Mifepristone_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mifepristone perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Mifepristone_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0978658
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0840852
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0809421
AHNAK AHNAK nucleoprotein 0.0804372
CENPF centromere protein F, 350/400kDa 0.0674241
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0575108
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0561805
RBM39 RNA binding motif protein 39 0.0538348
LDHA lactate dehydrogenase A 0.0526276
KIF5B kinesin family member 5B 0.051659
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0509117
YAP1 Yes-associated protein 1 0.0500214
ERRFI1 ERBB receptor feedback inhibitor 1 0.0492187
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0469172
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0466644
MYH9 myosin, heavy chain 9, non-muscle 0.0460381
WAC WW domain containing adaptor with coiled-coil 0.0458585
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0457567
ANXA2 annexin A2 0.0455947
JMJD1C jumonji domain containing 1C 0.0453718
PCBP2 poly(rC) binding protein 2 0.0452234
WNK1 WNK lysine deficient protein kinase 1 0.043911
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0438767
CKAP5 cytoskeleton associated protein 5 0.0437907
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0435292
BCLAF1 BCL2-associated transcription factor 1 0.0434893
CAPRIN2 caprin family member 2 0.0432097
TOP2B topoisomerase (DNA) II beta 180kDa 0.0424752
BASP1 brain abundant, membrane attached signal protein 1 0.0424636
RPL4 ribosomal protein L4 0.0418916
MKI67 marker of proliferation Ki-67 0.0409324
XPO1 exportin 1 0.0407416
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0403823
ANXA1 annexin A1 0.0401422
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0401042
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0400016
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0399667
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0393269
FMNL2 formin-like 2 0.0380989
ATP13A3 ATPase type 13A3 0.0373039
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0371267
TRA2A transformer 2 alpha homolog (Drosophila) 0.0369426
AKAP12 A kinase (PRKA) anchor protein 12 0.0366833
ADAM17 ADAM metallopeptidase domain 17 0.0364598
IPO7 importin 7 0.0361099
GOLGA4 golgin A4 0.0350612
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0350502
NAMPT nicotinamide phosphoribosyltransferase 0.0346116
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0338162
ZBTB38 zinc finger and BTB domain containing 38 0.0337914
GOLIM4 golgi integral membrane protein 4 0.0335308
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0334759
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0333911
UBE2O ubiquitin-conjugating enzyme E2O 0.0332951
PDE4D phosphodiesterase 4D, cAMP-specific 0.0326231
SET SET nuclear proto-oncogene 0.0324423
CNTRL centriolin 0.0323948
DEK DEK proto-oncogene 0.03232
HSPA8 heat shock 70kDa protein 8 0.0322336
SEC23A Sec23 homolog A (S. cerevisiae) 0.0320996
HELZ helicase with zinc finger 0.0317039
KIF4A kinesin family member 4A 0.0308809
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0307633
PDE10A phosphodiesterase 10A 0.0305886
KTN1 kinectin 1 (kinesin receptor) 0.0299467
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0299113
SFPQ splicing factor proline/glutamine-rich 0.0298931
PRELID2 PRELI domain containing 2 0.0297437
HMGB2 high mobility group box 2 0.0294306
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0293549
APLP2 amyloid beta (A4) precursor-like protein 2 0.0291206
ZNF292 zinc finger protein 292 0.0286294
RANBP2 RAN binding protein 2 0.0286137
TLN1 talin 1 0.0282543
RAD21 RAD21 homolog (S. pombe) 0.0280328
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0280321
PABPC1 poly(A) binding protein, cytoplasmic 1 0.027979
CSDE1 cold shock domain containing E1, RNA-binding 0.0278631
CHD1 chromodomain helicase DNA binding protein 1 0.0276005
MYOF myoferlin 0.0275302
POTEF POTE ankyrin domain family, member F 0.0275292
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0274171
SCAF8 SR-related CTD-associated factor 8 0.0272798
SCFD1 sec1 family domain containing 1 0.0271347
TPX2 TPX2, microtubule-associated 0.0269836
CAPRIN1 cell cycle associated protein 1 0.0267029
CLINT1 clathrin interactor 1 0.0266519
LNPK lunapark, ER junction formation factor 0.0264173
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.02633
SCAF11 SR-related CTD-associated factor 11 0.0263134
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0261191
CEP250 centrosomal protein 250kDa 0.0260999
ZC3H13 zinc finger CCCH-type containing 13 0.0260604
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0259409
ZNF148 zinc finger protein 148 0.0258861
FAM13A family with sequence similarity 13, member A 0.025779
AGTPBP1 ATP/GTP binding protein 1 0.0256629
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0255917
PTTG1 pituitary tumor-transforming 1 0.0255885
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0254544

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.259553
TMSB10 thymosin beta 10 -0.151044
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0970389
IGFBP3 insulin-like growth factor binding protein 3 -0.087818
FNDC3B fibronectin type III domain containing 3B -0.0784668
VIM vimentin -0.0741926
IGF2 insulin-like growth factor 2 -0.0715982
TPT1 tumor protein, translationally-controlled 1 -0.0608604
ZBTB20 zinc finger and BTB domain containing 20 -0.054622
DPYD dihydropyrimidine dehydrogenase -0.0534703
CD44 CD44 molecule (Indian blood group) -0.0531168
PTMA prothymosin, alpha -0.0487248
HMGA2 high mobility group AT-hook 2 -0.044293
PRKCA protein kinase C, alpha -0.0439288
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.042412
DENND5B DENN/MADD domain containing 5B -0.0411094
RPL35A ribosomal protein L35a -0.0409028
PBX3 pre-B-cell leukemia homeobox 3 -0.0388594
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0384179
PRSS23 protease, serine, 23 -0.0365084
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0363785
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.036123
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.035643
NALCN sodium leak channel, non selective -0.0352462
ATG7 autophagy related 7 -0.0348426
RUNX1 runt-related transcription factor 1 -0.0342515
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0340427
RIGI RNA sensor RIG-I -0.033486
FMN1 formin 1 -0.0332174
SLC38A2 solute carrier family 38, member 2 -0.0331392
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0325782
SVIL supervillin -0.0324977
RPLP1 ribosomal protein, large, P1 -0.0322976
TRIM56 tripartite motif containing 56 -0.0318967
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.030563
RAI14 retinoic acid induced 14 -0.0301691
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0301685
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.029249
FTL ferritin, light polypeptide -0.0291502
SH3KBP1 SH3-domain kinase binding protein 1 -0.0290872
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0289524
H3-3B H3.3 histone B -0.0284435
TUBA1B tubulin, alpha 1b -0.0280127
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0278998
DST dystonin -0.0277724
PTK2 protein tyrosine kinase 2 -0.0275561
PRH1 proline-rich protein HaeIII subfamily 1 -0.0274935
GNAS GNAS complex locus -0.0272196
TRIO trio Rho guanine nucleotide exchange factor -0.027216
ETV6 ets variant 6 -0.0271772
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0271376
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0270261
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0267427
EIF1 eukaryotic translation initiation factor 1 -0.0265341
IFITM3 interferon induced transmembrane protein 3 -0.0263456
MYADM myeloid-associated differentiation marker -0.0260844
ZC3H12B zinc finger CCCH-type containing 12B -0.0258312
MT2A metallothionein 2A -0.0255768
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0255275
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0254379
RPL38 ribosomal protein L38 -0.025253
RPL26 ribosomal protein L26 -0.0251886
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.025142
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0250802
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0250183
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0249707
BICD1 bicaudal D homolog 1 (Drosophila) -0.0249117
EGFR epidermal growth factor receptor -0.0248519
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0248465
SH3D19 SH3 domain containing 19 -0.0245519
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0245221
SBF2 SET binding factor 2 -0.0245034
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0244697
USP34 ubiquitin specific peptidase 34 -0.0241802
ATM ATM serine/threonine kinase -0.024158
PODXL podocalyxin-like -0.0241128
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0239854
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0239844
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0239781
SLC35F3 solute carrier family 35, member F3 -0.0238139
SATB2 SATB homeobox 2 -0.0237188
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0236471
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0235587
HMGA1 high mobility group AT-hook 1 -0.0235494
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0235461
TAS2R14 taste receptor, type 2, member 14 -0.0235234
CCNH cyclin H -0.0234109
ZBTB43 zinc finger and BTB domain containing 43 -0.0234084
NUP214 nucleoporin 214kDa -0.0232839
MAP4 microtubule-associated protein 4 -0.0232344
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0230468
HLA-C major histocompatibility complex, class I, C -0.022997
MAP2K5 mitogen-activated protein kinase kinase 5 -0.0228599
LOC112694756 uncharaterized LOC112694756 -0.022791
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -0.0227355
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0225792
ANKRD28 ankyrin repeat domain 28 -0.022392
CDK12 cyclin-dependent kinase 12 -0.0223351
RPS14 ribosomal protein S14 -0.0222854
UFM1 ubiquitin-fold modifier 1 -0.0222057