Mifepristone_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mifepristone perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mifepristone_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITPRID2 ITPR interacting domain containing 2 0.0519732
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0505725
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0505168
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0500529
NRG1 neuregulin 1 0.0485917
FMN1 formin 1 0.0475815
AHNAK AHNAK nucleoprotein 0.0361337
DST dystonin 0.034315
PARP14 poly (ADP-ribose) polymerase family, member 14 0.033775
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0328572
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0322108
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0318096
MYH9 myosin, heavy chain 9, non-muscle 0.0314084
PLPP1 phospholipid phosphatase 1 0.0314069
CENPF centromere protein F, 350/400kDa 0.0296485
STAT1 signal transducer and activator of transcription 1, 91kDa 0.029185
ASPH aspartate beta-hydroxylase 0.0291446
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0285974
RPL4 ribosomal protein L4 0.028391
ADAR adenosine deaminase, RNA-specific 0.0278743
PTEN phosphatase and tensin homolog 0.0278111
RNF213 ring finger protein 213 0.0275741
PLAT plasminogen activator, tissue 0.0272189
PDE4D phosphodiesterase 4D, cAMP-specific 0.0271317
TENT5A terminal nucleotidyltransferase 5A 0.0271313
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0266879
ANGPT1 angiopoietin 1 0.0266364
PCBP3 poly(rC) binding protein 3 0.0265775
MAP1B microtubule-associated protein 1B 0.0263003
SVIL supervillin 0.0260065
PTPRD protein tyrosine phosphatase, receptor type, D 0.0257173
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.0254534
ZFC3H1 zinc finger, C3H1-type containing 0.0254308
DNMBP dynamin binding protein 0.0252037
TENM4 teneurin transmembrane protein 4 0.0243514
TLE4 transducin-like enhancer of split 4 0.0242909
DPH6 diphthamine biosynthesis 6 0.0241139
RAB30 RAB30, member RAS oncogene family 0.0232899
WDFY3 WD repeat and FYVE domain containing 3 0.0230854
THBS1 thrombospondin 1 0.0228459
LIMCH1 LIM and calponin homology domains 1 0.0226236
AHR aryl hydrocarbon receptor 0.0226012
TPST1 tyrosylprotein sulfotransferase 1 0.0221874
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0220501
ATRNL1 attractin-like 1 0.0218736
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.02177
EIF4B eukaryotic translation initiation factor 4B 0.0216632
CEMIP2 cell migration inducing hyaluronidase 2 0.0213829
DENND4C DENN/MADD domain containing 4C 0.0212418
PCBP2 poly(rC) binding protein 2 0.0212115
ERRFI1 ERBB receptor feedback inhibitor 1 0.0209269
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0209129
ARHGAP9 Rho GTPase activating protein 9 0.0207269
PTPRM protein tyrosine phosphatase, receptor type, M 0.0206518
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0203686
FRMD6 FERM domain containing 6 0.0202542
TRIM25 tripartite motif containing 25 0.019888
HAS2 hyaluronan synthase 2 0.0197582
PTPRK protein tyrosine phosphatase, receptor type, K 0.019441
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0191721
PSD3 pleckstrin and Sec7 domain containing 3 0.0190609
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0189834
KCTD3 potassium channel tetramerization domain containing 3 0.0189593
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.018902
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0187292
SLITRK6 SLIT and NTRK-like family, member 6 0.0185005
UBAP2L ubiquitin associated protein 2-like 0.0183765
NRIP1 nuclear receptor interacting protein 1 0.0183648
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0182868
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0179373
BICD1 bicaudal D homolog 1 (Drosophila) 0.0177488
PLIN2 perilipin 2 0.017647
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.017542
PLAGL1 pleiomorphic adenoma gene-like 1 0.0171272
CLCN3 chloride channel, voltage-sensitive 3 0.017044
HSPA8 heat shock 70kDa protein 8 0.0170076
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0164364
SEPTIN9 septin 9 0.0163725
FNDC3B fibronectin type III domain containing 3B 0.0163606
ADGRG6 adhesion G protein-coupled receptor G6 0.0160555
SLC35F3 solute carrier family 35, member F3 0.0159945
PITPNB phosphatidylinositol transfer protein, beta 0.0159687
PELI1 pellino E3 ubiquitin protein ligase 1 0.0159611
RPL3 ribosomal protein L3 0.0157509
CDK19 cyclin-dependent kinase 19 0.0154788
ADGRB3 adhesion G protein-coupled receptor B3 0.0153206
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0153093
GIGYF2 GRB10 interacting GYF protein 2 0.0150134
CCNY cyclin Y 0.0149838
GLI3 GLI family zinc finger 3 0.0149767
SDK1 sidekick cell adhesion molecule 1 0.0148989
ITGAV integrin, alpha V 0.0148467
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0147959
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 0.014744
NRP1 neuropilin 1 0.0147375
