Mifepristone_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mifepristone perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mifepristone_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLIN2 perilipin 2 0.258282
APOB apolipoprotein B 0.154575
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.124958
FN1 fibronectin 1 0.114398
ERRFI1 ERBB receptor feedback inhibitor 1 0.109796
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0890163
SAMD4A sterile alpha motif domain containing 4A 0.0845211
FBF1 Fas (TNFRSF6) binding factor 1 0.0799913
DSPP dentin sialophosphoprotein 0.0683305
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0673742
STAU1 staufen double-stranded RNA binding protein 1 0.0588902
AFDN afadin, adherens junction formation factor 0.0503857
GPC3 glypican 3 0.0489382
TF transferrin 0.0473614
DST dystonin 0.047211
ENO1 enolase 1, (alpha) 0.0450623
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0428467
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0416698
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0413726
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0407912
DSCAM Down syndrome cell adhesion molecule 0.0406383
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0398975
EEF2 eukaryotic translation elongation factor 2 0.0393798
DLC1 DLC1 Rho GTPase activating protein 0.0392081
ZFAND3 zinc finger, AN1-type domain 3 0.0369515
FNDC3B fibronectin type III domain containing 3B 0.0363294
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0355733
PEG3 paternally expressed 3 0.0350809
PTPRM protein tyrosine phosphatase, receptor type, M 0.0329864
RBM39 RNA binding motif protein 39 0.0327793
MACF1 microtubule-actin crosslinking factor 1 0.0327361
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0321807
GMDS GDP-mannose 4,6-dehydratase 0.0321642
DOCK4 dedicator of cytokinesis 4 0.0318851
VMP1 vacuole membrane protein 1 0.0318529
PCBP2 poly(rC) binding protein 2 0.03131
ITGAV integrin, alpha V 0.0307616
LDHA lactate dehydrogenase A 0.0300802
FOXN3 forkhead box N3 0.0297362
AHNAK AHNAK nucleoprotein 0.029667
TRIO trio Rho guanine nucleotide exchange factor 0.0273529
CANX calnexin 0.0268049
RPL4 ribosomal protein L4 0.0267255
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0262819
EXT1 exostosin glycosyltransferase 1 0.026144
MYH9 myosin, heavy chain 9, non-muscle 0.0258114
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0257051
NCOR1 nuclear receptor corepressor 1 0.0255579
WWC2 WW and C2 domain containing 2 0.0251557
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0251383
ARFGEF3 ARFGEF family member 3 0.0250707
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0250176
NPEPPS aminopeptidase puromycin sensitive 0.0249505
ASPH aspartate beta-hydroxylase 0.0246452
YAP1 Yes-associated protein 1 0.0244511
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0243178
FAM107B family with sequence similarity 107, member B 0.0242669
KIAA1217 KIAA1217 0.0241373
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.024096
SQSTM1 sequestosome 1 0.0239954
CSDE1 cold shock domain containing E1, RNA-binding 0.0238199
PTK2 protein tyrosine kinase 2 0.0235684
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0233802
HDLBP high density lipoprotein binding protein 0.0233199
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0231079
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0229458
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0228593
FMNL2 formin-like 2 0.0226858
SBF2 SET binding factor 2 0.0225682
VCL vinculin 0.0223883
TBC1D22A TBC1 domain family, member 22A 0.0221252
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0220911
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0220493
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0216784
ATXN1 ataxin 1 0.0216248
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0214861
NIPBL Nipped-B homolog (Drosophila) 0.0214273
WAC WW domain containing adaptor with coiled-coil 0.0214266
PGK1 phosphoglycerate kinase 1 0.0213686
PHF3 PHD finger protein 3 0.0211303
KIF5B kinesin family member 5B 0.0210926
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0209318
IPO7 importin 7 0.0209288
CNOT1 CCR4-NOT transcription complex, subunit 1 0.02085
CEMIP2 cell migration inducing hyaluronidase 2 0.0206225
SIK3 SIK family kinase 3 0.0205005
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0204652
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0201874
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0200949
RYBP RING1 and YY1 binding protein 0.0200565
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0197866
KIZ kizuna centrosomal protein 0.0196409
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0196355
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0196063
CORO1C coronin, actin binding protein, 1C 0.0194309
