Minodronic acid_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSPP dentin sialophosphoprotein 0.116241
MYH9 myosin, heavy chain 9, non-muscle 0.102039
LMO7 LIM domain 7 0.100524
ITPRID2 ITPR interacting domain containing 2 0.0976655
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0947365
HSPA8 heat shock 70kDa protein 8 0.086814
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0828862
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0825524
KRT18 keratin 18, type I 0.0819311
TPT1 tumor protein, translationally-controlled 1 0.0759383
EZR ezrin 0.0756892
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0748011
MPRIP myosin phosphatase Rho interacting protein 0.0679218
MYO5B myosin VB 0.0653543
FRMD5 FERM domain containing 5 0.0637782
RPL4 ribosomal protein L4 0.062949
INTS6 integrator complex subunit 6 0.0626168
MYO1E myosin IE 0.0623157
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0603122
PLEC plectin 0.0550883
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.053169
LOC105378220 macrophage receptor MARCO-like 0.0520136
ZSWIM6 zinc finger, SWIM-type containing 6 0.0502371
PTMA prothymosin, alpha 0.0495875
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0481218
RPL3 ribosomal protein L3 0.0478613
MYH14 myosin, heavy chain 14, non-muscle 0.0473285
KRT8 keratin 8, type II 0.0466299
CTBP2 C-terminal binding protein 2 0.0449326
RIMKLB ribosomal modification protein rimK-like family member B 0.0447809
AHNAK AHNAK nucleoprotein 0.0432581
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0431701
ATF3 activating transcription factor 3 0.0419276
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0405647
KLF5 Kruppel-like factor 5 (intestinal) 0.0386444
CANX calnexin 0.038178
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0368633
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0368384
EIF4A2 eukaryotic translation initiation factor 4A2 0.0365148
CATSPERB catsper channel auxiliary subunit beta 0.0361747
APP amyloid beta (A4) precursor protein 0.0356007
SLC38A2 solute carrier family 38, member 2 0.0349719
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.034803
RPS6 ribosomal protein S6 0.0342299
SRRM2 serine/arginine repetitive matrix 2 0.0338176
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0336518
NAP1L1 nucleosome assembly protein 1-like 1 0.0331126
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0328251
NCOR2 nuclear receptor corepressor 2 0.0319625
DST dystonin 0.031887
IFRD1 interferon-related developmental regulator 1 0.0314332
FUS FUS RNA binding protein 0.031134
HDLBP high density lipoprotein binding protein 0.0306771
SKP1 S-phase kinase-associated protein 1 0.0302786
RPL14 ribosomal protein L14 0.0302517
RPL6 ribosomal protein L6 0.0301951
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0301441
ERRFI1 ERBB receptor feedback inhibitor 1 0.029882
LAMB3 laminin, beta 3 0.0297598
LRRC23 leucine rich repeat containing 23 0.0296712
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0295602
CCNYL1 cyclin Y-like 1 0.0293654
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0291623
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0291539
RPS27 ribosomal protein S27 0.029151
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0281366
CUX1 cut-like homeobox 1 0.0280505
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0279578
LDHA lactate dehydrogenase A 0.027898
SFTPA2 surfactant protein A2 0.0277054
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0275753
ASPH aspartate beta-hydroxylase 0.0275297
HSPH1 heat shock 105kDa/110kDa protein 1 0.0275277
LOC112694756 uncharaterized LOC112694756 0.0273696
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0272741
RPS8 ribosomal protein S8 0.027233
CCND2 cyclin D2 0.0271518
APLP2 amyloid beta (A4) precursor-like protein 2 0.027095
PSD3 pleckstrin and Sec7 domain containing 3 0.0270881
SERINC5 serine incorporator 5 0.0269392
SQSTM1 sequestosome 1 0.0268251
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0267714
NABP1 nucleic acid binding protein 1 0.0267078
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0266944
AEBP2 AE binding protein 2 0.0266788
DSG2 desmoglein 2 0.0265642
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0263949
KDM3A lysine (K)-specific demethylase 3A 0.0261334
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0261074
FBXO11 F-box protein 11 0.0260553
APOL1 apolipoprotein L, 1 0.0260166
OXSR1 oxidative stress responsive 1 0.0257372
RPL41 ribosomal protein L41 0.0255896
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0254091
PKM pyruvate kinase, muscle 0.0249511
RPL7A ribosomal protein L7a 0.0249081
PLK2 polo-like kinase 2 0.0243321
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0238799
TRAPPC9 trafficking protein particle complex 9 0.0238693
FMNL2 formin-like 2 0.0237923

decreased expression

Symbol Name Standardized Value
EPS8 epidermal growth factor receptor pathway substrate 8 -0.178463
