Mifepristone_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mifepristone perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mifepristone_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0634479
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0549599
ERRFI1 ERBB receptor feedback inhibitor 1 0.0538011
YAP1 Yes-associated protein 1 0.0506504
PCBP2 poly(rC) binding protein 2 0.0475153
PDE4D phosphodiesterase 4D, cAMP-specific 0.0418308
DST dystonin 0.0414693
EIF4B eukaryotic translation initiation factor 4B 0.0367648
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0329821
PDGFC platelet derived growth factor C 0.0329572
CCNL1 cyclin L1 0.0301079
TPM3 tropomyosin 3 0.0298022
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0290412
RPL3 ribosomal protein L3 0.028727
AHNAK AHNAK nucleoprotein 0.0267611
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0264212
CENPF centromere protein F, 350/400kDa 0.0263859
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0262418
EEF2 eukaryotic translation elongation factor 2 0.0248798
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0244154
ECT2 epithelial cell transforming 2 0.0236704
IPO7 importin 7 0.0231672
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0231494
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.023144
TENM3 teneurin transmembrane protein 3 0.0225908
XPO1 exportin 1 0.0224515
DSPP dentin sialophosphoprotein 0.0223382
KIF5B kinesin family member 5B 0.0220278
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0216832
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0216492
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0208873
WDR43 WD repeat domain 43 0.0207745
POTEF POTE ankyrin domain family, member F 0.0198679
PCM1 pericentriolar material 1 0.0197188
USP9X ubiquitin specific peptidase 9, X-linked 0.0192588
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0191084
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0190671
ANXA1 annexin A1 0.0190593
HSPA8 heat shock 70kDa protein 8 0.0188302
MKI67 marker of proliferation Ki-67 0.0185855
EIF3A eukaryotic translation initiation factor 3, subunit A 0.018293
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0179829
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0179357
PREPL prolyl endopeptidase-like 0.0174885
CLDND1 claudin domain containing 1 0.0174168
RPL4 ribosomal protein L4 0.0173921
MYH9 myosin, heavy chain 9, non-muscle 0.0173723
NEK7 NIMA-related kinase 7 0.0170761
ENO1 enolase 1, (alpha) 0.0170242
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.01673
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0166644
CKAP5 cytoskeleton associated protein 5 0.0164735
FAT1 FAT atypical cadherin 1 0.0160106
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0158522
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0157488
MAP1B microtubule-associated protein 1B 0.0148241
MCL1 myeloid cell leukemia 1 0.0147019
MED13L mediator complex subunit 13-like 0.0144219
PLK2 polo-like kinase 2 0.0143235
TOP2B topoisomerase (DNA) II beta 180kDa 0.0143059
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0140787
ANKRD36 ankyrin repeat domain 36 0.0140703
GASK1B golgi associated kinase 1B 0.0140267
APP amyloid beta (A4) precursor protein 0.014015
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0138085
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0138034
TNPO1 transportin 1 0.0137845
RB1CC1 RB1-inducible coiled-coil 1 0.0137224
CLTC clathrin, heavy chain (Hc) 0.0136881
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0136732
HLTF helicase-like transcription factor 0.0135011
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0134303
NFE2L1 nuclear factor, erythroid 2-like 1 0.013399
SFPQ splicing factor proline/glutamine-rich 0.0133287
GOLT1A golgi transport 1A 0.0131671
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.013158
KDM6A lysine (K)-specific demethylase 6A 0.0130875
RIMKLB ribosomal modification protein rimK-like family member B 0.0129684
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0128812
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0128563
CEP70 centrosomal protein 70kDa 0.0127062
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0126216
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0126152
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0125429
NCKAP1 NCK-associated protein 1 0.0124576
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0124451
NSUN2 NOP2/Sun RNA methyltransferase family, member 2 0.012351
ADAR adenosine deaminase, RNA-specific 0.0123436
WNK1 WNK lysine deficient protein kinase 1 0.0122617
TPR translocated promoter region, nuclear basket protein 0.0122236
AFDN afadin, adherens junction formation factor 0.0121589
SPAG5 sperm associated antigen 5 0.0118445
SET SET nuclear proto-oncogene 0.0118182
SS18 synovial sarcoma translocation, chromosome 18 0.0116774
