Minodronic acid_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.148177
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.119903
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.113727
AKAP12 A kinase (PRKA) anchor protein 12 0.111479
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0975527
CD44 CD44 molecule (Indian blood group) 0.0896747
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.088672
VIM vimentin 0.0793097
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0673538
HMGA2 high mobility group AT-hook 2 0.0662419
MYH9 myosin, heavy chain 9, non-muscle 0.0638794
GRB10 growth factor receptor-bound protein 10 0.0603043
ANGPTL4 angiopoietin-like 4 0.0600564
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0593149
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0564776
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0551087
TMSB10 thymosin beta 10 0.0536204
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0527344
PSD3 pleckstrin and Sec7 domain containing 3 0.0519098
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0511479
LOXL2 lysyl oxidase-like 2 0.0495513
SMAD3 SMAD family member 3 0.0487027
DST dystonin 0.0474071
AADAC arylacetamide deacetylase 0.0469069
EXT1 exostosin glycosyltransferase 1 0.0460344
SFTPA2 surfactant protein A2 0.044606
SEPTIN9 septin 9 0.0445715
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0439911
TIMP1 TIMP metallopeptidase inhibitor 1 0.0423688
LOX lysyl oxidase 0.042355
PKM pyruvate kinase, muscle 0.041034
CDH13 cadherin 13 0.039689
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0393812
LRMDA leucine rich melanocyte differentiation associated 0.0391813
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0389676
NTN4 netrin 4 0.0387734
MACF1 microtubule-actin crosslinking factor 1 0.0373085
ASPH aspartate beta-hydroxylase 0.0371139
FAM20C family with sequence similarity 20, member C 0.0370386
ENO1 enolase 1, (alpha) 0.0367588
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0364446
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0363288
MYO10 myosin X 0.0362412
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0360777
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0356389
ZSWIM6 zinc finger, SWIM-type containing 6 0.0355672
AHNAK AHNAK nucleoprotein 0.0355061
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0354726
ECE1 endothelin converting enzyme 1 0.0346725
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0343864
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0340199
NAV1 neuron navigator 1 0.0337289
HIPK2 homeodomain interacting protein kinase 2 0.0334849
MAML3 mastermind-like 3 (Drosophila) 0.0327318
RAI14 retinoic acid induced 14 0.0323556
FBN1 fibrillin 1 0.0323541
PLEC plectin 0.0319673
RNF213 ring finger protein 213 0.0318955
MTSS1 metastasis suppressor 1 0.0318344
SQSTM1 sequestosome 1 0.0317375
TGFB1 transforming growth factor, beta 1 0.0315467
TMSB4X thymosin beta 4, X-linked 0.0311174
RAD51B RAD51 paralog B 0.0310917
LDHA lactate dehydrogenase A 0.0307619
NCOR2 nuclear receptor corepressor 2 0.0307425
NDRG1 N-myc downstream regulated 1 0.0304024
SYT1 synaptotagmin I 0.0300765
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0299838
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.029873
ERRFI1 ERBB receptor feedback inhibitor 1 0.0298679
WLS wntless Wnt ligand secretion mediator 0.0296801
PDE4D phosphodiesterase 4D, cAMP-specific 0.0295884
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0295398
GLIS3 GLIS family zinc finger 3 0.0292714
TRIO trio Rho guanine nucleotide exchange factor 0.0292403
PRKCA protein kinase C, alpha 0.0291904
CA12 carbonic anhydrase XII 0.0291029
ATXN1 ataxin 1 0.0287471
APLP2 amyloid beta (A4) precursor-like protein 2 0.0287061
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0285784
B2M beta-2-microglobulin 0.0284832
COL7A1 collagen, type VII, alpha 1 0.027912
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0277106
IFI44L interferon-induced protein 44-like 0.027646
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0274585
SAMD9 sterile alpha motif domain containing 9 0.0272695
PRSS23 protease, serine, 23 0.0271427
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0271379
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0270782
IFI6 interferon, alpha-inducible protein 6 0.0270279
S100A10 S100 calcium binding protein A10 0.0267557
SVIL supervillin 0.0262507
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0256214
INTS6 integrator complex subunit 6 0.0254759
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0248802
SYNJ2 synaptojanin 2 0.0248605
FAM107B family with sequence similarity 107, member B 0.0247761
TPT1 tumor protein, translationally-controlled 1 0.0244495
TNIP1 TNFAIP3 interacting protein 1 0.0241387
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0238057

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.177166
GOLGA4 golgin A4 -0.0786911
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0705409
RBM39 RNA binding motif protein 39 -0.0686627