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0193789
PDIA6 protein disulfide isomerase family A, member 6 0.0192881
CAMTA1 calmodulin binding transcription activator 1 0.0192467
RB1CC1 RB1-inducible coiled-coil 1 0.0190839
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0190695

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.407563
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.131316
MT2A metallothionein 2A -0.126362
RPL37A ribosomal protein L37a -0.114422
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.101104
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0896253
RPLP1 ribosomal protein, large, P1 -0.0860115
RPS12 ribosomal protein S12 -0.0810819
RPS6 ribosomal protein S6 -0.0786028
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0685488
TMSB10 thymosin beta 10 -0.0677006
RPS8 ribosomal protein S8 -0.0674268
RPL11 ribosomal protein L11 -0.0635838
RPL26 ribosomal protein L26 -0.0608305
RPL35A ribosomal protein L35a -0.0599679
RPS19 ribosomal protein S19 -0.0590886
FTL ferritin, light polypeptide -0.0565585
RPS17 ribosomal protein S17 -0.0532336
TPT1 tumor protein, translationally-controlled 1 -0.0504997
C3 complement component 3 -0.0496422
RPL23 ribosomal protein L23 -0.0496234
RPLP2 ribosomal protein, large, P2 -0.0491025
RPL31 ribosomal protein L31 -0.0484591
RPL9 ribosomal protein L9 -0.0482322
IGFBP1 insulin-like growth factor binding protein 1 -0.0458651
RPS3 ribosomal protein S3 -0.0455225
RPL37 ribosomal protein L37 -0.0415708
HMGA1 high mobility group AT-hook 1 -0.0408035
RPS24 ribosomal protein S24 -0.0402586
RPL18 ribosomal protein L18 -0.0385991
RPL34 ribosomal protein L34 -0.0383466
RPS27A ribosomal protein S27a -0.037627
RPL36 ribosomal protein L36 -0.0375247
MAML2 mastermind-like 2 (Drosophila) -0.0358516
RPS14 ribosomal protein S14 -0.0350309
RPS29 ribosomal protein S29 -0.0338745
GDF15 growth differentiation factor 15 -0.0333261
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0305389
RPL5 ribosomal protein L5 -0.0303764
RPL19 ribosomal protein L19 -0.0302946
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0300867
B2M beta-2-microglobulin -0.0288676
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.028631
RPL30 ribosomal protein L30 -0.0281987
ISG15 ISG15 ubiquitin-like modifier -0.0278971
RPL12 ribosomal protein L12 -0.0277357
RPL27 ribosomal protein L27 -0.0277089
EGR1 early growth response 1 -0.0273061
RACK1 receptor for activated C kinase 1 -0.0270495
APOA1 apolipoprotein A-I -0.0268811
APOE apolipoprotein E -0.0260271
PTMA prothymosin, alpha -0.0254173
RPS21 ribosomal protein S21 -0.0252754
RPS10 ribosomal protein S10 -0.0251749
IFI6 interferon, alpha-inducible protein 6 -0.0250096
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0244752
RPL13A ribosomal protein L13a -0.023184
S100A9 S100 calcium binding protein A9 -0.0230088
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0227367
RPLP0 ribosomal protein, large, P0 -0.0227332
RPL27A ribosomal protein L27a -0.022716
AKAP12 A kinase (PRKA) anchor protein 12 -0.0226253
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0214775
RPS25 ribosomal protein S25 -0.0213022
SLC38A2 solute carrier family 38, member 2 -0.0211454
SOX5 SRY (sex determining region Y)-box 5 -0.0210141
AMBP alpha-1-microglobulin/bikunin precursor -0.0207441
GNAS GNAS complex locus -0.0196648
IFITM1 interferon induced transmembrane protein 1 -0.0196456
RPS16 ribosomal protein S16 -0.0195764
CST3 cystatin C -0.0193898
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0193787
PDGFB platelet-derived growth factor beta polypeptide -0.0193155
LOC112694756 uncharaterized LOC112694756 -0.0193056
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -0.019181
APOA2 apolipoprotein A-II -0.0191561
S100A6 S100 calcium binding protein A6 -0.0188879
IFITM3 interferon induced transmembrane protein 3 -0.0183534
RPS5 ribosomal protein S5 -0.0183165
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0177985
APOC1 apolipoprotein C-I -0.0177797
HLA-A major histocompatibility complex, class I, A -0.0176775
RPL7 ribosomal protein L7 -0.0176512
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0173835
NKD1 naked cuticle homolog 1 (Drosophila) -0.0171862
RPL28 ribosomal protein L28 -0.0171547
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0167797
IFITM2 interferon induced transmembrane protein 2 -0.0167793
RPS27 ribosomal protein S27 -0.0167525
LYZ lysozyme -0.016614
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0161828
SLC38A1 solute carrier family 38, member 1 -0.0161747
ENAH enabled homolog (Drosophila) -0.0161324
RPL35 ribosomal protein L35 -0.0158626
LCN2 lipocalin 2 -0.0158305
ATP5F1E ATP synthase F1 subunit epsilon -0.0157236
S100P S100 calcium binding protein P -0.0151357
RNF213 ring finger protein 213 -0.0150995
RNASET2 ribonuclease T2 -0.0150959
RPL38 ribosomal protein L38 -0.0149628