Mineral absorption Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Minerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an intracellular messenger in muscle contraction/relaxation, neural networks, the immune system, and endocrine/exocrine cells. Iron, copper, and other metals are required for redox reactions (as cofactors) and for oxygen transport and binding (in hemoglobin and myoglobin). Many enzymes require specific metal atoms to complete their catalytic functions. Animal tissues need moderate quantities of some elements (Ca, P, K, Na, Mg, S, and Cl) and trace amounts of others (Mn, Fe, I, Co, Cr, Cu, Zn, and Se). The minerals are absorbed by either passive or active transport systems through the intestinal mucosa, often using specialized transport proteins, such as ferritin for Fe3+ and vitamin D-induced protein for calcium. (Kyoto Encyclopedia of Genes and Genomes, hsa04978)
External Link https://www.kegg.jp/entry/hsa04978
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Genes

58 proteins participating in the Mineral absorption pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ATOX1 antioxidant 1 copper chaperone
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP1B4 ATPase, Na+/K+ transporting, beta 4 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP7A ATPase, Cu++ transporting, alpha polypeptide
ATP7B ATPase, Cu++ transporting, beta polypeptide
CLCN2 chloride channel, voltage-sensitive 2
CYBRD1 cytochrome b reductase 1
FTH1 ferritin, heavy polypeptide 1
FTL ferritin, light polypeptide
FXYD2 FXYD domain containing ion transport regulator 2
HEPH hephaestin
HEPHL1 hephaestin-like 1
HMOX1 heme oxygenase 1
HMOX2 heme oxygenase 2
MT1A metallothionein 1A
MT1B metallothionein 1B
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
S100G S100 calcium binding protein G
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC26A9 solute carrier family 26 (anion exchanger), member 9
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC31A1 solute carrier family 31 (copper transporter), member 1
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC40A1 solute carrier family 40 (iron-regulated transporter), member 1
SLC46A1 solute carrier family 46 (folate transporter), member 1
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP2 STEAP family member 2, metalloreductase
TF transferrin
TRPM6 transient receptor potential cation channel, subfamily M, member 6
TRPM7 transient receptor potential cation channel, subfamily M, member 7
TRPV6 transient receptor potential cation channel, subfamily V, member 6
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor