Minodronic acid_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.239117
RPS12 ribosomal protein S12 0.111277
RPS6 ribosomal protein S6 0.106165
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0945528
PTMA prothymosin, alpha 0.0917086
RPL37A ribosomal protein L37a 0.0915115
RPS3 ribosomal protein S3 0.0871106
RPS8 ribosomal protein S8 0.0836422
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0766132
TMSB10 thymosin beta 10 0.0755129
RPL11 ribosomal protein L11 0.0751128
RPL13A ribosomal protein L13a 0.0736635
RPLP1 ribosomal protein, large, P1 0.0690548
SET SET nuclear proto-oncogene 0.0641831
RPL35 ribosomal protein L35 0.0608391
ACTG1 actin gamma 1 0.0603016
SRRM2 serine/arginine repetitive matrix 2 0.0593837
RPS29 ribosomal protein S29 0.0589664
RPLP2 ribosomal protein, large, P2 0.0557288
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0544996
LOC112694756 uncharaterized LOC112694756 0.054221
EEF1G eukaryotic translation elongation factor 1 gamma 0.0532466
RPS13 ribosomal protein S13 0.0531274
IFI6 interferon, alpha-inducible protein 6 0.0528179
VIM vimentin 0.0527998
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0520079
RPL3 ribosomal protein L3 0.0517106
EEF2 eukaryotic translation elongation factor 2 0.0512416
NAP1L1 nucleosome assembly protein 1-like 1 0.0511349
RPS19 ribosomal protein S19 0.0490318
RPL26 ribosomal protein L26 0.0487182
RPS11 ribosomal protein S11 0.0479635
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0465774
LDHA lactate dehydrogenase A 0.0463098
RPL7A ribosomal protein L7a 0.0462619
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0456965
RPS27 ribosomal protein S27 0.0423815
RPS17 ribosomal protein S17 0.0422891
RPS27A ribosomal protein S27a 0.0415261
APLP2 amyloid beta (A4) precursor-like protein 2 0.0404423
RPL28 ribosomal protein L28 0.0403361
RPS5 ribosomal protein S5 0.0397839
RPL19 ribosomal protein L19 0.0390701
RPL12 ribosomal protein L12 0.0389814
RACK1 receptor for activated C kinase 1 0.0378128
RPL36 ribosomal protein L36 0.0374313
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0363733
PNN pinin, desmosome associated protein 0.0362199
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0359119
RPL18 ribosomal protein L18 0.0350329
RPS10 ribosomal protein S10 0.034652
FAM162A family with sequence similarity 162, member A 0.0345807
RPS15 ribosomal protein S15 0.0344929
YBX1 Y box binding protein 1 0.0343293
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0342719
RPL9 ribosomal protein L9 0.03426
PKM pyruvate kinase, muscle 0.0340767
RPL31 ribosomal protein L31 0.0331803
RPL23 ribosomal protein L23 0.0321914
ENO1 enolase 1, (alpha) 0.0316217
NONO non-POU domain containing, octamer-binding 0.0311053
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0307533
RPS4X ribosomal protein S4, X-linked 0.0302308
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0301928
TPI1 triosephosphate isomerase 1 0.030121
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.029987
B2M beta-2-microglobulin 0.0298988
DST dystonin 0.0298812
RPL32 ribosomal protein L32 0.029867
RPL4 ribosomal protein L4 0.0292593
RPS15A ribosomal protein S15a 0.0291191
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0288408
RPL37 ribosomal protein L37 0.0288032
RPS23 ribosomal protein S23 0.0284413
MYH9 myosin, heavy chain 9, non-muscle 0.0284197
RPL34 ribosomal protein L34 0.0283634
HILPDA hypoxia inducible lipid droplet-associated 0.0279592
PCM1 pericentriolar material 1 0.0278664
PNISR PNN-interacting serine/arginine-rich protein 0.0271724
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0268548
RPL5 ribosomal protein L5 0.0268298
CCDC88A coiled-coil domain containing 88A 0.0267387
RPLP0 ribosomal protein, large, P0 0.0266869
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0263272
MKI67 marker of proliferation Ki-67 0.026264
TPT1 tumor protein, translationally-controlled 1 0.0260702
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0253148
SMC1A structural maintenance of chromosomes 1A 0.0252723
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0244875
FTL ferritin, light polypeptide 0.0241673
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0239479
RPS2 ribosomal protein S2 0.0239377
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.023842
RPS25 ribosomal protein S25 0.0236508
RPL7 ribosomal protein L7 0.0236098
RPL8 ribosomal protein L8 0.0235545
GOLGA4 golgin A4 0.0234276
RPS21 ribosomal protein S21 0.0233672
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0233158
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.023204

decreased expression

Symbol Name Standardized Value
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0980322
TENM3 teneurin transmembrane protein 3 -0.0836558
RAD51B RAD51 paralog B -0.0781159
SLIT2 slit homolog 2 (Drosophila) -0.0763368
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0709883
