Minodronic acid_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.161325
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0978101
RPS6 ribosomal protein S6 0.0799277
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0688462
LPIN1 lipin 1 0.0631245
RPL37A ribosomal protein L37a 0.0559015
VIM vimentin 0.0557927
ACTG1 actin gamma 1 0.0531576
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0487711
PTMA prothymosin, alpha 0.0464019
RPS3 ribosomal protein S3 0.0463511
MYH9 myosin, heavy chain 9, non-muscle 0.0457968
SEPTIN9 septin 9 0.0440866
B2M beta-2-microglobulin 0.0436767
RPL35 ribosomal protein L35 0.043072
RPL19 ribosomal protein L19 0.0430117
NCOR2 nuclear receptor corepressor 2 0.0419482
TRIO trio Rho guanine nucleotide exchange factor 0.0415254
RPS27 ribosomal protein S27 0.0399192
RPS12 ribosomal protein S12 0.0398435
RPS17 ribosomal protein S17 0.035878
EEF2 eukaryotic translation elongation factor 2 0.0348854
RPLP1 ribosomal protein, large, P1 0.0347717
RPS27A ribosomal protein S27a 0.0337622
RPS5 ribosomal protein S5 0.0325708
CRH corticotropin releasing hormone 0.0324461
RPL36 ribosomal protein L36 0.0314179
EIF1 eukaryotic translation initiation factor 1 0.0311453
PTPRD protein tyrosine phosphatase, receptor type, D 0.0309877
SMAD3 SMAD family member 3 0.0309132
RPL34 ribosomal protein L34 0.0306345
PCBP3 poly(rC) binding protein 3 0.029856
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0290216
RPL3 ribosomal protein L3 0.0287866
RACK1 receptor for activated C kinase 1 0.0287724
PTPRG protein tyrosine phosphatase, receptor type, G 0.0285638
RPL4 ribosomal protein L4 0.0283341
RPS29 ribosomal protein S29 0.0282651
RPS19 ribosomal protein S19 0.0276591
RPL28 ribosomal protein L28 0.0275206
MYH10 myosin, heavy chain 10, non-muscle 0.0272935
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0269596
TMSB10 thymosin beta 10 0.0269174
GPBP1 GC-rich promoter binding protein 1 0.0267752
RPS2 ribosomal protein S2 0.0265037
SSBP3 single stranded DNA binding protein 3 0.0263645
PLAT plasminogen activator, tissue 0.0261134
VGF VGF nerve growth factor inducible 0.0260243
RPS14 ribosomal protein S14 0.0259498
LOC112694756 uncharaterized LOC112694756 0.0259476
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0259028
RPL23 ribosomal protein L23 0.0258314
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.0257705
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0257701
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0255562
MYO6 myosin VI 0.0255488
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0254761
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0254385
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0253309
VEGFA vascular endothelial growth factor A 0.0252288
RPS23 ribosomal protein S23 0.025195
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.025131
MACF1 microtubule-actin crosslinking factor 1 0.0245774
RPS15 ribosomal protein S15 0.0245016
EIF4A1 eukaryotic translation initiation factor 4A1 0.0244538
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0244412
FAM162A family with sequence similarity 162, member A 0.0241426
RPL37 ribosomal protein L37 0.0236097
DCAF7 DDB1 and CUL4 associated factor 7 0.023323
SRRM2 serine/arginine repetitive matrix 2 0.0232749
ANGPTL4 angiopoietin-like 4 0.0232683
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0232069
H1-0 H1.0 linker histone 0.0230713
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0230284
RPS8 ribosomal protein S8 0.0229798
ANTXR1 anthrax toxin receptor 1 0.0229076
RGS5 regulator of G-protein signaling 5 0.022882
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0228142
APP amyloid beta (A4) precursor protein 0.0227888
RPL9 ribosomal protein L9 0.0225351
RPL27 ribosomal protein L27 0.0217244
RPS25 ribosomal protein S25 0.0216904
GLG1 golgi glycoprotein 1 0.021407
FAM107B family with sequence similarity 107, member B 0.0212168
PCM1 pericentriolar material 1 0.0210949
IFI6 interferon, alpha-inducible protein 6 0.0208566
ITPRID2 ITPR interacting domain containing 2 0.0207018
RPL7 ribosomal protein L7 0.0205412
RPL13A ribosomal protein L13a 0.0205125
FLT1 fms-related tyrosine kinase 1 0.0200737
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0198924
LMNA lamin A/C 0.0196191
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0192229
RET ret proto-oncogene 0.018874
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0187874
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0186026
RBM25 RNA binding motif protein 25 0.0185605
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0185403
PRRC2C proline-rich coiled-coil 2C 0.0182894
PDZRN3 PDZ domain containing ring finger 3 0.0182177

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.121914
EXT1 exostosin glycosyltransferase 1 -0.0640383
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0601339
LSAMP limbic system-associated membrane protein -0.0562915
SYT1 synaptotagmin I -0.0508346
