| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A member of the class of bipyridines that is 2-pyridone which is substituted at positions 3, 5, and 6 by cyano, pyrid-4-yl, and methyl groups, respectively. It is used (particularly intravenously, as the lactate) for the short-term management of severe heart failure. (Chemical Entities of Biological Interest Ontology, CHEBI_50693) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/4197 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Milrinone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KLHL23 | kelch-like family member 23 | 1.92 |
| ADAM22 | ADAM metallopeptidase domain 22 | 0.82 |
| TRIM23 | tripartite motif containing 23 | 0.73 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.56 |
| ESAM | endothelial cell adhesion molecule | 0.53 |
| ZNF567 | zinc finger protein 567 | 0.49 |
| KIAA1324L | KIAA1324-like | 0.49 |
| NEO1 | neogenin 1 | 0.46 |
| AKAP6 | A kinase (PRKA) anchor protein 6 | 0.46 |
| MUC16 | mucin 16, cell surface associated | 0.43 |
| TMEM64 | transmembrane protein 64 | 0.42 |
| LRRK2 | leucine-rich repeat kinase 2 | 0.42 |
| E2F2 | E2F transcription factor 2 | 0.41 |
| CEP63 | centrosomal protein 63kDa | 0.41 |
| PKM | pyruvate kinase, muscle | 0.4 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.4 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 | 0.4 |
| RETREG1 | reticulophagy regulator 1 | 0.38 |
| ST5 | suppression of tumorigenicity 5 | 0.37 |
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | 0.37 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | 0.37 |
| OSBPL7 | oxysterol binding protein-like 7 | 0.36 |
| PLK4 | polo-like kinase 4 | 0.35 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | 0.35 |
| CR2 | complement component (3d/Epstein Barr virus) receptor 2 | 0.34 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 0.34 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.34 |
| USP45 | ubiquitin specific peptidase 45 | 0.33 |
| KLHL21 | kelch-like family member 21 | 0.33 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 0.32 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | 0.32 |
| EMILIN2 | elastin microfibril interfacer 2 | 0.32 |
| EPB41L4B | erythrocyte membrane protein band 4.1 like 4B | 0.32 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.31 |
| MYLK | myosin light chain kinase | 0.31 |
| PIP5K1C | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | 0.31 |
| LSM8 | LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.31 |
| SDC1 | syndecan 1 | 0.3 |
| AGRN | agrin | 0.3 |
| CKM | creatine kinase, muscle | 0.3 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | 0.29 |
| BCL3 | B-cell CLL/lymphoma 3 | 0.29 |
| UNC5B | unc-5 homolog B (C. elegans) | 0.28 |
| HEXD | hexosaminidase D | 0.28 |
| MNT | MAX network transcriptional repressor | 0.28 |
| XTBD1 | XRN2 binding domain containing 1 | 0.28 |
| MFSD10 | major facilitator superfamily domain containing 10 | 0.28 |
| MCTS2P | malignant T cell amplified sequence 2, pseudogene | 0.28 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | 0.28 |
| EMC10 | ER membrane protein complex subunit 10 | 0.27 |
| BOLA3 | bolA family member 3 | 0.27 |
| SNX8 | sorting nexin 8 | 0.27 |
| TMEM106B | transmembrane protein 106B | 0.26 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.26 |
| ZNF121 | zinc finger protein 121 | 0.26 |
| RELT | RELT tumor necrosis factor receptor | 0.26 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.25 |
| ARSB | arylsulfatase B | 0.25 |
| VPS26B | vacuolar protein sorting 26 homolog B (S. pombe) | 0.25 |
| PDCL3 | phosducin-like 3 | 0.25 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.25 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.25 |
