Minodronic acid_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 0.124799
TM4SF1 transmembrane 4 L six family member 1 0.105131
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0870558
ERRFI1 ERBB receptor feedback inhibitor 1 0.0819384
CAPRIN2 caprin family member 2 0.0801326
DST dystonin 0.073924
UBC ubiquitin C 0.0687863
MT2A metallothionein 2A 0.0679757
BCAR3 breast cancer anti-estrogen resistance 3 0.0677214
WWTR1 WW domain containing transcription regulator 1 0.0617416
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0529022
CFLAR CASP8 and FADD-like apoptosis regulator 0.0427892
EMP1 epithelial membrane protein 1 0.0420161
MYH9 myosin, heavy chain 9, non-muscle 0.0416209
JUN jun proto-oncogene 0.0406841
EZR ezrin 0.0398412
LOC112694756 uncharaterized LOC112694756 0.0396768
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.038443
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0378679
ANGPTL4 angiopoietin-like 4 0.0369059
SDC4 syndecan 4 0.03622
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0351718
AHNAK AHNAK nucleoprotein 0.0350522
PRELID2 PRELI domain containing 2 0.0349946
EEF2 eukaryotic translation elongation factor 2 0.0349389
BIRC3 baculoviral IAP repeat containing 3 0.0334731
VCL vinculin 0.0332848
FMNL2 formin-like 2 0.0331661
ENO1 enolase 1, (alpha) 0.0327346
EREG epiregulin 0.0327294
TP63 tumor protein p63 0.032453
CD44 CD44 molecule (Indian blood group) 0.0321426
NPAS2 neuronal PAS domain protein 2 0.032072
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0320598
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0313842
HSPA8 heat shock 70kDa protein 8 0.0302979
SQSTM1 sequestosome 1 0.0299564
TMSB4X thymosin beta 4, X-linked 0.0297116
MACF1 microtubule-actin crosslinking factor 1 0.0296894
SPAG9 sperm associated antigen 9 0.0294739
ZSWIM6 zinc finger, SWIM-type containing 6 0.0294116
NT5E 5'-nucleotidase, ecto (CD73) 0.0293894
MT1E metallothionein 1E 0.0284844
PLEC plectin 0.028259
PDE10A phosphodiesterase 10A 0.0282133
RPS27A ribosomal protein S27a 0.0272086
ZBTB38 zinc finger and BTB domain containing 38 0.0269405
SOD2 superoxide dismutase 2, mitochondrial 0.0262409
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0261083
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0257912
KMT2E lysine (K)-specific methyltransferase 2E 0.025692
APLP2 amyloid beta (A4) precursor-like protein 2 0.0255391
TGM2 transglutaminase 2 0.0253693
ADARB1 adenosine deaminase, RNA-specific, B1 0.0252323
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0252283
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.024902
PYGL phosphorylase, glycogen, liver 0.0246027
SVIL supervillin 0.0245859
MT1X metallothionein 1X 0.0237389
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0236007
GCLM glutamate-cysteine ligase, modifier subunit 0.0232236
VMP1 vacuole membrane protein 1 0.0226566
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0224673
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.022311
ACTN1 actinin, alpha 1 0.0212365
APP amyloid beta (A4) precursor protein 0.0212106
MCL1 myeloid cell leukemia 1 0.0210938
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0210719
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0208993
EIF4A1 eukaryotic translation initiation factor 4A1 0.0205206
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0202808
BICD1 bicaudal D homolog 1 (Drosophila) 0.019991
SMAD3 SMAD family member 3 0.0199216
ARHGAP5 Rho GTPase activating protein 5 0.0198732
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.0196363
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0196244
RUNX1 runt-related transcription factor 1 0.019577
WARS1 tryptophanyl-tRNA synthetase 1 0.0195536
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.019359
SDK1 sidekick cell adhesion molecule 1 0.0190793
USP12 ubiquitin specific peptidase 12 0.0188092
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0187501
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0187449
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0187425
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0186916
NIBAN2 niban apoptosis regulator 2 0.0185107
SP100 SP100 nuclear antigen 0.0183386
HOMER1 homer scaffolding protein 1 0.0183274
BIRC2 baculoviral IAP repeat containing 2 0.0181557
PKM pyruvate kinase, muscle 0.0178895
H1-0 H1.0 linker histone 0.0177583
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0175193
S100A6 S100 calcium binding protein A6 0.0174967
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0171883
HPCAL1 hippocalcin-like 1 0.0170782
CXCL8 chemokine (C-X-C motif) ligand 8 0.01701
IL6ST interleukin 6 signal transducer 0.0168687
PRKCE protein kinase C, epsilon 0.0168685
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0168164
NEK10 NIMA-related kinase 10 0.0167691

decreased expression

Symbol Name Standardized Value
DLG1 discs, large homolog 1 (Drosophila) -0.103607
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0688241
