Minodronic acid_A498 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in A498 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.104538
FTL ferritin, light polypeptide 0.0950526
HLA-B major histocompatibility complex, class I, B 0.0867086
TMSB10 thymosin beta 10 0.083693
CD44 CD44 molecule (Indian blood group) 0.0751397
NAV2 neuron navigator 2 0.0744369
EXT1 exostosin glycosyltransferase 1 0.07232
MYH9 myosin, heavy chain 9, non-muscle 0.069052
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0687056
TPT1 tumor protein, translationally-controlled 1 0.0677315
B2M beta-2-microglobulin 0.0657286
NDRG1 N-myc downstream regulated 1 0.0648247
IGFBP3 insulin-like growth factor binding protein 3 0.0630288
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0628133
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0608026
RPL35A ribosomal protein L35a 0.0543937
ZSWIM6 zinc finger, SWIM-type containing 6 0.0541323
MT2A metallothionein 2A 0.0525975
RPS6 ribosomal protein S6 0.0503293
APOL1 apolipoprotein L, 1 0.0472676
PLEC plectin 0.0457993
RPS8 ribosomal protein S8 0.0451765
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0440012
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.043983
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0409315
MCL1 myeloid cell leukemia 1 0.0396116
FRMD4A FERM domain containing 4A 0.0388583
SEPTIN9 septin 9 0.0385055
RPL34 ribosomal protein L34 0.0385005
RPL31 ribosomal protein L31 0.0383594
SFTPA2 surfactant protein A2 0.0382519
ATF3 activating transcription factor 3 0.0382272
SMAD3 SMAD family member 3 0.037646
RPL37A ribosomal protein L37a 0.0372364
HDAC9 histone deacetylase 9 0.0368671
RPL23 ribosomal protein L23 0.0365217
RNF213 ring finger protein 213 0.0364319
CREB5 cAMP responsive element binding protein 5 0.0359993
RPS19 ribosomal protein S19 0.0335017
HLA-A major histocompatibility complex, class I, A 0.0333448
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0329789
S100A10 S100 calcium binding protein A10 0.0327102
LMNA lamin A/C 0.0322464
RND3 Rho family GTPase 3 0.032246
RPLP1 ribosomal protein, large, P1 0.031776
RPL26 ribosomal protein L26 0.0309895
CTBP2 C-terminal binding protein 2 0.0309315
RPLP2 ribosomal protein, large, P2 0.030005
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0299563
EGR1 early growth response 1 0.0299113
RPS17 ribosomal protein S17 0.0298532
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0297015
RPL19 ribosomal protein L19 0.0296834
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0296468
EIF1 eukaryotic translation initiation factor 1 0.0295415
RPS13 ribosomal protein S13 0.029221
RPS24 ribosomal protein S24 0.0291542
PTMA prothymosin, alpha 0.0284325
HLA-C major histocompatibility complex, class I, C 0.0280672
IFITM3 interferon induced transmembrane protein 3 0.0279932
ARL4C ADP-ribosylation factor-like 4C 0.0279817
RPL12 ribosomal protein L12 0.0279438
MYO1E myosin IE 0.027708
PDE4D phosphodiesterase 4D, cAMP-specific 0.0275197
EGFR epidermal growth factor receptor 0.0270827
RPL7A ribosomal protein L7a 0.0266201
HM13 histocompatibility (minor) 13 0.0264466
CA12 carbonic anhydrase XII 0.0263944
VEGFA vascular endothelial growth factor A 0.025921
SHB Src homology 2 domain containing adaptor protein B 0.0257415
TGM2 transglutaminase 2 0.0256455
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0256162
RPL35 ribosomal protein L35 0.0254563
CALR calreticulin 0.0254194
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0252927
INTS6 integrator complex subunit 6 0.0251096
KYNU kynureninase 0.0250579
RPS27A ribosomal protein S27a 0.0250567
SP100 SP100 nuclear antigen 0.0249352
RPL28 ribosomal protein L28 0.0249279
DOCK5 dedicator of cytokinesis 5 0.0237722
UBC ubiquitin C 0.0236896
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0231624
SAMD4A sterile alpha motif domain containing 4A 0.0231109
IFI6 interferon, alpha-inducible protein 6 0.0230324
RIGI RNA sensor RIG-I 0.0229403
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0229273
RPS27 ribosomal protein S27 0.0228849
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0228555
LOXL2 lysyl oxidase-like 2 0.02282
NFE2L1 nuclear factor, erythroid 2-like 1 0.022729
HLA-E major histocompatibility complex, class I, E 0.0225859
MX1 MX dynamin-like GTPase 1 0.0225771
CUX1 cut-like homeobox 1 0.0224236
RPL9 ribosomal protein L9 0.0221778
OSMR oncostatin M receptor 0.0221678
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0221049
SQSTM1 sequestosome 1 0.0219922
ANXA1 annexin A1 0.02192
IFI27 interferon, alpha-inducible protein 27 0.0217342

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.0765637
PTBP3 polypyrimidine tract binding protein 3 -0.0689365
GLS2 glutaminase 2 (liver, mitochondrial) -0.0681646
GPC6 glypican 6 -0.0680242
ATP13A3 ATPase type 13A3 -0.0491365
