Minodronic acid_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.152973
TXNRD1 thioredoxin reductase 1 0.1301
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.123384
FAM13A family with sequence similarity 13, member A 0.0996384
NDRG1 N-myc downstream regulated 1 0.0822948
THSD4 thrombospondin, type I, domain containing 4 0.0789634
SMAD3 SMAD family member 3 0.0788491
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.07745
LRP1B low density lipoprotein receptor-related protein 1B 0.0748479
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0746337
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0716828
GCLC glutamate-cysteine ligase, catalytic subunit 0.0643872
FNDC3B fibronectin type III domain containing 3B 0.06395
NAMPT nicotinamide phosphoribosyltransferase 0.0636104
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0607041
CES1 carboxylesterase 1 0.0583891
OSMR oncostatin M receptor 0.0562186
LOC112694756 uncharaterized LOC112694756 0.0547451
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.054121
PKM pyruvate kinase, muscle 0.0525872
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0510598
RICTOR RPTOR independent companion of MTOR, complex 2 0.0499633
PDE4D phosphodiesterase 4D, cAMP-specific 0.0468217
ELL2 elongation factor, RNA polymerase II, 2 0.0450455
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0435291
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0421874
MT2A metallothionein 2A 0.0419989
DOCK5 dedicator of cytokinesis 5 0.0375055
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0368766
JMJD1C jumonji domain containing 1C 0.03436
TSC22D2 TSC22 domain family, member 2 0.0343383
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0336749
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0334349
ZNF292 zinc finger protein 292 0.0333749
FTH1 ferritin, heavy polypeptide 1 0.0330644
WDFY3 WD repeat and FYVE domain containing 3 0.032879
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0328573
ZMYND8 zinc finger, MYND-type containing 8 0.0322844
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.031455
IGFBP3 insulin-like growth factor binding protein 3 0.0314253
SIK3 SIK family kinase 3 0.0311813
MCL1 myeloid cell leukemia 1 0.0307758
CEMIP cell migration inducing protein, hyaluronan binding 0.0305547
NGLY1 N-glycanase 1 0.0301471
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0298489
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0298438
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0296618
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.028904
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0287307
PM20D1 peptidase M20 domain containing 1 0.0283128
RNF213 ring finger protein 213 0.0282053
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0275894
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.027305
VEGFC vascular endothelial growth factor C 0.0272796
TNRC6A trinucleotide repeat containing 6A 0.0266936
PDE8A phosphodiesterase 8A 0.0264444
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0262323
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0260738
TPD52 tumor protein D52 0.0259575
ZNF638 zinc finger protein 638 0.0257142
KMT5B lysine methyltransferase 5B 0.0256466
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0255738
PHF21A PHD finger protein 21A 0.0253778
RUNX1 runt-related transcription factor 1 0.0249314
STK24 serine/threonine kinase 24 0.024837
ARRDC3 arrestin domain containing 3 0.0247925
EFNA5 ephrin-A5 0.0246258
SMYD3 SET and MYND domain containing 3 0.0243111
MED13L mediator complex subunit 13-like 0.0242611
ADNP activity-dependent neuroprotector homeobox 0.0242338
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0241907
VMP1 vacuole membrane protein 1 0.0241624
TMEM165 transmembrane protein 165 0.0240948
FOXP1 forkhead box P1 0.0240927
TBC1D22A TBC1 domain family, member 22A 0.023699
RNF145 ring finger protein 145 0.0236649
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0232736
RNF149 ring finger protein 149 0.0231514
ADAM9 ADAM metallopeptidase domain 9 0.0225344
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0223938
HELZ helicase with zinc finger 0.0223084
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0222688
NCKAP1 NCK-associated protein 1 0.0222272
ATP11A ATPase, class VI, type 11A 0.0221502
KYNU kynureninase 0.0219057
EPAS1 endothelial PAS domain protein 1 0.0217743
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0217075
XDH xanthine dehydrogenase 0.0215216
YEATS2 YEATS domain containing 2 0.0213422
PTPRM protein tyrosine phosphatase, receptor type, M 0.0210861
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0209931
STRN3 striatin, calmodulin binding protein 3 0.0208451
CUL4A cullin 4A 0.0208308
UBA6 ubiquitin-like modifier activating enzyme 6 0.0207734
PLEC plectin 0.0205624
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0205308
