Minodronic acid_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.296929
VEGFA vascular endothelial growth factor A 0.0748818
EEF2 eukaryotic translation elongation factor 2 0.0625799
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0565283
TMSB4X thymosin beta 4, X-linked 0.0505353
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0461638
THSD4 thrombospondin, type I, domain containing 4 0.0448783
FN1 fibronectin 1 0.0399899
PRELID2 PRELI domain containing 2 0.0378007
PEG10 paternally expressed 10 0.0373225
MYH9 myosin, heavy chain 9, non-muscle 0.0360752
H1-4 H1.4 linker histone, cluster member 0.0354857
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.033628
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0325578
RPL3 ribosomal protein L3 0.0322252
H1-2 H1.2 linker histone, cluster member 0.0305461
LOC112694756 uncharaterized LOC112694756 0.0299347
PKM pyruvate kinase, muscle 0.0284036
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.028011
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0279309
EGFR epidermal growth factor receptor 0.0274943
SFTPA2 surfactant protein A2 0.0274408
GSE1 Gse1 coiled-coil protein 0.0268729
SET SET nuclear proto-oncogene 0.0254776
PCDH7 protocadherin 7 0.0252201
VIM vimentin 0.0251373
NONO non-POU domain containing, octamer-binding 0.02503
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0232826
SMC1A structural maintenance of chromosomes 1A 0.0230839
LINGO2 leucine rich repeat and Ig domain containing 2 0.0229349
COL5A2 collagen, type V, alpha 2 0.0228478
RAD51B RAD51 paralog B 0.0221703
SRRM2 serine/arginine repetitive matrix 2 0.022078
FOXP1 forkhead box P1 0.0220778
FBXL7 F-box and leucine-rich repeat protein 7 0.0219113
HYOU1 hypoxia up-regulated 1 0.0214619
PDE10A phosphodiesterase 10A 0.0205995
NUMA1 nuclear mitotic apparatus protein 1 0.0201618
ACTG1 actin gamma 1 0.0201198
APLP2 amyloid beta (A4) precursor-like protein 2 0.0199864
TUBB tubulin, beta class I 0.0193561
ITGAV integrin, alpha V 0.0193363
ZNF516 zinc finger protein 516 0.0184932
ANKRD17 ankyrin repeat domain 17 0.0183601
NFIB nuclear factor I/B 0.018318
DOCK1 dedicator of cytokinesis 1 0.0183099
DBN1 drebrin 1 0.0181051
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0179968
EEF1G eukaryotic translation elongation factor 1 gamma 0.0179694
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0175657
HSPA8 heat shock 70kDa protein 8 0.0173995
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.0170054
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0168735
BRD2 bromodomain containing 2 0.0166505
LDHA lactate dehydrogenase A 0.0166004
NIN ninein (GSK3B interacting protein) 0.016599
DDIT4 DNA-damage-inducible transcript 4 0.0165701
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0164917
PDE4D phosphodiesterase 4D, cAMP-specific 0.0164485
TBC1D5 TBC1 domain family, member 5 0.0163534
TPI1 triosephosphate isomerase 1 0.0163135
RPL35 ribosomal protein L35 0.0162551
IGFBP3 insulin-like growth factor binding protein 3 0.0161079
WWOX WW domain containing oxidoreductase 0.0160682
RPL4 ribosomal protein L4 0.0160233
RPL7A ribosomal protein L7a 0.0159679
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0158992
RPS3 ribosomal protein S3 0.0158792
MPRIP myosin phosphatase Rho interacting protein 0.0156787
ASPH aspartate beta-hydroxylase 0.0156227
MYH10 myosin, heavy chain 10, non-muscle 0.0156208
DST dystonin 0.0155677
NRDC nardilysin convertase 0.0155252
ZNF638 zinc finger protein 638 0.0154264
TBX2 T-box 2 0.0153559
SEPTIN11 septin 11 0.0150014
PLEC plectin 0.0149646
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0147921
SON SON DNA binding protein 0.0147233
EGR1 early growth response 1 0.0145708
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0145165
POTEF POTE ankyrin domain family, member F 0.0143927
TSHZ2 teashirt zinc finger homeobox 2 0.0142722
TXNRD1 thioredoxin reductase 1 0.0140347
LAMC2 laminin, gamma 2 0.0139981
BCOR BCL6 corepressor 0.0136475
CHD3 chromodomain helicase DNA binding protein 3 0.0135872
LMO7 LIM domain 7 0.0134932
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0134889
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0134774
NFE2L1 nuclear factor, erythroid 2-like 1 0.0134601
CBX5 chromobox homolog 5 0.0134032
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0133907
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 0.0133792
R3HDM2 R3H domain containing 2 0.0133332
MSN moesin 0.0133325
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0131245
CALR calreticulin 0.0130746
CHD4 chromodomain helicase DNA binding protein 4 0.013025
BPTF bromodomain PHD finger transcription factor 0.0128542

decreased expression

Symbol Name Standardized Value
ZEB1 zinc finger E-box binding homeobox 1 -0.0908749
ERBIN erbb2 interacting protein -0.0568706
