Mifepristone_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mifepristone perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mifepristone_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.245311
AHNAK AHNAK nucleoprotein 0.186698
FLNB filamin B, beta 0.182028
ENO1 enolase 1, (alpha) 0.137718
KRT17 keratin 17, type I 0.132004
SLC35F3 solute carrier family 35, member F3 0.131095
PODXL podocalyxin-like 0.105468
PLIN2 perilipin 2 0.101647
POTEF POTE ankyrin domain family, member F 0.0943735
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0912325
ITGA6 integrin, alpha 6 0.0858478
LDHA lactate dehydrogenase A 0.078231
KRT14 keratin 14, type I 0.0690307
LMO7 LIM domain 7 0.0651024
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0621485
PSD3 pleckstrin and Sec7 domain containing 3 0.0621339
TRIO trio Rho guanine nucleotide exchange factor 0.0602805
ANXA1 annexin A1 0.0552992
AKAP13 A kinase (PRKA) anchor protein 13 0.054208
MYH9 myosin, heavy chain 9, non-muscle 0.0531747
FTH1 ferritin, heavy polypeptide 1 0.0520504
ANO1 anoctamin 1, calcium activated chloride channel 0.0516716
KRT6A keratin 6A, type II 0.0511819
EZR ezrin 0.050016
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0436651
SULF2 sulfatase 2 0.0432074
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0426827
MYOF myoferlin 0.0406946
PLCE1 phospholipase C, epsilon 1 0.0405163
SQSTM1 sequestosome 1 0.0400659
TSC22D1 TSC22 domain family, member 1 0.039626
DENND4C DENN/MADD domain containing 4C 0.0394828
ANKRD11 ankyrin repeat domain 11 0.0391196
PDE4D phosphodiesterase 4D, cAMP-specific 0.0388217
EIF4A1 eukaryotic translation initiation factor 4A1 0.0385093
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0384295
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0384161
PLS3 plastin 3 0.0383933
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0377736
RNF217 ring finger protein 217 0.0375405
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0373545
APLP2 amyloid beta (A4) precursor-like protein 2 0.0366043
BZW1 basic leucine zipper and W2 domains 1 0.0362202
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0357957
ITGB4 integrin, beta 4 0.0353852
CALR calreticulin 0.0349668
PLEC plectin 0.0349367
RABGAP1L RAB GTPase activating protein 1-like 0.0348821
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0348719
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0346291
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0328321
ACTN4 actinin, alpha 4 0.0326338
MCL1 myeloid cell leukemia 1 0.0325332
RASA3 RAS p21 protein activator 3 0.0319986
DSPP dentin sialophosphoprotein 0.0316282
KIAA1671 KIAA1671 0.0316173
RPL4 ribosomal protein L4 0.0313019
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0313017
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0310284
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0309237
PRSS23 protease, serine, 23 0.0300103
MPRIP myosin phosphatase Rho interacting protein 0.0295391
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 0.0293574
ALCAM activated leukocyte cell adhesion molecule 0.0286707
PDLIM5 PDZ and LIM domain 5 0.0285813
ZMYND8 zinc finger, MYND-type containing 8 0.0276596
ENO2 enolase 2 (gamma, neuronal) 0.0275845
DIAPH1 diaphanous-related formin 1 0.0272335
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0272138
STK10 serine/threonine kinase 10 0.0269116
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0267735
AMOTL1 angiomotin like 1 0.0266507
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0264118
DGKD diacylglycerol kinase, delta 130kDa 0.0263923
CALB1 calbindin 1, 28kDa 0.0263206
AHNAK2 AHNAK nucleoprotein 2 0.0262324
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0256318
RASAL2 RAS protein activator like 2 0.0253686
RPL3 ribosomal protein L3 0.0252365
MXRA5 matrix-remodelling associated 5 0.0250695
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0250327
RCOR1 REST corepressor 1 0.0250224
YBX1 Y box binding protein 1 0.0249983
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0248474
LAMB3 laminin, beta 3 0.0244653
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0244353
PGK1 phosphoglycerate kinase 1 0.0242659
HMGA2 high mobility group AT-hook 2 0.023997
NCOR2 nuclear receptor corepressor 2 0.0238173
EFNB2 ephrin-B2 0.0235908
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0232886
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0230909
FOXO1 forkhead box O1 0.0228173
PICALM phosphatidylinositol binding clathrin assembly protein 0.0227491
TNS3 tensin 3 0.0224983
CSNK1E casein kinase 1, epsilon 0.0217962
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0217039
EEF2 eukaryotic translation elongation factor 2 0.0215701
OXSR1 oxidative stress responsive 1 0.0214302
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0213218