ANTXR2 anthrax toxin receptor 2 0.014726
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0146657
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0146467
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0146288
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0146268

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.41736
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.202192
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.194229
PTMA prothymosin, alpha -0.167327
RPL23 ribosomal protein L23 -0.126568
RPS6 ribosomal protein S6 -0.120824
RPLP1 ribosomal protein, large, P1 -0.0902731
VIM vimentin -0.0821381
RPL19 ribosomal protein L19 -0.0769021
RPL35A ribosomal protein L35a -0.0757607
NALF1 NALCN channel auxiliary factor 1 -0.0723417
TMSB10 thymosin beta 10 -0.0722076
TPT1 tumor protein, translationally-controlled 1 -0.0684179
COL1A1 collagen, type I, alpha 1 -0.0663185
EXT1 exostosin glycosyltransferase 1 -0.0656516
RPL38 ribosomal protein L38 -0.0651035
RPL37A ribosomal protein L37a -0.0638381
LSAMP limbic system-associated membrane protein -0.0632486
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0590173
RPL34 ribosomal protein L34 -0.0583541
NDRG1 N-myc downstream regulated 1 -0.057891
RPS19 ribosomal protein S19 -0.0575135
RPS3 ribosomal protein S3 -0.056438
FTL ferritin, light polypeptide -0.0533567
RPS24 ribosomal protein S24 -0.0525358
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0520556
B2M beta-2-microglobulin -0.0488157
AKAP12 A kinase (PRKA) anchor protein 12 -0.0485514
RPL12 ribosomal protein L12 -0.0478477
RPS12 ribosomal protein S12 -0.0462615
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0458395
RPL26 ribosomal protein L26 -0.0439142
RPL32 ribosomal protein L32 -0.0438854
RPS14 ribosomal protein S14 -0.0434908
HIP1 huntingtin interacting protein 1 -0.0428357
RPS8 ribosomal protein S8 -0.0418714
WSB1 WD repeat and SOCS box containing 1 -0.0414244
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0410297
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0399039
EIF1 eukaryotic translation initiation factor 1 -0.0385602
RPL31 ribosomal protein L31 -0.0385167
RPS17 ribosomal protein S17 -0.038186
RPL37 ribosomal protein L37 -0.0376553
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0372443
RPS29 ribosomal protein S29 -0.036962
VCL vinculin -0.0369516
RPS27 ribosomal protein S27 -0.0358543
IGFBP3 insulin-like growth factor binding protein 3 -0.0352114
RPL7A ribosomal protein L7a -0.0347079
RPS25 ribosomal protein S25 -0.0345336
IER3 immediate early response 3 -0.0343594
RPL36A ribosomal protein L36a -0.0335384
RPL27 ribosomal protein L27 -0.0333192
RPL36 ribosomal protein L36 -0.0330289
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0325694
RPL11 ribosomal protein L11 -0.0323863
RPL28 ribosomal protein L28 -0.0322966
NREP neuronal regeneration related protein -0.0320164
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0318584
ENAH enabled homolog (Drosophila) -0.0317051
RPS27A ribosomal protein S27a -0.0315752
RAB7A RAB7A, member RAS oncogene family -0.0312956
RPLP2 ribosomal protein, large, P2 -0.0312798
RACK1 receptor for activated C kinase 1 -0.0310396
RPL5 ribosomal protein L5 -0.0309981
S100A9 S100 calcium binding protein A9 -0.030763
EGR1 early growth response 1 -0.0304762
BPTF bromodomain PHD finger transcription factor -0.0303575
RPS21 ribosomal protein S21 -0.0302475
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0302065
RPS23 ribosomal protein S23 -0.0299673
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0297886
KPNB1 karyopherin (importin) beta 1 -0.0295394
RPS5 ribosomal protein S5 -0.0293943
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0289129
RPS11 ribosomal protein S11 -0.0288124
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0286808
CEMIP cell migration inducing protein, hyaluronan binding -0.0284393
GLG1 golgi glycoprotein 1 -0.028228
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0281058
PKM pyruvate kinase, muscle -0.0279346
RPLP0 ribosomal protein, large, P0 -0.0278853
SOX9 SRY (sex determining region Y)-box 9 -0.0270478
GOLGA4 golgin A4 -0.0268611
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.02684
RGS5 regulator of G-protein signaling 5 -0.0267491
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0267128
RPL18 ribosomal protein L18 -0.0266537
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0266372
RPL9 ribosomal protein L9 -0.0263615
CUX1 cut-like homeobox 1 -0.0263407
DDIT4 DNA-damage-inducible transcript 4 -0.026014
SLC38A2 solute carrier family 38, member 2 -0.0257832
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0257507
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0256065
LMNA lamin A/C -0.0255763
GNAS GNAS complex locus -0.0254243
S100A6 S100 calcium binding protein A6 -0.0249629
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.024935
MSI2 musashi RNA-binding protein 2 -0.0248703