Minodronic acid_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.208843
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.166511
MYH9 myosin, heavy chain 9, non-muscle 0.138121
ASPH aspartate beta-hydroxylase 0.112251
APOL1 apolipoprotein L, 1 0.109913
TMSB10 thymosin beta 10 0.10385
SPTBN1 spectrin, beta, non-erythrocytic 1 0.088045
ENO1 enolase 1, (alpha) 0.0747342
TNIP1 TNFAIP3 interacting protein 1 0.0731192
APLP2 amyloid beta (A4) precursor-like protein 2 0.0695642
LAMC2 laminin, gamma 2 0.0655288
MT2A metallothionein 2A 0.0607151
IFI27 interferon, alpha-inducible protein 27 0.0577894
LAMA4 laminin, alpha 4 0.0558015
KRT19 keratin 19, type I 0.055365
PTMA prothymosin, alpha 0.0539891
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0524351
VIM vimentin 0.0523447
RPS3 ribosomal protein S3 0.0517621
DST dystonin 0.0480269
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0476221
B2M beta-2-microglobulin 0.0473708
RPL37A ribosomal protein L37a 0.0468309
IFI6 interferon, alpha-inducible protein 6 0.0462754
CALR calreticulin 0.0458992
RPL19 ribosomal protein L19 0.0457543
LOC112694756 uncharaterized LOC112694756 0.044611
RPS8 ribosomal protein S8 0.0428093
FTL ferritin, light polypeptide 0.0425465
TXNIP thioredoxin interacting protein 0.0403511
LCN2 lipocalin 2 0.0391792
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0388044
PKM pyruvate kinase, muscle 0.0384779
APP amyloid beta (A4) precursor protein 0.0364434
RPS12 ribosomal protein S12 0.0355113
EZR ezrin 0.0353789
TGM2 transglutaminase 2 0.0349647
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.033828
RPS29 ribosomal protein S29 0.0337775
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0331789
RPLP1 ribosomal protein, large, P1 0.0329692
AKAP12 A kinase (PRKA) anchor protein 12 0.0329039
AREG amphiregulin 0.0327227
ISG15 ISG15 ubiquitin-like modifier 0.0315188
RPS27 ribosomal protein S27 0.0314895
RNF213 ring finger protein 213 0.0310241
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0300347
SFTPA2 surfactant protein A2 0.0296648
RPS27A ribosomal protein S27a 0.029634
HLA-B major histocompatibility complex, class I, B 0.029135
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0286506
DSPP dentin sialophosphoprotein 0.0286474
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0286443
LDHA lactate dehydrogenase A 0.0283578
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0282411
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0269751
MKI67 marker of proliferation Ki-67 0.0268357
SRRM2 serine/arginine repetitive matrix 2 0.0261316
TPM3 tropomyosin 3 0.0261066
HYOU1 hypoxia up-regulated 1 0.0259866
CYBA cytochrome b-245, alpha polypeptide 0.0257754
TM4SF1 transmembrane 4 L six family member 1 0.0257647
ACTN1 actinin, alpha 1 0.0257614
PDIA4 protein disulfide isomerase family A, member 4 0.0254732
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0250218
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0250124
RPL11 ribosomal protein L11 0.0248581
RRBP1 ribosome binding protein 1 0.0247673
NFE2L1 nuclear factor, erythroid 2-like 1 0.024761
RPS17 ribosomal protein S17 0.0247513
MMP7 matrix metallopeptidase 7 0.0246655
S100A10 S100 calcium binding protein A10 0.0244324
DSG2 desmoglein 2 0.0243798
LMNA lamin A/C 0.0240769
PLEC plectin 0.0238201
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0236967
TMSB4X thymosin beta 4, X-linked 0.0235858
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0234072
H1-0 H1.0 linker histone 0.0233464
PDIA3 protein disulfide isomerase family A, member 3 0.0233013
CANX calnexin 0.0229721
RPL35 ribosomal protein L35 0.0228933
ANGPTL4 angiopoietin-like 4 0.0227455
AHNAK AHNAK nucleoprotein 0.0225646
CD44 CD44 molecule (Indian blood group) 0.0219754
RPS19 ribosomal protein S19 0.0215422
APOL2 apolipoprotein L, 2 0.0215375
VEGFA vascular endothelial growth factor A 0.021481
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0214096
RACK1 receptor for activated C kinase 1 0.0211246
CD2AP CD2-associated protein 0.0209595
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0208148
LOC102724023 ES1 protein homolog, mitochondrial 0.0207033
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0206878
MSN moesin 0.0205883
PDIA6 protein disulfide isomerase family A, member 6 0.0203051
EEF1G eukaryotic translation elongation factor 1 gamma 0.0202815
RPL28 ribosomal protein L28 0.0202769
TPI1 triosephosphate isomerase 1 0.0200456
AHNAK2 AHNAK nucleoprotein 2 0.0200426

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0868275
DTNA dystrobrevin, alpha -0.054627
RAB7A RAB7A, member RAS oncogene family -0.0386316
IGFBP3 insulin-like growth factor binding protein 3 -0.0363851
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0358963
SAMD4A sterile alpha motif domain containing 4A -0.0323168
