| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/176077 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Migalastat relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA1 | integrin, alpha 1 | 2.05 |
| KLHL23 | kelch-like family member 23 | 1.93 |
| TPM4 | tropomyosin 4 | 1.22 |
| PPHLN1 | periphilin 1 | 1.17 |
| SUMO2 | small ubiquitin-like modifier 2 | 1.17 |
| IRX4 | iroquois homeobox 4 | 1.14 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.85 |
| HINFP | histone H4 transcription factor | 0.76 |
| PRKAB2 | protein kinase, AMP-activated, beta 2 non-catalytic subunit | 0.75 |
| DYNLL1 | dynein, light chain, LC8-type 1 | 0.72 |
| B2M | beta-2-microglobulin | 0.71 |
| RPL26 | ribosomal protein L26 | 0.64 |
| TJP3 | tight junction protein 3 | 0.63 |
| ATP5PB | ATP synthase peripheral stalk-membrane subunit b | 0.63 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.59 |
| TRAPPC6B | trafficking protein particle complex 6B | 0.56 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.56 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.55 |
| TRIM28 | tripartite motif containing 28 | 0.55 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.52 |
| RPL31 | ribosomal protein L31 | 0.52 |
| ZSCAN5A | zinc finger and SCAN domain containing 5A | 0.51 |
| CWC15 | CWC15 spliceosome-associated protein | 0.51 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.51 |
| FBRS | fibrosin | 0.49 |
| PKM | pyruvate kinase, muscle | 0.49 |
| CDC42 | cell division cycle 42 | 0.48 |
| TPM3 | tropomyosin 3 | 0.47 |
| MBP | myelin basic protein | 0.47 |
| GMCL1 | germ cell-less, spermatogenesis associated 1 | 0.47 |
| PFN1 | profilin 1 | 0.46 |
| PTMA | prothymosin, alpha | 0.46 |
| FSCN1 | fascin actin-bundling protein 1 | 0.45 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.45 |
| COPRS | coordinator of PRMT5, differentiation stimulator | 0.44 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | 0.44 |
| MRC2 | mannose receptor, C type 2 | 0.44 |
| HSPA8 | heat shock 70kDa protein 8 | 0.44 |
| JPT1 | Jupiter microtubule associated homolog 1 | 0.44 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | 0.42 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 0.42 |
| PICK1 | protein interacting with PRKCA 1 | 0.42 |
| VMP1 | vacuole membrane protein 1 | 0.41 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.41 |
| RPL18A | ribosomal protein L18a | 0.41 |
| PROSER2 | proline and serine rich 2 | 0.41 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.41 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.4 |
| HMGB2 | high mobility group box 2 | 0.4 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | 0.4 |
| BUD31 | BUD31 homolog (S. cerevisiae) | 0.4 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.39 |
| SKA3 | spindle and kinetochore associated complex subunit 3 | 0.39 |
| SCAF4 | SR-related CTD-associated factor 4 | 0.39 |
| KIAA1107 | KIAA1107 | 0.39 |
| SFI1 | Sfi1 homolog, spindle assembly associated (yeast) | 0.39 |
| RPL13A | ribosomal protein L13a | 0.38 |
| BLOC1S4 | biogenesis of lysosomal organelles complex-1, subunit 4, cappuccino | 0.38 |
| ANKRD10 | ankyrin repeat domain 10 | 0.38 |
| LGALSL | lectin, galactoside-binding-like | 0.38 |
| LASP1 | LIM and SH3 protein 1 | 0.38 |
| RNASEH2C | ribonuclease H2, subunit C | 0.38 |
| LNX2 | ligand of numb-protein X 2 | 0.38 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.38 |
| RPS16 | ribosomal protein S16 | 0.37 |
| ACTBL2 | actin, beta-like 2 | 0.37 |
| RPL10A | ribosomal protein L10a | 0.37 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.37 |
| RPS17 | ribosomal protein S17 | 0.37 |
| CYBRD1 | cytochrome b reductase 1 | 0.37 |
| PRMT2IP | PRMT2 interacting protein | 0.37 |
| SUMO1 | small ubiquitin-like modifier 1 | 0.36 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | 0.36 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | 0.36 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.36 |
| FMNL1 | formin-like 1 | 0.36 |
| TEN1 | TEN1 CST complex subunit | 0.36 |
| TRIB3 | tribbles pseudokinase 3 | 0.36 |
| KLK6 | kallikrein-related peptidase 6 | 0.36 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.36 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | 0.36 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | 0.35 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.35 |
| TSC22D1 | TSC22 domain family, member 1 | 0.35 |
| RAB10 | RAB10, member RAS oncogene family | 0.35 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.35 |
| ZNF584 | zinc finger protein 584 | 0.35 |
| RBAK | RB-associated KRAB zinc finger | 0.34 |
| GATD1 | glutamine amidotransferase class 1 domain containing 1 | 0.34 |
| MIEN1 | migration and invasion enhancer 1 | 0.34 |
| CRCP | CGRP receptor component | 0.34 |
| TRMT12 | tRNA methyltransferase 12 homolog (S. cerevisiae) | 0.34 |
| ESAM | endothelial cell adhesion molecule | 0.34 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 0.34 |
| SKIL | SKI-like proto-oncogene | 0.34 |
| B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) | 0.33 |
| GEMIN2 | gem (nuclear organelle) associated protein 2 | 0.33 |
| MIIP | migration and invasion inhibitory protein | 0.33 |
