Minodronic acid_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.203137
MYH9 myosin, heavy chain 9, non-muscle 0.202636
PLEC plectin 0.127959
HMGA2 high mobility group AT-hook 2 0.101261
FN1 fibronectin 1 0.0992567
AHNAK AHNAK nucleoprotein 0.09448
COL5A1 collagen, type V, alpha 1 0.0939038
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0785947
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0762924
ERRFI1 ERBB receptor feedback inhibitor 1 0.0747861
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0675489
ASPH aspartate beta-hydroxylase 0.0669145
COL6A3 collagen, type VI, alpha 3 0.0646415
DST dystonin 0.0591216
SEPTIN9 septin 9 0.0590503
EXT1 exostosin glycosyltransferase 1 0.0569345
CAVIN1 caveolae associated protein 1 0.0527888
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0526507
ANGPTL4 angiopoietin-like 4 0.0509982
COL6A2 collagen, type VI, alpha 2 0.050778
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0501168
PTMA prothymosin, alpha 0.0436921
CANX calnexin 0.0431353
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0416402
MPRIP myosin phosphatase Rho interacting protein 0.0395795
VEGFA vascular endothelial growth factor A 0.0380545
BICD1 bicaudal D homolog 1 (Drosophila) 0.0359942
FLNA filamin A, alpha 0.0358597
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0353883
TRIO trio Rho guanine nucleotide exchange factor 0.0353609
HDLBP high density lipoprotein binding protein 0.0350989
HSPA8 heat shock 70kDa protein 8 0.0340203
CALR calreticulin 0.0325919
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0321075
COL7A1 collagen, type VII, alpha 1 0.0320685
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0319618
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0312648
SMAD3 SMAD family member 3 0.0312364
RPS8 ribosomal protein S8 0.0311913
RPS12 ribosomal protein S12 0.0310897
MLPH melanophilin 0.0306981
RPS3 ribosomal protein S3 0.0304835
RRBP1 ribosome binding protein 1 0.0300054
CD44 CD44 molecule (Indian blood group) 0.0296301
NAP1L1 nucleosome assembly protein 1-like 1 0.0294094
TPT1 tumor protein, translationally-controlled 1 0.0293308
RPL37A ribosomal protein L37a 0.0291658
FLNB filamin B, beta 0.0290224
CAPRIN2 caprin family member 2 0.0288062
PHF3 PHD finger protein 3 0.028776
NCOR2 nuclear receptor corepressor 2 0.0285757
SFTPA2 surfactant protein A2 0.0285284
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0281878
APP amyloid beta (A4) precursor protein 0.0280747
NONO non-POU domain containing, octamer-binding 0.0278292
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0275947
LOXL2 lysyl oxidase-like 2 0.027255
INTS6 integrator complex subunit 6 0.0271446
OGA O-GlcNAcase 0.0267775
EEF2 eukaryotic translation elongation factor 2 0.0265536
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0264781
RPS27A ribosomal protein S27a 0.0260735
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0257155
RPL4 ribosomal protein L4 0.0256128
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0252826
HPCAL1 hippocalcin-like 1 0.0252376
LOC112694756 uncharaterized LOC112694756 0.0248503
APLP2 amyloid beta (A4) precursor-like protein 2 0.0247358
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0247238
IER3 immediate early response 3 0.0246913
EGFR epidermal growth factor receptor 0.0243278
RPL19 ribosomal protein L19 0.0242622
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0242369
CPNE1 copine I 0.0240869
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0240516
PDIA4 protein disulfide isomerase family A, member 4 0.0239214
ANXA2 annexin A2 0.0237877
RPL3 ribosomal protein L3 0.0236653
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0235687
MACF1 microtubule-actin crosslinking factor 1 0.0235084
ACTN1 actinin, alpha 1 0.0227468
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0221039
GOLGA3 golgin A3 0.0219619
RPLP1 ribosomal protein, large, P1 0.0219403
EEF1G eukaryotic translation elongation factor 1 gamma 0.0218759
TNIP1 TNFAIP3 interacting protein 1 0.0217472
PCBP3 poly(rC) binding protein 3 0.0214946
SRRM2 serine/arginine repetitive matrix 2 0.0212835
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0211271
RASA3 RAS p21 protein activator 3 0.0210865
RPL35 ribosomal protein L35 0.0210431
GOLGB1 golgin B1 0.0207054
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0200623
RPS27 ribosomal protein S27 0.0200335
EIF1 eukaryotic translation initiation factor 1 0.0198006
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0196994
ACTN4 actinin, alpha 4 0.0195941
SQSTM1 sequestosome 1 0.0193422
EHBP1L1 EH domain binding protein 1-like 1 0.0191565
RPS17 ribosomal protein S17 0.0190443

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.25112
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.182159
