Mifepristone_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mifepristone perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mifepristone_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.36427
FN1 fibronectin 1 0.241138
MYH9 myosin, heavy chain 9, non-muscle 0.152135
ENO1 enolase 1, (alpha) 0.137331
AHNAK AHNAK nucleoprotein 0.0892298
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0731161
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0700334
LDHA lactate dehydrogenase A 0.0650201
ANGPTL4 angiopoietin-like 4 0.0643558
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0640454
CALR calreticulin 0.062969
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0592279
NAV2 neuron navigator 2 0.0546319
TRIO trio Rho guanine nucleotide exchange factor 0.0529765
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0526158
PRELID2 PRELI domain containing 2 0.0520526
FTH1 ferritin, heavy polypeptide 1 0.052023
ERRFI1 ERBB receptor feedback inhibitor 1 0.0518317
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0490123
FNDC3B fibronectin type III domain containing 3B 0.0485364
NAV1 neuron navigator 1 0.0471623
CNTN5 contactin 5 0.0465249
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0458592
APP amyloid beta (A4) precursor protein 0.0424719
VEGFA vascular endothelial growth factor A 0.0420968
ANXA1 annexin A1 0.0415356
EEF2 eukaryotic translation elongation factor 2 0.0410335
POTEF POTE ankyrin domain family, member F 0.040094
NFE2L1 nuclear factor, erythroid 2-like 1 0.0397598
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0392716
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0392695
HIPK2 homeodomain interacting protein kinase 2 0.0384288
MACF1 microtubule-actin crosslinking factor 1 0.0381177
COL4A1 collagen, type IV, alpha 1 0.0369013
PDE10A phosphodiesterase 10A 0.036093
HAUS6 HAUS augmin-like complex, subunit 6 0.0358406
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0352396
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.034133
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0339531
ADAM12 ADAM metallopeptidase domain 12 0.0337875
ASPH aspartate beta-hydroxylase 0.0326633
MSN moesin 0.0326447
TNS1 tensin 1 0.0325435
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0322033
RPL3 ribosomal protein L3 0.0319589
ITGAV integrin, alpha V 0.0313916
DST dystonin 0.0312821
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0309566
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0301362
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0299806
VCAN versican 0.0297297
TMSB4X thymosin beta 4, X-linked 0.029604
TNIP1 TNFAIP3 interacting protein 1 0.0295818
CENPF centromere protein F, 350/400kDa 0.0294552
EIF4A1 eukaryotic translation initiation factor 4A1 0.0285969
ANXA2 annexin A2 0.0283186
LOXL2 lysyl oxidase-like 2 0.0283113
DSPP dentin sialophosphoprotein 0.0281972
BZW1 basic leucine zipper and W2 domains 1 0.0281051
PCBP2 poly(rC) binding protein 2 0.0273557
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0272113
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0272043
YBX1 Y box binding protein 1 0.0271775
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0271655
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0262253
LTBP1 latent transforming growth factor beta binding protein 1 0.0262118
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0261541
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0261215
ATP13A3 ATPase type 13A3 0.0258837
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0256876
TLN1 talin 1 0.0256435
FAM13A family with sequence similarity 13, member A 0.0247536
CSDE1 cold shock domain containing E1, RNA-binding 0.0246481
FLNA filamin A, alpha 0.0244501
NAMPT nicotinamide phosphoribosyltransferase 0.0241491
CUL4B cullin 4B 0.0239451
PICALM phosphatidylinositol binding clathrin assembly protein 0.0238877
ANXA5 annexin A5 0.0235264
JARID2 jumonji, AT rich interactive domain 2 0.0234945
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0231149
RUNX1 runt-related transcription factor 1 0.0226804
STK10 serine/threonine kinase 10 0.0225031
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0224803
PLEC plectin 0.0224263
IL6ST interleukin 6 signal transducer 0.0223444
TPM3 tropomyosin 3 0.0220755
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0219266
MYOF myoferlin 0.0218412
CANX calnexin 0.0216936
APLP2 amyloid beta (A4) precursor-like protein 2 0.0216067
ANKRD11 ankyrin repeat domain 11 0.0215262
FLNB filamin B, beta 0.0213362
SFPQ splicing factor proline/glutamine-rich 0.0212313
MYO1B myosin IB 0.0208197
DOCK5 dedicator of cytokinesis 5 0.0207783
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0205725
HSPA8 heat shock 70kDa protein 8 0.0202938
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0202736
ATXN1 ataxin 1 0.0201775
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0201075

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.435727
