Mifepristone_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Mifepristone perturbation in SW 900 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Mifepristone_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.096982
PLIN2 perilipin 2 0.0831989
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.080667
MYH9 myosin, heavy chain 9, non-muscle 0.0738254
NAMPT nicotinamide phosphoribosyltransferase 0.0714824
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.070498
EXT1 exostosin glycosyltransferase 1 0.0693241
AHR aryl hydrocarbon receptor 0.0658197
CENPF centromere protein F, 350/400kDa 0.0650209
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0649448
FNDC3B fibronectin type III domain containing 3B 0.063284
DST dystonin 0.0606647
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0591311
FN1 fibronectin 1 0.0547695
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0540123
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0533769
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0494466
CANX calnexin 0.049391
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0492846
OSMR oncostatin M receptor 0.0473634
AHNAK AHNAK nucleoprotein 0.0472626
ZC3H11A zinc finger CCCH-type containing 11A 0.0435138
NRP1 neuropilin 1 0.0406993
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0402211
TPR translocated promoter region, nuclear basket protein 0.0399456
PTK2 protein tyrosine kinase 2 0.0394775
PRELID2 PRELI domain containing 2 0.0388174
VCL vinculin 0.0387717
CLTC clathrin, heavy chain (Hc) 0.0378826
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0378661
TXNIP thioredoxin interacting protein 0.0375557
CD109 CD109 molecule 0.0374409
TMEM156 transmembrane protein 156 0.0371387
RUNX2 runt-related transcription factor 2 0.0368638
OGA O-GlcNAcase 0.0367007
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.036418
MACF1 microtubule-actin crosslinking factor 1 0.0360529
LIFR leukemia inhibitory factor receptor alpha 0.0358573
IL6ST interleukin 6 signal transducer 0.0351691
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0349268
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0348038
BIRC6 baculoviral IAP repeat containing 6 0.0343764
TM9SF3 transmembrane 9 superfamily member 3 0.0337424
SPRED2 sprouty-related, EVH1 domain containing 2 0.033277
LCORL ligand dependent nuclear receptor corepressor-like 0.0331492
RAD21 RAD21 homolog (S. pombe) 0.0331141
WDR26 WD repeat domain 26 0.0330591
SEC23A Sec23 homolog A (S. cerevisiae) 0.0330201
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0328324
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0327059
GLIS3 GLIS family zinc finger 3 0.0326502
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0319606
NEK7 NIMA-related kinase 7 0.0316067
ZFAND3 zinc finger, AN1-type domain 3 0.0312863
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0312471
ERRFI1 ERBB receptor feedback inhibitor 1 0.0310118
SFTPA2 surfactant protein A2 0.030974
RB1CC1 RB1-inducible coiled-coil 1 0.0307034
NPC1 Niemann-Pick disease, type C1 0.0302844
NRIP1 nuclear receptor interacting protein 1 0.0301658
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0301606
EPS8 epidermal growth factor receptor pathway substrate 8 0.0301593
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0301356
NPAS2 neuronal PAS domain protein 2 0.0300445
SMAD3 SMAD family member 3 0.0297384
FNDC3A fibronectin type III domain containing 3A 0.0295132
USP34 ubiquitin specific peptidase 34 0.0293685
ARHGAP35 Rho GTPase activating protein 35 0.0293606
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0291033
SQSTM1 sequestosome 1 0.0289007
LTBP1 latent transforming growth factor beta binding protein 1 0.0286939
USP9X ubiquitin specific peptidase 9, X-linked 0.0283157
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0282712
HIPK2 homeodomain interacting protein kinase 2 0.0281457
ACTN4 actinin, alpha 4 0.0279866
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0279586
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0279085
APP amyloid beta (A4) precursor protein 0.0278102
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.027795
CAB39 calcium binding protein 39 0.0276262
THBS1 thrombospondin 1 0.0276249
ANLN anillin, actin binding protein 0.0274702
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0273442
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0273345
ATXN1 ataxin 1 0.0272728
SMYD3 SET and MYND domain containing 3 0.0272573
AFDN afadin, adherens junction formation factor 0.026986
CDC73 cell division cycle 73 0.0269236
SUCO SUN domain containing ossification factor 0.0268581
FLNA filamin A, alpha 0.026747
ZNF292 zinc finger protein 292 0.0264258
MAP1B microtubule-associated protein 1B 0.0263309
CD44 CD44 molecule (Indian blood group) 0.0262464
CEP350 centrosomal protein 350kDa 0.0259805