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0463715
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0454931
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0448267
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0401222
PLK2 polo-like kinase 2 -0.0388913
VCAM1 vascular cell adhesion molecule 1 -0.0375636
BIRC6 baculoviral IAP repeat containing 6 -0.0374154
SBF2 SET binding factor 2 -0.037355
GOLGA4 golgin A4 -0.0365392
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0351055
TTC3 tetratricopeptide repeat domain 3 -0.0348118
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0343008
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0338364
KMT2C lysine (K)-specific methyltransferase 2C -0.0335836
MAP1B microtubule-associated protein 1B -0.0334701
SRPK2 SRSF protein kinase 2 -0.0333424
GARS1 glycyl-tRNA synthetase 1 -0.0332408
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0324312
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0321905
ANKRD10 ankyrin repeat domain 10 -0.0315541
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0305613
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.030376
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0300424
WDR43 WD repeat domain 43 -0.0290126
USP3 ubiquitin specific peptidase 3 -0.0289716
CLINT1 clathrin interactor 1 -0.0289203
SP3 Sp3 transcription factor -0.0288443
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0287868
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0282954
GLIS3 GLIS family zinc finger 3 -0.0281071
WAC WW domain containing adaptor with coiled-coil -0.028094
COG5 component of oligomeric golgi complex 5 -0.0280402
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0279486
PBX1 pre-B-cell leukemia homeobox 1 -0.027885
OSBPL3 oxysterol binding protein-like 3 -0.0272625
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0272095
SCFD2 sec1 family domain containing 2 -0.0270597
CLTC clathrin, heavy chain (Hc) -0.0269827
RTN4 reticulon 4 -0.0269809
POTEF POTE ankyrin domain family, member F -0.0267261
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0267259
ZFAND3 zinc finger, AN1-type domain 3 -0.0262083
FTH1 ferritin, heavy polypeptide 1 -0.026085
EML4 echinoderm microtubule associated protein like 4 -0.025555
PRRC1 proline-rich coiled-coil 1 -0.0255019
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0252914
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.0252442
QKI QKI, KH domain containing, RNA binding -0.0251666
NF1 neurofibromin 1 -0.0250062
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0249746
MARCHF6 membrane associated ring-CH-type finger 6 -0.024806
ADAM10 ADAM metallopeptidase domain 10 -0.0244792
RAD21 RAD21 homolog (S. pombe) -0.0243947
VCAN versican -0.0243825
IARS1 isoleucyl-tRNA synthetase 1 -0.0243523
ANKRD17 ankyrin repeat domain 17 -0.0242319
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0236456
RIC1 RAB6A GEF complex partner 1 -0.0236312
TCEA1 transcription elongation factor A (SII), 1 -0.0232995
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.023264
RHEB Ras homolog enriched in brain -0.0231082
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0230785
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0230175
GOLM2 golgi membrane protein 2 -0.0229765
SPAG9 sperm associated antigen 9 -0.0227601
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0227439
RAB10 RAB10, member RAS oncogene family -0.0226673
THOC2 THO complex 2 -0.022422
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0224169
AVL9 AVL9 homolog (S. cerevisiase) -0.022413
CDK13 cyclin-dependent kinase 13 -0.0223177
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0222393
OLA1 Obg-like ATPase 1 -0.0221751
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0221606
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0221072
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0214058
RAB18 RAB18, member RAS oncogene family -0.0212507
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0212022
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.021172
DAPK1 death-associated protein kinase 1 -0.0211707
AKAP9 A kinase (PRKA) anchor protein 9 -0.0210533
GIGYF2 GRB10 interacting GYF protein 2 -0.0209712
FN1 fibronectin 1 -0.0206351
CDC27 cell division cycle 27 -0.0205894
STK17A serine/threonine kinase 17a -0.0205231
HELZ helicase with zinc finger -0.0203726
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0203507
BAZ1B bromodomain adjacent to zinc finger domain, 1B -0.0201892
TSC22D2 TSC22 domain family, member 2 -0.0201843
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0201107
RBM25 RNA binding motif protein 25 -0.0200642
SOD2 superoxide dismutase 2, mitochondrial -0.019963
TXNRD1 thioredoxin reductase 1 -0.0198791
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0198263
PHKB phosphorylase kinase, beta -0.0197122