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.130517
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.129494
CALB1 calbindin 1, 28kDa -0.111312
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.109609
PTPRR protein tyrosine phosphatase, receptor type, R -0.0896978
PKP2 plakophilin 2 -0.0776905
PRSS3 protease, serine, 3 -0.0770733
AKAP9 A kinase (PRKA) anchor protein 9 -0.0769749
PLAC8 placenta-specific 8 -0.074491
FLNB filamin B, beta -0.07325
TXNRD1 thioredoxin reductase 1 -0.0726264
POTEF POTE ankyrin domain family, member F -0.0687946
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0686348
FOXO1 forkhead box O1 -0.0680315
GOLGA4 golgin A4 -0.0665803
MON2 MON2 homolog (S. cerevisiae) -0.0640405
TRIM2 tripartite motif containing 2 -0.0622695
PDE4D phosphodiesterase 4D, cAMP-specific -0.0614587
ITGA6 integrin, alpha 6 -0.060259
PCDHB16 protocadherin beta 16 -0.059918
THSD4 thrombospondin, type I, domain containing 4 -0.0545266
RPL35A ribosomal protein L35a -0.0524742
PRELID2 PRELI domain containing 2 -0.0522021
CLDN4 claudin 4 -0.0513476
PTEN phosphatase and tensin homolog -0.0512286
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0507581
SHROOM3 shroom family member 3 -0.0505634
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0491345
RAD51B RAD51 paralog B -0.0486997
WWC1 WW and C2 domain containing 1 -0.0486931
PCBP2 poly(rC) binding protein 2 -0.0480677
P3H2 prolyl 3-hydroxylase 2 -0.046325
ETNK1 ethanolamine kinase 1 -0.0462752
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0459173
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0448009
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.044079
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.043526
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0432567
HMGA1 high mobility group AT-hook 1 -0.0408278
PTPRK protein tyrosine phosphatase, receptor type, K -0.0405884
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0405372
GARS1 glycyl-tRNA synthetase 1 -0.0404452
MYOF myoferlin -0.0399237
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0373022
CSTPP1 centriolar satellite-associated tubulin polyglutamylase complex regulator 1 -0.037109
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0367013
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0366975
CDK19 cyclin-dependent kinase 19 -0.0360931
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein -0.0360599
BTBD9 BTB (POZ) domain containing 9 -0.0359645
ZNF292 zinc finger protein 292 -0.035659
RAP1B RAP1B, member of RAS oncogene family -0.0355642
SH3RF2 SH3 domain containing ring finger 2 -0.0353293
ABHD17C abhydrolase domain containing 17C -0.0352362
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0352112
AVL9 AVL9 homolog (S. cerevisiase) -0.0350134
TMEM165 transmembrane protein 165 -0.0347514
WARS1 tryptophanyl-tRNA synthetase 1 -0.0347316
MAML2 mastermind-like 2 (Drosophila) -0.0346411
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0344205
RPL37A ribosomal protein L37a -0.0340808
ETV6 ets variant 6 -0.0338964
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0336586
COG5 component of oligomeric golgi complex 5 -0.0335581
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.033426
FAT1 FAT atypical cadherin 1 -0.0332078
ANXA11 annexin A11 -0.0331425
VCL vinculin -0.0329294
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0328598
ANTXR2 anthrax toxin receptor 2 -0.0324072
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0323819
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0322761
RIN2 Ras and Rab interactor 2 -0.0322162
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0316011
BACE2 beta-site APP-cleaving enzyme 2 -0.0316005
SH3RF1 SH3 domain containing ring finger 1 -0.0315943
ARHGAP29 Rho GTPase activating protein 29 -0.0311921
TLN2 talin 2 -0.0311618
CCNL1 cyclin L1 -0.0311397
KLF3 Kruppel-like factor 3 (basic) -0.0310218
TRIM31 tripartite motif containing 31 -0.0308014
NKTR natural killer cell triggering receptor -0.0307802
FTH1 ferritin, heavy polypeptide 1 -0.0306364
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.030472
EGR1 early growth response 1 -0.0301861
RTN4 reticulon 4 -0.0301425
RPS12 ribosomal protein S12 -0.0301396
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0301347
CENPF centromere protein F, 350/400kDa -0.0299886
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0298894
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 -0.0298065
SREBF2 sterol regulatory element binding transcription factor 2 -0.0297713
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0295247
BIRC6 baculoviral IAP repeat containing 6 -0.0293853
METTL15 methyltransferase like 15 -0.029369
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.0293284
DYNC2I1 dynein 2 intermediate chain 1 -0.0292086
ARHGAP26 Rho GTPase activating protein 26 -0.0291517
USP3 ubiquitin specific peptidase 3 -0.0288347