Minodronic acid_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SACK1A scaffolding CK1 anchoring protein A 0.207431
NDRG1 N-myc downstream regulated 1 0.151919
EGFR epidermal growth factor receptor 0.123726
BAIAP2L1 BAI1-associated protein 2-like 1 0.117771
MYH9 myosin, heavy chain 9, non-muscle 0.103087
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0997621
FLNB filamin B, beta 0.0974263
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0936937
TMSB10 thymosin beta 10 0.0911306
TXNIP thioredoxin interacting protein 0.0888869
RPL37A ribosomal protein L37a 0.0883734
TXNRD1 thioredoxin reductase 1 0.085706
LAMA4 laminin, alpha 4 0.0843094
LAMC2 laminin, gamma 2 0.0807032
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.0797829
SRRM2 serine/arginine repetitive matrix 2 0.0779026
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0777863
VIM vimentin 0.0745066
APLP2 amyloid beta (A4) precursor-like protein 2 0.0744481
KLK10 kallikrein-related peptidase 10 0.0740323
RPS3 ribosomal protein S3 0.0695403
EXT1 exostosin glycosyltransferase 1 0.0688617
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0671469
IGFBP3 insulin-like growth factor binding protein 3 0.0667034
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0645256
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0642518
TPM3 tropomyosin 3 0.0627869
TM4SF1 transmembrane 4 L six family member 1 0.0618866
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0601131
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0598327
GOLGB1 golgin B1 0.0598325
FTL ferritin, light polypeptide 0.0570722
LAMB3 laminin, beta 3 0.0565134
RPS12 ribosomal protein S12 0.0554841
MXD1 MAX dimerization protein 1 0.054717
CD44 CD44 molecule (Indian blood group) 0.0541002
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.05111
ENO1 enolase 1, (alpha) 0.0510756
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0506432
S100A11 S100 calcium binding protein A11 0.0505903
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.049675
DSPP dentin sialophosphoprotein 0.0491451
EZR ezrin 0.0490615
RPL31 ribosomal protein L31 0.0480121
IFI6 interferon, alpha-inducible protein 6 0.0465679
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0453215
SLC35F3 solute carrier family 35, member F3 0.0444067
RPLP2 ribosomal protein, large, P2 0.0436965
PLEC plectin 0.0436053
LDHA lactate dehydrogenase A 0.043467
ABTB3 ankyrin repeat and BTB domain containing 3 0.0431511
TNIP1 TNFAIP3 interacting protein 1 0.0431382
RPS27A ribosomal protein S27a 0.0423606
PKM pyruvate kinase, muscle 0.0421437
LMO7 LIM domain 7 0.0419784
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0419483
ASPH aspartate beta-hydroxylase 0.041421
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0410413
HM13 histocompatibility (minor) 13 0.0410302
UBC ubiquitin C 0.0406091
RPS8 ribosomal protein S8 0.0403293
FAM107B family with sequence similarity 107, member B 0.0401435
MSN moesin 0.0401352
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0401023
ZSWIM6 zinc finger, SWIM-type containing 6 0.0397608
DOCK5 dedicator of cytokinesis 5 0.0395953
RPS27 ribosomal protein S27 0.0392215
RPS13 ribosomal protein S13 0.0388545
B2M beta-2-microglobulin 0.0386451
NPSR1 neuropeptide S receptor 1 0.0383575
PDE4D phosphodiesterase 4D, cAMP-specific 0.0379907
RPS17 ribosomal protein S17 0.0377474
TGM2 transglutaminase 2 0.0375055
MAML2 mastermind-like 2 (Drosophila) 0.0368543
CLMP CXADR-like membrane protein 0.0365949
UPP1 uridine phosphorylase 1 0.036347
LPP LIM domain containing preferred translocation partner in lipoma 0.0362345
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0360789
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0348784
NCOR2 nuclear receptor corepressor 2 0.0348197
AKAP12 A kinase (PRKA) anchor protein 12 0.0345297
AKAP9 A kinase (PRKA) anchor protein 9 0.0343275
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0343199
FNDC3B fibronectin type III domain containing 3B 0.0341872
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0341195
SKAP2 src kinase associated phosphoprotein 2 0.0340611
NAP1L1 nucleosome assembly protein 1-like 1 0.0340238
RPS6 ribosomal protein S6 0.033558
ARHGAP42 Rho GTPase activating protein 42 0.0332602
BMP6 bone morphogenetic protein 6 0.0330399
EFNA5 ephrin-A5 0.0330209
ZBTB20 zinc finger and BTB domain containing 20 0.032941
DIAPH2 diaphanous-related formin 2 0.0328336
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0326756
MCL1 myeloid cell leukemia 1 0.0326116
LOC112694756 uncharaterized LOC112694756 0.0322568
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0318756
SMAD3 SMAD family member 3 0.031724
GUK1 guanylate kinase 1 0.0314782
OSMR oncostatin M receptor 0.0314568

decreased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0602129
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0589872