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0204884
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0203704
KDM2A lysine (K)-specific demethylase 2A 0.0202886
KCMF1 potassium channel modulatory factor 1 0.0202701

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.130139
EGFR epidermal growth factor receptor -0.111205
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0817113
LAMC2 laminin, gamma 2 -0.0673743
INTS6 integrator complex subunit 6 -0.065306
BZW1 basic leucine zipper and W2 domains 1 -0.0618396
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0591346
PTMA prothymosin, alpha -0.0559522
CANX calnexin -0.0558603
ACTG1 actin gamma 1 -0.0531489
TPT1 tumor protein, translationally-controlled 1 -0.0516649
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0478041
CAV1 caveolin 1, caveolae protein, 22kDa -0.0421353
S100A10 S100 calcium binding protein A10 -0.0414563
AHNAK AHNAK nucleoprotein -0.0411661
RPS24 ribosomal protein S24 -0.0404918
NABP1 nucleic acid binding protein 1 -0.0395269
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0378371
KRT18 keratin 18, type I -0.0362904
PDLIM5 PDZ and LIM domain 5 -0.0361991
ANXA2 annexin A2 -0.0357354
SP100 SP100 nuclear antigen -0.035194
NSUN6 NOP2/Sun domain family, member 6 -0.0340651
HOMER1 homer scaffolding protein 1 -0.0334997
SCEL sciellin -0.0330097
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0325386
VCL vinculin -0.0320296
GOLGB1 golgin B1 -0.0314958
DSPP dentin sialophosphoprotein -0.0307899
AGR2 anterior gradient 2 -0.0294231
LMO7 LIM domain 7 -0.0291673
ASPH aspartate beta-hydroxylase -0.0290912
HDLBP high density lipoprotein binding protein -0.0285619
RPS8 ribosomal protein S8 -0.0283659
RPL37A ribosomal protein L37a -0.026982
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0267784
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.026463
TPM4 tropomyosin 4 -0.0262567
FBXO11 F-box protein 11 -0.0261753
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0256859
RPL34 ribosomal protein L34 -0.0255787
GM2A GM2 ganglioside activator -0.025197
RPS3 ribosomal protein S3 -0.024681
SEC61G Sec61 gamma subunit -0.0246523
RPL31 ribosomal protein L31 -0.0236851
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0233588
RPL11 ribosomal protein L11 -0.0230647
TMEM184B transmembrane protein 184B -0.0229728
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0229344
USP53 ubiquitin specific peptidase 53 -0.022549
SENP5 SUMO1/sentrin specific peptidase 5 -0.0223113
RPS25 ribosomal protein S25 -0.0222993
RPL19 ribosomal protein L19 -0.0222674
EIF1 eukaryotic translation initiation factor 1 -0.0221857
RPLP1 ribosomal protein, large, P1 -0.0219016
PATJ PATJ crumbs cell polarity complex component -0.021475
ADAM32 ADAM metallopeptidase domain 32 -0.0212264
KRT86 keratin 86, type II -0.0209557
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0207371
PMM2 phosphomannomutase 2 -0.0206423
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0196082
RSL1D1 ribosomal L1 domain containing 1 -0.019592
SRP72 signal recognition particle 72kDa -0.0193557
GOSR2 golgi SNAP receptor complex member 2 -0.0191956
TRIM56 tripartite motif containing 56 -0.0191668
WNT2B wingless-type MMTV integration site family, member 2B -0.0189927
BLZF1 basic leucine zipper nuclear factor 1 -0.0189821
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0187134
GOLGA3 golgin A3 -0.0186991
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.0186348
RPS27A ribosomal protein S27a -0.0185916
CCND1 cyclin D1 -0.0184939
LAMB3 laminin, beta 3 -0.0182619
RAB1A RAB1A, member RAS oncogene family -0.0181133
AHNAK2 AHNAK nucleoprotein 2 -0.0179724
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0179711
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0179449
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0179254
ARCN1 archain 1 -0.0178928
ATF4 activating transcription factor 4 -0.0176659
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0176186
RPL9 ribosomal protein L9 -0.0176002
MCU mitochondrial calcium uniporter -0.0175981
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.017501
LRRC23 leucine rich repeat containing 23 -0.0174744
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.017326
GNAS GNAS complex locus -0.017195
TRIP11 thyroid hormone receptor interactor 11 -0.0171517
RPLP0 ribosomal protein, large, P0 -0.0170987
EHBP1 EH domain binding protein 1 -0.0170031
IFI6 interferon, alpha-inducible protein 6 -0.0169669
KRT7 keratin 7, type II -0.0167162
RPL35A ribosomal protein L35a -0.0166761
HLA-B major histocompatibility complex, class I, B -0.0166434
HMGA1 high mobility group AT-hook 1 -0.0166105
MRPS35 mitochondrial ribosomal protein S35 -0.016505
CAPN2 calpain 2, (m/II) large subunit -0.0164051
ARF1 ADP-ribosylation factor 1 -0.0161422
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0160129
SPIRE1 spire-type actin nucleation factor 1 -0.0159424