Mifepristone_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mifepristone perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mifepristone_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA6 integrin, alpha 6 0.156989
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.14972
TXNIP thioredoxin interacting protein 0.142324
KRT18 keratin 18, type I 0.138708
AHNAK AHNAK nucleoprotein 0.124654
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.123712
KRT8 keratin 8, type II 0.113547
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.112085
DSPP dentin sialophosphoprotein 0.110017
LDHA lactate dehydrogenase A 0.104816
FLNB filamin B, beta 0.101168
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.100752
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0949234
EZR ezrin 0.0943099
ANXA2 annexin A2 0.094228
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0904024
CEMIP cell migration inducing protein, hyaluronan binding 0.0899717
FAM13A family with sequence similarity 13, member A 0.0857265
FAT1 FAT atypical cadherin 1 0.0822447
ARHGAP26 Rho GTPase activating protein 26 0.0769835
ENO1 enolase 1, (alpha) 0.0768593
MYH9 myosin, heavy chain 9, non-muscle 0.0702546
NDRG1 N-myc downstream regulated 1 0.0689506
LMO7 LIM domain 7 0.0662097
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0661085
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0636127
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0632402
DENND4C DENN/MADD domain containing 4C 0.0599845
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.059547
CPT1A carnitine palmitoyltransferase 1A (liver) 0.0577367
PGK1 phosphoglycerate kinase 1 0.0562509
PLIN2 perilipin 2 0.0559909
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0551027
ANXA1 annexin A1 0.0545636
ASPH aspartate beta-hydroxylase 0.0524973
ACTG1 actin gamma 1 0.0524229
FNBP1L formin binding protein 1-like 0.0513033
HSPA8 heat shock 70kDa protein 8 0.0512649
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0511946
PTPRR protein tyrosine phosphatase, receptor type, R 0.0509231
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0506376
MED13 mediator complex subunit 13 0.0498204
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0493356
CCNY cyclin Y 0.0489314
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0488262
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0486724
CENPF centromere protein F, 350/400kDa 0.0484477
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0476738
DSG2 desmoglein 2 0.0475786
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0473542
ANKRD11 ankyrin repeat domain 11 0.0472791
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0458113
ERRFI1 ERBB receptor feedback inhibitor 1 0.0455505
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0453593
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0447882
MYO5B myosin VB 0.0442548
ACTN4 actinin, alpha 4 0.0436735
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0435083
EEF2 eukaryotic translation elongation factor 2 0.0432471
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0428699
ARHGAP12 Rho GTPase activating protein 12 0.0416152
ARHGAP21 Rho GTPase activating protein 21 0.0397926
UBA6 ubiquitin-like modifier activating enzyme 6 0.0391583
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0382945
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0382458
EMP1 epithelial membrane protein 1 0.0381022
TPM3 tropomyosin 3 0.0378905
WDR45B WD repeat domain 45B 0.0372772
APP amyloid beta (A4) precursor protein 0.0371068
POTEF POTE ankyrin domain family, member F 0.0367997
RAB1A RAB1A, member RAS oncogene family 0.0364767
ALCAM activated leukocyte cell adhesion molecule 0.0364562
TSC22D1 TSC22 domain family, member 1 0.0359514
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0357502
WAC WW domain containing adaptor with coiled-coil 0.0357483
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0356891
PRELID2 PRELI domain containing 2 0.0356436
OXSR1 oxidative stress responsive 1 0.0350397
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0350109
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0343856
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0339725
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0337797
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0337736
DIAPH2 diaphanous-related formin 2 0.0336799
TPM4 tropomyosin 4 0.0336261
EPCAM epithelial cell adhesion molecule 0.0334724
IFRD1 interferon-related developmental regulator 1 0.0332131
AUTS2 autism susceptibility candidate 2 0.0331611
ITPRID2 ITPR interacting domain containing 2 0.0329259
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0328402
TPD52 tumor protein D52 0.0325168
RREB1 ras responsive element binding protein 1 0.0321901
MCL1 myeloid cell leukemia 1 0.0321822
CEMIP2 cell migration inducing hyaluronidase 2 0.0316149
KRT19 keratin 19, type I 0.0314306
