Minodronic acid_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Minodronic acid_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.234659
SAMD4A sterile alpha motif domain containing 4A 0.16039
MYH9 myosin, heavy chain 9, non-muscle 0.11639
EXT1 exostosin glycosyltransferase 1 0.113346
ACTG1 actin gamma 1 0.110575
LPP LIM domain containing preferred translocation partner in lipoma 0.110303
LIMCH1 LIM and calponin homology domains 1 0.103576
EFNA5 ephrin-A5 0.0943034
PLEC plectin 0.0900963
FBXO32 F-box protein 32 0.0798612
TMSB10 thymosin beta 10 0.0793099
LMO7 LIM domain 7 0.0765663
TRIO trio Rho guanine nucleotide exchange factor 0.0761514
LAMC2 laminin, gamma 2 0.071938
TMSB4X thymosin beta 4, X-linked 0.0703818
ZSWIM6 zinc finger, SWIM-type containing 6 0.0700253
SOX4 SRY (sex determining region Y)-box 4 0.0657713
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0657128
PARP14 poly (ADP-ribose) polymerase family, member 14 0.060519
AHNAK AHNAK nucleoprotein 0.0599783
LAMB3 laminin, beta 3 0.0596587
PTMA prothymosin, alpha 0.0596037
DSPP dentin sialophosphoprotein 0.0595943
IFI27 interferon, alpha-inducible protein 27 0.0579907
FTL ferritin, light polypeptide 0.055242
NAV2 neuron navigator 2 0.0525259
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0515215
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0502498
IGFBP3 insulin-like growth factor binding protein 3 0.0474527
MYO1E myosin IE 0.0474511
GOLGB1 golgin B1 0.0474118
RNF213 ring finger protein 213 0.0471743
MACF1 microtubule-actin crosslinking factor 1 0.0470366
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0467997
CTNND1 catenin (cadherin-associated protein), delta 1 0.0465861
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0460377
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0453273
ARHGAP5 Rho GTPase activating protein 5 0.0433196
WSB1 WD repeat and SOCS box containing 1 0.0429168
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0424315
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0421214
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0419455
AKAP13 A kinase (PRKA) anchor protein 13 0.0418615
ERBIN erbb2 interacting protein 0.0410117
VEGFA vascular endothelial growth factor A 0.0406699
APLP2 amyloid beta (A4) precursor-like protein 2 0.0404157
IFI6 interferon, alpha-inducible protein 6 0.0402729
ATXN1 ataxin 1 0.0402409
MYO6 myosin VI 0.0400158
PDLIM5 PDZ and LIM domain 5 0.0391659
UBE2H ubiquitin-conjugating enzyme E2H 0.0389567
PGBD5 piggyBac transposable element derived 5 0.0389279
RAI14 retinoic acid induced 14 0.0379962
SH3KBP1 SH3-domain kinase binding protein 1 0.0376816
LMNA lamin A/C 0.0376588
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0374604
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0373483
AFF1 AF4/FMR2 family, member 1 0.0372527
ZBTB20 zinc finger and BTB domain containing 20 0.0368694
VCL vinculin 0.0368487
SMAD3 SMAD family member 3 0.0367013
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0366754
EIF1 eukaryotic translation initiation factor 1 0.0366439
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0365062
RBM47 RNA binding motif protein 47 0.0364052
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0363966
TXNIP thioredoxin interacting protein 0.0362726
MX1 MX dynamin-like GTPase 1 0.0355746
ETV6 ets variant 6 0.0350752
SDC4 syndecan 4 0.034807
RCOR1 REST corepressor 1 0.0347959
ERRFI1 ERBB receptor feedback inhibitor 1 0.0345167
HLA-B major histocompatibility complex, class I, B 0.0341472
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0340577
BASP1 brain abundant, membrane attached signal protein 1 0.0340328
SVIL supervillin 0.0338224
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.033744
PATJ PATJ crumbs cell polarity complex component 0.0336845
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0335369
FNIP1 folliculin interacting protein 1 0.0334673
MX2 MX dynamin-like GTPase 2 0.032717
CSTB cystatin B (stefin B) 0.0322361
RAD51B RAD51 paralog B 0.0319514
TMEM165 transmembrane protein 165 0.0315176
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0312878
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0311669
CTBP2 C-terminal binding protein 2 0.0308892
BBX bobby sox homolog (Drosophila) 0.030884
AHNAK2 AHNAK nucleoprotein 2 0.0304004
ALCAM activated leukocyte cell adhesion molecule 0.0303364
MACC1 metastasis associated in colon cancer 1 0.0301249
FLNB filamin B, beta 0.0299316
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0297039
MAP1B microtubule-associated protein 1B 0.0296836
ANKRD17 ankyrin repeat domain 17 0.0296228
KDM2A lysine (K)-specific demethylase 2A 0.0293686
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0291301
LOC112694756 uncharaterized LOC112694756 0.0291177
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0290846
IFI16 interferon, gamma-inducible protein 16 0.028421

decreased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F -0.0662445
