
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon -0.78
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.77
AAGAB alpha- and gamma-adaptin binding protein -0.77
STYK1 serine/threonine/tyrosine kinase 1 -0.77
CDR2L cerebellar degeneration-related protein 2-like -0.76
ZCCHC2 zinc finger, CCHC domain containing 2 -0.75
ST5 suppression of tumorigenicity 5 -0.74
MID1IP1 MID1 interacting protein 1 -0.74
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -0.73
AKAP11 A kinase (PRKA) anchor protein 11 -0.73
HSBP1 heat shock factor binding protein 1 -0.73
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -0.73
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.72
MCF2L MCF.2 cell line derived transforming sequence-like -0.72
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.72
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.72
KLK6 kallikrein-related peptidase 6 -0.71
CDC25C cell division cycle 25C -0.71
TTLL4 tubulin tyrosine ligase-like family member 4 -0.71
CDC14A cell division cycle 14A -0.71
CDON cell adhesion associated, oncogene regulated -0.71
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.71
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.7
LIX1L Lix1 homolog (chicken) like -0.7
ZFAND5 zinc finger, AN1-type domain 5 -0.7
TYRO3 TYRO3 protein tyrosine kinase -0.7
FGFBP1 fibroblast growth factor binding protein 1 -0.7
UBE2C ubiquitin-conjugating enzyme E2C -0.7
PCDH1 protocadherin 1 -0.68
PNPLA6 patatin-like phospholipase domain containing 6 -0.68
CRTC2 CREB regulated transcription coactivator 2 -0.68
ADGRF1 adhesion G protein-coupled receptor F1 -0.67
FAM53C family with sequence similarity 53, member C -0.67
DGKH diacylglycerol kinase, eta -0.67
MIEF1 mitochondrial elongation factor 1 -0.67