Mifepristone_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mifepristone perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mifepristone_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.13989
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.120519
PLIN2 perilipin 2 0.0948579
MYH9 myosin, heavy chain 9, non-muscle 0.0802825
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0785075
FN1 fibronectin 1 0.0709326
ACTG1 actin gamma 1 0.0628358
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0621067
APLP2 amyloid beta (A4) precursor-like protein 2 0.0600107
ERRFI1 ERBB receptor feedback inhibitor 1 0.0587758
POTEF POTE ankyrin domain family, member F 0.0559186
AHNAK AHNAK nucleoprotein 0.0551481
ANXA1 annexin A1 0.0530393
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.052323
NDRG1 N-myc downstream regulated 1 0.0492656
ASPH aspartate beta-hydroxylase 0.0467067
SDC4 syndecan 4 0.0433686
EEF2 eukaryotic translation elongation factor 2 0.0400226
ENO1 enolase 1, (alpha) 0.0384602
FLNB filamin B, beta 0.037462
LDHA lactate dehydrogenase A 0.0373718
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0369447
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0362443
PCBP2 poly(rC) binding protein 2 0.0354484
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0344377
FNDC3B fibronectin type III domain containing 3B 0.0342167
ELL2 elongation factor, RNA polymerase II, 2 0.0323461
ANXA5 annexin A5 0.0317967
FAM13A family with sequence similarity 13, member A 0.0316493
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0315068
MSN moesin 0.0308893
TPM3 tropomyosin 3 0.0308357
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0301151
PLEC plectin 0.0298476
DSPP dentin sialophosphoprotein 0.0284539
NAMPT nicotinamide phosphoribosyltransferase 0.0281523
HSPA8 heat shock 70kDa protein 8 0.0278977
TACSTD2 tumor-associated calcium signal transducer 2 0.0278969
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0275356
YAP1 Yes-associated protein 1 0.026768
VEGFA vascular endothelial growth factor A 0.0261668
TNIP1 TNFAIP3 interacting protein 1 0.0255827
RPL3 ribosomal protein L3 0.0254942
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0243959
CCNL1 cyclin L1 0.0237756
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0229654
AREG amphiregulin 0.0228071
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0227806
CCNY cyclin Y 0.0225958
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0222899
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0222322
NRIP1 nuclear receptor interacting protein 1 0.0220263
ADAM9 ADAM metallopeptidase domain 9 0.0218642
GLS2 glutaminase 2 (liver, mitochondrial) 0.0217872
EIF4B eukaryotic translation initiation factor 4B 0.0215882
EREG epiregulin 0.0215881
MCL1 myeloid cell leukemia 1 0.0213932
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0207323
HOMER2 homer scaffolding protein 2 0.0204933
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0204016
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0202902
HMGB2 high mobility group box 2 0.0201841
CENPF centromere protein F, 350/400kDa 0.02013
DIAPH1 diaphanous-related formin 1 0.0200286
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.019923
PTK2B protein tyrosine kinase 2 beta 0.019841
SFPQ splicing factor proline/glutamine-rich 0.019829
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.019795
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0197114
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0195712
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0193695
BCL9L B-cell CLL/lymphoma 9-like 0.0193326
CKAP5 cytoskeleton associated protein 5 0.0192139
USP9X ubiquitin specific peptidase 9, X-linked 0.019125
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0189614
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0188148
LAMC2 laminin, gamma 2 0.0185645
EZR ezrin 0.0179944
DOCK5 dedicator of cytokinesis 5 0.0179548
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0178368
KTN1 kinectin 1 (kinesin receptor) 0.0177195
BIRC3 baculoviral IAP repeat containing 3 0.0177143
KDM6A lysine (K)-specific demethylase 6A 0.0175912
BZW1 basic leucine zipper and W2 domains 1 0.017537
NPTN neuroplastin 0.017514
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0173023
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.017231
RPL4 ribosomal protein L4 0.0171118
B3GNT5 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 0.0170464
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0169809
PDIA4 protein disulfide isomerase family A, member 4 0.0167083
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0164611
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0163164
ARRDC3 arrestin domain containing 3 0.0162481
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0160962
ANLN anillin, actin binding protein 0.016059