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.13592
CLU clusterin -0.135821
KIAA1217 KIAA1217 -0.0886772
RIN2 Ras and Rab interactor 2 -0.0794051
NDRG1 N-myc downstream regulated 1 -0.0755907
KMT2E lysine (K)-specific methyltransferase 2E -0.0742245
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0694449
SMAD3 SMAD family member 3 -0.0682241
RPS6 ribosomal protein S6 -0.0629018
NRIP1 nuclear receptor interacting protein 1 -0.0565723
ITCH itchy E3 ubiquitin protein ligase -0.0562289
NRG1 neuregulin 1 -0.0553939
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0541465
RPS2 ribosomal protein S2 -0.0536925
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0530182
DPYD dihydropyrimidine dehydrogenase -0.0529774
GOLGA4 golgin A4 -0.0527971
DSTN destrin (actin depolymerizing factor) -0.0464646
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0463768
STC1 stanniocalcin 1 -0.0456264
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0448406
RBM39 RNA binding motif protein 39 -0.0442202
FOXP1 forkhead box P1 -0.0437808
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0434998
RPS21 ribosomal protein S21 -0.0402095
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.040093
OSMR oncostatin M receptor -0.0394605
H1-0 H1.0 linker histone -0.0392602
ANKRD33B ankyrin repeat domain 33B -0.038681
NCEH1 neutral cholesterol ester hydrolase 1 -0.0380511
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.037275
HM13 histocompatibility (minor) 13 -0.0362552
KTN1 kinectin 1 (kinesin receptor) -0.0361953
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.036094
TGM2 transglutaminase 2 -0.0360021
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0356558
BMAL2 basic helix-loop-helix ARNT like 2 -0.0349133
IGF2 insulin-like growth factor 2 -0.0349117
COG5 component of oligomeric golgi complex 5 -0.0347648
MBNL1 muscleblind-like splicing regulator 1 -0.0346412
DLG1 discs, large homolog 1 (Drosophila) -0.0344405
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0343909
LMNA lamin A/C -0.0336805
YBX3 Y box binding protein 3 -0.0335815
TRAM1 translocation associated membrane protein 1 -0.0332477
ANKRD10 ankyrin repeat domain 10 -0.0325632
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.032443
DOK5 docking protein 5 -0.0323083
MBNL2 muscleblind-like splicing regulator 2 -0.0322488
CEMIP cell migration inducing protein, hyaluronan binding -0.0314938
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.031413
WSB1 WD repeat and SOCS box containing 1 -0.0312616
FN1 fibronectin 1 -0.0309228
RPL21 ribosomal protein L21 -0.0308479
MTSS1 metastasis suppressor 1 -0.0308105
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0302541
PIBF1 progesterone immunomodulatory binding factor 1 -0.0299351
ANO6 anoctamin 6 -0.029773
ARRDC3 arrestin domain containing 3 -0.029672
NAP1L1 nucleosome assembly protein 1-like 1 -0.029382
LOC112694756 uncharaterized LOC112694756 -0.0293704
FNIP1 folliculin interacting protein 1 -0.0291821
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0290747
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0289587
MYO9A myosin IXA -0.0286292
HIP1 huntingtin interacting protein 1 -0.0286157
METTL15 methyltransferase like 15 -0.0285417
PTK2 protein tyrosine kinase 2 -0.0283595
RPS13 ribosomal protein S13 -0.028258
TPX2 TPX2, microtubule-associated -0.0277032
AKAP9 A kinase (PRKA) anchor protein 9 -0.0274359
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0273561
BZW2 basic leucine zipper and W2 domains 2 -0.0269977
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0269161
EHF ets homologous factor -0.0268565
FNBP1 formin binding protein 1 -0.0267267
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0266661
CLTC clathrin, heavy chain (Hc) -0.0265761
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0265577
RPL8 ribosomal protein L8 -0.026024
CMIP c-Maf inducing protein -0.0256859
GOLT1B golgi transport 1B -0.0256587
RLF rearranged L-myc fusion -0.0254775
RSRP1 arginine/serine-rich protein 1 -0.0250123
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0250118
PNISR PNN-interacting serine/arginine-rich protein -0.0249177
ACER3 alkaline ceramidase 3 -0.0248852
SEPTIN9 septin 9 -0.0248623
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0245281
EFHD2 EF-hand domain family, member D2 -0.0245258
UFM1 ubiquitin-fold modifier 1 -0.0245156
SEC31A SEC31 homolog A (S. cerevisiae) -0.0242177
NDE1 nudE neurodevelopment protein 1 -0.0241816
SUCO SUN domain containing ossification factor -0.0241086
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0239856
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0239308
SSBP2 single-stranded DNA binding protein 2 -0.0237232
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0236018
ZFAND3 zinc finger, AN1-type domain 3 -0.0235927
ANTXR2 anthrax toxin receptor 2 -0.023561