| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5. (Chemical Entities of Biological Interest Ontology, CHEBI_50694) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/54675783 |
| Similar Terms | |
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200 proteins with high or low expression in Minocycline relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRAPPC5 | trafficking protein particle complex 5 | 0.65 |
| ZNF623 | zinc finger protein 623 | 0.6 |
| PIP | prolactin-induced protein | 0.59 |
| TRIB3 | tribbles pseudokinase 3 | 0.58 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | 0.58 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 0.56 |
| XRCC2 | X-ray repair complementing defective repair in Chinese hamster cells 2 | 0.55 |
| SESN2 | sestrin 2 | 0.55 |
| XIRP2 | xin actin binding repeat containing 2 | 0.54 |
| ST5 | suppression of tumorigenicity 5 | 0.53 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 0.51 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 0.51 |
| ZG16B | zymogen granule protein 16B | 0.49 |
| PLXNB1 | plexin B1 | 0.49 |
| IFRD1 | interferon-related developmental regulator 1 | 0.49 |
| DALRD3 | DALR anticodon binding domain containing 3 | 0.48 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.48 |
| ARHGDIB | Rho GDP dissociation inhibitor (GDI) beta | 0.47 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.46 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.46 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.45 |
| NOL3 | nucleolar protein 3 (apoptosis repressor with CARD domain) | 0.44 |
| NAV2 | neuron navigator 2 | 0.44 |
| ZNF100 | zinc finger protein 100 | 0.44 |
| GTF2A1 | general transcription factor IIA, 1, 19/37kDa | 0.44 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.44 |
| POF1B | premature ovarian failure, 1B | 0.42 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.42 |
| MACC1 | metastasis associated in colon cancer 1 | 0.42 |
| GIN1 | gypsy retrotransposon integrase 1 | 0.42 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | 0.42 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.41 |
| GPT2 | glutamic pyruvate transaminase (alanine aminotransferase) 2 | 0.41 |
| EGR1 | early growth response 1 | 0.41 |
| OSGIN1 | oxidative stress induced growth inhibitor 1 | 0.41 |
| SLC38A1 | solute carrier family 38, member 1 | 0.41 |
| ELF4 | E74-like factor 4 (ets domain transcription factor) | 0.41 |
| HOXB9 | homeobox B9 | 0.4 |
| ZFP62 | ZFP62 zinc finger protein | 0.4 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.4 |
| METTL26 | methyltransferase like 26 | 0.4 |
| AFG1L | AFG1 like ATPase | 0.4 |
| RC3H1 | ring finger and CCCH-type domains 1 | 0.39 |
| MCTS2P | malignant T cell amplified sequence 2, pseudogene | 0.39 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.39 |
| PKHD1 | polycystic kidney and hepatic disease 1 (autosomal recessive) | 0.38 |
| TIGD2 | tigger transposable element derived 2 | 0.38 |
| B3GALNT1 | beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) | 0.37 |
| SNAP91 | synaptosomal-associated protein, 91kDa | 0.37 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | 0.37 |
| ZNF658 | zinc finger protein 658 | 0.37 |
| ABHD18 | abhydrolase domain containing 18 | 0.36 |
| PLEKHM1 | pleckstrin homology domain containing, family M (with RUN domain) member 1 | 0.36 |
| UBL7 | ubiquitin-like 7 | 0.36 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.35 |
| RIOK3 | RIO kinase 3 | 0.35 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.35 |
| MCRIP2 | MAPK regulated corepressor interacting protein 2 | 0.35 |
| NIBAN1 | niban apoptosis regulator 1 | 0.35 |
| VRK1 | vaccinia related kinase 1 | 0.34 |
| SNX33 | sorting nexin 33 | 0.34 |
| C1ORF109 | chromosome 1 open reading frame 109 | 0.34 |
| LRRC8B | leucine rich repeat containing 8 family, member B | 0.33 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | 0.33 |
| C15ORF61 | chromosome 15 open reading frame 61 | 0.33 |
| IFFO2 | intermediate filament family orphan 2 | 0.33 |
| ARSB | arylsulfatase B | 0.33 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.33 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.33 |
| FBXL4 | F-box and leucine-rich repeat protein 4 | 0.33 |
| MIER3 | mesoderm induction early response 1, family member 3 | 0.33 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | 0.32 |
| ERCC8 | excision repair cross-complementation group 8 | 0.32 |
| COL7A1 | collagen, type VII, alpha 1 | 0.32 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | 0.32 |
| PTBP1 | polypyrimidine tract binding protein 1 | 0.32 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.32 |
| DENND5A | DENN/MADD domain containing 5A | 0.32 |
| MYBPC1 | myosin binding protein C, slow type | 0.32 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.32 |
| RNF111 | ring finger protein 111 | 0.32 |
| PHGDH | phosphoglycerate dehydrogenase | 0.31 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.31 |
| MTIF3 | mitochondrial translational initiation factor 3 | 0.31 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.31 |
| KIAA1191 | KIAA1191 | 0.31 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.31 |
| TTYH3 | tweety family member 3 | 0.31 |
| MICALL1 | MICAL-like 1 | 0.31 |
| CES2 | carboxylesterase 2 | 0.3 |
| INO80D | INO80 complex subunit D | 0.3 |
| BBS1 | Bardet-Biedl syndrome 1 | 0.3 |
| FZD2 | frizzled class receptor 2 | 0.3 |
| DST | dystonin | 0.3 |
| PSPH | phosphoserine phosphatase | 0.3 |
| FANCC | Fanconi anemia, complementation group C | 0.3 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 0.3 |
| CORO2B | coronin, actin binding protein, 2B | 0.3 |