FN1 fibronectin 1 -0.0638474
HMGA1 high mobility group AT-hook 1 -0.0589809
NAMPT nicotinamide phosphoribosyltransferase -0.055258
CCNL1 cyclin L1 -0.0406727
TFG TRK-fused gene -0.0382707
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0379304
TSC22D2 TSC22 domain family, member 2 -0.0331233
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0321709
RNF145 ring finger protein 145 -0.0315779
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0311773
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0298228
USP3 ubiquitin specific peptidase 3 -0.0296841
GARS1 glycyl-tRNA synthetase 1 -0.0284942
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0275737
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0273219
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0273072
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0267893
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0264109
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0253702
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0239892
NUP58 nucleoporin 58 -0.0235116
MSMO1 methylsterol monooxygenase 1 -0.022927
MARCHF6 membrane associated ring-CH-type finger 6 -0.0228374
QKI QKI, KH domain containing, RNA binding -0.0216807
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0215194
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.020857
AZIN1 antizyme inhibitor 1 -0.0205049
ZNF292 zinc finger protein 292 -0.0204973
RYBP RING1 and YY1 binding protein -0.0201827
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0199462
ADAM9 ADAM metallopeptidase domain 9 -0.0194391
BHLHE40 basic helix-loop-helix family, member e40 -0.0193272
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0192301
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0187878
FOSL1 FOS-like antigen 1 -0.0186941
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0185569
CD46 CD46 molecule, complement regulatory protein -0.0182967
SMC4 structural maintenance of chromosomes 4 -0.0180184
SLC38A1 solute carrier family 38, member 1 -0.0176388
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0172604
ANXA5 annexin A5 -0.0168803
TRA2B transformer 2 beta homolog (Drosophila) -0.016677
PEG10 paternally expressed 10 -0.0161826
WAC WW domain containing adaptor with coiled-coil -0.015674
CD83 CD83 molecule -0.0155773
RHEB Ras homolog enriched in brain -0.015529
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0154281
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0153171
ECT2 epithelial cell transforming 2 -0.0153142
RLF rearranged L-myc fusion -0.0150363
TMEM131L transmembrane 131 like -0.0150271
KMT2E lysine (K)-specific methyltransferase 2E -0.0149814
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0148608
LDHB lactate dehydrogenase B -0.0147298
PRRC1 proline-rich coiled-coil 1 -0.0146681
SSBP2 single-stranded DNA binding protein 2 -0.0145593
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0141975
RYK receptor-like tyrosine kinase -0.014134
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0139694
YBX1 Y box binding protein 1 -0.0139438
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0138542
FAM162A family with sequence similarity 162, member A -0.0138099
WDR43 WD repeat domain 43 -0.0136497
MATR3 matrin 3 -0.0135926
RPL35A ribosomal protein L35a -0.0135921
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0135903
OLA1 Obg-like ATPase 1 -0.0135448
MIS18BP1 MIS18 binding protein 1 -0.0135047
WDR36 WD repeat domain 36 -0.0130939
UGCG UDP-glucose ceramide glucosyltransferase -0.012939
WTAP Wilms tumor 1 associated protein -0.0126883
CDC73 cell division cycle 73 -0.0125352
ATP13A3 ATPase type 13A3 -0.0125109
CDK17 cyclin-dependent kinase 17 -0.0123877
BIRC3 baculoviral IAP repeat containing 3 -0.0121764
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0120009
PCBP2 poly(rC) binding protein 2 -0.0119496
PDS5B PDS5 cohesin associated factor B -0.0119275
NUP54 nucleoporin 54kDa -0.0118637
DENND4A DENN/MADD domain containing 4A -0.011833
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -0.0117977
TUBA1B tubulin, alpha 1b -0.0116043
LRRC1 leucine rich repeat containing 1 -0.0115477
ZBTB10 zinc finger and BTB domain containing 10 -0.0115162
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0114972
U2SURP U2 snRNP-associated SURP domain containing -0.011433
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0113693
NPTN neuroplastin -0.0108271
CHMP2B charged multivesicular body protein 2B -0.0107103
SEPTIN7 septin 7 -0.0107064
ATP5F1B ATP synthase F1 subunit beta -0.0106454
DEK DEK proto-oncogene -0.0106174
MEF2A myocyte enhancer factor 2A -0.0106104
IARS1 isoleucyl-tRNA synthetase 1 -0.0104713
PNISR PNN-interacting serine/arginine-rich protein -0.0103502
AGFG1 ArfGAP with FG repeats 1 -0.0103404
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0103361
FIP1L1 factor interacting with PAPOLA and CPSF1 -0.0102507
FOXJ3 forkhead box J3 -0.0102125