Minodronic acid_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.377319
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.178076
IGFBP3 insulin-like growth factor binding protein 3 0.161403
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.114295
VIM vimentin 0.112954
TMSB10 thymosin beta 10 0.0892967
MYH9 myosin, heavy chain 9, non-muscle 0.0873704
MT2A metallothionein 2A 0.0864223
FN1 fibronectin 1 0.0863183
HLA-B major histocompatibility complex, class I, B 0.0787562
AKAP12 A kinase (PRKA) anchor protein 12 0.0740389
CALR calreticulin 0.0733466
PTMA prothymosin, alpha 0.0679879
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0672692
IGFBP5 insulin-like growth factor binding protein 5 0.067109
NALF1 NALCN channel auxiliary factor 1 0.0668875
PLEC plectin 0.0653897
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0647496
B2M beta-2-microglobulin 0.0634201
ASPH aspartate beta-hydroxylase 0.046286
TGFBI transforming growth factor, beta-induced, 68kDa 0.0434193
TPT1 tumor protein, translationally-controlled 1 0.0425178
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0422299
COL5A1 collagen, type V, alpha 1 0.0417927
SFTPA2 surfactant protein A2 0.0417765
VEGFA vascular endothelial growth factor A 0.0414088
PRSS23 protease, serine, 23 0.0409803
TIMP3 TIMP metallopeptidase inhibitor 3 0.0387507
HYOU1 hypoxia up-regulated 1 0.0387151
SDC4 syndecan 4 0.0361824
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0346548
RPS3 ribosomal protein S3 0.0335312
DST dystonin 0.0332774
RPS6 ribosomal protein S6 0.0329848
APP amyloid beta (A4) precursor protein 0.0325359
RPS8 ribosomal protein S8 0.0324432
MACF1 microtubule-actin crosslinking factor 1 0.0321565
PDIA4 protein disulfide isomerase family A, member 4 0.0321234
ENO1 enolase 1, (alpha) 0.0317217
TMED9 transmembrane emp24 protein transport domain containing 9 0.0317107
RPL37A ribosomal protein L37a 0.0314451
HLA-A major histocompatibility complex, class I, A 0.0312221
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0306213
TIMP1 TIMP metallopeptidase inhibitor 1 0.0290424
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0286647
C1S complement component 1, s subcomponent 0.0280678
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0275728
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0273909
NAP1L1 nucleosome assembly protein 1-like 1 0.0269637
LDHA lactate dehydrogenase A 0.026803
LMNA lamin A/C 0.0265825
TNIP1 TNFAIP3 interacting protein 1 0.0257822
HILPDA hypoxia inducible lipid droplet-associated 0.0257583
ACTG1 actin gamma 1 0.0256434
APLP2 amyloid beta (A4) precursor-like protein 2 0.0253917
FSTL1 follistatin-like 1 0.0252693
MKI67 marker of proliferation Ki-67 0.0248381
EXT1 exostosin glycosyltransferase 1 0.0246511
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0245225
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0244713
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0244317
RPL31 ribosomal protein L31 0.0243139
KYNU kynureninase 0.0236789
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0236215
ENO2 enolase 2 (gamma, neuronal) 0.0231676
AHNAK AHNAK nucleoprotein 0.0231221
HIP1 huntingtin interacting protein 1 0.0229526
RPS27A ribosomal protein S27a 0.0226613
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0219495
RPL7A ribosomal protein L7a 0.021537
H1-4 H1.4 linker histone, cluster member 0.0210702
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0209655
RIGI RNA sensor RIG-I 0.0208087
RPS13 ribosomal protein S13 0.0206821
RPS27 ribosomal protein S27 0.0204996
RACK1 receptor for activated C kinase 1 0.0204648
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 0.0203821
TMSB4X thymosin beta 4, X-linked 0.0201776
TPI1 triosephosphate isomerase 1 0.0198524
NUMA1 nuclear mitotic apparatus protein 1 0.0198493
RPS12 ribosomal protein S12 0.0198258
PDIA3 protein disulfide isomerase family A, member 3 0.0195155
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0194474
EIF1 eukaryotic translation initiation factor 1 0.0193933
PLAUR plasminogen activator, urokinase receptor 0.0192855
CLMP CXADR-like membrane protein 0.0192558
PYGL phosphorylase, glycogen, liver 0.0191885
ARHGAP22 Rho GTPase activating protein 22 0.019068
RPLP2 ribosomal protein, large, P2 0.0190103
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0187739
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0187003
PDIA6 protein disulfide isomerase family A, member 6 0.018691
PDLIM5 PDZ and LIM domain 5 0.0184299
S100A10 S100 calcium binding protein A10 0.0183946
CARS1 cysteinyl-tRNA synthetase 1 0.018204
NONO non-POU domain containing, octamer-binding 0.0180676
SRRM2 serine/arginine repetitive matrix 2 0.0179929
STC1 stanniocalcin 1 0.0179087
CALD1 caldesmon 1 0.0178739
EHBP1L1 EH domain binding protein 1-like 1 0.0177542

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.101251
FNDC3B fibronectin type III domain containing 3B -0.0852605
