Mifepristone Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/55245
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Genes

199 proteins with high or low expression in Mifepristone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
SEPTIN4 septin 4 2.02
NALCN sodium leak channel, non selective 1.76
ALPK3 alpha-kinase 3 1.5
EPHA4 EPH receptor A4 1.32
SET SET nuclear proto-oncogene 1.18
SLC30A6 solute carrier family 30 (zinc transporter), member 6 1.08
CKM creatine kinase, muscle 1.02
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.92
ANGPTL4 angiopoietin-like 4 0.85
CAV2 caveolin 2 0.84
SUMO1 small ubiquitin-like modifier 1 0.78
TMEM135 transmembrane protein 135 0.73
RPL26 ribosomal protein L26 0.72
F13A1 coagulation factor XIII, A1 polypeptide 0.68
RPL36AL ribosomal protein L36a-like 0.68
MRPS11 mitochondrial ribosomal protein S11 0.68
ZMYM6 zinc finger, MYM-type 6 0.64
JAGN1 jagunal homolog 1 (Drosophila) 0.6
LASP1 LIM and SH3 protein 1 0.58
SRSF4 serine/arginine-rich splicing factor 4 0.57
DYNLL1 dynein, light chain, LC8-type 1 0.57
FLNA filamin A, alpha 0.56
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.54
TMED2 transmembrane emp24 domain trafficking protein 2 0.53
MOB1B MOB kinase activator 1B 0.53
MRPL30 mitochondrial ribosomal protein L30 0.52
SDF2L1 stromal cell-derived factor 2-like 1 0.51
RPL29 ribosomal protein L29 0.51
ACTA1 actin, alpha 1, skeletal muscle 0.5
RPF2 ribosome production factor 2 homolog (S. cerevisiae) 0.5
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 0.49
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A 0.49
EZR ezrin 0.48
GRHL1 grainyhead-like 1 (Drosophila) 0.47
TKT transketolase 0.47
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 0.47
LAP3 leucine aminopeptidase 3 0.47
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.46
SEC23A Sec23 homolog A (S. cerevisiae) 0.46
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.46
MYH9 myosin, heavy chain 9, non-muscle 0.46
RPL18A ribosomal protein L18a 0.45
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.45
NUDC nudC nuclear distribution protein 0.44
TEN1 TEN1 CST complex subunit 0.43
UBE2O ubiquitin-conjugating enzyme E2O 0.43
RPL23A ribosomal protein L23a 0.43
RCC2 regulator of chromosome condensation 2 0.43
NONO non-POU domain containing, octamer-binding 0.43
PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 0.43
PKM pyruvate kinase, muscle 0.43
FERMT1 fermitin family member 1 0.42
CTNND2 catenin (cadherin-associated protein), delta 2 0.42
PMM2 phosphomannomutase 2 0.42
CDC23 cell division cycle 23 0.42
PA2G4 proliferation-associated 2G4, 38kDa 0.41
TBX3 T-box 3 0.41
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 0.41
PDIK1L PDLIM1 interacting kinase 1 like 0.41
TSN translin 0.41
ATAD3A ATPase family, AAA domain containing 3A 0.41
ATP5IF1 ATP synthase inhibitory factor subunit 1 0.41
RPL7 ribosomal protein L7 0.4
VMP1 vacuole membrane protein 1 0.4
TUBA1A tubulin, alpha 1a 0.4
HSPA8 heat shock 70kDa protein 8 0.4
PLEC plectin 0.4
ABHD4 abhydrolase domain containing 4 0.4
LGALS1 lectin, galactoside-binding, soluble, 1 0.39
BSN bassoon presynaptic cytomatrix protein 0.39
RPS16 ribosomal protein S16 0.39
DDN dendrin 0.38
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 0.38
GSTO1 glutathione S-transferase omega 1 0.38
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 0.38
MSH5 mutS homolog 5 0.37
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 0.37
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.37
HNRNPA0 heterogeneous nuclear ribonucleoprotein A0 0.37
CASZ1 castor zinc finger 1 0.37
PTPRD protein tyrosine phosphatase, receptor type, D 0.37
HIST2H2BF histone cluster 2, H2bf 0.37
RAVER1 ribonucleoprotein, PTB-binding 1 0.37
NOTCH3 notch 3 0.37
RAB10 RAB10, member RAS oncogene family 0.36
ITGA6 integrin, alpha 6 0.36
CPOX coproporphyrinogen oxidase 0.36
SOD1 superoxide dismutase 1, soluble 0.36
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 0.35
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.35
FAM49B family with sequence similarity 49, member B 0.35
TRIM28 tripartite motif containing 28 0.35
MRPS16 mitochondrial ribosomal protein S16 0.35
TACSTD2 tumor-associated calcium signal transducer 2 0.35
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.34
ADIRF adipogenesis regulatory factor 0.34
RBX1 ring-box 1, E3 ubiquitin protein ligase 0.34
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 0.34
MAT2A methionine adenosyltransferase II, alpha 0.34
MSN moesin 0.34

