Mifepristone_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mifepristone perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mifepristone_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.278214
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.125462
EEF2 eukaryotic translation elongation factor 2 0.121156
CSDE1 cold shock domain containing E1, RNA-binding 0.11104
PABPC1 poly(A) binding protein, cytoplasmic 1 0.102692
PTMA prothymosin, alpha 0.0991186
ENO1 enolase 1, (alpha) 0.088917
PCBP2 poly(rC) binding protein 2 0.0836745
POTEF POTE ankyrin domain family, member F 0.0831307
RPS3 ribosomal protein S3 0.0821429
TPM3 tropomyosin 3 0.0807549
YBX1 Y box binding protein 1 0.0766774
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0750154
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0735553
EIF4A1 eukaryotic translation initiation factor 4A1 0.0676139
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0625867
RPL3 ribosomal protein L3 0.0576605
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0567615
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0546314
EIF4B eukaryotic translation initiation factor 4B 0.0520445
SET SET nuclear proto-oncogene 0.0513735
ERRFI1 ERBB receptor feedback inhibitor 1 0.0513062
RPS12 ribosomal protein S12 0.0507206
RPL23 ribosomal protein L23 0.0480501
RPL37A ribosomal protein L37a 0.0466558
VIM vimentin 0.0453917
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0429819
RPL4 ribosomal protein L4 0.041731
ACTG1 actin gamma 1 0.0400206
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0398381
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0397681
LDHA lactate dehydrogenase A 0.0370497
ADAR adenosine deaminase, RNA-specific 0.0369299
MCL1 myeloid cell leukemia 1 0.0365236
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0359371
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0359226
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0350591
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0341511
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0336169
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0335882
TLN1 talin 1 0.0334214
TPI1 triosephosphate isomerase 1 0.0332512
RPS27 ribosomal protein S27 0.0329904
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0329749
RPL37 ribosomal protein L37 0.0322102
MYH9 myosin, heavy chain 9, non-muscle 0.0320101
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0310635
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0303782
AHNAK AHNAK nucleoprotein 0.0299294
SRRM2 serine/arginine repetitive matrix 2 0.0298811
SFPQ splicing factor proline/glutamine-rich 0.0297469
RPS4X ribosomal protein S4, X-linked 0.0296839
RPL12 ribosomal protein L12 0.0294891
EIF5AL1 eukaryotic translation initiation factor 5A-like 1 0.0289819
RPS8 ribosomal protein S8 0.0288998
RPS27A ribosomal protein S27a 0.0285913
PDIA6 protein disulfide isomerase family A, member 6 0.0283331
LDHB lactate dehydrogenase B 0.0282479
KRT18 keratin 18, type I 0.0273094
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0268788
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0267247
CENPF centromere protein F, 350/400kDa 0.02569
GPX4 glutathione peroxidase 4 0.0256074
RPS17 ribosomal protein S17 0.0254866
HSPA8 heat shock 70kDa protein 8 0.024978
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0249364
HDGF hepatoma-derived growth factor 0.0248036
RPS7 ribosomal protein S7 0.0244383
RPL5 ribosomal protein L5 0.0239258
FBL fibrillarin 0.0238449
SRSF5 serine/arginine-rich splicing factor 5 0.0231251
BZW1 basic leucine zipper and W2 domains 1 0.0230152
RPL27 ribosomal protein L27 0.0228748
PGK1 phosphoglycerate kinase 1 0.0226526
NACA nascent polypeptide-associated complex alpha subunit 0.02239
NFE2L1 nuclear factor, erythroid 2-like 1 0.0222128
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0219731
PA2G4 proliferation-associated 2G4, 38kDa 0.0215025
RRM2 ribonucleotide reductase M2 0.021376
PTMS parathymosin 0.0212093
TMSB10 thymosin beta 10 0.0211897
RAD51B RAD51 paralog B 0.0210152
SSB Sjogren syndrome antigen B (autoantigen La) 0.0209745
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.020811
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0207438
TOP2B topoisomerase (DNA) II beta 180kDa 0.0205076
RACK1 receptor for activated C kinase 1 0.020445
CALR calreticulin 0.020225
IPO7 importin 7 0.0199886
RPLP1 ribosomal protein, large, P1 0.0197757
PKM pyruvate kinase, muscle 0.0196802
CKAP5 cytoskeleton associated protein 5 0.019658
RPL13A ribosomal protein L13a 0.0194627
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.01946
MKI67 marker of proliferation Ki-67 0.0194112
RPL11 ribosomal protein L11 0.0193663
RPL26 ribosomal protein L26 0.0193407
HTATSF1 HIV-1 Tat specific factor 1 0.0191875
DSPP dentin sialophosphoprotein 0.0191594
MSH6 mutS homolog 6 0.0191356

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.222776
TFPI2 tissue factor pathway inhibitor 2 -0.128207