PARD3 par-3 family cell polarity regulator -0.0322071
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.030235
MCU mitochondrial calcium uniporter -0.0278924
CP ceruloplasmin (ferroxidase) -0.0275758
HMGA1 high mobility group AT-hook 1 -0.0274934
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0264079
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0257997
F3 coagulation factor III (thromboplastin, tissue factor) -0.0256236
UBE2H ubiquitin-conjugating enzyme E2H -0.0255394
RCOR1 REST corepressor 1 -0.0254765
NUMB numb homolog (Drosophila) -0.0252519
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0248353
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0248024
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0247253
GRB10 growth factor receptor-bound protein 10 -0.0229348
SPAG9 sperm associated antigen 9 -0.022166
SESTD1 SEC14 and spectrin domains 1 -0.021803
KDM5B lysine (K)-specific demethylase 5B -0.0211262
STRN3 striatin, calmodulin binding protein 3 -0.0210861
FOXO3 forkhead box O3 -0.0210019
JUP junction plakoglobin -0.0209878
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0209782
PICALM phosphatidylinositol binding clathrin assembly protein -0.0207366
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0206046
TSC22D2 TSC22 domain family, member 2 -0.0196626
HELZ helicase with zinc finger -0.0195989
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0191239
RPL35A ribosomal protein L35a -0.0181554
PATJ PATJ crumbs cell polarity complex component -0.0176678
FBXO11 F-box protein 11 -0.0174901
SEC31A SEC31 homolog A (S. cerevisiae) -0.0172326
WIPF2 WAS/WASL interacting protein family, member 2 -0.0170556
BLZF1 basic leucine zipper nuclear factor 1 -0.0168914
GNAS GNAS complex locus -0.0165702
FOSL1 FOS-like antigen 1 -0.0163054
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0162915
GLS2 glutaminase 2 (liver, mitochondrial) -0.0162697
DENND4A DENN/MADD domain containing 4A -0.0159908
ITCH itchy E3 ubiquitin protein ligase -0.015988
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.015743
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0156294
SEC24A SEC24 family member A -0.0154519
KDM2A lysine (K)-specific demethylase 2A -0.0153522
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0152546
PLS3 plastin 3 -0.0151354
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0150271
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0149172
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0149033
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0147663
TMEM165 transmembrane protein 165 -0.0147253
POTEF POTE ankyrin domain family, member F -0.0146066
ERBIN erbb2 interacting protein -0.0145918
NT5C2 5'-nucleotidase, cytosolic II -0.0145152
SRP54 signal recognition particle 54kDa -0.0144905
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0144537
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0138934
MON2 MON2 homolog (S. cerevisiae) -0.0137722
RAP1B RAP1B, member of RAS oncogene family -0.0136497
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0135886
CLIC4 chloride intracellular channel 4 -0.0135328
COG5 component of oligomeric golgi complex 5 -0.0134319
KMT2C lysine (K)-specific methyltransferase 2C -0.0132304
SLMAP sarcolemma associated protein -0.0131341
ZFAND3 zinc finger, AN1-type domain 3 -0.0130307
NPC1 Niemann-Pick disease, type C1 -0.0129272
NPAS2 neuronal PAS domain protein 2 -0.0128973
NPEPPS aminopeptidase puromycin sensitive -0.0128809
WAC WW domain containing adaptor with coiled-coil -0.0126895
CERT1 ceramide transporter 1 -0.0124244
MEF2A myocyte enhancer factor 2A -0.0123766
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.012294
FBXL20 F-box and leucine-rich repeat protein 20 -0.0122176
RASA2 RAS p21 protein activator 2 -0.012197
MICU1 mitochondrial calcium uptake 1 -0.012189
PCBP2 poly(rC) binding protein 2 -0.0121413
CDC73 cell division cycle 73 -0.0121367
PPARD peroxisome proliferator-activated receptor delta -0.0118478
KDM6A lysine (K)-specific demethylase 6A -0.0117896
VCL vinculin -0.0117839
TTC3 tetratricopeptide repeat domain 3 -0.0117621
UGCG UDP-glucose ceramide glucosyltransferase -0.0117408
PIAS1 protein inhibitor of activated STAT, 1 -0.0117109
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0116574
USP15 ubiquitin specific peptidase 15 -0.0116013
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0115549
RAB6A RAB6A, member RAS oncogene family -0.0113885
MUC16 mucin 16, cell surface associated -0.0113725
TAOK1 TAO kinase 1 -0.0112539
TRAF3 TNF receptor-associated factor 3 -0.0112094
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0110962
ATOSA atos homolog A -0.0110756
PRKCA protein kinase C, alpha -0.0110498
MARCHF6 membrane associated ring-CH-type finger 6 -0.0110334
NUP58 nucleoporin 58 -0.0110278