Minodronic acid_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Minodronic acid_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0918325
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0774599
GRAMD1B GRAM domain containing 1B 0.0724327
MYH9 myosin, heavy chain 9, non-muscle 0.0557014
TMSB10 thymosin beta 10 0.0511014
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0460672
PDE4D phosphodiesterase 4D, cAMP-specific 0.0459204
TPM3 tropomyosin 3 0.0438036
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0406101
RPL3 ribosomal protein L3 0.0310305
TPI1 triosephosphate isomerase 1 0.0269131
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0268038
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0256139
DST dystonin 0.0254206
LDHA lactate dehydrogenase A 0.0251225
MSN moesin 0.0235391
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0225825
WWOX WW domain containing oxidoreductase 0.0222455
RPS12 ribosomal protein S12 0.0219074
PKM pyruvate kinase, muscle 0.0208978
LOC112694756 uncharaterized LOC112694756 0.0208926
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0207955
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0205584
HYOU1 hypoxia up-regulated 1 0.0204544
PYGL phosphorylase, glycogen, liver 0.0199621
SFTPA2 surfactant protein A2 0.0195195
ASPH aspartate beta-hydroxylase 0.0193219
FAM107B family with sequence similarity 107, member B 0.0190046
VIM vimentin 0.018605
RPS3 ribosomal protein S3 0.0184064
ACTG1 actin gamma 1 0.0182301
PLEC plectin 0.0180111
FTH1 ferritin, heavy polypeptide 1 0.017896
ENO1 enolase 1, (alpha) 0.0177426
NRG1 neuregulin 1 0.0176168
TXNRD1 thioredoxin reductase 1 0.0171442
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0168528
CLU clusterin 0.0167469
ANGPTL4 angiopoietin-like 4 0.0166517
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.016593
APLP2 amyloid beta (A4) precursor-like protein 2 0.0165621
THSD4 thrombospondin, type I, domain containing 4 0.0162698
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0160373
FGB fibrinogen beta chain 0.0159056
EEF2 eukaryotic translation elongation factor 2 0.0158873
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0152001
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0151232
MCL1 myeloid cell leukemia 1 0.0150166
ERRFI1 ERBB receptor feedback inhibitor 1 0.0149865
MKI67 marker of proliferation Ki-67 0.0147403
CALR calreticulin 0.0146618
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0145891
TUBB tubulin, beta class I 0.0145685
RPL35 ribosomal protein L35 0.0141911
BASP1 brain abundant, membrane attached signal protein 1 0.0141625
HSPA8 heat shock 70kDa protein 8 0.0139662
SMOC1 SPARC related modular calcium binding 1 0.0139192
PFN1 profilin 1 0.0136099
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0134718
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0134692
SON SON DNA binding protein 0.0132985
RPL19 ribosomal protein L19 0.0132064
H1-2 H1.2 linker histone, cluster member 0.0131276
RRM2 ribonucleotide reductase M2 0.0128501
PFKP phosphofructokinase, platelet 0.0122759
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.012242
RPS27 ribosomal protein S27 0.0122412
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0122288
EEF1G eukaryotic translation elongation factor 1 gamma 0.0119933
STC1 stanniocalcin 1 0.0119425
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0119219
NUMA1 nuclear mitotic apparatus protein 1 0.011839
FLNB filamin B, beta 0.0116907
PRDX1 peroxiredoxin 1 0.0116269
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0115984
DOCK4 dedicator of cytokinesis 4 0.0114934
TFPI2 tissue factor pathway inhibitor 2 0.0113648
PM20D1 peptidase M20 domain containing 1 0.0111441
FLNA filamin A, alpha 0.0110882
FAT1 FAT atypical cadherin 1 0.011081
RPS15A ribosomal protein S15a 0.0110295
ANXA1 annexin A1 0.0109372
TNIP1 TNFAIP3 interacting protein 1 0.0109133
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0109071
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.010852
RPL37A ribosomal protein L37a 0.010793
EIF4A1 eukaryotic translation initiation factor 4A1 0.0105819
KRT18 keratin 18, type I 0.0105818
IQGAP1 IQ motif containing GTPase activating protein 1 0.0105032
PDIA3 protein disulfide isomerase family A, member 3 0.010501
LAMC2 laminin, gamma 2 0.0104509
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0104325
EZR ezrin 0.0103597
HDGF hepatoma-derived growth factor 0.0103349
MCFD2 multiple coagulation factor deficiency 2 0.0102563
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0101078
LAMB1 laminin, beta 1 0.00997757
TOP2A topoisomerase (DNA) II alpha 170kDa 0.00993743
NNMT nicotinamide N-methyltransferase 0.00993164
H1-4 H1.4 linker histone, cluster member 0.00958596

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.0749616
IGF2 insulin-like growth factor 2 -0.041132
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.033926
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0314782
