Minodronic acid_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Minodronic acid perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

159 genes differentially expressed following the Minodronic acid_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.123589
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.120749
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.10452
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0974499
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0959339
CDH13 cadherin 13 0.0879234
NDRG1 N-myc downstream regulated 1 0.081726
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.069302
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0692217
SMAD3 SMAD family member 3 0.0630593
PTMA prothymosin, alpha 0.062762
TNIP1 TNFAIP3 interacting protein 1 0.0623143
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.06109
ANLN anillin, actin binding protein 0.0596889
NHSL1 NHS-like 1 0.0577029
MYH9 myosin, heavy chain 9, non-muscle 0.0530778
PDE10A phosphodiesterase 10A 0.0528542
NAV2 neuron navigator 2 0.0513876
MYOF myoferlin 0.0503107
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0458652
PTK2 protein tyrosine kinase 2 0.0441527
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0438298
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0437933
PLEC plectin 0.0436152
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0427159
RPS13 ribosomal protein S13 0.042423
ACTG1 actin gamma 1 0.0420465
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0412378
RPS3 ribosomal protein S3 0.0403077
EIF1 eukaryotic translation initiation factor 1 0.0400825
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0398655
UBE2H ubiquitin-conjugating enzyme E2H 0.0392422
MAML3 mastermind-like 3 (Drosophila) 0.0389282
MSN moesin 0.0388759
TPT1 tumor protein, translationally-controlled 1 0.0371211
DST dystonin 0.0362132
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0359142
FNIP1 folliculin interacting protein 1 0.0331124
TRIO trio Rho guanine nucleotide exchange factor 0.0312199
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0306517
NALF1 NALCN channel auxiliary factor 1 0.0304362
SLMAP sarcolemma associated protein 0.0299705
OXSR1 oxidative stress responsive 1 0.0299468
NLGN1 neuroligin 1 0.0296493
UBA6 ubiquitin-like modifier activating enzyme 6 0.0295109
EGFR epidermal growth factor receptor 0.0288342
MT2A metallothionein 2A 0.0287183
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0281197
DSCAM Down syndrome cell adhesion molecule 0.0269692
RPLP1 ribosomal protein, large, P1 0.0268639
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0267088
SBF2 SET binding factor 2 0.0245976
PSD3 pleckstrin and Sec7 domain containing 3 0.0231678
RCOR1 REST corepressor 1 0.0217421
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0198852
SND1 staphylococcal nuclease and tudor domain containing 1 0.0181961
FNDC3A fibronectin type III domain containing 3A 0.0168011
TTC3 tetratricopeptide repeat domain 3 0.0155913
RPS6 ribosomal protein S6 0.0146459
ENO1 enolase 1, (alpha) 0.0138308
KDM2A lysine (K)-specific demethylase 2A 0.0136896
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0099785
FNDC3B fibronectin type III domain containing 3B 0.00911522
IGFBP3 insulin-like growth factor binding protein 3 0.00790164
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.00687504
SPAG9 sperm associated antigen 9 0.00656579
CANX calnexin 0.00609706
RPL23 ribosomal protein L23 0.00592338
KANSL1 KAT8 regulatory NSL complex subunit 1 0.00563428
FTH1 ferritin, heavy polypeptide 1 0.00276727
B2M beta-2-microglobulin 0.00248317
DOCK4 dedicator of cytokinesis 4 0.00163827
RERE arginine-glutamic acid dipeptide (RE) repeats 2.37216E-5

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.136793
FN1 fibronectin 1 -0.136692
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0778574
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.06999
AKAP13 A kinase (PRKA) anchor protein 13 -0.0649486
EXT1 exostosin glycosyltransferase 1 -0.0622759
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0608427
RTN4 reticulon 4 -0.0604172
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0600141
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0593063
RPL35A ribosomal protein L35a -0.0592629
PRRC2C proline-rich coiled-coil 2C -0.058764
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0583841
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0578489
DTNA dystrobrevin, alpha -0.0577458
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0550207
RAB7A RAB7A, member RAS oncogene family -0.0549109
RYBP RING1 and YY1 binding protein -0.0536921
LMO7 LIM domain 7 -0.0515855
VCL vinculin -0.0515168
RBM39 RNA binding motif protein 39 -0.0510887
HELZ helicase with zinc finger -0.0505494
OGA O-GlcNAcase -0.0501732
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0485169
HMGA2 high mobility group AT-hook 2 -0.0468987
IGF2 insulin-like growth factor 2 -0.0464648
GOLGA4 golgin A4 -0.0446086
KMT2C lysine (K)-specific methyltransferase 2C -0.0436682
MACF1 microtubule-actin crosslinking factor 1 -0.0436171
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.040616
GCC2 GRIP and coiled-coil domain containing 2 -0.0400434
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0395251
ZFAND3 zinc finger, AN1-type domain 3 -0.0379089
EEF2 eukaryotic translation elongation factor 2 -0.0367233
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.036324
EXOC4 exocyst complex component 4 -0.035134
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0344722
TNS3 tensin 3 -0.0334819
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0330456
GPC6 glypican 6 -0.0329571
MED13 mediator complex subunit 13 -0.0322134
FBXO11 F-box protein 11 -0.0321648
ZBTB20 zinc finger and BTB domain containing 20 -0.029708
WSB1 WD repeat and SOCS box containing 1 -0.0296447
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0266543
SMYD3 SET and MYND domain containing 3 -0.0265065
NAMPT nicotinamide phosphoribosyltransferase -0.0264552
MED13L mediator complex subunit 13-like -0.025918
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0259043
ELL2 elongation factor, RNA polymerase II, 2 -0.0248992
FTL ferritin, light polypeptide -0.0247651
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0244232
EFNA5 ephrin-A5 -0.0238203
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0236783
TPM4 tropomyosin 4 -0.02243
PKM pyruvate kinase, muscle -0.0221681
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0217699
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0206639
PGK1 phosphoglycerate kinase 1 -0.0200838
FLNB filamin B, beta -0.0187338
BIRC6 baculoviral IAP repeat containing 6 -0.0178725
NAP1L1 nucleosome assembly protein 1-like 1 -0.0176874
CD44 CD44 molecule (Indian blood group) -0.0157558
CCNI cyclin I -0.0154547
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.015342
JMJD1C jumonji domain containing 1C -0.0141772
FAM13A family with sequence similarity 13, member A -0.0140022
ZNF292 zinc finger protein 292 -0.013591
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0130243
NKD1 naked cuticle homolog 1 (Drosophila) -0.0127059
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0124478
ASPH aspartate beta-hydroxylase -0.01176
TMSB10 thymosin beta 10 -0.0108151
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0106675
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.00930523
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.00921851
USP34 ubiquitin specific peptidase 34 -0.00904988
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.00835727
PDLIM5 PDZ and LIM domain 5 -0.00609371
PRELID2 PRELI domain containing 2 -0.00480581
KMT2E lysine (K)-specific methyltransferase 2E -0.00240251
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.00217003
AKAP12 A kinase (PRKA) anchor protein 12 -0.00210069
VIM vimentin -0.00181487
FMNL2 formin-like 2 -0.00117677
MYO1E myosin IE -2.71136E-4