| PLA2G12A | phospholipase A2, group XIIA | 0.3 |
| BTBD7 | BTB (POZ) domain containing 7 | 0.3 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PRDM16 | PR domain containing 16 | -2.71 |
| EIF4EBP2 | eukaryotic translation initiation factor 4E binding protein 2 | -0.91 |
| COA5 | cytochrome c oxidase assembly factor 5 | -0.91 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.84 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | -0.79 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.77 |
| COA4 | cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) | -0.72 |
| HSPA1L | heat shock 70kDa protein 1-like | -0.69 |
| SEPTIN5 | septin 5 | -0.69 |
| SET | SET nuclear proto-oncogene | -0.67 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -0.67 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | -0.59 |
| CRCP | CGRP receptor component | -0.59 |
| INPP5J | inositol polyphosphate-5-phosphatase J | -0.59 |
| MIB2 | mindbomb E3 ubiquitin protein ligase 2 | -0.58 |
| RPL26 | ribosomal protein L26 | -0.58 |
| BLOC1S3 | biogenesis of lysosomal organelles complex-1, subunit 3 | -0.55 |
| HMBOX1 | homeobox containing 1 | -0.54 |
| TTLL5 | tubulin tyrosine ligase-like family member 5 | -0.54 |
| ZNF654 | zinc finger protein 654 | -0.54 |
| KRT8 | keratin 8, type II | -0.53 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | -0.53 |
| SLC19A2 | solute carrier family 19 (thiamine transporter), member 2 | -0.51 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.51 |
| ACTN4 | actinin, alpha 4 | -0.5 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.49 |
| ZNF227 | zinc finger protein 227 | -0.48 |
| ZDHHC2 | zinc finger, DHHC-type containing 2 | -0.48 |
| ZSWIM3 | zinc finger, SWIM-type containing 3 | -0.48 |
| ANKRD36C | ankyrin repeat domain 36C | -0.47 |
| PET100 | PET100 homolog (S. cerevisiae) | -0.47 |
| MSLN | mesothelin | -0.46 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.45 |
| B2M | beta-2-microglobulin | -0.45 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | -0.44 |
| RABAC1 | Rab acceptor 1 (prenylated) | -0.43 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.43 |
| PDLIM5 | PDZ and LIM domain 5 | -0.43 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -0.42 |
| CCDC102A | coiled-coil domain containing 102A | -0.42 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | -0.42 |
| ZNF239 | zinc finger protein 239 | -0.42 |
| HEMK1 | HemK methyltransferase family member 1 | -0.41 |
| NR1H2 | nuclear receptor subfamily 1, group H, member 2 | -0.41 |
| NDUFB7 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18kDa | -0.41 |
| GALNT11 | polypeptide N-acetylgalactosaminyltransferase 11 | -0.41 |
| ARL4A | ADP-ribosylation factor-like 4A | -0.41 |
| ZNF428 | zinc finger protein 428 | -0.41 |
| CENPT | centromere protein T | -0.4 |
| ZNF362 | zinc finger protein 362 | -0.4 |
| OSBPL7 | oxysterol binding protein-like 7 | -0.39 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | -0.39 |
| STOML1 | stomatin (EPB72)-like 1 | -0.38 |
| ABHD4 | abhydrolase domain containing 4 | -0.38 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.37 |
| MRPL52 | mitochondrial ribosomal protein L52 | -0.37 |
| MT-CO2 | cytochrome c oxidase subunit II | -0.36 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.36 |
| VKORC1L1 | vitamin K epoxide reductase complex, subunit 1-like 1 | -0.36 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.36 |
| CLASRP | CLK4-associating serine/arginine rich protein | -0.36 |
| C9ORF72 | chromosome 9 open reading frame 72 | -0.35 |
| NDUFS5 | NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) | -0.35 |
| FKBP14 | FK506 binding protein 14, 22 kDa | -0.35 |
| ZNF707 | zinc finger protein 707 | -0.35 |
| CD58 | CD58 molecule | -0.35 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -0.34 |
| HSPA8 | heat shock 70kDa protein 8 | -0.34 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | -0.34 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 | -0.34 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.34 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.33 |
| UQCC2 | ubiquinol-cytochrome c reductase complex assembly factor 2 | -0.33 |
| NOTCH3 | notch 3 | -0.33 |
| BCORL1 | BCL6 corepressor-like 1 | -0.33 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.33 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | -0.33 |
| TET1 | tet methylcytosine dioxygenase 1 | -0.33 |
| BCO2 | beta-carotene oxygenase 2 | -0.32 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.32 |
| NDUFA7 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa | -0.32 |
| PRELID3B | PRELI domain containing 3B | -0.32 |
| NDUFS4 | NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) | -0.32 |
| KSR2 | kinase suppressor of ras 2 | -0.31 |
| COX6C | cytochrome c oxidase subunit VIc | -0.31 |
| MAGEA12 | melanoma antigen family A12 | -0.31 |
| REEP3 | receptor accessory protein 3 | -0.31 |
| COX5B | cytochrome c oxidase subunit Vb | -0.31 |
| ANKRD10 | ankyrin repeat domain 10 | -0.3 |
| COMMD9 | COMM domain containing 9 | -0.3 |
| PPP2R2D | protein phosphatase 2, regulatory subunit B, delta | -0.3 |
| CLDN3 | claudin 3 | -0.3 |
| RPS26P11 | ribosomal protein S26 pseudogene 11 | -0.3 |
| CDK11A | cyclin-dependent kinase 11A | -0.3 |
| NDUFB4 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa | -0.3 |
| ZNF175 | zinc finger protein 175 | -0.3 |
| OBSL1 | obscurin-like 1 | -0.3 |
| CEP104 | centrosomal protein 104kDa | -0.29 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | -0.29 |
| LMLN | leishmanolysin-like (metallopeptidase M8 family) | -0.29 |