| TRMT13 | tRNA methyltransferase 13 homolog (S. cerevisiae) | 0.25 |
| MARK1 | MAP/microtubule affinity-regulating kinase 1 | 0.25 |
| ODC1 | ornithine decarboxylase 1 | 0.25 |
| BPTF | bromodomain PHD finger transcription factor | 0.25 |
| POMGNT1 | protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) | 0.24 |
| SRD5A3 | steroid 5 alpha-reductase 3 | 0.24 |
| ARF4 | ADP-ribosylation factor 4 | 0.24 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.24 |
| WWC2 | WW and C2 domain containing 2 | 0.24 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.24 |
| GSTA1 | glutathione S-transferase alpha 1 | 0.24 |
| METTL26 | methyltransferase like 26 | 0.24 |
| S100PBP | S100P binding protein | 0.24 |
| MT-ND1 | NADH dehydrogenase, subunit 1 (complex I) | 0.24 |
| ADAM15 | ADAM metallopeptidase domain 15 | 0.24 |
| TADA2B | transcriptional adaptor 2B | 0.24 |
| ALDH8A1 | aldehyde dehydrogenase 8 family, member A1 | 0.24 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | 0.24 |
| PAAF1 | proteasomal ATPase-associated factor 1 | 0.24 |
| SEMA6B | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B | 0.24 |
| IFT122 | intraflagellar transport 122 | 0.24 |
| SGMS1 | sphingomyelin synthase 1 | 0.24 |
| ANXA6 | annexin A6 | 0.24 |
| PISD | phosphatidylserine decarboxylase | 0.24 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | 0.24 |
| OGG1 | 8-oxoguanine DNA glycosylase | 0.23 |
| RETREG3 | reticulophagy regulator family member 3 | 0.23 |
| ASCC1 | activating signal cointegrator 1 complex subunit 1 | 0.23 |
| MT-ATP6 | ATP synthase F0 subunit 6 | 0.23 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.23 |
| FEM1A | fem-1 homolog a (C. elegans) | 0.23 |
| RPS9 | ribosomal protein S9 | 0.23 |
| HOXB7 | homeobox B7 | 0.23 |
| SELENBP1 | selenium binding protein 1 | 0.23 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.23 |
| FKRP | fukutin related protein | 0.23 |
| PPP2R5A | protein phosphatase 2, regulatory subunit B', alpha | 0.23 |
| BTBD1 | BTB (POZ) domain containing 1 | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | -0.8 |
| TBX3 | T-box 3 | -0.77 |
| GPR161 | G protein-coupled receptor 161 | -0.59 |
| TMSB10 | thymosin beta 10 | -0.58 |
| COL1A1 | collagen, type I, alpha 1 | -0.53 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -0.52 |
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | -0.52 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.5 |
| FZD3 | frizzled class receptor 3 | -0.5 |
| RAB36 | RAB36, member RAS oncogene family | -0.49 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.47 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.44 |
| FAM104A | family with sequence similarity 104, member A | -0.44 |
| ADIRF | adipogenesis regulatory factor | -0.43 |
| KIF16B | kinesin family member 16B | -0.42 |
| SEPTIN7 | septin 7 | -0.42 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.42 |
| ARHGAP23 | Rho GTPase activating protein 23 | -0.41 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.4 |
| EIF3C | eukaryotic translation initiation factor 3, subunit C | -0.4 |
| KDSR | 3-ketodihydrosphingosine reductase | -0.4 |
| ABCC9 | ATP-binding cassette, sub-family C (CFTR/MRP), member 9 | -0.4 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.4 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | -0.39 |
| SMARCC2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 | -0.39 |
| ATP6V1F | ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F | -0.39 |
| TRIM35 | tripartite motif containing 35 | -0.38 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | -0.38 |
| SS18 | synovial sarcoma translocation, chromosome 18 | -0.37 |
| TANGO2 | transport and golgi organization 2 homolog (Drosophila) | -0.37 |
| POLQ | polymerase (DNA directed), theta | -0.37 |
| ZNF581 | zinc finger protein 581 | -0.37 |
| MYZAP | myocardial zonula adherens protein | -0.37 |
| YAE1 | YAE1 maturation factor of ABCE1 | -0.37 |
| CNTNAP3 | contactin associated protein-like 3 | -0.36 |
| HIST3H2BB | histone cluster 3, H2bb | -0.36 |
| NPDC1 | neural proliferation, differentiation and control, 1 | -0.36 |
| HOMEZ | homeobox and leucine zipper encoding | -0.36 |
| INPP5E | inositol polyphosphate-5-phosphatase, 72 kDa | -0.36 |
| C19ORF54 | chromosome 19 open reading frame 54 | -0.35 |
| LDHD | lactate dehydrogenase D | -0.35 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | -0.35 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | -0.34 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | -0.34 |
| RNF130 | ring finger protein 130 | -0.34 |
| ACTB | actin, beta | -0.34 |
| STEAP2 | STEAP family member 2, metalloreductase | -0.34 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.34 |
| HMBOX1 | homeobox containing 1 | -0.34 |
| PPP1R11 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | -0.32 |
| TDG | thymine-DNA glycosylase | -0.32 |
| TBRG1 | transforming growth factor beta regulator 1 | -0.32 |
| HBA1 | hemoglobin, alpha 1 | -0.32 |
| MINDY4 | MINDY lysine 48 deubiquitinase 4 | -0.32 |
| PSAP | prosaposin | -0.32 |
| DPY19L4 | dpy-19-like 4 (C. elegans) | -0.31 |
| MYBPC1 | myosin binding protein C, slow type | -0.31 |
| RPAP2 | RNA polymerase II associated protein 2 | -0.31 |
| PFDN1 | prefoldin subunit 1 | -0.31 |
| RGS3 | regulator of G-protein signaling 3 | -0.31 |
| UBXN8 | UBX domain protein 8 | -0.31 |
| MYCBP | MYC binding protein | -0.31 |
| CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) | -0.31 |
| CLIC3 | chloride intracellular channel 3 | -0.3 |
| MRPL12 | mitochondrial ribosomal protein L12 | -0.3 |
| COMMD6 | COMM domain containing 6 | -0.3 |
| S100A11 | S100 calcium binding protein A11 | -0.3 |
| FN1 | fibronectin 1 | -0.3 |
| ALG1 | ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase | -0.29 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.29 |
| TTC30A | tetratricopeptide repeat domain 30A | -0.29 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.29 |
| GON7 | GON7 subunit of KEOPS complex | -0.29 |
| RBM20 | RNA binding motif protein 20 | -0.29 |
| PPP1R14B | protein phosphatase 1, regulatory (inhibitor) subunit 14B | -0.29 |
| RBP1 | retinol binding protein 1, cellular | -0.28 |
| TMEM104 | transmembrane protein 104 | -0.28 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | -0.28 |
| LSM1 | LSM1, U6 small nuclear RNA associated | -0.28 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.28 |
| TAF6L | TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa | -0.28 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) | -0.28 |
| ZNF276 | zinc finger protein 276 | -0.28 |
| S100A14 | S100 calcium binding protein A14 | -0.28 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | -0.27 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.27 |
| GSE1 | Gse1 coiled-coil protein | -0.27 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.27 |
| NABP2 | nucleic acid binding protein 2 | -0.26 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.26 |
| PTMS | parathymosin | -0.26 |
| MPDZ | multiple PDZ domain protein | -0.26 |
| VAMP8 | vesicle-associated membrane protein 8 | -0.26 |
| ITGA7 | integrin, alpha 7 | -0.26 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -0.26 |
| PAH | phenylalanine hydroxylase | -0.26 |
| SMOX | spermine oxidase | -0.26 |
| CA13 | carbonic anhydrase XIII | -0.25 |
| CINP | cyclin-dependent kinase 2 interacting protein | -0.25 |
| CRAT | carnitine O-acetyltransferase | -0.25 |