| MED16 | mediator complex subunit 16 | 0.33 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.33 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RAB19 | RAB19, member RAS oncogene family | -1.1 |
| MKRN4P | makorin ring finger protein 4, pseudogene | -0.77 |
| TMEM222 | transmembrane protein 222 | -0.73 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.69 |
| FTL | ferritin, light polypeptide | -0.67 |
| MAGEA2 | melanoma antigen family A2 | -0.66 |
| LYST | lysosomal trafficking regulator | -0.63 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | -0.61 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.6 |
| PIP | prolactin-induced protein | -0.58 |
| MERTK | MER proto-oncogene, tyrosine kinase | -0.58 |
| NEU3 | sialidase 3 (membrane sialidase) | -0.54 |
| NRXN3 | neurexin 3 | -0.52 |
| CARD8 | caspase recruitment domain family, member 8 | -0.5 |
| KALRN | kalirin, RhoGEF kinase | -0.5 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.49 |
| FANCF | Fanconi anemia, complementation group F | -0.49 |
| TDRD9 | tudor domain containing 9 | -0.47 |
| F2R | coagulation factor II (thrombin) receptor | -0.47 |
| TMEM219 | transmembrane protein 219 | -0.45 |
| CCDC158 | coiled-coil domain containing 158 | -0.44 |
| MYT1 | myelin transcription factor 1 | -0.43 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | -0.43 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -0.43 |
| SPAG17 | sperm associated antigen 17 | -0.42 |
| SLC26A6 | solute carrier family 26 (anion exchanger), member 6 | -0.42 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.42 |
| ANKRD18B | ankyrin repeat domain 18B | -0.41 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.41 |
| TM7SF2 | transmembrane 7 superfamily member 2 | -0.4 |
| CYP4V2 | cytochrome P450, family 4, subfamily V, polypeptide 2 | -0.4 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.4 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | -0.4 |
| KIF21B | kinesin family member 21B | -0.4 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.4 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | -0.39 |
| LYSMD2 | LysM, putative peptidoglycan-binding, domain containing 2 | -0.39 |
| HYKK | hydroxylysine kinase | -0.39 |
| CENPT | centromere protein T | -0.39 |
| TSPYL4 | TSPY-like 4 | -0.38 |
| PAH | phenylalanine hydroxylase | -0.38 |
| DNAH1 | dynein, axonemal, heavy chain 1 | -0.38 |
| MEST | mesoderm specific transcript | -0.37 |
| RAB36 | RAB36, member RAS oncogene family | -0.36 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.36 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | -0.36 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.36 |
| IER3IP1 | immediate early response 3 interacting protein 1 | -0.36 |
| ABHD2 | abhydrolase domain containing 2 | -0.36 |
| CRAMP1 | cramped chromatin regulator homolog 1 | -0.35 |
| SGCE | sarcoglycan, epsilon | -0.35 |
| RAD51D | RAD51 paralog D | -0.35 |
| TSPAN9 | tetraspanin 9 | -0.35 |
| COL1A2 | collagen, type I, alpha 2 | -0.35 |
| QSOX1 | quiescin Q6 sulfhydryl oxidase 1 | -0.35 |
| KLHL2 | kelch-like family member 2 | -0.35 |
| WARS2 | tryptophanyl tRNA synthetase 2, mitochondrial | -0.35 |
| FGFR4 | fibroblast growth factor receptor 4 | -0.34 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | -0.34 |
| WWOX | WW domain containing oxidoreductase | -0.34 |
| DYNLT3 | dynein, light chain, Tctex-type 3 | -0.34 |
| PDE9A | phosphodiesterase 9A | -0.34 |
| EPHX4 | epoxide hydrolase 4 | -0.34 |
| FLNA | filamin A, alpha | -0.34 |
| CCND3 | cyclin D3 | -0.33 |
| GRAMD4 | GRAM domain containing 4 | -0.33 |
| TFPT | TCF3 (E2A) fusion partner (in childhood Leukemia) | -0.33 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 | -0.33 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | -0.33 |
| TMEM104 | transmembrane protein 104 | -0.33 |
| ELK4 | ELK4, ETS-domain protein (SRF accessory protein 1) | -0.33 |
| CXXC5 | CXXC finger protein 5 | -0.33 |
| CCDC167 | coiled-coil domain containing 167 | -0.32 |
| CES2 | carboxylesterase 2 | -0.32 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | -0.32 |
| IGF1R | insulin-like growth factor 1 receptor | -0.32 |
| ZNF611 | zinc finger protein 611 | -0.32 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | -0.31 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.31 |
| HM13 | histocompatibility (minor) 13 | -0.31 |
| GNPTG | N-acetylglucosamine-1-phosphate transferase, gamma subunit | -0.31 |
| VMA21 | VMA21 vacuolar H+-ATPase homolog (S. cerevisiae) | -0.31 |
| TCP11L1 | t-complex 11, testis-specific-like 1 | -0.31 |
| BAK1 | BCL2-antagonist/killer 1 | -0.31 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.31 |
| MYRF | myelin regulatory factor | -0.3 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.3 |
| TMEM160 | transmembrane protein 160 | -0.3 |
| TP53 | tumor protein p53 | -0.3 |
| PARL | presenilin associated, rhomboid-like | -0.29 |
| MATR3 | matrin 3 | -0.29 |
| MT-CO1 | cytochrome c oxidase subunit I | -0.29 |
| ELK1 | ELK1, member of ETS oncogene family | -0.29 |
| TMEM161B | transmembrane protein 161B | -0.29 |
| SLC35B1 | solute carrier family 35, member B1 | -0.29 |
| EPHB3 | EPH receptor B3 | -0.29 |
| ETV5 | ets variant 5 | -0.29 |
| PHF1 | PHD finger protein 1 | -0.29 |
| EPDR1 | ependymin related 1 | -0.29 |
| ATP6V0C | ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c | -0.28 |