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0626972
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0515007
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.047399
PCBP2 poly(rC) binding protein 2 -0.0463329
KDM2A lysine (K)-specific demethylase 2A -0.046269
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0455049
NPC1 Niemann-Pick disease, type C1 -0.0376036
KMT2C lysine (K)-specific methyltransferase 2C -0.0372082
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0359705
ZNF292 zinc finger protein 292 -0.0343311
OGA O-GlcNAcase -0.0339902
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0335621
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0323738
COG5 component of oligomeric golgi complex 5 -0.0320491
SRP54 signal recognition particle 54kDa -0.0313058
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0304329
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0296515
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0295787
USP34 ubiquitin specific peptidase 34 -0.029305
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0291927
BIRC6 baculoviral IAP repeat containing 6 -0.0282274
AKAP9 A kinase (PRKA) anchor protein 9 -0.027862
STRN3 striatin, calmodulin binding protein 3 -0.02733
USP3 ubiquitin specific peptidase 3 -0.0270984
RB1CC1 RB1-inducible coiled-coil 1 -0.026877
ITCH itchy E3 ubiquitin protein ligase -0.0267631
OSMR oncostatin M receptor -0.0258994
MON2 MON2 homolog (S. cerevisiae) -0.0256911
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0256744
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.025663
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.024968
FTH1 ferritin, heavy polypeptide 1 -0.024714
PID1 phosphotyrosine interaction domain containing 1 -0.0245612
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0244439
CD109 CD109 molecule -0.024377
UGCG UDP-glucose ceramide glucosyltransferase -0.0242862
NBAS neuroblastoma amplified sequence -0.024211
SEC23A Sec23 homolog A (S. cerevisiae) -0.0239609
RNF145 ring finger protein 145 -0.0235447
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.022545
MIS18BP1 MIS18 binding protein 1 -0.0225255
COPA coatomer protein complex, subunit alpha -0.0217816
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0205367
RUNX2 runt-related transcription factor 2 -0.0205358
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.0204909
ATP13A3 ATPase type 13A3 -0.0204593
SPAG9 sperm associated antigen 9 -0.0204038
PDIA3 protein disulfide isomerase family A, member 3 -0.0202392
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0200702
ACBD3 acyl-CoA binding domain containing 3 -0.0199501
PRRC2C proline-rich coiled-coil 2C -0.0199326
SEC31A SEC31 homolog A (S. cerevisiae) -0.019785
GCC2 GRIP and coiled-coil domain containing 2 -0.0197427
PCNX1 pecanex 1 -0.019672
FBXL13 F-box and leucine-rich repeat protein 13 -0.0195177
FAM13A family with sequence similarity 13, member A -0.0195149
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0193697
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0192907
ZFC3H1 zinc finger, C3H1-type containing -0.0190668
RBM25 RNA binding motif protein 25 -0.0189443
SS18 synovial sarcoma translocation, chromosome 18 -0.0187372
RNF149 ring finger protein 149 -0.0186857
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0186721
LMAN1 lectin, mannose-binding, 1 -0.0186513
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0186143
NIPBL Nipped-B homolog (Drosophila) -0.0185547
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0185166
SETD5 SET domain containing 5 -0.0184624
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0184142
LCORL ligand dependent nuclear receptor corepressor-like -0.018298
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0180875
VRK2 vaccinia related kinase 2 -0.0178985
LRRC49 leucine rich repeat containing 49 -0.0178341
SUCO SUN domain containing ossification factor -0.0178135
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0177461
HELZ helicase with zinc finger -0.0176693
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0175863
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0173292
SEC24A SEC24 family member A -0.0172919
DLG1 discs, large homolog 1 (Drosophila) -0.0171592
CCNL1 cyclin L1 -0.0171511
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0171103
RAP1B RAP1B, member of RAS oncogene family -0.0171065
PNPLA8 patatin-like phospholipase domain containing 8 -0.0168743
CDK17 cyclin-dependent kinase 17 -0.0168622
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0168497
MRPS6 mitochondrial ribosomal protein S6 -0.0168358
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0168061
TBC1D15 TBC1 domain family, member 15 -0.0166055
BLZF1 basic leucine zipper nuclear factor 1 -0.0166023
FAM3C family with sequence similarity 3, member C -0.0165899
POU2F1 POU class 2 homeobox 1 -0.0165468
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0164948
IGFBP3 insulin-like growth factor binding protein 3 -0.0164163
POM121C POM121 transmembrane nucleoporin C -0.0164108
DENND4A DENN/MADD domain containing 4A -0.0163511