OSMR oncostatin M receptor -0.0911497
YBX3 Y box binding protein 3 -0.0865
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0694058
NF1 neurofibromin 1 -0.0652173
THSD4 thrombospondin, type I, domain containing 4 -0.0638487
TXNRD1 thioredoxin reductase 1 -0.0623408
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0621733
AKAP12 A kinase (PRKA) anchor protein 12 -0.0610933
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0600215
ZFAND3 zinc finger, AN1-type domain 3 -0.0592786
EGR1 early growth response 1 -0.0529511
TM4SF1 transmembrane 4 L six family member 1 -0.052896
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0528814
TAS2R14 taste receptor, type 2, member 14 -0.0522136
NABP1 nucleic acid binding protein 1 -0.05117
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0505796
FBXO11 F-box protein 11 -0.0502221
EML4 echinoderm microtubule associated protein like 4 -0.0485817
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0472222
TRIO trio Rho guanine nucleotide exchange factor -0.0466993
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0456255
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0429853
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0422495
WSB1 WD repeat and SOCS box containing 1 -0.0411851
EXT1 exostosin glycosyltransferase 1 -0.0410722
ELL2 elongation factor, RNA polymerase II, 2 -0.0386543
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0386296
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0382328
STC1 stanniocalcin 1 -0.0382047
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0381522
RAB7A RAB7A, member RAS oncogene family -0.0381392
IER3 immediate early response 3 -0.0381169
HMGA2 high mobility group AT-hook 2 -0.0380236
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0374772
BPTF bromodomain PHD finger transcription factor -0.0365535
FUS FUS RNA binding protein -0.0355178
CDK17 cyclin-dependent kinase 17 -0.0350671
EGFR epidermal growth factor receptor -0.0347008
ANO6 anoctamin 6 -0.0345459
ATF6 activating transcription factor 6 -0.034515
PTK2 protein tyrosine kinase 2 -0.0344126
NFE2L2 nuclear factor, erythroid 2-like 2 -0.034174
WNT2B wingless-type MMTV integration site family, member 2B -0.0336888
HLA-B major histocompatibility complex, class I, B -0.0321868
USP34 ubiquitin specific peptidase 34 -0.03197
BMAL2 basic helix-loop-helix ARNT like 2 -0.0319488
ATP11A ATPase, class VI, type 11A -0.0314686
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0312938
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.030755
VCL vinculin -0.0304145
SLC38A2 solute carrier family 38, member 2 -0.0303242
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0300212
RPS15 ribosomal protein S15 -0.0299401
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0299378
RIMS2 regulating synaptic membrane exocytosis 2 -0.0298916
NCOA7 nuclear receptor coactivator 7 -0.029772
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0297171
SPAG9 sperm associated antigen 9 -0.0295681
LARP4B La ribonucleoprotein domain family, member 4B -0.0293831
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0292779
AFF3 AF4/FMR2 family, member 3 -0.0290707
RAB10 RAB10, member RAS oncogene family -0.0289761
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0288141
NIPBL Nipped-B homolog (Drosophila) -0.0285786
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0285286
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0280634
IGF2 insulin-like growth factor 2 -0.0279949
STK4 serine/threonine kinase 4 -0.0278185
NBEAL1 neurobeachin-like 1 -0.0276691
IGF1R insulin-like growth factor 1 receptor -0.0273444
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.027245
ARMH4 armadillo like helical domain containing 4 -0.0265201
ATG7 autophagy related 7 -0.0264612
CCND2 cyclin D2 -0.0263929
PRH1 proline-rich protein HaeIII subfamily 1 -0.0261463
CCND1 cyclin D1 -0.0260926
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0260004
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0258984
PLSCR1 phospholipid scramblase 1 -0.0258543
SETD5 SET domain containing 5 -0.0257544
SENP6 SUMO1/sentrin specific peptidase 6 -0.0257144
GPATCH8 G patch domain containing 8 -0.0256549
ZNF638 zinc finger protein 638 -0.0255962
RPL38 ribosomal protein L38 -0.0254098
RAP1B RAP1B, member of RAS oncogene family -0.0253467
E2F3 E2F transcription factor 3 -0.0253193
CLTC clathrin, heavy chain (Hc) -0.0250584
TAOK1 TAO kinase 1 -0.0249588
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0246924
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0245398
DNAH14 dynein, axonemal, heavy chain 14 -0.0244054
BIRC6 baculoviral IAP repeat containing 6 -0.0241786
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0240933
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0239963
IFI6 interferon, alpha-inducible protein 6 -0.0237914
AGO3 argonaute RISC catalytic component 3 -0.0236648
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0233688
DENND5B DENN/MADD domain containing 5B -0.023292