Mifepristone_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mifepristone perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mifepristone_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.2104
MYH9 myosin, heavy chain 9, non-muscle 0.143718
NAMPT nicotinamide phosphoribosyltransferase 0.131608
AHNAK AHNAK nucleoprotein 0.0907239
FAM13A family with sequence similarity 13, member A 0.0893536
ENO1 enolase 1, (alpha) 0.0867815
FNDC3B fibronectin type III domain containing 3B 0.0840957
ERRFI1 ERBB receptor feedback inhibitor 1 0.0720325
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0704397
HIPK2 homeodomain interacting protein kinase 2 0.0662592
CALR calreticulin 0.0652448
FNDC3A fibronectin type III domain containing 3A 0.064233
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0602196
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0597884
SOD2 superoxide dismutase 2, mitochondrial 0.0582865
ATP13A3 ATPase type 13A3 0.056212
MACF1 microtubule-actin crosslinking factor 1 0.0535163
TPM4 tropomyosin 4 0.0518218
RNF145 ring finger protein 145 0.0505539
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0499933
FTH1 ferritin, heavy polypeptide 1 0.0482541
MYOF myoferlin 0.0478059
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0477168
TNS3 tensin 3 0.0475097
IQGAP1 IQ motif containing GTPase activating protein 1 0.0470039
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0465277
PID1 phosphotyrosine interaction domain containing 1 0.0464574
TNPO3 transportin 3 0.0456622
TNIP1 TNFAIP3 interacting protein 1 0.0449209
PTBP2 polypyrimidine tract binding protein 2 0.0446123
B2M beta-2-microglobulin 0.0418341
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.041637
JARID2 jumonji, AT rich interactive domain 2 0.0410367
ZFP36L1 ZFP36 ring finger protein-like 1 0.0402484
PGK1 phosphoglycerate kinase 1 0.0385665
SMAD3 SMAD family member 3 0.0383758
TRIO trio Rho guanine nucleotide exchange factor 0.0383691
DENND4C DENN/MADD domain containing 4C 0.0382301
ANXA5 annexin A5 0.0381563
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0381144
SKAP2 src kinase associated phosphoprotein 2 0.0376385
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.0375601
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.037262
QKI QKI, KH domain containing, RNA binding 0.0369489
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0365257
MYO1E myosin IE 0.035557
SYNJ2 synaptojanin 2 0.0354767
ESYT2 extended synaptotagmin-like protein 2 0.0354198
ZNF148 zinc finger protein 148 0.0353807
PCBP2 poly(rC) binding protein 2 0.0348184
TTC3 tetratricopeptide repeat domain 3 0.0345147
SFXN1 sideroflexin 1 0.0339845
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0336243
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0334367
SNX13 sorting nexin 13 0.0334021
ANXA2 annexin A2 0.0333312
ITGAV integrin, alpha V 0.0327026
APP amyloid beta (A4) precursor protein 0.0325089
CUL4B cullin 4B 0.0324256
EEF2 eukaryotic translation elongation factor 2 0.0320358
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0315639
ARRDC3 arrestin domain containing 3 0.0310967
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0307899
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0304172
BACE2 beta-site APP-cleaving enzyme 2 0.030385
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.030321
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0302724
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0300961
FRMD6 FERM domain containing 6 0.0298971
TPM3 tropomyosin 3 0.0297075
SBF2 SET binding factor 2 0.0290933
RNF216 ring finger protein 216 0.0290778
KDM6A lysine (K)-specific demethylase 6A 0.0289903
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0286717
VEGFA vascular endothelial growth factor A 0.0286575
KIDINS220 kinase D-interacting substrate, 220kDa 0.0286109
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 0.0284635
C1D C1D nuclear receptor corepressor 0.0281828
FMNL2 formin-like 2 0.0281088
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0280269
KMT2C lysine (K)-specific methyltransferase 2C 0.027659
WDR43 WD repeat domain 43 0.0276041
FAT1 FAT atypical cadherin 1 0.0273497
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.02728
PDIA6 protein disulfide isomerase family A, member 6 0.0271917
AVL9 AVL9 homolog (S. cerevisiase) 0.0271305
DSCAM Down syndrome cell adhesion molecule 0.0271225
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0271151
EGFR epidermal growth factor receptor 0.0269648
IL6ST interleukin 6 signal transducer 0.0268837
CADM1 cell adhesion molecule 1 0.0268118
CYLD cylindromatosis (turban tumor syndrome) 0.0266981
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0264119
PTK2 protein tyrosine kinase 2 0.0261525
TENT5A terminal nucleotidyltransferase 5A 0.026022
TNPO1 transportin 1 0.0258666
LIMA1 LIM domain and actin binding 1 0.0258261
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.025685
CTSA cathepsin A 0.0255198
