Mifepristone_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mifepristone perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mifepristone_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLIN2 perilipin 2 0.168463
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.129174
MBNL2 muscleblind-like splicing regulator 2 0.109637
RUNX1 runt-related transcription factor 1 0.0926252
MACC1 metastasis associated in colon cancer 1 0.0828405
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0781474
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0721754
DENND4C DENN/MADD domain containing 4C 0.0692992
SPATA13 spermatogenesis associated 13 0.0620886
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0555402
DSPP dentin sialophosphoprotein 0.0532999
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0529337
ENO1 enolase 1, (alpha) 0.0507076
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0492939
ERRFI1 ERBB receptor feedback inhibitor 1 0.0487495
LMO7 LIM domain 7 0.0476011
YAP1 Yes-associated protein 1 0.0475929
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0472481
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0471989
RNF43 ring finger protein 43 0.0458161
SORBS1 sorbin and SH3 domain containing 1 0.0457413
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0442175
FNDC3A fibronectin type III domain containing 3A 0.0433326
STK24 serine/threonine kinase 24 0.0432897
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0422169
MYH9 myosin, heavy chain 9, non-muscle 0.0418838
PRELID2 PRELI domain containing 2 0.0409127
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0387197
ARHGAP26 Rho GTPase activating protein 26 0.038678
TXNIP thioredoxin interacting protein 0.0386409
CCNL1 cyclin L1 0.0381615
MKI67 marker of proliferation Ki-67 0.035459
APLP2 amyloid beta (A4) precursor-like protein 2 0.0347103
PTEN phosphatase and tensin homolog 0.0343285
PTBP3 polypyrimidine tract binding protein 3 0.0337819
EPHB2 EPH receptor B2 0.0332179
ARHGAP32 Rho GTPase activating protein 32 0.0320473
MYO1E myosin IE 0.0320205
BCLAF1 BCL2-associated transcription factor 1 0.0318108
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0317207
SPRED1 sprouty-related, EVH1 domain containing 1 0.0313366
VMP1 vacuole membrane protein 1 0.0311708
TC2N tandem C2 domains, nuclear 0.0306543
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0302174
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0299487
DSCAM Down syndrome cell adhesion molecule 0.0296549
IFNGR1 interferon gamma receptor 1 0.0296192
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0293774
FRK fyn-related Src family tyrosine kinase 0.0292997
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0292949
UBAC2 UBA domain containing 2 0.0292795
MCTP2 multiple C2 domains, transmembrane 2 0.0287524
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0286446
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0283011
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0281861
EREG epiregulin 0.0281502
TMEM62 transmembrane protein 62 0.0280825
ASPH aspartate beta-hydroxylase 0.0280684
ARGLU1 arginine and glutamate rich 1 0.0278283
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0277041
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.0276981
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0273326
ATXN1 ataxin 1 0.0262232
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0261451
NRIP1 nuclear receptor interacting protein 1 0.0257848
USP9X ubiquitin specific peptidase 9, X-linked 0.0256789
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0255964
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0254373
ABHD2 abhydrolase domain containing 2 0.0252769
EHF ets homologous factor 0.0251764
AHNAK AHNAK nucleoprotein 0.024709
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0241274
CEMIP2 cell migration inducing hyaluronidase 2 0.0241134
CENPF centromere protein F, 350/400kDa 0.0239201
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0236505
SLK STE20-like kinase 0.0230922
TUFT1 tuftelin 1 0.0230562
NKD1 naked cuticle homolog 1 (Drosophila) 0.0228528
NCOA3 nuclear receptor coactivator 3 0.0227394
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0225047
DST dystonin 0.0224777
OCLN occludin 0.0223827
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0222878
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0222464
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0221811
CD46 CD46 molecule, complement regulatory protein 0.022173
RBM26 RNA binding motif protein 26 0.0220985
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase 0.0218447
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0218135
AOPEP aminopeptidase O (putative) 0.0217551
UTRN utrophin 0.0216524
SP3 Sp3 transcription factor 0.0215439
FAT1 FAT atypical cadherin 1 0.0215413
KLF3 Kruppel-like factor 3 (basic) 0.0212927
LDHA lactate dehydrogenase A 0.0210879
TNNC1 troponin C type 1 (slow) 0.0208981
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0207865