ADAM17 ADAM metallopeptidase domain 17 0.0116435
VCL vinculin 0.0115109
DIAPH1 diaphanous-related formin 1 0.0115071
NBAS neuroblastoma amplified sequence 0.0112556
GARS1 glycyl-tRNA synthetase 1 0.0112096
PTEN phosphatase and tensin homolog 0.0112011

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.277038
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.271134
TMSB10 thymosin beta 10 -0.212977
AREG amphiregulin -0.159767
FTL ferritin, light polypeptide -0.119059
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0935954
PTMA prothymosin, alpha -0.0749822
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0749085
RPL35A ribosomal protein L35a -0.0660994
RPS8 ribosomal protein S8 -0.0621092
PCDH7 protocadherin 7 -0.0602369
RPS6 ribosomal protein S6 -0.058485
HMGA2 high mobility group AT-hook 2 -0.0565231
RPLP1 ribosomal protein, large, P1 -0.0557904
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.052033
RPL19 ribosomal protein L19 -0.0520009
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0517879
TPT1 tumor protein, translationally-controlled 1 -0.0508414
MYL12B myosin, light chain 12B, regulatory -0.0501505
RPS27A ribosomal protein S27a -0.0493539
RPL23 ribosomal protein L23 -0.048276
RPS3 ribosomal protein S3 -0.0463844
RPS19 ribosomal protein S19 -0.0447426
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.043037
RPLP2 ribosomal protein, large, P2 -0.0428462
RPL12 ribosomal protein L12 -0.0421777
RPL34 ribosomal protein L34 -0.0420077
RPS13 ribosomal protein S13 -0.0401667
CNRIP1 cannabinoid receptor interacting protein 1 -0.0399932
RPL8 ribosomal protein L8 -0.0398432
PFN1 profilin 1 -0.0397569
RPL36 ribosomal protein L36 -0.0396314
HSPB1 heat shock 27kDa protein 1 -0.0387181
RPS24 ribosomal protein S24 -0.0384374
RPL31 ribosomal protein L31 -0.0382803
RPL26 ribosomal protein L26 -0.0369144
GNAS GNAS complex locus -0.0361742
RPS29 ribosomal protein S29 -0.0361673
HMGA1 high mobility group AT-hook 1 -0.0360337
RPS23 ribosomal protein S23 -0.0331776
RPS21 ribosomal protein S21 -0.0325251
ZNF804A zinc finger protein 804A -0.032249
EHBP1 EH domain binding protein 1 -0.032115
RPS16 ribosomal protein S16 -0.0321035
ANKRD12 ankyrin repeat domain 12 -0.0318373
CCND1 cyclin D1 -0.031632
EIF1 eukaryotic translation initiation factor 1 -0.030826
GCG glucagon -0.0307212
RPL37A ribosomal protein L37a -0.0300371
TUBA1B tubulin, alpha 1b -0.0297562
RPL28 ribosomal protein L28 -0.0296372
ATP5F1B ATP synthase F1 subunit beta -0.0296018
RPS27 ribosomal protein S27 -0.0294321
S100A6 S100 calcium binding protein A6 -0.0291189
VDAC1 voltage-dependent anion channel 1 -0.0285679
YBX3 Y box binding protein 3 -0.0285198
RPS12 ribosomal protein S12 -0.0284218
RPL9 ribosomal protein L9 -0.0282558
RPL38 ribosomal protein L38 -0.0282318
RPL11 ribosomal protein L11 -0.0280605
RPS14 ribosomal protein S14 -0.0278716
RPS15 ribosomal protein S15 -0.0278699
TPI1 triosephosphate isomerase 1 -0.0273279
RPS5 ribosomal protein S5 -0.0273244
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0270511
RPL37 ribosomal protein L37 -0.0270321
EGR1 early growth response 1 -0.027022
RPLP0 ribosomal protein, large, P0 -0.026799
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0260059
LOC112694756 uncharaterized LOC112694756 -0.0258662
RPS25 ribosomal protein S25 -0.0258439
DPYD dihydropyrimidine dehydrogenase -0.0251996
RPS10 ribosomal protein S10 -0.0246889
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0241377
RACK1 receptor for activated C kinase 1 -0.0239918
NAP1L1 nucleosome assembly protein 1-like 1 -0.023849
SLC38A2 solute carrier family 38, member 2 -0.0232681
BPTF bromodomain PHD finger transcription factor -0.0231866
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0229288
RPL36A ribosomal protein L36a -0.0229259
S100A10 S100 calcium binding protein A10 -0.0229162
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0228385
HMGB1 high mobility group box 1 -0.0227845
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0227629
RPL32 ribosomal protein L32 -0.0226834
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0226638
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0225464
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0225122
FUS FUS RNA binding protein -0.0224843
INTS6 integrator complex subunit 6 -0.0224315
IFIH1 interferon induced with helicase C domain 1 -0.0221012
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0220327
RPL27A ribosomal protein L27a -0.0218255
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0216918
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0215766
SYT1 synaptotagmin I -0.0208101
RPL5 ribosomal protein L5 -0.0207561
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0206674
DLC1 DLC1 Rho GTPase activating protein -0.0203787
SLC38A1 solute carrier family 38, member 1 -0.0203572