GLS2 glutaminase 2 (liver, mitochondrial) -0.0465257
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0460557
HMGA1 high mobility group AT-hook 1 -0.0424881
TSC22D2 TSC22 domain family, member 2 -0.0418632
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0402387
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0401098
S100A4 S100 calcium binding protein A4 -0.0397882
CDH17 cadherin 17, LI cadherin (liver-intestine) -0.0348981
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0331689
LMTK2 lemur tyrosine kinase 2 -0.0313871
ITGA6 integrin, alpha 6 -0.0295769
VCL vinculin -0.0293794
FOSL1 FOS-like antigen 1 -0.0292208
ADAM9 ADAM metallopeptidase domain 9 -0.0277556
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0264072
NPC1 Niemann-Pick disease, type C1 -0.0257417
FOXO3 forkhead box O3 -0.0254463
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0253238
OSBPL3 oxysterol binding protein-like 3 -0.0251078
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0249849
PDLIM5 PDZ and LIM domain 5 -0.0247514
MATR3 matrin 3 -0.0231414
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0226393
SPAG9 sperm associated antigen 9 -0.0224715
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0224171
PRSS3 protease, serine, 3 -0.0222399
VEZT vezatin, adherens junctions transmembrane protein -0.0220729
LY6E lymphocyte antigen 6 complex, locus E -0.0209973
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0209339
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0208823
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0208501
KIF5B kinesin family member 5B -0.0208249
TRA2A transformer 2 alpha homolog (Drosophila) -0.0204726
TMEM41B transmembrane protein 41B -0.0201637
NPAS2 neuronal PAS domain protein 2 -0.0200008
CCNL1 cyclin L1 -0.0199727
S100A6 S100 calcium binding protein A6 -0.0196999
SAMD4A sterile alpha motif domain containing 4A -0.0196788
CORO1C coronin, actin binding protein, 1C -0.0194678
MYO6 myosin VI -0.0187722
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0187293
TMEM164 transmembrane protein 164 -0.0187261
KCMF1 potassium channel modulatory factor 1 -0.0184968
MCU mitochondrial calcium uniporter -0.0180527
EPCAM epithelial cell adhesion molecule -0.0178681
ANLN anillin, actin binding protein -0.0177098
MARCHF6 membrane associated ring-CH-type finger 6 -0.0167367
SEPTIN7 septin 7 -0.0166896
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0164644
CDC42SE2 CDC42 small effector 2 -0.0163249
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0160868
WASF2 WAS protein family, member 2 -0.0160592
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0160394
PARD3 par-3 family cell polarity regulator -0.015989
SEM1 SEM1 26S proteasome subunit -0.0157039
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0155664
NAMPT nicotinamide phosphoribosyltransferase -0.0155545
NCOA3 nuclear receptor coactivator 3 -0.015384
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0153728
HPCAL1 hippocalcin-like 1 -0.0152769
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0152697
NPTN neuroplastin -0.0149487
AGFG1 ArfGAP with FG repeats 1 -0.0149302
PUM2 pumilio RNA-binding family member 2 -0.0148277
NEK7 NIMA-related kinase 7 -0.0146812
ZMYM2 zinc finger, MYM-type 2 -0.0146205
BCL2L1 BCL2-like 1 -0.0145886
RBM39 RNA binding motif protein 39 -0.0145128
EPHA2 EPH receptor A2 -0.014489
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0143695
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -0.0139067
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0138392
TMC7 transmembrane channel-like 7 -0.013414
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0133668
UGCG UDP-glucose ceramide glucosyltransferase -0.0133108
TUFT1 tuftelin 1 -0.0132443
RTN4 reticulon 4 -0.0131456
RCOR1 REST corepressor 1 -0.0130399
RAP1B RAP1B, member of RAS oncogene family -0.0127662
PON2 paraoxonase 2 -0.0127199
CHD1 chromodomain helicase DNA binding protein 1 -0.0126688
RAB7A RAB7A, member RAS oncogene family -0.0125533
PTPRR protein tyrosine phosphatase, receptor type, R -0.0124266
PROSER2 proline and serine rich 2 -0.012389
USP3 ubiquitin specific peptidase 3 -0.0123421
STRN3 striatin, calmodulin binding protein 3 -0.0123125
NRIP1 nuclear receptor interacting protein 1 -0.0122383
CUL3 cullin 3 -0.0119513
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0118163
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0117073
FAM133B family with sequence similarity 133, member B -0.011665
LDLR low density lipoprotein receptor -0.0116615
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0116397
CAB39 calcium binding protein 39 -0.0116111
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.011485
RLF rearranged L-myc fusion -0.0114796
THOC2 THO complex 2 -0.0114221
ATAD2B ATPase family, AAA domain containing 2B -0.0113792