SEC23A Sec23 homolog A (S. cerevisiae) 0.0254842

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.230561
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.180815
TMSB10 thymosin beta 10 -0.139225
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.112344
VIM vimentin -0.097468
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0918285
MT2A metallothionein 2A -0.0889545
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0854436
HLA-B major histocompatibility complex, class I, B -0.0827676
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0757379
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0718651
S100A10 S100 calcium binding protein A10 -0.0708172
TGFBI transforming growth factor, beta-induced, 68kDa -0.0662602
COL6A2 collagen, type VI, alpha 2 -0.0644003
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0611912
COL6A1 collagen, type VI, alpha 1 -0.056767
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0561479
HLA-C major histocompatibility complex, class I, C -0.0551072
LMAN1 lectin, mannose-binding, 1 -0.052252
HLA-A major histocompatibility complex, class I, A -0.0507593
FTL ferritin, light polypeptide -0.0493268
HELZ helicase with zinc finger -0.0464647
COL1A2 collagen, type I, alpha 2 -0.0457456
PTMA prothymosin, alpha -0.0454183
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0447779
LOC112694756 uncharaterized LOC112694756 -0.0442803
PTGES2 prostaglandin E synthase 2 -0.043506
PDIA3 protein disulfide isomerase family A, member 3 -0.0427366
PRRC1 proline-rich coiled-coil 1 -0.04206
RPS8 ribosomal protein S8 -0.0416518
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0409698
F3 coagulation factor III (thromboplastin, tissue factor) -0.0409453
PSD3 pleckstrin and Sec7 domain containing 3 -0.0407428
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0405502
CCNI cyclin I -0.0382106
EIF1 eukaryotic translation initiation factor 1 -0.0380552
OGA O-GlcNAcase -0.0380028
RPL28 ribosomal protein L28 -0.0379887
CDH13 cadherin 13 -0.0375826
PRSS23 protease, serine, 23 -0.0372261
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0368034
HM13 histocompatibility (minor) 13 -0.036103
RTN4 reticulon 4 -0.0360482
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0351064
NAV1 neuron navigator 1 -0.0349174
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0342543
NDRG1 N-myc downstream regulated 1 -0.033563
LOX lysyl oxidase -0.0334149
LOXL2 lysyl oxidase-like 2 -0.0333374
THY1 Thy-1 cell surface antigen -0.0333054
SEPTIN7 septin 7 -0.0330676
EIF5B eukaryotic translation initiation factor 5B -0.032248
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0316602
HMGB1 high mobility group box 1 -0.0314101
TMEM165 transmembrane protein 165 -0.0312837
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0310371
COL1A1 collagen, type I, alpha 1 -0.0307662
S100A9 S100 calcium binding protein A9 -0.0306577
RSRC2 arginine/serine-rich coiled-coil 2 -0.0306088
VCL vinculin -0.0304648
ARF1 ADP-ribosylation factor 1 -0.0300857
CDK13 cyclin-dependent kinase 13 -0.0298178
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0296767
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0296119
RPL34 ribosomal protein L34 -0.0295348
SRP54 signal recognition particle 54kDa -0.0293918
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0291176
RPL36A ribosomal protein L36a -0.0290271
RPLP1 ribosomal protein, large, P1 -0.0287484
WASF2 WAS protein family, member 2 -0.0285597
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0284177
COL7A1 collagen, type VII, alpha 1 -0.0282602
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0282186
NABP1 nucleic acid binding protein 1 -0.0279513
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0277925
NT5C2 5'-nucleotidase, cytosolic II -0.0273741
STC1 stanniocalcin 1 -0.0273365
INTS6 integrator complex subunit 6 -0.0272867
LARP1B La ribonucleoprotein domain family, member 1B -0.0266157
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0263762
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0263548
FUS FUS RNA binding protein -0.0263009
GNAS GNAS complex locus -0.0262843
TBCA tubulin folding cofactor A -0.0262773
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0257494
FAM177A1 family with sequence similarity 177, member A1 -0.0257445
TAS2R14 taste receptor, type 2, member 14 -0.0256366
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0251705
DPYD dihydropyrimidine dehydrogenase -0.0250698
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0248823
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.0248535
RPL35A ribosomal protein L35a -0.0247797
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0247515
RPL26 ribosomal protein L26 -0.0245977
MON2 MON2 homolog (S. cerevisiae) -0.0245786
DDIT4 DNA-damage-inducible transcript 4 -0.0245314
UBC ubiquitin C -0.0245069
XPO7 exportin 7 -0.024362
BRD2 bromodomain containing 2 -0.0242247
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0242123