RBM39 RNA binding motif protein 39 -0.0310717
TPT1 tumor protein, translationally-controlled 1 -0.0306053
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0297729
RPL35A ribosomal protein L35a -0.0289813
EIF1 eukaryotic translation initiation factor 1 -0.0250958
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0250958
FBXO11 F-box protein 11 -0.0246419
ERBIN erbb2 interacting protein -0.0230619
RBM25 RNA binding motif protein 25 -0.0223911
USP34 ubiquitin specific peptidase 34 -0.0206138
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.020358
ZFAND3 zinc finger, AN1-type domain 3 -0.0201559
WDR43 WD repeat domain 43 -0.0192121
DENND4A DENN/MADD domain containing 4A -0.018906
CFLAR CASP8 and FADD-like apoptosis regulator -0.0178015
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0177892
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.017402
ZNF207 zinc finger protein 207 -0.0173978
PTMA prothymosin, alpha -0.0166019
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0165346
KHDC4 KH domain containing 4, pre-mRNA splicing factor -0.0165162
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0163903
MARCHF6 membrane associated ring-CH-type finger 6 -0.0162666
RICTOR RPTOR independent companion of MTOR, complex 2 -0.016105
IER3 immediate early response 3 -0.0160841
RPS25 ribosomal protein S25 -0.0157418
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0156664
KPNB1 karyopherin (importin) beta 1 -0.0156398
COG5 component of oligomeric golgi complex 5 -0.0154236
ANKRD11 ankyrin repeat domain 11 -0.0151888
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0149202
NOP58 NOP58 ribonucleoprotein -0.0147296
FTL ferritin, light polypeptide -0.0145478
RCC1 regulator of chromosome condensation 1 -0.0145307
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0144225
PTK2 protein tyrosine kinase 2 -0.0142661
SLC38A1 solute carrier family 38, member 1 -0.0142592
PCNX4 pecanex 4 -0.0141599
TRA2A transformer 2 alpha homolog (Drosophila) -0.0141562
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0141327
FDPS farnesyl diphosphate synthase -0.0140997
RPL23 ribosomal protein L23 -0.0139145
PUM2 pumilio RNA-binding family member 2 -0.0138899
DSCAM Down syndrome cell adhesion molecule -0.0135412
KDM3A lysine (K)-specific demethylase 3A -0.0134001
RPS24 ribosomal protein S24 -0.0133421
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0132108
SMAD2 SMAD family member 2 -0.0129883
COPA coatomer protein complex, subunit alpha -0.0127048
USP15 ubiquitin specific peptidase 15 -0.0126519
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0125783
UBASH3B ubiquitin associated and SH3 domain containing B -0.0125619
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0123831
TFG TRK-fused gene -0.0123523
RAB1A RAB1A, member RAS oncogene family -0.0122761
PARD3 par-3 family cell polarity regulator -0.0122287
RAB7A RAB7A, member RAS oncogene family -0.0121778
CDK13 cyclin-dependent kinase 13 -0.0121763
MAPK8 mitogen-activated protein kinase 8 -0.0120438
INTS6 integrator complex subunit 6 -0.0120226
CYRIB CYFIP related Rac1 interactor B -0.0118744
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0118347
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0118082
TNRC6B trinucleotide repeat containing 6B -0.0116628
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0116625
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -0.0116256
USP3 ubiquitin specific peptidase 3 -0.0115103
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0114862
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0114249
RPL34 ribosomal protein L34 -0.0113556
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0113278
SREBF2 sterol regulatory element binding transcription factor 2 -0.0113244
NF1 neurofibromin 1 -0.0112731
ASXL1 additional sex combs like transcriptional regulator 1 -0.0111352
STRN3 striatin, calmodulin binding protein 3 -0.0109537
GGNBP2 gametogenetin binding protein 2 -0.010901
VRK2 vaccinia related kinase 2 -0.0108459
FUS FUS RNA binding protein -0.0107724
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0106776
VEZT vezatin, adherens junctions transmembrane protein -0.0105834
FBXL20 F-box and leucine-rich repeat protein 20 -0.0105724
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0105512
BABAM2 BRISC and BRCA1 A complex member 2 -0.0105275
HLA-E major histocompatibility complex, class I, E -0.0105188
GNAS GNAS complex locus -0.0102962
CCNL1 cyclin L1 -0.0102471
SRP54 signal recognition particle 54kDa -0.0101896
GPBP1 GC-rich promoter binding protein 1 -0.0101648
NEMF nuclear export mediator factor -0.0101525
NUMB numb homolog (Drosophila) -0.0100744
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0100337
TMEM87A transmembrane protein 87A -0.00995008
HLA-B major histocompatibility complex, class I, B -0.00978593
PTGES2 prostaglandin E synthase 2 -0.00975764
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.00973734
ANKHD1 ankyrin repeat and KH domain containing 1 -0.00968276