QKI QKI, KH domain containing, RNA binding -0.0534815
GOLGA4 golgin A4 -0.0528559
JMJD1C jumonji domain containing 1C -0.0528254
ZNF292 zinc finger protein 292 -0.0522849
ZFAND3 zinc finger, AN1-type domain 3 -0.0507296
FBXO11 F-box protein 11 -0.0455918
KDM5B lysine (K)-specific demethylase 5B -0.0444512
AFF4 AF4/FMR2 family, member 4 -0.0435102
ANKRD12 ankyrin repeat domain 12 -0.0402833
NIPBL Nipped-B homolog (Drosophila) -0.0397297
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0394262
RPL35A ribosomal protein L35a -0.0373179
MGP matrix Gla protein -0.0365328
MED13L mediator complex subunit 13-like -0.0350792
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0349365
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0345659
CTBP2 C-terminal binding protein 2 -0.0341371
MICU1 mitochondrial calcium uptake 1 -0.0331789
TPK1 thiamin pyrophosphokinase 1 -0.0331583
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0320529
PHF3 PHD finger protein 3 -0.0312471
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0309537
KMT2C lysine (K)-specific methyltransferase 2C -0.0308485
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0308443
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0306387
RHEB Ras homolog enriched in brain -0.030527
OGA O-GlcNAcase -0.0303211
PUM2 pumilio RNA-binding family member 2 -0.0299778
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0299615
SBF2 SET binding factor 2 -0.0298838
SEPTIN7 septin 7 -0.0293712
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0293555
SIK3 SIK family kinase 3 -0.0289688
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0288279
IGF2R insulin-like growth factor 2 receptor -0.0286645
IER3 immediate early response 3 -0.0283351
ZMYM2 zinc finger, MYM-type 2 -0.0282488
MEF2A myocyte enhancer factor 2A -0.0280943
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0277036
TRA2A transformer 2 alpha homolog (Drosophila) -0.0272678
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0270451
RNF130 ring finger protein 130 -0.0269739
PRKG1 protein kinase, cGMP-dependent, type I -0.026964
HMGA1 high mobility group AT-hook 1 -0.0265902
MARCHF6 membrane associated ring-CH-type finger 6 -0.0265407
PARD3 par-3 family cell polarity regulator -0.0264914
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0259865
KMT2E lysine (K)-specific methyltransferase 2E -0.0258762
TSC22D2 TSC22 domain family, member 2 -0.0258743
KANK1 KN motif and ankyrin repeat domains 1 -0.0258112
SSBP2 single-stranded DNA binding protein 2 -0.0256338
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0255511
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0255287
NT5C2 5'-nucleotidase, cytosolic II -0.0252587
SENP6 SUMO1/sentrin specific peptidase 6 -0.0251306
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.025072
POU2F1 POU class 2 homeobox 1 -0.0248548
SRPK2 SRSF protein kinase 2 -0.0246312
ARHGAP12 Rho GTPase activating protein 12 -0.0244859
CANX calnexin -0.0244117
RPS24 ribosomal protein S24 -0.0244027
SPPL3 signal peptide peptidase like 3 -0.0242859
WSB1 WD repeat and SOCS box containing 1 -0.0242431
MT2A metallothionein 2A -0.0240887
RBM25 RNA binding motif protein 25 -0.0233563
GTF2IRD1 GTF2I repeat domain containing 1 -0.0229294
PRRC2C proline-rich coiled-coil 2C -0.0228288
USP15 ubiquitin specific peptidase 15 -0.0227504
TUT4 terminal uridylyl transferase 4 -0.0224259
CDK13 cyclin-dependent kinase 13 -0.0224142
ZFHX3 zinc finger homeobox 3 -0.0221201
GPHN gephyrin -0.0220754
NCOA1 nuclear receptor coactivator 1 -0.0219917
ITSN2 intersectin 2 -0.0218869
CERT1 ceramide transporter 1 -0.0215793
USP3 ubiquitin specific peptidase 3 -0.021575
FGFR1 fibroblast growth factor receptor 1 -0.0214807
NAMPT nicotinamide phosphoribosyltransferase -0.0214224
RLF rearranged L-myc fusion -0.021346
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0211474
ACVR1 activin A receptor, type I -0.0211349
LCORL ligand dependent nuclear receptor corepressor-like -0.020822
RAB7A RAB7A, member RAS oncogene family -0.0207178
NAP1L1 nucleosome assembly protein 1-like 1 -0.0205931
DENND4C DENN/MADD domain containing 4C -0.0204572
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.020066
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0200611
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0200537
PHTF2 putative homeodomain transcription factor 2 -0.0200095
FNIP1 folliculin interacting protein 1 -0.0199774
RBM33 RNA binding motif protein 33 -0.0198644
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -0.0198251
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0197388
RBM27 RNA binding motif protein 27 -0.0197256
TTC3 tetratricopeptide repeat domain 3 -0.0196975
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -0.0194872
PIAS2 protein inhibitor of activated STAT, 2 -0.0194515
MYOF myoferlin -0.0193487