ADAR adenosine deaminase, RNA-specific 0.0159461
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.015843
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.015829
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0155717

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.215758
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.210938
TMSB10 thymosin beta 10 -0.197692
PTMA prothymosin, alpha -0.184427
LPP LIM domain containing preferred translocation partner in lipoma -0.138882
EXT1 exostosin glycosyltransferase 1 -0.0970546
FBXO32 F-box protein 32 -0.0969623
TM4SF1 transmembrane 4 L six family member 1 -0.0957924
RPL35A ribosomal protein L35a -0.0914119
IFI27 interferon, alpha-inducible protein 27 -0.0872253
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0825471
SOX4 SRY (sex determining region Y)-box 4 -0.077822
RPL34 ribosomal protein L34 -0.0772399
WSB1 WD repeat and SOCS box containing 1 -0.0768165
CCND1 cyclin D1 -0.0760484
IGFBP3 insulin-like growth factor binding protein 3 -0.0755546
TPT1 tumor protein, translationally-controlled 1 -0.0745131
IFI6 interferon, alpha-inducible protein 6 -0.0683971
ISG15 ISG15 ubiquitin-like modifier -0.0670143
HLA-A major histocompatibility complex, class I, A -0.0633385
RPLP1 ribosomal protein, large, P1 -0.0619352
HLA-B major histocompatibility complex, class I, B -0.0609805
SAMD4A sterile alpha motif domain containing 4A -0.0587893
RPS19 ribosomal protein S19 -0.0587472
EIF1 eukaryotic translation initiation factor 1 -0.0587378
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0567321
LMO7 LIM domain 7 -0.0557391
GNAS GNAS complex locus -0.0545015
S100A6 S100 calcium binding protein A6 -0.0540778
RPS29 ribosomal protein S29 -0.0534581
S100A10 S100 calcium binding protein A10 -0.0516656
CD2AP CD2-associated protein -0.0511565
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0503406
RPLP2 ribosomal protein, large, P2 -0.0498183
IFI16 interferon, gamma-inducible protein 16 -0.049617
RPL19 ribosomal protein L19 -0.0494709
CSTB cystatin B (stefin B) -0.0489736
IFITM3 interferon induced transmembrane protein 3 -0.0489642
RPS13 ribosomal protein S13 -0.0486483
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0483215
MDK midkine (neurite growth-promoting factor 2) -0.0470677
RPS8 ribosomal protein S8 -0.0468493
RPL8 ribosomal protein L8 -0.045344
RPL32 ribosomal protein L32 -0.04533
RPS24 ribosomal protein S24 -0.0445859
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0443679
TMSB4X thymosin beta 4, X-linked -0.0441391
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0437308
RPS6 ribosomal protein S6 -0.0429843
NPEPPS aminopeptidase puromycin sensitive -0.0428457
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0427918
RPS23 ribosomal protein S23 -0.0417329
RPS21 ribosomal protein S21 -0.0417199
RPS3 ribosomal protein S3 -0.0412872
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0395577
H1-0 H1.0 linker histone -0.0389626
MYO6 myosin VI -0.0385686
RPL23 ribosomal protein L23 -0.038469
LIMCH1 LIM and calponin homology domains 1 -0.0383745
TPM4 tropomyosin 4 -0.0381766
RPS25 ribosomal protein S25 -0.037491
MX2 MX dynamin-like GTPase 2 -0.0369112
HSPB1 heat shock 27kDa protein 1 -0.0365169
RPL37A ribosomal protein L37a -0.0365112
RNF213 ring finger protein 213 -0.0360554
LMNA lamin A/C -0.035901
MCU mitochondrial calcium uniporter -0.0357642
RPL31 ribosomal protein L31 -0.035468
VIM vimentin -0.0353323
RBM47 RNA binding motif protein 47 -0.034992
RPS14 ribosomal protein S14 -0.0347016
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0344923
RPS17 ribosomal protein S17 -0.0341149
FRMD5 FERM domain containing 5 -0.0340707
F3 coagulation factor III (thromboplastin, tissue factor) -0.0336973
IFITM1 interferon induced transmembrane protein 1 -0.0334188
RPL30 ribosomal protein L30 -0.0331174
LY6E lymphocyte antigen 6 complex, locus E -0.0330271
RPL9 ribosomal protein L9 -0.032907
PDLIM5 PDZ and LIM domain 5 -0.032664
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0325935
RPS16 ribosomal protein S16 -0.0321291
RPL37 ribosomal protein L37 -0.0315297
MSI2 musashi RNA-binding protein 2 -0.0313835
UBE2H ubiquitin-conjugating enzyme E2H -0.031273
RPL15 ribosomal protein L15 -0.0312286
F11R F11 receptor -0.031062
C15ORF48 chromosome 15 open reading frame 48 -0.0310337
H3-3B H3.3 histone B -0.0309402
KDM5B lysine (K)-specific demethylase 5B -0.0309176
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0307193
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0305519
TPI1 triosephosphate isomerase 1 -0.0304619
TMEM165 transmembrane protein 165 -0.030327
RPL36 ribosomal protein L36 -0.0301693
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0301409
RPS27 ribosomal protein S27 -0.0300873
RPL5 ribosomal protein L5 -0.0296848
HLA-E major histocompatibility complex, class I, E -0.0295324
PLAU plasminogen activator, urokinase -0.029403