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0535627
NPAS3 neuronal PAS domain protein 3 -0.0483804
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0458442
TOX thymocyte selection-associated high mobility group box -0.0386894
NEBL nebulette -0.0378643
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.036287
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.035938
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0279775
ADGRG6 adhesion G protein-coupled receptor G6 -0.0265203
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0264353
ARHGAP32 Rho GTPase activating protein 32 -0.0248094
CADM2 cell adhesion molecule 2 -0.0245883
CELF2 CUGBP, Elav-like family member 2 -0.0229073
PRICKLE1 prickle homolog 1 (Drosophila) -0.0211537
TTC28 tetratricopeptide repeat domain 28 -0.0194587
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0182592
CCSER1 coiled-coil serine-rich protein 1 -0.01824
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0177363
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0168911
SHROOM3 shroom family member 3 -0.0167303
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0166758
MCTP1 multiple C2 domains, transmembrane 1 -0.0159594
ZFAND3 zinc finger, AN1-type domain 3 -0.015602
TBC1D32 TBC1 domain family, member 32 -0.0154632
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0153341
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0147791
CDH18 cadherin 18, type 2 -0.0144662
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0142575
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0139378
SOX5 SRY (sex determining region Y)-box 5 -0.0138385
PKP4 plakophilin 4 -0.0135376
TOM1L2 target of myb1-like 2 (chicken) -0.0134109
ATP9A ATPase, class II, type 9A -0.0132384
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0130423
PDE3B phosphodiesterase 3B, cGMP-inhibited -0.0126374
KPNB1 karyopherin (importin) beta 1 -0.012472
ACACA acetyl-CoA carboxylase alpha -0.012416
PCNX4 pecanex 4 -0.0123988
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0122338
BNC2 basonuclin 2 -0.0121577
PARD3 par-3 family cell polarity regulator -0.0121529
IARS1 isoleucyl-tRNA synthetase 1 -0.0120186
NF1 neurofibromin 1 -0.0118537
NRG1 neuregulin 1 -0.0117557
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0117329
RABGAP1L RAB GTPase activating protein 1-like -0.0115715
DENND1A DENN/MADD domain containing 1A -0.0113862
TCF20 transcription factor 20 (AR1) -0.0113798
TCF12 transcription factor 12 -0.0113622
GAB2 GRB2-associated binding protein 2 -0.0112123
ARB2A ARB2 cotranscriptional regulator A -0.0111527
SOX2 SRY (sex determining region Y)-box 2 -0.0110716
MLIP muscular LMNA-interacting protein -0.0110538
VCL vinculin -0.0109237
ZBTB20 zinc finger and BTB domain containing 20 -0.0109218
AFG2A AFG2 AAA ATPase homolog A -0.010758
ATP11A ATPase, class VI, type 11A -0.0107351
EMP1 epithelial membrane protein 1 -0.0106407
VMP1 vacuole membrane protein 1 -0.0105142
SMARCAD1 SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 -0.0102752
TRAF3 TNF receptor-associated factor 3 -0.0101829
TAS2R14 taste receptor, type 2, member 14 -0.00997776
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.00993023
PRH1 proline-rich protein HaeIII subfamily 1 -0.00992089
ZNF721 zinc finger protein 721 -0.00990325
HMGA1 high mobility group AT-hook 1 -0.00988082
KCNH5 potassium channel, voltage gated eag related subfamily H, member 5 -0.00986549
SUGCT succinyl-CoA:glutarate-CoA transferase -0.00981011
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.00979137
AUTS2 autism susceptibility candidate 2 -0.00977971
CAMKMT calmodulin-lysine N-methyltransferase -0.00977949
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 -0.00966553
RPTOR regulatory associated protein of MTOR, complex 1 -0.00964107
DNAH14 dynein, axonemal, heavy chain 14 -0.00958501
PUM1 pumilio RNA-binding family member 1 -0.00946086
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.00938171
LRPPRC leucine-rich pentatricopeptide repeat containing -0.00934293
OLA1 Obg-like ATPase 1 -0.00921878
TMCC1 transmembrane and coiled-coil domain family 1 -0.00917906
NT5C2 5'-nucleotidase, cytosolic II -0.00913501
QSER1 glutamine and serine rich 1 -0.00910805
OSBPL10 oxysterol binding protein-like 10 -0.00910354
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.00904618
STRN3 striatin, calmodulin binding protein 3 -0.00903171
ZMYM4 zinc finger, MYM-type 4 -0.00896585
ADARB1 adenosine deaminase, RNA-specific, B1 -0.00894513
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.00892733
METTL2B methyltransferase like 2B -0.00889009
AFG1L AFG1 like ATPase -0.00885778
RAB10 RAB10, member RAS oncogene family -0.0087884
PCNX1 pecanex 1 -0.00872259
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.00870131
ITSN1 intersectin 1 (SH3 domain protein) -0.0086616
ZNF609 zinc finger protein 609 -0.00863487
AKAP6 A kinase (PRKA) anchor protein 6 -0.00855489