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0519261
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0496079
PTMA prothymosin, alpha -0.0417641
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0415544
POTEF POTE ankyrin domain family, member F -0.0337374
EFNA5 ephrin-A5 -0.0334981
EHBP1 EH domain binding protein 1 -0.031789
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0310863
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0310103
EPHA4 EPH receptor A4 -0.0304331
ENO2 enolase 2 (gamma, neuronal) -0.0303084
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0297474
HMGA1 high mobility group AT-hook 1 -0.02921
SLC38A2 solute carrier family 38, member 2 -0.0284763
GOLGA4 golgin A4 -0.0272406
CANX calnexin -0.0270035
CENPF centromere protein F, 350/400kDa -0.0267854
WASF2 WAS protein family, member 2 -0.0261982
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0261463
RPL35A ribosomal protein L35a -0.0260638
CFAP299 cilia and flagella associated protein 299 -0.0256276
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0249247
TMEM123 transmembrane protein 123 -0.0247301
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0235931
GARS1 glycyl-tRNA synthetase 1 -0.0229972
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0220425
VDAC1 voltage-dependent anion channel 1 -0.0214605
RAI1 retinoic acid induced 1 -0.0212996
FTL ferritin, light polypeptide -0.0211505
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0209908
IARS1 isoleucyl-tRNA synthetase 1 -0.0209677
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0203697
LMAN1 lectin, mannose-binding, 1 -0.0201971
AKAP9 A kinase (PRKA) anchor protein 9 -0.0198647
TTC3 tetratricopeptide repeat domain 3 -0.0195033
MAP4 microtubule-associated protein 4 -0.0189884
PDIA3 protein disulfide isomerase family A, member 3 -0.0187993
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0185595
BIRC6 baculoviral IAP repeat containing 6 -0.0183019
MBNL2 muscleblind-like splicing regulator 2 -0.0178894
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0177498
EPB41 erythrocyte membrane protein band 4.1 -0.0177419
THOC2 THO complex 2 -0.0174619
KDM5B lysine (K)-specific demethylase 5B -0.0172693
CD109 CD109 molecule -0.0169741
MYADM myeloid-associated differentiation marker -0.0168583
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0166226
FTH1 ferritin, heavy polypeptide 1 -0.0163697
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0162205
TOP2A topoisomerase (DNA) II alpha 170kDa -0.01583
BRWD1 bromodomain and WD repeat domain containing 1 -0.0157697
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0155047
KPNB1 karyopherin (importin) beta 1 -0.0154776
PTPRF protein tyrosine phosphatase, receptor type, F -0.0149878
LRRC49 leucine rich repeat containing 49 -0.0149527
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0148805
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0148462
EIF1 eukaryotic translation initiation factor 1 -0.0147112
ANKRD28 ankyrin repeat domain 28 -0.0146713
CDK19 cyclin-dependent kinase 19 -0.0146605
MYOF myoferlin -0.0145869
WSB1 WD repeat and SOCS box containing 1 -0.0145246
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.014515
FNBP4 formin binding protein 4 -0.0144621
NDRG1 N-myc downstream regulated 1 -0.014432
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0141452
ANKRD12 ankyrin repeat domain 12 -0.0139741
SPIRE1 spire-type actin nucleation factor 1 -0.0139688
PIAS2 protein inhibitor of activated STAT, 2 -0.0139205
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0138997
DOCK11 dedicator of cytokinesis 11 -0.0138925
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0138527
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0137717
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0136689
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.013619
SYT1 synaptotagmin I -0.0135122
RBM25 RNA binding motif protein 25 -0.0134305
RPL37A ribosomal protein L37a -0.0132724
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.01324
ARHGAP12 Rho GTPase activating protein 12 -0.0132041
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0131683
NUCB2 nucleobindin 2 -0.0131662
FAM162A family with sequence similarity 162, member A -0.0130159
MTDH metadherin -0.0129769
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0128293
PKN2 protein kinase N2 -0.0127019
RPS6 ribosomal protein S6 -0.012434
COL5A2 collagen, type V, alpha 2 -0.0123977
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0123896
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0123804
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0123677
LARS1 leucyl-tRNA synthetase 1 -0.0123061
AMBRA1 autophagy/beclin-1 regulator 1 -0.0122295
WDR43 WD repeat domain 43 -0.0122279
RAD50 RAD50 homolog (S. cerevisiae) -0.0121954
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0121882
UBXN4 UBX domain protein 4 -0.0121472
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0120476