low expression

Symbol Name Standardized Value
ZMYM1 zinc finger, MYM-type 1 -1.09
WLS wntless Wnt ligand secretion mediator -0.96
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.88
TMEM175 transmembrane protein 175 -0.82
LTBP4 latent transforming growth factor beta binding protein 4 -0.8
RNF145 ring finger protein 145 -0.76
ARG2 arginase 2 -0.7
KLF2 Kruppel-like factor 2 -0.64
RWDD2A RWD domain containing 2A -0.57
DNAH9 dynein, axonemal, heavy chain 9 -0.57
MYH13 myosin, heavy chain 13, skeletal muscle -0.57
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -0.55
RAD52 RAD52 homolog (S. cerevisiae) -0.52
NFE2L3 nuclear factor, erythroid 2-like 3 -0.51
IL17RB interleukin 17 receptor B -0.51
SAYSD1 SAYSVFN motif domain containing 1 -0.5
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.49
CABLES1 Cdk5 and Abl enzyme substrate 1 -0.49
SARAF store-operated calcium entry-associated regulatory factor -0.49
EYS eyes shut homolog (Drosophila) -0.49
ERMARD ER membrane-associated RNA degradation -0.48
SEZ6L2 seizure related 6 homolog (mouse)-like 2 -0.45
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 -0.44
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -0.41
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -0.41
CMC1 C-x(9)-C motif containing 1 -0.41
COL6A3 collagen, type VI, alpha 3 -0.41
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.4
SCNN1A sodium channel, non voltage gated 1 alpha subunit -0.4
ZNF33A zinc finger protein 33A -0.4
KIAA1210 KIAA1210 -0.4
STK16 serine/threonine kinase 16 -0.39
ZBTB4 zinc finger and BTB domain containing 4 -0.38
SF1 splicing factor 1 -0.38
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.38
ZNF142 zinc finger protein 142 -0.37
NF1 neurofibromin 1 -0.36
TNNC2 troponin C type 2 (fast) -0.36
MTMR4 myotubularin related protein 4 -0.36
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -0.36
OSBPL2 oxysterol binding protein-like 2 -0.36
ZBTB25 zinc finger and BTB domain containing 25 -0.36
TSPAN5 tetraspanin 5 -0.35
UBE2F ubiquitin-conjugating enzyme E2F (putative) -0.35
DBNL drebrin-like -0.35
GVINP1 GTPase, very large interferon inducible pseudogene 1 -0.35
GJC1 gap junction protein, gamma 1, 45kDa -0.35
CISD2 CDGSH iron sulfur domain 2 -0.34
ARL16 ADP-ribosylation factor-like 16 -0.34
F3 coagulation factor III (thromboplastin, tissue factor) -0.34
SLC25A39 solute carrier family 25, member 39 -0.34
ACSL6 acyl-CoA synthetase long-chain family member 6 -0.33
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 -0.33
HDAC8 histone deacetylase 8 -0.33
SPEG SPEG complex locus -0.33
PRKCQ protein kinase C, theta -0.33
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -0.33
JUN jun proto-oncogene -0.33
AADAT aminoadipate aminotransferase -0.33
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.33
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 -0.32
ZNF219 zinc finger protein 219 -0.32
ALG10B ALG10B, alpha-1,2-glucosyltransferase -0.32
RETREG2 reticulophagy regulator family member 2 -0.32
POLR1D polymerase (RNA) I polypeptide D, 16kDa -0.32
ZBTB5 zinc finger and BTB domain containing 5 -0.31
STK19 serine/threonine kinase 19 -0.31
ZNF711 zinc finger protein 711 -0.31
RGS19 regulator of G-protein signaling 19 -0.31
GEMIN2 gem (nuclear organelle) associated protein 2 -0.31
FBF1 Fas (TNFRSF6) binding factor 1 -0.31
ZMYND19 zinc finger, MYND-type containing 19 -0.31
DCLRE1A DNA cross-link repair 1A -0.31
RND3 Rho family GTPase 3 -0.3
CCDC14 coiled-coil domain containing 14 -0.3
ZDHHC23 zinc finger, DHHC-type containing 23 -0.3
CLK1 CDC-like kinase 1 -0.3
ZNF658 zinc finger protein 658 -0.3
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) -0.3
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -0.3
PDE2A phosphodiesterase 2A, cGMP-stimulated -0.3
MROH6 maestro heat-like repeat family member 6 -0.3
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.3
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) -0.29
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.29
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -0.29
BRWD3 bromodomain and WD repeat domain containing 3 -0.29
CPA4 carboxypeptidase A4 -0.29
LMF1 lipase maturation factor 1 -0.29
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.29
KIF1B kinesin family member 1B -0.29
PIGU phosphatidylinositol glycan anchor biosynthesis, class U -0.29
RNASEH1 ribonuclease H1 -0.29
NGFR nerve growth factor receptor -0.29
APOB apolipoprotein B -0.29
C6ORF89 chromosome 6 open reading frame 89 -0.29
ZFAND2A zinc finger, AN1-type domain 2A -0.29
VSIR V-set immunoregulatory receptor -0.29
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -0.28