Minodronic acid_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.225032
SPTBN1 spectrin, beta, non-erythrocytic 1 0.144835
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.133187
SMAD3 SMAD family member 3 0.123703
MYH9 myosin, heavy chain 9, non-muscle 0.113118
PLEC plectin 0.111813
KYNU kynureninase 0.101887
AHNAK AHNAK nucleoprotein 0.083335
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0821185
TM4SF1 transmembrane 4 L six family member 1 0.0810911
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0797516
STC1 stanniocalcin 1 0.0788893
TNIP1 TNFAIP3 interacting protein 1 0.0740182
ARHGAP26 Rho GTPase activating protein 26 0.0717871
FAM107B family with sequence similarity 107, member B 0.0651689
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.06317
EEF2 eukaryotic translation elongation factor 2 0.0621535
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0612235
RPL4 ribosomal protein L4 0.0569012
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0561852
AHNAK2 AHNAK nucleoprotein 2 0.0518549
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0515353
ERRFI1 ERBB receptor feedback inhibitor 1 0.0511576
CEMIP cell migration inducing protein, hyaluronan binding 0.0500752
SOD2 superoxide dismutase 2, mitochondrial 0.0477336
ACTN4 actinin, alpha 4 0.0443845
TRIO trio Rho guanine nucleotide exchange factor 0.0429776
SFTPA2 surfactant protein A2 0.0428431
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0408037
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0403901
ELL2 elongation factor, RNA polymerase II, 2 0.040206
IGF1R insulin-like growth factor 1 receptor 0.0391549
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0390961
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0390244
HSPA8 heat shock 70kDa protein 8 0.0390042
APP amyloid beta (A4) precursor protein 0.0378063
NAP1L1 nucleosome assembly protein 1-like 1 0.0375442
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0371611
MYO10 myosin X 0.0363058
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0355031
EXT1 exostosin glycosyltransferase 1 0.0353153
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0349668
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0347883
NONO non-POU domain containing, octamer-binding 0.0345168
THSD4 thrombospondin, type I, domain containing 4 0.034139
GRAMD1B GRAM domain containing 1B 0.0337853
EZR ezrin 0.0333888
STAT1 signal transducer and activator of transcription 1, 91kDa 0.03326
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0329926
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0324524
AGO2 argonaute RISC catalytic component 2 0.0323398
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0318353
ACTG1 actin gamma 1 0.0313067
NCOA7 nuclear receptor coactivator 7 0.0311202
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0307538
WWOX WW domain containing oxidoreductase 0.0307093
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0305805
CXCL5 chemokine (C-X-C motif) ligand 5 0.0303808
RNF213 ring finger protein 213 0.030338
SHB Src homology 2 domain containing adaptor protein B 0.030174
KDM3A lysine (K)-specific demethylase 3A 0.0301392
EIF4A1 eukaryotic translation initiation factor 4A1 0.0299778
FMNL2 formin-like 2 0.0298154
RHCG Rh family, C glycoprotein 0.0297534
BMAL2 basic helix-loop-helix ARNT like 2 0.0296966
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0295864
ALCAM activated leukocyte cell adhesion molecule 0.0294332
UBASH3B ubiquitin associated and SH3 domain containing B 0.0284604
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0284469
SEPTIN9 septin 9 0.0284299
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0283643
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0282711
BMP6 bone morphogenetic protein 6 0.0281284
ASPH aspartate beta-hydroxylase 0.0281175
FAT1 FAT atypical cadherin 1 0.0280109
FNDC3B fibronectin type III domain containing 3B 0.0278033
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0276018
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0273725
ANGPTL4 angiopoietin-like 4 0.0271707
ITPRID2 ITPR interacting domain containing 2 0.0270754
EREG epiregulin 0.0269335
FLNB filamin B, beta 0.0267263
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0266039
TMSB4X thymosin beta 4, X-linked 0.0263786
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0262376
KRT18 keratin 18, type I 0.0261761
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0260095
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.025961
SQSTM1 sequestosome 1 0.0259208
LMO7 LIM domain 7 0.0259206
DSCAM Down syndrome cell adhesion molecule 0.0258895
LMNA lamin A/C 0.0258411
PAQR5 progestin and adipoQ receptor family member V 0.0257461
LOC112694756 uncharaterized LOC112694756 0.0256589
MYO1E myosin IE 0.0256164
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0254904
RIGI RNA sensor RIG-I 0.0250599