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0469677
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0438465
GREM2 gremlin 2, DAN family BMP antagonist -0.0416241
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0396138
FNDC3A fibronectin type III domain containing 3A -0.0344557
GPC5 glypican 5 -0.0316901
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0315484
AEBP2 AE binding protein 2 -0.03042
NRG1 neuregulin 1 -0.0287197
LINGO2 leucine rich repeat and Ig domain containing 2 -0.028633
COL3A1 collagen, type III, alpha 1 -0.0284421
PSD3 pleckstrin and Sec7 domain containing 3 -0.0283978
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0276042
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0274687
CNTN4 contactin 4 -0.0272381
FNDC3B fibronectin type III domain containing 3B -0.0270984
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0261535
GLCCI1 glucocorticoid induced 1 -0.0255369
P4HB prolyl 4-hydroxylase, beta polypeptide -0.025463
KCNIP4 Kv channel interacting protein 4 -0.0253971
SIK2 salt-inducible kinase 2 -0.0249486
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0241373
RAP1B RAP1B, member of RAS oncogene family -0.0239845
KPNB1 karyopherin (importin) beta 1 -0.0236918
ZNF804A zinc finger protein 804A -0.0234389
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0232236
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.023097
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0229482
PIBF1 progesterone immunomodulatory binding factor 1 -0.0224226
TTC17 tetratricopeptide repeat domain 17 -0.0220639
CEP350 centrosomal protein 350kDa -0.0214179
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0212917
FERMT2 fermitin family member 2 -0.0212658
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0211562
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0206847
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0206216
STC1 stanniocalcin 1 -0.0203557
RAB7A RAB7A, member RAS oncogene family -0.0202109
UBAP2L ubiquitin associated protein 2-like -0.0199342
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0199296
MAPK10 mitogen-activated protein kinase 10 -0.0197112
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.0196612
CCDC47 coiled-coil domain containing 47 -0.0195473
TPST1 tyrosylprotein sulfotransferase 1 -0.0194621
RABGAP1 RAB GTPase activating protein 1 -0.0194145
STK38L serine/threonine kinase 38 like -0.0193199
ODR4 odr-4 GPCR localization factor homolog -0.0191639
CANX calnexin -0.0190231
LRP1B low density lipoprotein receptor-related protein 1B -0.0187614
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0183746
TENT5A terminal nucleotidyltransferase 5A -0.018048
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0180381
SYNPO2 synaptopodin 2 -0.0179188
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0178037
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0174502
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0172982
MON2 MON2 homolog (S. cerevisiae) -0.017261
FMN1 formin 1 -0.0171897
NCOR1 nuclear receptor corepressor 1 -0.0169443
ADGRG6 adhesion G protein-coupled receptor G6 -0.0168701
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.016671
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0163528
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0163185
MSI2 musashi RNA-binding protein 2 -0.0163011
MED13 mediator complex subunit 13 -0.0161331
PCDH7 protocadherin 7 -0.0160214
TPM1 tropomyosin 1 (alpha) -0.0159722
ACBD6 acyl-CoA binding domain containing 6 -0.0159453
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0159084
RAI14 retinoic acid induced 14 -0.0157524
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0157327
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0156463
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0155965
CFDP1 craniofacial development protein 1 -0.0155242
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.015446
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0153722
WTAP Wilms tumor 1 associated protein -0.0152894
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0152156
DENND4A DENN/MADD domain containing 4A -0.0151547
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0151233
TPR translocated promoter region, nuclear basket protein -0.0151103
SKIL SKI-like proto-oncogene -0.0148191
MARCHF7 membrane associated ring-CH-type finger 7 -0.0147667
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0147322
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0146938
FN1 fibronectin 1 -0.0146317
CEP95 centrosomal protein 95kDa -0.0145941
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0144864
JMJD1C jumonji domain containing 1C -0.0144849
TPM4 tropomyosin 4 -0.0144716
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0144534
ZBTB20 zinc finger and BTB domain containing 20 -0.014251
RB1 retinoblastoma 1 -0.0140361
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0140293
MEMO1 mediator of cell motility 1 -0.0139209