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.175524
COL1A1 collagen, type I, alpha 1 -0.144508
VIM vimentin -0.141374
NDRG1 N-myc downstream regulated 1 -0.119545
EXT1 exostosin glycosyltransferase 1 -0.112567
TMSB10 thymosin beta 10 -0.0848441
IER3 immediate early response 3 -0.0779718
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0732847
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0669278
COL1A2 collagen, type I, alpha 2 -0.0635802
TGFBI transforming growth factor, beta-induced, 68kDa -0.0545185
TM4SF1 transmembrane 4 L six family member 1 -0.0537544
PALLD palladin, cytoskeletal associated protein -0.0445504
FTL ferritin, light polypeptide -0.0429036
RPL35A ribosomal protein L35a -0.0394265
CALD1 caldesmon 1 -0.0390596
FBN1 fibrillin 1 -0.0381241
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0370213
GLIS3 GLIS family zinc finger 3 -0.034889
ALCAM activated leukocyte cell adhesion molecule -0.0341795
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0328087
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0326831
CDH13 cadherin 13 -0.0320059
EGR1 early growth response 1 -0.0313484
HLA-B major histocompatibility complex, class I, B -0.0299404
MRPS6 mitochondrial ribosomal protein S6 -0.0293343
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0287689
MBNL1 muscleblind-like splicing regulator 1 -0.0287364
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.028722
LOX lysyl oxidase -0.0275911
ZFAND3 zinc finger, AN1-type domain 3 -0.0259649
SLC38A2 solute carrier family 38, member 2 -0.025801
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0257278
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.025632
RPS6 ribosomal protein S6 -0.0251994
HMGA2 high mobility group AT-hook 2 -0.0249495
RASA2 RAS p21 protein activator 2 -0.0248914
ZBTB20 zinc finger and BTB domain containing 20 -0.0240036
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0234493
TPT1 tumor protein, translationally-controlled 1 -0.0227226
FOXP1 forkhead box P1 -0.0225017
WSB1 WD repeat and SOCS box containing 1 -0.0223403
TAPBP TAP binding protein (tapasin) -0.0220613
LOC112694756 uncharaterized LOC112694756 -0.0212932
ZCCHC7 zinc finger, CCHC domain containing 7 -0.021258
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0212263
RPL28 ribosomal protein L28 -0.0211248
CAVIN1 caveolae associated protein 1 -0.0211193
OSMR oncostatin M receptor -0.0205509
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0205186
MTDH metadherin -0.0202423
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.01994
TTC3 tetratricopeptide repeat domain 3 -0.0198927
STC1 stanniocalcin 1 -0.0196591
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0196102
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0193157
CCND1 cyclin D1 -0.0193077
RAP1B RAP1B, member of RAS oncogene family -0.0191967
LMAN1 lectin, mannose-binding, 1 -0.0190648
CLMP CXADR-like membrane protein -0.0189647
AHI1 Abelson helper integration site 1 -0.0189622
IL6 interleukin 6 -0.0188436
TRPS1 trichorhinophalangeal syndrome I -0.0186678
ANTXR2 anthrax toxin receptor 2 -0.0186647
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0185597
CD44 CD44 molecule (Indian blood group) -0.0184074
GNAS GNAS complex locus -0.0184068
TRAM1 translocation associated membrane protein 1 -0.0183356
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0181878
HM13 histocompatibility (minor) 13 -0.0181533
H1-0 H1.0 linker histone -0.0180389
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.018
NREP neuronal regeneration related protein -0.0179691
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0177312
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.0175384
S100A9 S100 calcium binding protein A9 -0.0174795
ABI3BP ABI family, member 3 (NESH) binding protein -0.0173896
F3 coagulation factor III (thromboplastin, tissue factor) -0.0172641
RPL34 ribosomal protein L34 -0.0169913
SQLE squalene epoxidase -0.0168382
EBF1 early B-cell factor 1 -0.0165929
RAB2A RAB2A, member RAS oncogene family -0.0165024
RPL36 ribosomal protein L36 -0.0164403
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0164141
RPS8 ribosomal protein S8 -0.0163449
ZFPM2 zinc finger protein, FOG family member 2 -0.0163179
IGFBP7 insulin-like growth factor binding protein 7 -0.0163052
PPARD peroxisome proliferator-activated receptor delta -0.0161899
FKBP10 FK506 binding protein 10, 65 kDa -0.0159902
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0159844
HLA-A major histocompatibility complex, class I, A -0.0158602
S100A6 S100 calcium binding protein A6 -0.015818
RIGI RNA sensor RIG-I -0.0157993
NALF1 NALCN channel auxiliary factor 1 -0.0156974
AGO3 argonaute RISC catalytic component 3 -0.0156613
DPYSL3 dihydropyrimidinase-like 3 -0.0156593
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0155396
TMEM263 transmembrane protein 263 -0.015534
UGDH UDP-glucose 6-dehydrogenase -0.0154649