NAMPT nicotinamide phosphoribosyltransferase -0.0683516
DGKD diacylglycerol kinase, delta 130kDa -0.0525381
GLIS3 GLIS family zinc finger 3 -0.0451979
MAP1B microtubule-associated protein 1B -0.0437456
SBF2 SET binding factor 2 -0.0419924
RTN4 reticulon 4 -0.0417115
NDRG1 N-myc downstream regulated 1 -0.0408391
SMAD3 SMAD family member 3 -0.0378648
EGFR epidermal growth factor receptor -0.0349236
TNNC1 troponin C type 1 (slow) -0.0288449
BIRC6 baculoviral IAP repeat containing 6 -0.0284598
ATP13A3 ATPase type 13A3 -0.0282863
TXNRD1 thioredoxin reductase 1 -0.0275536
OSMR oncostatin M receptor -0.0271179
ANKRD17 ankyrin repeat domain 17 -0.0270024
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0268565
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0266483
ANKRD28 ankyrin repeat domain 28 -0.0266275
METTL15 methyltransferase like 15 -0.0252032
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0251466
COG5 component of oligomeric golgi complex 5 -0.0251097
MBD5 methyl-CpG binding domain protein 5 -0.0250548
LRRC49 leucine rich repeat containing 49 -0.0249965
SNX13 sorting nexin 13 -0.024793
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0246414
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0245692
TNS3 tensin 3 -0.023921
GARS1 glycyl-tRNA synthetase 1 -0.0235567
FOXJ3 forkhead box J3 -0.0234682
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0234594
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0233661
PHF14 PHD finger protein 14 -0.0233182
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0229514
GLS2 glutaminase 2 (liver, mitochondrial) -0.0227942
ELL2 elongation factor, RNA polymerase II, 2 -0.0227125
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0225846
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0221881
KMT2E lysine (K)-specific methyltransferase 2E -0.0218731
GPC6 glypican 6 -0.0218571
JMJD1C jumonji domain containing 1C -0.0217335
DLG1 discs, large homolog 1 (Drosophila) -0.0214432
ZNF292 zinc finger protein 292 -0.0212829
SMC5 structural maintenance of chromosomes 5 -0.0212712
RNF216 ring finger protein 216 -0.0212592
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0211024
CLTC clathrin, heavy chain (Hc) -0.0209882
LPP LIM domain containing preferred translocation partner in lipoma -0.0207558
TUSC3 tumor suppressor candidate 3 -0.02062
SMYD3 SET and MYND domain containing 3 -0.0205619
ATXN1 ataxin 1 -0.0201771
CADM1 cell adhesion molecule 1 -0.0200489
FTH1 ferritin, heavy polypeptide 1 -0.0199008
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0198711
TM9SF3 transmembrane 9 superfamily member 3 -0.0196731
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0192982
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0191023
AVL9 AVL9 homolog (S. cerevisiase) -0.0189943
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0189923
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0186256
ZNF148 zinc finger protein 148 -0.0185734
STK17B serine/threonine kinase 17b -0.0184714
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -0.0182848
ANXA5 annexin A5 -0.0182384
AKAP9 A kinase (PRKA) anchor protein 9 -0.0181184
HMGA1 high mobility group AT-hook 1 -0.0177164
TSC22D2 TSC22 domain family, member 2 -0.01743
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0173839
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0167888
BTBD10 BTB (POZ) domain containing 10 -0.016454
TMEM39A transmembrane protein 39A -0.0164325
ZFAND3 zinc finger, AN1-type domain 3 -0.0163544
SCAF11 SR-related CTD-associated factor 11 -0.0162627
ADAM9 ADAM metallopeptidase domain 9 -0.0161933
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0161267
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0159744
LCORL ligand dependent nuclear receptor corepressor-like -0.0158592
SEC24D SEC24 family member D -0.0158472
VMP1 vacuole membrane protein 1 -0.0157976
TUT4 terminal uridylyl transferase 4 -0.0157027
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0156688
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0156084
RASA2 RAS p21 protein activator 2 -0.0155605
EPAS1 endothelial PAS domain protein 1 -0.0155066
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0153136
WDR26 WD repeat domain 26 -0.0153058
USP3 ubiquitin specific peptidase 3 -0.0152727
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0151286
MON2 MON2 homolog (S. cerevisiae) -0.0151182
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0150705
RARS1 arginyl-tRNA synthetase 1 -0.0150356
MARCHF7 membrane associated ring-CH-type finger 7 -0.0148577
TRA2B transformer 2 beta homolog (Drosophila) -0.0147849
ERBIN erbb2 interacting protein -0.0147057
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0145802
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0144643
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0143284
MAML2 mastermind-like 2 (Drosophila) -0.0143166
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0143116