USP9X ubiquitin specific peptidase 9, X-linked 0.0248839
RPL3 ribosomal protein L3 0.0245752
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0243454

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.173785
FTH1 ferritin, heavy polypeptide 1 -0.111659
NDRG1 N-myc downstream regulated 1 -0.111454
IGFBP4 insulin-like growth factor binding protein 4 -0.107746
TMSB10 thymosin beta 10 -0.1019
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0905446
HMGA1 high mobility group AT-hook 1 -0.0670541
PDE4D phosphodiesterase 4D, cAMP-specific -0.0627735
EFNA5 ephrin-A5 -0.0591687
MYADM myeloid-associated differentiation marker -0.0549235
POTEF POTE ankyrin domain family, member F -0.0525965
AUTS2 autism susceptibility candidate 2 -0.0496077
PFN1 profilin 1 -0.0490904
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.045921
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0455632
EHBP1 EH domain binding protein 1 -0.0440842
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0438106
LAMA5 laminin, alpha 5 -0.0428283
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0413366
EGFR epidermal growth factor receptor -0.0389107
AKR1C2 aldo-keto reductase family 1, member C2 -0.0381918
MAP1B microtubule-associated protein 1B -0.0380804
EGR1 early growth response 1 -0.0374241
ZBTB20 zinc finger and BTB domain containing 20 -0.0371247
VIM vimentin -0.0349646
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0349079
MT2A metallothionein 2A -0.0327326
PCBP2 poly(rC) binding protein 2 -0.0317295
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0316817
GPC6 glypican 6 -0.0306078
RPS19 ribosomal protein S19 -0.0296905
RPL28 ribosomal protein L28 -0.0285965
VCL vinculin -0.0278653
ANXA4 annexin A4 -0.0275411
RPL37A ribosomal protein L37a -0.0273049
TNS3 tensin 3 -0.0265781
IGSF11 immunoglobulin superfamily, member 11 -0.0251404
ZFP36 ZFP36 ring finger protein -0.0250853
MAML3 mastermind-like 3 (Drosophila) -0.0244607
ABTB3 ankyrin repeat and BTB domain containing 3 -0.0244455
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0243117
LTBP4 latent transforming growth factor beta binding protein 4 -0.0242194
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0241579
C1D C1D nuclear receptor corepressor -0.0241397
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0235742
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0232878
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0232195
S100A11 S100 calcium binding protein A11 -0.0229173
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0224411
TCF12 transcription factor 12 -0.0219946
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0219901
PKM pyruvate kinase, muscle -0.0217852
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0212959
IGFBP1 insulin-like growth factor binding protein 1 -0.0209391
RPS29 ribosomal protein S29 -0.0208419
AKAP9 A kinase (PRKA) anchor protein 9 -0.0205377
RIN2 Ras and Rab interactor 2 -0.0203545
AGRN agrin -0.0200854
GGNBP2 gametogenetin binding protein 2 -0.0198227
WASF2 WAS protein family, member 2 -0.0196404
THOC2 THO complex 2 -0.0196129
RBM25 RNA binding motif protein 25 -0.0195952
TMEM165 transmembrane protein 165 -0.0189565
PRKCA protein kinase C, alpha -0.0187085
PTK2 protein tyrosine kinase 2 -0.0186028
TAPBP TAP binding protein (tapasin) -0.0181043
N4BP2L2 NEDD4 binding protein 2-like 2 -0.018101
RPL35A ribosomal protein L35a -0.0180164
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 -0.017914
USP47 ubiquitin specific peptidase 47 -0.0178886
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0178406
CAPNS1 calpain, small subunit 1 -0.0177737
SOS2 son of sevenless homolog 2 (Drosophila) -0.0175104
PGM3 phosphoglucomutase 3 -0.017383
CCDC88A coiled-coil domain containing 88A -0.0173413
RPS13 ribosomal protein S13 -0.0172234
RPLP1 ribosomal protein, large, P1 -0.0171291
KRT81 keratin 81, type II -0.0170593
RAD51B RAD51 paralog B -0.0170531
PLSCR1 phospholipid scramblase 1 -0.0170235
SCFD1 sec1 family domain containing 1 -0.0170147
COPA coatomer protein complex, subunit alpha -0.0169029
COL5A2 collagen, type V, alpha 2 -0.0167406
RPLP2 ribosomal protein, large, P2 -0.0167218
TMOD3 tropomodulin 3 (ubiquitous) -0.0166898
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0166636
SEC24D SEC24 family member D -0.0163798
ENO2 enolase 2 (gamma, neuronal) -0.0161231
GOSR1 golgi SNAP receptor complex member 1 -0.0160368
KAT6B K(lysine) acetyltransferase 6B -0.0159827
RPL31 ribosomal protein L31 -0.0159619
NRP1 neuropilin 1 -0.0159287
RPL27 ribosomal protein L27 -0.0159085
PIAS1 protein inhibitor of activated STAT, 1 -0.0159081
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0158591
SBF2 SET binding factor 2 -0.0157833
FTL ferritin, light polypeptide -0.0157803
RCOR1 REST corepressor 1 -0.0156861
CD68 CD68 molecule -0.015644
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0156186