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0312817
TFRC transferrin receptor 0.0311658
FTH1 ferritin, heavy polypeptide 1 0.0307482
CAB39 calcium binding protein 39 0.0307063
SERINC5 serine incorporator 5 0.0306624

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.109821
RPS19 ribosomal protein S19 -0.0796993
RPS12 ribosomal protein S12 -0.073574
RPLP1 ribosomal protein, large, P1 -0.0698127
RPS6 ribosomal protein S6 -0.0672971
GOLGA4 golgin A4 -0.0653325
RPL37A ribosomal protein L37a -0.0637695
RPS3 ribosomal protein S3 -0.0526584
RPL36 ribosomal protein L36 -0.0490094
RPL12 ribosomal protein L12 -0.0487503
RPL9 ribosomal protein L9 -0.0486247
S100P S100 calcium binding protein P -0.0466366
RPL26 ribosomal protein L26 -0.0455511
FTL ferritin, light polypeptide -0.0455245
RPL35A ribosomal protein L35a -0.0454334
RPL23 ribosomal protein L23 -0.0450564
ISG15 ISG15 ubiquitin-like modifier -0.0446853
RPS27 ribosomal protein S27 -0.043301
RPL34 ribosomal protein L34 -0.0420895
RPS8 ribosomal protein S8 -0.0397214
RPLP2 ribosomal protein, large, P2 -0.0390023
RPL31 ribosomal protein L31 -0.0368555
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0357287
RPL5 ribosomal protein L5 -0.0354555
RPS17 ribosomal protein S17 -0.034862
ANTXR2 anthrax toxin receptor 2 -0.0346619
BTBD9 BTB (POZ) domain containing 9 -0.0321912
RPL11 ribosomal protein L11 -0.0316634
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0309537
GDF15 growth differentiation factor 15 -0.0309198
PTPRK protein tyrosine phosphatase, receptor type, K -0.0306926
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0301774
MBD5 methyl-CpG binding domain protein 5 -0.02953
RPL13A ribosomal protein L13a -0.0284654
RPL19 ribosomal protein L19 -0.0283865
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0280983
AKAP9 A kinase (PRKA) anchor protein 9 -0.0276868
RPL27 ribosomal protein L27 -0.0272472
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0271345
ZBTB20 zinc finger and BTB domain containing 20 -0.0270144
RPS29 ribosomal protein S29 -0.02663
RPL18 ribosomal protein L18 -0.0259624
RPS27A ribosomal protein S27a -0.0257835
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.025607
RPS13 ribosomal protein S13 -0.0255833
PNISR PNN-interacting serine/arginine-rich protein -0.0245064
NFIA nuclear factor I/A -0.0242256
RPL37 ribosomal protein L37 -0.0239072
S100A14 S100 calcium binding protein A14 -0.0235569
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0235361
METTL15 methyltransferase like 15 -0.0234364
SCFD1 sec1 family domain containing 1 -0.0230413
XPC xeroderma pigmentosum, complementation group C -0.0228867
MON2 MON2 homolog (S. cerevisiae) -0.0224711
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0219306
RPL35 ribosomal protein L35 -0.0218774
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0211883
TNS4 tensin 4 -0.021063
RPS14 ribosomal protein S14 -0.0209147
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0202739
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0201577
RPS10 ribosomal protein S10 -0.0201199
TAS2R14 taste receptor, type 2, member 14 -0.0200248
TMEM165 transmembrane protein 165 -0.0197068
PMM2 phosphomannomutase 2 -0.0196079
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0193744
FOXP2 forkhead box P2 -0.0192086
NEBL nebulette -0.0189897
RPL30 ribosomal protein L30 -0.018894
RPS25 ribosomal protein S25 -0.0188218
DDB2 damage-specific DNA binding protein 2, 48kDa -0.0180888
RPS24 ribosomal protein S24 -0.0177608
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0176989
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0173249
ATXN1 ataxin 1 -0.0172303
NALF1 NALCN channel auxiliary factor 1 -0.0169784
RNF43 ring finger protein 43 -0.0168971
RPS26 ribosomal protein S26 -0.0166766
RPL36AL ribosomal protein L36a-like -0.0165858
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0164593
PNN pinin, desmosome associated protein -0.0163876
FRMD5 FERM domain containing 5 -0.0163168
RPL21 ribosomal protein L21 -0.0162067
RBM25 RNA binding motif protein 25 -0.0160086
RPS20 ribosomal protein S20 -0.0159108
DYM dymeclin -0.0158219
COX5A cytochrome c oxidase subunit Va -0.0158112
SLC30A7 solute carrier family 30 (zinc transporter), member 7 -0.0156544
RPS16 ribosomal protein S16 -0.0153378
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) -0.0153285
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 -0.0152734
CADPS2 Ca++-dependent secretion activator 2 -0.0151586
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.0150793
SLC10A7 solute carrier family 10, member 7 -0.0150343
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0148113
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0147816
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.014735
SRSF11 serine/arginine-rich splicing factor 11 -0.0144653
EIF5B eukaryotic translation initiation factor 5B -0.0143035
HM13 histocompatibility (minor) 13 -0.0141592