KLHL5 kelch-like family member 5 0.0259642
ADAM17 ADAM metallopeptidase domain 17 0.0258671
XPO1 exportin 1 0.0256505
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0253883
MKI67 marker of proliferation Ki-67 0.0253254
LCOR ligand dependent nuclear receptor corepressor 0.0252538

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.188693
MT2A metallothionein 2A -0.18332
TMSB10 thymosin beta 10 -0.147781
FTL ferritin, light polypeptide -0.115546
RPL37A ribosomal protein L37a -0.0948552
NDRG1 N-myc downstream regulated 1 -0.0885345
RPS12 ribosomal protein S12 -0.0771206
B2M beta-2-microglobulin -0.0749053
S100A6 S100 calcium binding protein A6 -0.0743731
RPL35A ribosomal protein L35a -0.0740246
RPS19 ribosomal protein S19 -0.0739399
IFI27 interferon, alpha-inducible protein 27 -0.0738836
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0729095
RPS3 ribosomal protein S3 -0.0688334
RPS6 ribosomal protein S6 -0.0684812
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0668381
RPL31 ribosomal protein L31 -0.0667414
RPL26 ribosomal protein L26 -0.0663687
RPS8 ribosomal protein S8 -0.0663138
HLA-B major histocompatibility complex, class I, B -0.0656707
RPLP1 ribosomal protein, large, P1 -0.0655518
RPL9 ribosomal protein L9 -0.0643967
RPS27 ribosomal protein S27 -0.062824
VIM vimentin -0.061871
NRG1 neuregulin 1 -0.0591189
RPL37 ribosomal protein L37 -0.0568173
RPL36 ribosomal protein L36 -0.0567906
RPL12 ribosomal protein L12 -0.0550559
RPL23 ribosomal protein L23 -0.0532685
HMGA2 high mobility group AT-hook 2 -0.0531872
RPS27A ribosomal protein S27a -0.0529469
TMEM165 transmembrane protein 165 -0.0486839
RPS29 ribosomal protein S29 -0.0472693
RPL19 ribosomal protein L19 -0.0455241
MRPS6 mitochondrial ribosomal protein S6 -0.0442604
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0434469
RACK1 receptor for activated C kinase 1 -0.0432672
RPL18 ribosomal protein L18 -0.0405148
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0390623
S100A9 S100 calcium binding protein A9 -0.038815
HMGA1 high mobility group AT-hook 1 -0.0385041
LMNA lamin A/C -0.0379237
RPL34 ribosomal protein L34 -0.0372086
HLA-A major histocompatibility complex, class I, A -0.0363266
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0359932
RPS17 ribosomal protein S17 -0.0359351
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0358544
RPS20 ribosomal protein S20 -0.0345898
RPS21 ribosomal protein S21 -0.0342952
RPL30 ribosomal protein L30 -0.0342774
ENO2 enolase 2 (gamma, neuronal) -0.0341842
TMSB4X thymosin beta 4, X-linked -0.0337542
IFI6 interferon, alpha-inducible protein 6 -0.033001
GNAS GNAS complex locus -0.0327938
PKM pyruvate kinase, muscle -0.0327361
ITGA1 integrin, alpha 1 -0.0327073
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0313763
RPL36AL ribosomal protein L36a-like -0.0309252
TPT1 tumor protein, translationally-controlled 1 -0.0309248
RPL35 ribosomal protein L35 -0.0305279
RPL28 ribosomal protein L28 -0.0301005
RPL11 ribosomal protein L11 -0.0294641
EIF1 eukaryotic translation initiation factor 1 -0.0292754
ACTG1 actin gamma 1 -0.0291934
RPS16 ribosomal protein S16 -0.0286008
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0278474
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0267006
RPL5 ribosomal protein L5 -0.0266332
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0265364
SOX4 SRY (sex determining region Y)-box 4 -0.0265082
RPS14 ribosomal protein S14 -0.0260199
PFN1 profilin 1 -0.0258683
IFITM3 interferon induced transmembrane protein 3 -0.0258043
CXCL8 chemokine (C-X-C motif) ligand 8 -0.025423
CST3 cystatin C -0.0253607
EIF5B eukaryotic translation initiation factor 5B -0.0253108
RPL7 ribosomal protein L7 -0.0251638
RPLP2 ribosomal protein, large, P2 -0.0250725
SEC61G Sec61 gamma subunit -0.0249718
IGFBP3 insulin-like growth factor binding protein 3 -0.0249601
ATP5F1E ATP synthase F1 subunit epsilon -0.0247581
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0246352
RPL38 ribosomal protein L38 -0.0245838
RPS25 ribosomal protein S25 -0.02456
RPS23 ribosomal protein S23 -0.0244114
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0236006
NDUFA4 NDUFA4, mitochondrial complex associated -0.0236002
TFPI2 tissue factor pathway inhibitor 2 -0.0235061
POTEF POTE ankyrin domain family, member F -0.0235048
IFITM1 interferon induced transmembrane protein 1 -0.023477
RPS13 ribosomal protein S13 -0.0233993
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0233331
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0233059
LGALS1 lectin, galactoside-binding, soluble, 1 -0.022818
RPS24 ribosomal protein S24 -0.0222929
STC2 stanniocalcin 2 -0.0220032
IL6 interleukin 6 -0.0217255
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0214443
EGR1 early growth response 1 -0.0214182
CADM1 cell adhesion molecule 1 -0.0213719