IGF2 insulin-like growth factor 2 -0.137521
TMSB10 thymosin beta 10 -0.087233
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0587874
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0573117
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0544516
CLMP CXADR-like membrane protein -0.0540221
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0524623
EGR1 early growth response 1 -0.0495811
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0437348
HMGA1 high mobility group AT-hook 1 -0.0427599
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.041152
ANKRD12 ankyrin repeat domain 12 -0.0394514
POTEF POTE ankyrin domain family, member F -0.0365891
TMEM165 transmembrane protein 165 -0.0357925
CYB5R3 cytochrome b5 reductase 3 -0.0356159
PFN1 profilin 1 -0.0344569
NALF1 NALCN channel auxiliary factor 1 -0.0341504
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0339246
IGFBP4 insulin-like growth factor binding protein 4 -0.0310211
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0309817
MAP1B microtubule-associated protein 1B -0.0309138
RAB7A RAB7A, member RAS oncogene family -0.0295223
DIAPH2 diaphanous-related formin 2 -0.0290334
FOSL1 FOS-like antigen 1 -0.0288833
SMC4 structural maintenance of chromosomes 4 -0.0281907
COL6A1 collagen, type VI, alpha 1 -0.0273907
TAGLN2 transgelin 2 -0.0270289
DIAPH3 diaphanous-related formin 3 -0.0267209
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0258266
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0255535
MARCKS myristoylated alanine-rich protein kinase C substrate -0.025301
AXL AXL receptor tyrosine kinase -0.0242768
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0240293
S100A6 S100 calcium binding protein A6 -0.0239745
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0226427
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0225384
TUBA1B tubulin, alpha 1b -0.0225039
DTNA dystrobrevin, alpha -0.0223018
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -0.0220604
CENPF centromere protein F, 350/400kDa -0.0207479
MT1X metallothionein 1X -0.0206902
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0205909
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0199554
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0198098
CDH13 cadherin 13 -0.0193843
TUBB6 tubulin, beta 6 class V -0.019307
NF1 neurofibromin 1 -0.0190406
INHBA inhibin, beta A -0.0185298
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0183213
CLEC1B C-type lectin domain family 1, member B -0.0182438
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0180605
MT2A metallothionein 2A -0.0178387
GNAS GNAS complex locus -0.0178213
RPL35A ribosomal protein L35a -0.0177806
RNF24 ring finger protein 24 -0.0177093
RTN4 reticulon 4 -0.0173504
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0171556
AGRN agrin -0.017089
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0170067
TPI1 triosephosphate isomerase 1 -0.0169084
AFF3 AF4/FMR2 family, member 3 -0.0167435
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0164744
MAML3 mastermind-like 3 (Drosophila) -0.0163751
MYADM myeloid-associated differentiation marker -0.0161398
SEPTIN7 septin 7 -0.0161308
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0161267
MYO10 myosin X -0.0156767
ERGIC2 ERGIC and golgi 2 -0.0154869
JARID2 jumonji, AT rich interactive domain 2 -0.015245
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0149282
MARCHF7 membrane associated ring-CH-type finger 7 -0.0149279
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.014918
PCBP2 poly(rC) binding protein 2 -0.0148918
RAP1B RAP1B, member of RAS oncogene family -0.0146128
KIAA1549L KIAA1549-like -0.014427
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0143811
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0141789
SEC24A SEC24 family member A -0.0141124
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0140177
TPM4 tropomyosin 4 -0.0139485
L1CAM L1 cell adhesion molecule -0.0138759
CBX3 chromobox homolog 3 -0.0138517
ICAM1 intercellular adhesion molecule 1 -0.0137735
PLS3 plastin 3 -0.0135888
TUBA1C tubulin, alpha 1c -0.013506
TFG TRK-fused gene -0.0133692
KIRREL3 kin of IRRE like 3 (Drosophila) -0.0133446
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -0.0133024
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.0129734
WDPCP WD repeat containing planar cell polarity effector -0.0129252
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0129194
KIF18B kinesin family member 18B -0.0126943
SBF2 SET binding factor 2 -0.0126335
SDK1 sidekick cell adhesion molecule 1 -0.0125362
RNF145 ring finger protein 145 -0.0125031
CCDC91 coiled-coil domain containing 91 -0.0124773
PTK2 protein tyrosine kinase 2 -0.0124494
ANXA5 annexin A5 -0.0124188