ITGB6 integrin, beta 6 0.0207189
ITGA6 integrin, alpha 6 0.0203848
SAMD4A sterile alpha motif domain containing 4A 0.0203326

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.226998
EPSTI1 epithelial stromal interaction 1 (breast) -0.146321
B2M beta-2-microglobulin -0.131946
LYZ lysozyme -0.121635
LCN2 lipocalin 2 -0.119166
PTMA prothymosin, alpha -0.111024
HLA-B major histocompatibility complex, class I, B -0.100624
RNF213 ring finger protein 213 -0.0942902
RIGI RNA sensor RIG-I -0.0841188
EGR1 early growth response 1 -0.0825692
IFI6 interferon, alpha-inducible protein 6 -0.0819974
FTL ferritin, light polypeptide -0.0769926
NPSR1 neuropeptide S receptor 1 -0.0748744
XAF1 XIAP associated factor 1 -0.0743298
RPL35A ribosomal protein L35a -0.0737894
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0709736
STS steroid sulfatase (microsomal), isozyme S -0.0696694
TMSB10 thymosin beta 10 -0.0669544
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0656438
SP100 SP100 nuclear antigen -0.064658
RPS6 ribosomal protein S6 -0.062802
RPL34 ribosomal protein L34 -0.0619617
AHI1 Abelson helper integration site 1 -0.0593013
MX2 MX dynamin-like GTPase 2 -0.0541429
RPL37A ribosomal protein L37a -0.0514508
MAP7 microtubule-associated protein 7 -0.0507201
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0502776
RPL23 ribosomal protein L23 -0.0492773
MX1 MX dynamin-like GTPase 1 -0.0479891
SLC38A1 solute carrier family 38, member 1 -0.0479508
RAB7A RAB7A, member RAS oncogene family -0.0478197
PERP PERP, TP53 apoptosis effector -0.0476977
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0474197
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0465117
NDRG1 N-myc downstream regulated 1 -0.0462244
RPL31 ribosomal protein L31 -0.0455647
EIF1 eukaryotic translation initiation factor 1 -0.0440548
MUC20 mucin 20, cell surface associated -0.0439701
RPL26 ribosomal protein L26 -0.04308
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0423898
IGFBP3 insulin-like growth factor binding protein 3 -0.0419842
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0403916
RPS8 ribosomal protein S8 -0.0398194
RPL11 ribosomal protein L11 -0.0390402
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0390106
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0387218
IFIH1 interferon induced with helicase C domain 1 -0.0386955
RPS19 ribosomal protein S19 -0.0385442
IFI27 interferon, alpha-inducible protein 27 -0.0384954
GCLC glutamate-cysteine ligase, catalytic subunit -0.0384443
SAMD12 sterile alpha motif domain containing 12 -0.0384197
RPLP1 ribosomal protein, large, P1 -0.0380974
RPL7L1 ribosomal protein L7-like 1 -0.0377641
HLA-E major histocompatibility complex, class I, E -0.0376776
RRBP1 ribosome binding protein 1 -0.0371625
NCOA7 nuclear receptor coactivator 7 -0.0370939
RPL12 ribosomal protein L12 -0.0369969
TM4SF1 transmembrane 4 L six family member 1 -0.0369782
RPL9 ribosomal protein L9 -0.0368075
HLA-A major histocompatibility complex, class I, A -0.0365045
GCC2 GRIP and coiled-coil domain containing 2 -0.0359789
RPS3 ribosomal protein S3 -0.0352541
RPL19 ribosomal protein L19 -0.0352079
TRIO trio Rho guanine nucleotide exchange factor -0.0350605
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0350604
TMC5 transmembrane channel-like 5 -0.0346646
SQSTM1 sequestosome 1 -0.0346056
ZBTB20 zinc finger and BTB domain containing 20 -0.0345219
MPHOSPH8 M-phase phosphoprotein 8 -0.0344739
WSB1 WD repeat and SOCS box containing 1 -0.0343835
PMP22 peripheral myelin protein 22 -0.033825
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0334051
S100A6 S100 calcium binding protein A6 -0.03275
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.032689
RABGAP1L RAB GTPase activating protein 1-like -0.0325591
ISG15 ISG15 ubiquitin-like modifier -0.0322603
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0321783
INTS6 integrator complex subunit 6 -0.0320745
RPS24 ribosomal protein S24 -0.0318899
IFITM3 interferon induced transmembrane protein 3 -0.0316836
PLSCR1 phospholipid scramblase 1 -0.0315107
RPS12 ribosomal protein S12 -0.0314116
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0311504
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0310637
RPLP2 ribosomal protein, large, P2 -0.0308133
HM13 histocompatibility (minor) 13 -0.030689
RPL38 ribosomal protein L38 -0.0302046
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0301071
RPS17 ribosomal protein S17 -0.0299652
UBE2B ubiquitin-conjugating enzyme E2B -0.0297541
RPS25 ribosomal protein S25 -0.0295945
AREG amphiregulin -0.0295645
RPS13 ribosomal protein S13 -0.0295245
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0294969
TM4SF19 transmembrane 4 L six family member 19 -0.0293462
RPS29 ribosomal protein S29 -0.0292432
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0291777
HMGB1 high mobility group box 1 -0.0291492
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0290579
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0287195